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Glutamate Receptors (Metabotropic) / Related Products
You are here: Product Lines > Neurobiology > Excitatory Amino Acids & Receptors > Glutamate Receptors (Metabotropic) / Related Products
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ALX-106-024 Revised 14-Oct-08
O-Phospho-L-serine
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SYNONYMS L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-106-024-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C3H8NO6P
MW: 185.1
CAS NUMBER: 407-41-0
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Store tightly sealed. Use fresh solutions.

Product Description
L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor.
Product Specific Literature References
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes: W.E. Klunk, et al.; J. Neurochem. 56, 1997 (1991) Abstract
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor: C. Thomsen & P.D. Suzdak; Neuroreport 4, 1099 (1993) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis: K. Borodezt & S.R. D'Mello; J. Neurosci. Res. 53, 531 (1998) Abstract
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-550-377 Revised 29-Jan-05
(RS)-PPG
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SYNONYMS (RS)-Phosphonophenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-377-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C8H10NO5P
MW: 231.1
CAS NUMBER: 120667-15-4
PURITY: ≥95%
SOLUBILITY: Soluble in diluted NaOH.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent and selective group III mGluR agonist, with a subtype specificity towards the mGlu3 receptor.
Product Specific Literature References
Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists [published erratum appears in J. Med. Chem. 32, 2583 (1989)]: C.F. Bigge, et al.; J. Med. Chem. 32, 1580 (1989) Abstract
Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor antagonist: P.J. Flor; Soc. Neurosci. Abstr. 24, 431.11 (1998)
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999) Abstract
 
 
ALX-550-059 Revised 23-May-06
L-Quisqualic acid
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-059-M005   5 mg 70.00 USD Add To Cart
ALX-550-059-M025   25 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C5H7N3O5
MW: 189.1
CAS NUMBER: 52809-07-1
MERCK INDEX: 14: 8085
PURITY: ≥99% (free from glutamate)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent group I mGluR agonist and quis-qualate/AMPA ionotropic receptor agonist. Sensitizes neurons in hippocampus to depo-larization by L-AP6 (“quis” effect).
Product Specific Literature References
The action of natural and synthetic isomers of quisqualic acid at a well-defined glutamatergic synapse: P. Boden, et al.; Brain Res. 385, 205 (1986) Abstract
Metabotropic glutamate receptors in brain function and pathology: D.D. Schoepp and P.J. Conn; TIPS 14, 13 (1993), (Review) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
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AMPA Receptors / Related Products
 
 
ALX-550-367 Revised 06-Mar-03
SIB-1893
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SYNONYMS (E)-2-Methyl-6-(2-phenylethyl)-pyridine
(E)-2-Methyl-6-styryl-pyridine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-367-M005   5 mg 75.00 USD Add To Cart
ALX-550-367-M025   25 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C14H13N
MW: 195.3
CAS NUMBER: 6266-99-5
PURITY: ≥96%
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Selective, noncompetitive antagonist for the mGlu5 receptor. Crosses the blood-brain barrier.
Product Specific Literature References
SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5: M.A. Varney, et al.; J. Pharmacol. Exp. Ther. 290, 170 (1999) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999) Abstract
 
 
ALX-550-378 Revised 13-Jun-03
XE-CCG-I
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SYNONYMS UPF 711
(2S,1'S,2'S,3'R)-2-(2'-Carboxy-3'-(2-xanthylethyl)-cyclopropyl)glycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-378-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C21H21NO5
MW: 367.4
PURITY: ≥95%
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective and highly active group II mGluR antagonist with a subtype specificity towards the mGlu3 receptor. No activity towards group I and group III mGluRs.
Product Specific Literature References
Metabotropic glutamate receptors: new ligands and molecular modeling studies: R. Pellicciari, et al.; Neuropharmacology 38, A34 (1999)
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999) Abstract
 
 
ALX-550-525 Revised 13-Sep-07
ZJ-43
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY NAALADase / Related Products
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ALX-550-525-M002   2 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C12H20N2O7
MW: 304.3
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, methanol, 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Potent inhibitor of N- acetylaspartylglutamate (NAAG) peptidases, glutamate carboxypeptidase II (NAALADase I) (Ki=0.8nm) and glutamate carboxypeptidase III  (NAALADase II) (Ki=23nm). Group II metabotropic glutamate receptor (mGluR) agonist.
Product Specific Literature References
NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR: R.T. Olszewski, et al.; J. Neurochem. 89, 876 (2004) Abstract
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat: C. Zhong, et al.; J. Neurochem. 97, 1015 (2006) Abstract
Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats: T. Yamamoto, et al.; Eur. J. Neurosci. 25, 147 (2007) Abstract
Further Categories Containing This Product:
Neurodegenerative Diseases Other Products • Glutamate Receptors (Metabotropic) / Related Products
 
 
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