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Items 46 of 46
ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • NAALADase / Related Products • Peptides
 
 
ALX-550-017 Revised 17-Jan-05
cis-ACPD
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SYNONYMS (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-017-M005   5 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 39026-63-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1S,3S)-ACPD
(1R,3R)-ACPD
Product Description
Potent NMDA agonist. Equimolar mixture of (1R,3R)-ACPD (Prod. No. ALX-550-018) and (1S,3S)-ACPD (Prod. No. ALX-550-019).
Product Specific Literature References
Receptors for the excitatory amino acids in the mammalian central nervous system: H. McLennan; Prog. Neurobiol. 20, 251 (1983) Abstract
Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes: H.J. Olverman, et al.; Neuroscience 26, 17 (1988) Abstract
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects: D.D. Schoepp, et al.; J. Neurochem. 56, 1789 (1991) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids
 
 
ALX-550-018 Revised 03-Mar-05
(1R,3R)-ACPD
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SYNONYMS (1R,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-018-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 111900-33-5
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

(1R,3R)-ACPD
Product Description
Active isomer of cis-ACPD (Prod. No. ALX-550-017). Potent and specific NMDA receptor agonist.
Product Specific Literature References
Receptors for the excitatory amino acids in the mammalian central nervous system: H. McLennan; Prog. Neurobiol. 20, 251 (1983) Abstract
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid: K. Curry, et al.; J. Med. Chem. 31, 864 (1988) Abstract
Differences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover: R. Mistry & R.A. Challiss; Br. J. Pharmacol. 117, 1735 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids
 
 
ALX-550-001 Revised 20-Jun-07
Agmatine . sulfate
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SYNONYMS 1-Amino-4-guanidinobutane . sulfate
4-(Aminobutyl)guanidine . sulfate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Imidazoline Binding Site Ligands
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ALX-550-001-M100   100 mg 22.00 USD Add To Cart
ALX-550-001-M500   500 mg 44.00 USD Add To Cart
Product Specification
FORMULA: C5H14N4 . H2SO4
MW: 130.2 . 98.1
CAS NUMBER: 2482-00-0
MERCK INDEX: 14: 188
PURITY: ≥97%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Decarboxylation product of L-arginine. Endogenous clonidine-displacing substance in the brain. Putative endogenous neurotransmitter at imidazoline receptors. Antagonist of NMDA receptor. Endogenous inhibitor of nitric oxide synthase (NOS). Antiproliferative by its suppresive effect on polyamine.
Product Specific Literature References
Agmatine: an endogenous clonidine-displacing substance in the brain: G. Li, et al.; Science 263, 966 (1994) Abstract
Selective inhibition of inducible nitric oxide synthase by agmatine: M. Auguet, et al.; Jpn. J. Pharmacol. 69, 285 (1995) Abstract
Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine: E. Galea, et al.; Biochem. J. 316, 247 (1996) Abstract; Full Text
An emerging role for agmatine: J. Satriano, et al.; Kidney Int. 56, 1252 (1999), (Review) Abstract
Is agmatine a novel neurotransmitter in brain?: D.J. Reis & S. Regunathan; Trends Pharmacol. Sci. 21, 187 (2000) Abstract
Agmatine suppresses nitric oxide production in microglia: K. Abe, et al.; Brain Res. 872, 141 (2000) Abstract
Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme: D.R. Demady, et al.; Mol. Pharmacol. 59, 24 (2001) Abstract; Full Text
Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes: S. Regunathan & J.E. Piletz; Ann. N. Y. Acad. Sci. 1009, 20 (2003) Abstract
Agmatine: at the crossroads of the arginine pathways: J. Satriano; Ann. N. Y. Acad. Sci. 1009, 34 (2003), (Review) Abstract
Agmatine signaling: odds and threads: R. Berkels, et al.; Cardiovasc. Drug Rev. 22, 7 (2004), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • NOS Inhibitors (NOS Induction & Enzyme Activity)
 
 
ALX-550-013 Revised 07-May-03
1-Aminocyclobutane-cis-1,3-dicarboxylic acid
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SYNONYMS cis-ACBD
cis-2,4-Methanoglutamic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-013-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C6H9NO4
MW: 159.1
CAS NUMBER: 117488-23-0
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
HANDLING: Protect from light.

