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Adaptor Proteins & Interaction Domains / Related Products
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ALX-804-561 Revised 29-Nov-04
Monoclonal Antibody to Lck-interacting Molecule (human) (LIME-10)
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SYNONYMS anti-LIME (human) MAb (LIME-10)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-561-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: LIME-10
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml.
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 281-296 of human LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes human LIME.
APPLICATION: Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling: N. Brdickova, et al.; J. Exp. Med. 198, 1453 (2003) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Monoclonal Antibodies
 
 
ALX-804-560 Revised 30-May-05
Monoclonal Antibody to Lck-interacting Molecule (human) (LIME-06)
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SYNONYMS anti-LIME (human) MAb (LIME-06)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
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ALX-804-560-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: LIME-06
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE).
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant intracellular fragment corresponding to aa 141-295 of human LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes human LIME.
APPLICATION: Immunoprecipitation
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling: N. Brdickova, et al.; J. Exp. Med. 198, 1453 (2003) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Monoclonal Antibodies
 
 
ALX-804-863 Revised 29-Jan-08
Monoclonal Antibody to MDA5 (human) (Hely-1)
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SYNONYMS anti-Melanoma Differentiation-associated Gene 5 (human) MAb (Hely-1)
anti-Helicard (human) MAb (Hely-1)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases / Related Products
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ALX-804-863-C100   100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Hely-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555).
SPECIFICITY: Recognizes human MDA5.
APPLICATION: ELISA
Immunoprecipitation (1:100)
Western Blot (1:1‘000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002) Abstract
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses: H. Kato, et al.; Nature 441, 101 (2006) Abstract
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Further Categories Containing This Product:
Antiviral Signalling / Related Products • NF-kB Pathway Other Products • Caspase Recruitment Domain [CARD] Proteins / Related Products • Interferons & Interferon Receptors Other Products • Monoclonal Antibodies
 
 
ALX-804-803 Revised 26-Oct-07
Monoclonal Antibody to NALP1 (human) (Nalpy1-4)
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SYNONYMS anti-NACHT-, LRR- and PYD-containing Protein 1 (human) MAb (Nalpy1-4)
anti-DEFCAP (human) MAb (Nalpy1-4)
anti-NAC (human) MAb (Nalpy1-4)
anti-CARD7 (human) MAb (Nalpy1-4)
anti-Caspase Recruitment Domain-containing Protein 7 (human) MAb (Nalpy1-4)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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ALX-804-803-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Nalpy1-4
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human NALP1 (NACHT-, LRR- and PYD-containing protein 1) (pyrin domain).
SPECIFICITY: Recognizes the pyrin domain (PYD) of human NALP1. Does not cross-react with mouse NALP1.
APPLICATION: Immunocytochemistry (1:1'000)
Immunohistochemistry (frozen sections, paraffin sections (microwave treatment))
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL: For Positive Control (Western blot) see Prod. No. ALX-840-603.
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Product Specific Literature References
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response: J.A. Kummer, et al.; J. Histochem. Cytochem. 55, 443 (2007) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products • Monoclonal Antibodies
 
 
ALX-803-307 Revised 28-Jul-08
Monoclonal Antibody to Nod2 (human) (2D9)
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SYNONYMS anti-CARD15 (human) MAb (2D9)
anti-Caspase Recruitment Domain-containing Protein 15 (human) MAb (2D9)
anti-Ibd1 (human) MAb (2D9)
anti-Inflammatory Bowel Disease Protein 1 (human) PAb (2D9)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Nod-complex / Related Products
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ALX-803-307-1   1 Vial 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 2D9
ISOTYPE: Mouse IgG1κ
CONCENTRATION: 1mg/ml
PURITY DETAIL: Affinity-purified.
FORMULATION: Liquid. In 200μl PBS, pH 7.2, containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human Nod2 (CARD15) (aa 28-301).
SPECIFICITY: Recognizes human Nod2.
APPLICATION: Immunohistochemistry (2µg/ml)
Immunoprecipitation
Western Blot (transfected cells: 1:100 - 1:250)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least one year after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Literature References
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB: J. Bertin, et al.; J. Biol. Chem. 274, 12955 (1999) Abstract
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB: N. Inohara, et al. ; J. Biol. Chem. 274, 14560 (1999) Abstract
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways  : N. Inohara, et al. ; J. Biol. Chem. 275, 27823 (2000) Abstract
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB: Y. Ogura, et al.; J. Biol. Chem. 276, 4812 (2001) Abstract
Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation: O. Gutierrez, et al. ; J. Biol. Chem. 277, 41701 (2001) Abstract
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease: Y. Ogura, et al. ; Nature 411, 603 (2001) Abstract
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease: J.P. Hugot, et al. ; Nature 411, 599 (2001) Abstract
Human Nod1 confers responsiveness to bacterial lipopolysaccharides  : N. Inohara, et al. ; J. Biol. Chem. 276, 2551 (2001) Abstract
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis: Y. Ogura, et al. ; Gut 52, 1591 (2003) Abstract
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products • Monoclonal Antibodies
 
