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ALX-550-036
Revised 17-Jan-05
D-AP3
SYNONYMS
D(-)-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-036-M005
5 mg
75.00 USD
Product Specification
FORMULA:
C
3
H
8
NO
5
P
MW:
169.1
CAS NUMBER:
128241-72-5
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Specific Literature References
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons:
A.J. Irving, et al.; Eur. J. Pharmacol.
186
, 363 (1990)
Abstract
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid:
D.D. Schoepp, et al.; Mol. Pharmacol.
38
, 222 (1990)
Abstract
Metabotropic glutamate receptors in brain function and pathology:
D.D. Schoepp & P.J. Conn; TIPS
14
, 13 (1993), (Review)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-550-038
Revised 17-Jan-05
L-AP3
SYNONYMS
L(+)-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-038-M005
5 mg
55.00 USD
ALX-550-038-M025
25 mg
220.00 USD
Product Specification
FORMULA:
C
3
H
8
NO
5
P
MW:
169.1
CAS NUMBER:
23052-80-4
PURITY:
≥97%
APPEARANCE:
White hygroscopic solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Selective antagonist of the PI-linked metabotropic glutamate response.
Product Specific Literature References
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons:
A.J. Irving, et al.; Eur. J. Pharmacol.
186
, 363 (1990)
Abstract
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid:
D.D. Schoepp, et al.; Mol. Pharmacol.
38
, 222 (1990)
Abstract
Metabotropic glutamate receptors in brain function and pathology:
D.D. Schoepp & P.J. Conn; TIPS
14
, 13 (1993), (Review)
Abstract
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation:
J.J. O'Connor, et al.; Nature
367
, 557 (1994)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-550-037
Revised 17-Jan-05
DL-AP3
SYNONYMS
DL-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-037-M050
50 mg
30.00 USD
Product Specification
FORMULA:
C
3
H
8
NO
5
P
MW:
169.1
CAS NUMBER:
20263-06-3
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Hygroscopic.
Product Description
NMDA receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase:
J.E. Hawkinson, et al.; Eur. J. Pharmacol.
307
, 219 (1996)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-550-024
Revised 26-Nov-04
D-AP4
SYNONYMS
D(-)-2-Amino-4-phosphonobutanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-024-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
4
H
10
NO
5
P
MW:
183.1
CAS NUMBER:
78739-01-2
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Broad spectrum excitatory amino acid receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord:
J. Davies and J.C. Watkins; Brain Res.
235
, 378 (1982)
Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
ALX-550-026
Revised 27-Nov-04
L-AP4
SYNONYMS
L(+)-2-Amino-4-phosphonobutanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-026-M005
5 mg
65.00 USD
ALX-550-026-M025
25 mg
280.00 USD
Product Specification
FORMULA:
C
4
H
10
NO
5
P
MW:
183.1
CAS NUMBER:
23052-81-5
PURITY:
≥97%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Selective agonist for group III mGluRs.
Product Specific Literature References
Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex:
J.F. Koerner & C.W. Cotman; Brain Res.
216
, 192 (1981)
Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord:
J. Davies & J.C. Watkins; Brain Res.
235
, 378 (1982)
Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists:
J.C. Watkins, et al.; TIPS
11
, 25 (1990)
Abstract
L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase:
C. Thomsen, et al.; Eur. J. Pharmacol.
227
, 361 (1992)
Abstract
L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor:
P.Q. Trombley and G.L. Westbrook; J. Neurosci.
12
, 2043 (1992)
Abstract
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate:
Y. Nakajima, et al.; J. Biol. Chem.
268
, 11868 (1993)
Abstract
;
Full Text
Pharmacological agents acting at subtypes of metabotropic glutamate receptors:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-550-025
Revised 07-May-03
DL-AP4
SYNONYMS
DL-2-Amino-4-phosphonobutanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-550-025-M050
50 mg
25.00 USD
Product Specification
FORMULA:
C
4
H
10
NO
5
P
MW:
183.1
CAS NUMBER:
20263-07-4
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
First generation NMDA antagonist.
Product Specific Literature References
Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog:
R.H. Evans, et al.; Br. J. Pharmacol.
67
, 591 (1979)
Abstract
2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research:
M.M. Slaughter and R.F. Miller; Science
211
, 182 (1981)
Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra:
G. De Sarro, et al.; Eur. J. Pharmacol.
106
, 175 (1984)
Abstract
ALX-550-033
Revised 07-Aug-07
D-AP5
SYNONYMS
D(-)-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-033-M005
5 mg
65.00 USD
ALX-550-033-M025
25 mg
260.00 USD
Product Specification
FORMULA:
C
5
H
12
NO
5
P
MW:
197.1
CAS NUMBER:
79055-68-8
PURITY:
≥97%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (acidify for better solubility).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
More active form of DL-AP5 (Prod. No.
ALX-550-034
).
Widely used competitive NMDA receptor antagonist.
Product Specific Literature References
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids:
T.W. Stone, et al.; Neuroscience
6
, 2249 (1981)
Abstract
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation:
J. Davies, et al.; Neurosci. Lett.
21
, 77 (1981)
Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord:
J. Davies & J.C. Watkins; Brain Res.
235
, 378 (1982)
Abstract
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro:
J. Davis; J. Neurosci.
12
, 21 (1992)
Abstract
ALX-550-035
Revised 26-Nov-04
L-AP5
SYNONYMS
L(+)-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-035-M001
1 mg
40.00 USD
ALX-550-035-M005
5 mg
95.00 USD
Product Specification
FORMULA:
C
5
H
12
NO
5
P
MW:
197.1
CAS NUMBER:
79055-67-7
PURITY:
≥97%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Specific Literature References
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord:
J. Davies and J.C. Watkins; Brain Res.
235
, 378 (1982)
Abstract
ALX-550-034
Revised 25-Jul-08
DL-AP5
SYNONYMS
DL-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-034-M005
5 mg
30.00 USD
ALX-550-034-M025
25 mg
120.00 USD
Product Specification
FORMULA:
C
5
H
12
NO
5
P
MW:
197.1
CAS NUMBER:
76326-31-3
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 1M NaOH or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Potent and selective NMDA receptor antagonist.
Product Specific Literature References
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation:
J. Davies, et al.; Neurosci. Lett.
21
, 77 (1981)
Abstract
Excitatory amino acid transmitters:
J.C. Watkins and R.H. Evans; Ann. Rev. Pharmacol. Toxicol.
21
, 165 (1981), (Review)
Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations
:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord:
J. Davies and J.C. Watkins; Brain Res.
235
, 378 (1982)
Abstract
ALX-550-030
Revised 16-Dec-04
D-AP6
SYNONYMS
D(-)-2-Amino-6-phosphonohexanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-030-M005
5 mg
85.00 USD
Product Specification
FORMULA:
C
6
H
14
NO
5
P
MW:
211.2
CAS NUMBER:
131177-53-2
PURITY:
≥97%
APPEARANCE:
White hygroscopic powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Specific Literature References
Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons:
M.K. Schulte, et al.; Brain. Res.
649
, 203 (1994)
Abstract
ALX-550-032
Revised 16-Dec-04
L-AP6
SYNONYMS
L(+)-2-Amino-6-phosphonohexanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-032-M001
1 mg
50.00 USD
ALX-550-032-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
6
H
14
NO
5
P
MW:
211.2
CAS NUMBER:
78944-89-5
PURITY:
≥97%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