Product Description
Very potent and selective NMDA receptor agonist.
Product Specific Literature References
Cis-2,4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist: T.H. Lanthorn, et al.; Eur. J. Pharmacol. 182, 397 (1990) Abstract
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids: R.D. Allan, et al.; J. Med. Chem. 33, 2905 (1990) Abstract
Inhibition of high affinity L-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid: E.J. Fletcher, et al.; Neurosci. Lett. 121, 133 (1991) Abstract
 
 
ALX-550-073 Revised 16-Dec-04
1-Aminocyclobutane-trans-1,3-dicarboxylic acid
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SYNONYMS trans-ACBD
trans-2,4-Methanoglutamic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-073-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C6H9NO4
MW: 159.1
CAS NUMBER: 73550-55-7
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent and selective inhibitor of glutamate uptake.
Product Specific Literature References
Cis-2,4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist: T.H. Lanthorn, et al.; Eur. J. Pharmacol. 182, 397 (1990) Abstract
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids: R.D. Allan, et al.; J. Med. Chem. 33, 2905 (1990) Abstract
Inhibition of high affinity L-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid: E.J. Fletcher, et al.; Neurosci. Lett. 121, 133 (1991) Abstract
 
 
ALX-550-014 Revised 29-Nov-04
1-Aminocyclopentanecarboxylic acid
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SYNONYMS ACPC
Cycloleucine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-014-M010   10 mg 17.00 USD Add To Cart
Product Specification
FORMULA: C6H11NO2
MW: 129.2
CAS NUMBER: 52-52-8
MERCK INDEX: 14: 2734
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
NMDA receptor antagonist acting at the glycine site.
Product Specific Literature References
1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor: W.F. Hood, et al.; Eur. J. Pharmacol. 161, 281 (1989) Abstract
 
 
ALX-550-211 Revised 29-Nov-04
1-Aminocyclopropanecarboxylic acid
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SYNONYMS ACPC
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-211-M050   50 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C4H7NO2
MW: 101.1
CAS NUMBER: 22059-21-8
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Hygroscopic.

Product Description
NMDA receptor partial agonist acting at the glycine site.
Product Specific Literature References
1-Aminocyclopropane-1-carboxylic acid (ACC) mimics the effects of glycine on the NMDA receptor ion channel: V. Nadler, et al.; Eur. J. Pharmacol. 157, 115 (1988) Abstract
[3H]1-aminocyclopropanecarboxylic acid, a novel probe for strychnine- insensitive glycine receptors: P. Popik, et al.; Eur. J. Pharmacol. 291, 221 (1995) Abstract
Effect of 1-aminocyclopropanecarboxylic acid on N-methyl-D-aspartate- stimulated [3H]-noradrenaline release in rat hippocampal synaptosomes: M.V. Clos, et al.; Br. J. Pharmacol. 118, 901 (1996) Abstract
 
 
ALX-270-121 Revised 01-Dec-04
N-(3-Aminopropyl)cyclohexylamine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-270-121-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C9H20N2
MW: 156.3
CAS NUMBER: 3312-60-5
PURITY: ≥97% (contains traces of water)
APPEARANCE: Pale yellow clear liquid. d = 0.920.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Competitive inhibitor of spermine and spermidine synthases.
Product Specific Literature References
Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors: A. Shirahata, et al.; Biochem. Pharmacol. 41, 205 (1991) Abstract
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo: P.J. Chu, et al.; Eur. J. Pharmacol. 256, 155 (1994) Abstract
 
 
ALX-550-037 Revised 17-Jan-05
DL-AP3
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SYNONYMS DL-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-037-M050   50 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C3H8NO5P
MW: 169.1
CAS NUMBER: 20263-06-3
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.

Product Description
NMDA receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase: J.E. Hawkinson, et al.; Eur. J. Pharmacol. 307, 219 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-025 Revised 07-May-03
DL-AP4
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SYNONYMS DL-2-Amino-4-phosphonobutanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-025-M050   50 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C4H10NO5P
MW: 183.1
CAS NUMBER: 20263-07-4
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.