 
ALX-803-300 Revised 31-Oct-06
Monoclonal Antibody to p130Cas (1H9)
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SYNONYMS anti-CRK-associated Substrate MAb (1H9)
anti-CRKAS MAb (1H9)
anti-Breast Cancer anti-estrogen Resistance 1 Protein MAb (1H9)
anti-BCAR1 MAb (1H9)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adaptor Proteins & Interaction Domains Other Products
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ALX-803-300-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 1H9
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.2mg/ml
PURITY: Liquid. In PBS containing 0.05% sodium azide.
PURITY DETAIL: Protein A-affinity purified.
IMMUNOGEN: Recombinant mouse p130Cas (CRK-associated substrate; BCAR1) C-terminal portion (aa 375-630).
SPECIFICITY: Recognizes human, mouse and rat p130Cas.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry (frozen section, paraffin sections)
Immunoprecipitation (5µl per 5x106 cells)
Western Blot (1:20’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells: S. Cabodi, et al.; J. Cell Sci. 117, 1603 (2004) Abstract
Further Categories Containing This Product:
Cancer Other Products • Tyrosine Kinases Other Products • Monoclonal Antibodies
 
 
ALX-804-478 Revised 21-May-08
Monoclonal Antibody to PAG/Cbp (PAG-C1)
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SYNONYMS anti-Phosphoprotein Associated with GEMS MAb (PAG-C1)
anti-Csk-binding Protein MAb (PAG-C1)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-478-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: PAG-C1
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to C-terminal (last 15 aa) human PAG/Cbp (phosphoprotein associated with GEMS/Csk-binding protein).
SPECIFICITY: Recognizes human, mouse, rat and bovine PAG/Cbp.
APPLICATION: Immunoprecipitation
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-437 Revised 13-Feb-07
Monoclonal Antibody to PAG/Cbp (human) (MEM-255)
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SYNONYMS anti-Phosphoprotein Associated with GEMS (human) MAb (MEM-255)
anti-Csk-binding Protein (human) MAb (MEM-255)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
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ALX-804-437-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MEM-255
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant human PAG/Cbp (phosphoprotein associated with GEMS/Csk-binding protein) intracellular domain (aa 97-432).
SPECIFICITY: Recognizes human PAG/Cbp. Does not cross-react with mouse, rat and bovine PAG/Cbp. Detects a band of ~80kDa by Western blot (see below).
APPLICATION: Flow Cytometry (Intracellular staining, permeabilization required (2µg/ml))
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation: T. Brdicka, et al.; J. Exp. Med. 191, 1591 (2000) Abstract; Full Text
Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton: N. Brdickova, et al.; FEBS Lett. 507, 133 (2001) Abstract; Full Text
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts: K.M. Torgersen, et al.; J. Biol. Chem. 276, 29313 (2001) Abstract; Full Text
Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling: T. Vang, et al.; J. Biol. Chem. 278, 17597 (2003) Abstract; Full Text
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor: D. Davidson, et al.; Mol. Cell Biol. 23, 2017 (2003) Abstract
Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes: M. Baumgartner, et al.; Blood 101, 1874 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Note: PAG/Cbp is an ubiquitously expressed ~46kDa transmembrane adapter protein present in microdomains (rafts), which however migrates on SDS-PAGE gels anomalously as an ~80kDa molecule.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-837 Revised 06-Nov-07
Monoclonal Antibody to PIDD (Anto-1)
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SYNONYMS anti-PIDD MAb (Anto-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Adaptor Proteins for Death Receptors Other Products
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ALX-804-837-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Anto-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human PIDD death domain (aa 776-910).
SPECIFICITY: Recognizes human and mouse PIDD. Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot.
APPLICATION: Immunohistochemistry (paraffin sections)
Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway: A. Tinel, et al.; EMBO J. 26, 197 (2007) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
PIDD mediates NF-kappaB activation in response to DNA damage: S. Janssens, et al.; Cell