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ALX-164-003 Revised 10-Jun-03
Orexin B (rat, mouse)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Orexins / Related Products
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ALX-164-003-C100   100 µg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
FORMULA: C125H215N45O33S
MW: 2908.5
PURITY: ≥97%
FORMULATION: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior: T. Sakurai, et al.; Cell 92, 573 (1998) Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger: M.W. Schwartz; Nature Medicine 4, 385 (1998) Abstract
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Peptides • Neuropeptides & Receptors Other Products
 
 
ALX-165-003 Revised 17-Sep-07
PACAP (1-27) (human, sheep, rat)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenylyl Cyclase Activators
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ALX-165-003-MC05   0.5 mg 220.00 USD Add To Cart
ALX-165-003-M001   1 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2
FORMULA: C142H224N40O39S
MW: 3147.7
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Adenylate cyclase activator. More potent than vasoactive intestinal peptide (VIP).
Product Specific Literature References
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells: A. Miyata, et al.; BBRC 164, 567 (1989) Abstract
Isolation and characterization of novel hypothalamic polypeptides homologous with VIP: A. Miyata, et al.; Regul. Pept. 26, 170 (1989)
A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs: C. Kimura, et al.; BBRC 166, 81 (1990) Abstract
Demonstration of specific binding sites for pituitary adenylate cyclase activating polypeptide (PACAP) in rat astrocytes: I. Tatsuno, et al.; BBRC 168, 1027 (1990) Abstract
L.O. Cardell, et al.; Regul. Pept. 36, 379 (1991), (Review) Abstract
Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research: A. Arimura; Regul. Pept. 37, 287 (1992), (Review) Abstract
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Peptides
 
 
ALX-165-025 Revised 21-Dec-05
PACAP (1-38) (human, sheep, rat)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenylyl Cyclase Activators
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ALX-165-025-MC05   0.5 mg 260.00 USD Add To Cart
ALX-165-025-M001   1 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
FORMULA: C203H331N63O53S
MW: 4534.3
PURITY: ≥95%
APPEARANCE: Lyophilized
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Adenylate cyclase activator. More potent than vasoactive intestinal peptide (VIP).
Product Specific Literature References
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells: A. Miyata, et al.; BBRC 164, 567 (1989) Abstract
The novel VIP-like hypothalamic polypeptide PACAP interacts with high affinity receptors in the human neuroblastoma cell line NB-OK: A. Cauvin, et al.; Peptides 11, 773 (1990) Abstract
A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs: C. Kimura, et al.; BBRC 166, 81 (1990) Abstract
Molecular cloning and characterization of cDNA for the precursor of rat pituitary adenylate cyclase activating polypeptide (PACAP): K. Ogi, et al.; BBRC 173, 1271 (1990) Abstract
Pituitary adenylate cyclase activating peptide (PACAP) in guinea-pig lung: distribution and dilatory effects: L.O. Cardell, et al.; Regul. Pept. 36, 379 (1991), (Review) Abstract
A. Arimura; Regul. Pept. 37, 287 (1992), (Review) Abstract
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Peptides
 
 
ALX-165-026 Revised 15-Aug-08
PACAP (6-38) (human, sheep, rat)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenylyl Cyclase Inhibitors
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ALX-165-026-MC05   0.5 mg 210.00 USD Add To Cart
ALX-165-026-M001   1 mg 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
FORMULA: C182H300N56O45S
MW: 4024.8
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent and selective inhibitor of PACAP (1-27) (human, sheep, rat) (Prod. No. ALX-165-003) stimulated pituitary adenylate cyclase.
Product Specific Literature References
Structural requirements for the occupancy of pituitary adenylate- cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist: P. Robberecht, et al.; Eur. J. Biochem. 207, 239 (1992) Abstract
Receptor occupancy and adenylate cyclase activation in AR 4-2J rat pancreatic acinar cell membranes by analogs of pituitary adenylate cyclase-activating peptides amino-terminally shortened or modified at position 1, 2, 3, 20, or 21: P. Robberecht, et al.; Mol. Pharmacol. 42, 347 (1992) Abstract
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Peptides
 
 
ALX-165-066 Revised 08-Mar-07
Pam3Cys-Ser-(Lys)4 . trihydrochloride
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SYNONYMS Pam3CSK4 . 3HCl
(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys- (S)-Ser-(S)-Lys4-OH . 3HCl
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Agonists Other Products
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ALX-165-066-M002   2 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C81H156N10O13S . 3HCl
MW: 1510.3 . 109.4
CAS NUMBER: 112208-00-1
CONCENTRATION: 1mg/ml after reconstitution.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in water, saline or aqueous buffers at pH <7.5.
RECONSTITUTION: Reconstitute in 2ml distilled water. Use a homogeniser or sonicator to prepare a homogenous solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

