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ALX-270-150
Revised 05-Oct-06
Vinpocetine
SYNONYMS
Eburnamenine-14-carboxylic acid-ethyl ester
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphodiesterases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-150-M005
5 mg
30.00 USD
ALX-270-150-M025
25 mg
70.00 USD
Product Specification
FORMULA:
C
22
H
26
N
2
O
2
MW:
350.5
CAS NUMBER:
42971-09-5
MERCK INDEX:
14:
9991
RTECS:
JW4792000
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
HARMFUL.
Product Description
Selective inhibitor of Ca
2+
/calmodulin-dependent phosphodiesterase 1 (PDE1).
Product Specific Literature References
Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle:
M. Hagiwara, et al.; Biochem. Pharmacol.
33
, 453 (1984)
Abstract
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta:
H.S. Ahn, et al.; Biochem. Pharmacol.
38
, 3331 (1989)
Abstract
Regulation of cyclic AMP metabolism in bovine adrenal medullary cells:
P.D. Marley & K.A. Thomsom; Biochem. Pharmacol.
44
, 2105 (1992)
Abstract
Cyclic 3',5'-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells:
M. Yamaki, et al.; Am. J. Physiol.
262
, F957 (1992)
Abstract
Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors:
K. Molnar-Kimber, et al.; Agents Actions
39
, C77 (1993)
Abstract
ALX-270-151
Revised 10-May-05
W-5 . hydrochloride
SYNONYMS
N-(6-Aminohexyl)-1-naphthalenesulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-151-M005
5 mg
20.00 USD
ALX-270-151-M025
25 mg
60.00 USD
Product Specification
FORMULA:
C
16
H
22
N
2
O
2
S . HCl
MW:
306.4 . 36.5
CAS NUMBER:
61714-25-8
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in water, DMSO, 100% ethanol (hot) or methanol (hot).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years when stored at -20°C. Stock solutions are stable for up to 6 months when stored at +4°C.
HANDLING:
Protect from light.
Product Description
Antagonist of calmodulin, inhibiting Ca
2+
/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
Hydrophobic regions function in calmodulin-enzyme(s) interactions:
T. Tanaka & H. Hidaka; J. Biol. Chem.
255
, 11078 (1980)
Abstract
;
Full Text
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation:
H. Hidaka, et al.; PNAS
78
, 4354 (1981)
Abstract
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]:
H. Hidaka; Prot. Nucl. Acid Enz.
26
, 977 (1981)
Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
•
Myosin Light Chain Kinase Inhibitors
ALX-270-152
Revised 04-Apr-03
W-5 Analog . hydrochloride
SYNONYMS
N-(5-Aminopentyl)-1-naphthalenesulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-152-M001
1 mg
30.00 USD
ALX-270-152-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
15
H
20
N
2
O
2
S . HCl
MW:
292.4 . 36.5
PURITY:
≥98%
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Antagonist of calmodulin.
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation:
H. Hidaka, et al.; PNAS
78
, 4354 (1981)
Abstract
ALX-270-153
Revised 29-Feb-08
W-7 . hydrochloride
SYNONYMS
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-153-M005
5 mg
20.00 USD
ALX-270-153-M025
25 mg
60.00 USD
Product Specification
FORMULA:
C
16
H
21
ClN
2
O
2
S . HCl
MW:
340.9 . 36.5
CAS NUMBER:
61714-27-0
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (warm), methanol, 100% ethanol (warm), DMSO, dimethyl formamide or ethylene glycol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by H-NMR.
Product Description
Antagonist of calmodulin, inhibiting activation of Ca
2+
/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation:
H. Hidaka, et al.; PNAS
78
, 4354 (1981)
Abstract
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives:
H. Hidaka, et al.; Mol. Pharmacol.
20
, 571 (1981)
Abstract
Calmodulin antagonists enhance calcium binding to calmodulin:
M. Inagaki, et al.; Pharmacology
27
, 125 (1983)
Abstract
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase:
H. Itoh & H. Hidaka; J. Biochem.
96
, 1721 (1984)
Abstract
Related Products
ALX-270-175
W-7 Isomer . hydrochloride
Further Categories Containing This Product:
Phosphodiesterases / Related Products
•
Myosin Light Chain Kinase Inhibitors
ALX-270-155
Revised 04-Mar-05
W-12 . hydrochloride
SYNONYMS
N-(4-Aminobutyl)-2-naphthalenesulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-155-M005
5 mg
40.00 USD
ALX-270-155-M025
25 mg
160.00 USD
Product Specification
FORMULA:
C
14
H
18
N
2
O
2
S . HCl
MW:
278.4 . 36.5
CAS NUMBER:
89108-46-3
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in 100% ethanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Antagonist of calmodulin, inhibiting activation of Ca
2+
/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
T. Tanaka and H. Hidaka; J. Biol. Chem.
255
, 11078 (1980)
Abstract
;
Full Text
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]:
H. Hidaka; Prot. Nucl. Acid Enz.
26
, 977 (1981)
Abstract
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation:
H. Hidaka, et al.; PNAS
78
, 4354 (1981)
Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
•
Myosin Light Chain Kinase Inhibitors
ALX-270-156
Revised 20-Feb-07
W-13 . hydrochloride
SYNONYMS
N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-156-M005
5 mg
60.00 USD
ALX-270-156-M025
25 mg
240.00 USD
Product Specification
FORMULA:
C
14
H
17
ClN
2
O
2
S . HCl
MW:
312.8 . 36.5
CAS NUMBER:
88519-57-7
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (warm) or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Antagonist of calmodulin, inhibiting activation of Ca
2+
/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
Hydrophobic regions function in calmodulin-enzyme(s) interactions:
T. Tanaka & H. Hidaka; J. Biol. Chem.
255
, 11078 (1980)
Abstract
;
Full Text
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]:
H. Hidaka; Prot. Nucl. Acid Enz.
26
, 977 (1981)
Abstract
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives:
H. Hidaka, et al.; Mol. Pharmacol.
20
, 571 (1981)
Abstract
Naphthalenesulfonamides as calmodulin antagonists:
H. Hidaka & T. Tanaka; Meth. Enzymol.
102
, 185 (1983)
Abstract
Calmodulin antagonists enhance calcium binding to calmodulin:
M. Inagaki, et al.; Pharmacology
27
, 125 (1983)
Abstract
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase:
H. Itoh & H. Hidaka; J. Biochem.
96
, 1721 (1984)
Abstract
Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13:
J.S. Stroble & V.A. Peterson; J. Pharm. Exp. Ther.
263
, 186 (1992)
Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
•
Myosin Light Chain Kinase Inhibitors
ALX-270-158
Revised 09-Nov-07
W-13 Isomer, Decyl Analog . hydrochloride
SYNONYMS
N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-158-M005
5 mg
30.00 USD
ALX-270-158-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
20
H
29
ClN
2
O
2
S . HCl
MW:
397.0 . 36.5
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol or DMSO; almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Most potent isomer of the naphthalenesulfonamide family of calmodulin inhibitors.
Product Specific Literature References
Naphthalenesulfonamides as calmodulin antagonists:
H. Hidaka & T. Tanaka; Meth. Enzymol.
102
, 185 (1983)
Abstract
ALX-270-161
Revised 26-Nov-04
W-5 Isomer . hydrochloride
SYNONYMS
N-(6-Aminohexyl)-2-naphthalenesulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-161-M001
1 mg
30.00 USD
ALX-270-161-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
16
H
22
N
2
O
2
S . HCl
MW:
306.4 . 36.5
PURITY:
≥98%
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Isomer of W-5 (Prod. No.
ALX-270-151
).
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation:
H. Hidaka, et al.; PNAS
78
, 4354 (1981)
Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors
•
Phosphodiesterases / Related Products
ALX-270-166
Revised 11-Dec-04
Tyrphostin AG 10
SYNONYMS
Tyrphostin A8
4-Hydroxybenzylidenemalononitrile
α-Cyano-(4-hydroxy)-cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-166-M005
5 mg
35.00 USD
ALX-270-166-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
10
H
6
N
2
O
MW:
170.2
CAS NUMBER:
3785-90-8
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrosine phosphorylation is an obligatory event in IL-2 secretion [published erratum appears in J Immunol 1991 May 1;146(9):3260]:
J.B. Stanley, et al.; J. Immunol.
145
, 2189 (1990)
Abstract
Inhibition of GTP-utilizing enzymes by tyrphostins:
G. Wolbring, et al.; J. Biol. Chem.
269
, 22470 (1994)
Abstract
;
Full Text
ALX-270-167
Revised 16-Jun-06
Tyrphostin ST 638
SYNONYMS
α-Cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-167-M001
1 mg
45.00 USD
ALX-270-167-M005
5 mg
170.00 USD
Product Specification
FORMULA:
C
19
H
18
N
2
O
3
S
MW:
354.4
CAS NUMBER:
107761-24-0
PURITY:
≥98%
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