Product Description
Selective agonist of Toll-like receptor 1 (TLR1) complexed with TLR2. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Activates/represses an array of at least 140 genes partly involved in signal transduction and regulation of the immune response.
Product Specific Literature References
Induction of tumor cytotoxicity in murine bone marrow-derived macrophages by two synthetic lipopeptide analogues: P. Hoffmann, et al.; Biol. Chem. Hoppe Seyler 370, 575 (1989) Abstract
Lipopeptide derivatives of bacterial lipoprotein constitute potent immune adjuvants combined with or covalently coupled to antigen or hapten: A. Reitermann, et al.; Biol. Chem. Hoppe Seyler 370, 343 (1989) Abstract
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides: R. Seifert, et al.; Biochem. J. 267, 795 (1990) Abstract
Synthesis of novel immunologically active tripalmitoyl-S-glycerylcysteinyl lipopeptides as useful intermediates for immunogen preparations: J. Metzger, et al.; Int. J. Pept. Protein Res. 37, 46 (1991) Abstract
The influence of various adjuvants on antibody synthesis following immunization with an hapten: J. Kellner, et al.; Biol. Chem. Hoppe Seyler 373, 51 (1992) Abstract
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells: S. Offermanns, et al.; Biochem. J. 282, 551 (1992) Abstract
Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. Requirement of NF-kappaB activation after stimulation with bacterial cell wall products and phorbol esters: M.J. Diaz-Guerra, et al.; J. Biol. Chem. 271, 30114 (1996) Abstract; Full Text
Adjuvant lipopeptide interaction with model membranes: J. Gonzalez-Christen; Biochim. Biophys. Acta 1368, 97 (1998) Abstract
Alteration of the lateral organization of the plasma membrane of Chinese hamster ovary cells by synthetic lipopeptide, Pam3Cys-Ser-Lys4: I. Vergne & L. Cezanne; Eur. J. Biochem. 264, 369 (1999) Abstract; Full Text
Adjuvant effects of various lipopeptides and interferon-gamma on the humoral immune response of chickens: M.H. Erhard, et al.; Poult. Sci. 79, 1264 (2000) Abstract
Immunostimulation by the synthetic lipopeptide P3CSK4: TLR4-independent activation of the ERK1/2 signal transduction pathway in macrophages: M.R. Muller, et al.; Immunology 103, 49 (2001) Abstract
TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages: V. Toshchakov, et al.; Nat. Immunol. 3, 392 (2002) Abstract
The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract
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Peptides
 
 
ALX-165-069 Revised 22-Jul-08
Pam3Cys-Ser-(Lys)4 (Aca-Aca-Biotin) . 2 trifluoroacetate
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SYNONYMS Pam3CSK4 (Aca-Aca-Biotin) . 2TFA
(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH (Aca-Aca-Biotin) . 2TFA
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Agonists Other Products
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ALX-165-069-M001   1 mg 1'300.00 USD Add To Cart
Product Specification
FORMULA: C103H192N14O17S2 . 2C2HF3O2
MW: 1962.9 . 228.1
APPEARANCE: Colorless powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in water, saline or aqueous buffers at pH <7.5.
RECONSTITUTION: Reconstitute with water to 1mg/ml stock solution. Through the use of either a homogeniser or sonicator, a homogenous solution can be prepared.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Description
Selective, biotin-labelled ligand of Toll-like receptor 1 (TLR1) complexed with TLR2. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Activates/represses an array of at least 140 genes partly involved in signal transduction and regulation of the immune response.
Related Products
Further Categories Containing This Product:
Peptides
 
 
ALX-165-019 Revised 24-Feb-05
PDGF Fragment (phosphorylated) (cyclic)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SH2 & SH3 Domains
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ALX-165-019-MC01   0.1 mg 50.00 USD Add To Cart
ALX-165-019-M001   1 mg 250.00 USD Add To Cart
Product Specification
SEQUENCE: cyclo(Gly-Tyr(PO3H2)-Val-Pro-Met-Leu)
FORMULA: C32H49N6O10PS
MW: 740.8
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Cyclic hexapeptide inhibitor of SH2 interactions. The peptide sequence represents the autophosphorylation region around Tyr751 of the PDGF β-receptor.
Product Specific Literature References
Synthesis of phosphonomethyl-phenylalanine and phosphotryrosine containing cyclic peptides as inhibitors of protein kinase/SN2 interactions: M. Nomizu, et al.; Tetrahedron 50, 2691 (1994)
Further Categories Containing This Product:
Peptides • Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
 
 
ALX-165-005 Revised 16-Feb-05
PDGF β-Receptor (719-723) (phosphorylated)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SH2 & SH3 Domains
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ALX-165-005-M001   1 mg 130.00 USD Add To Cart
ALX-165-005-M005   5 mg 520.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr(PO3H2)-Val-Pro-Met-Leu-OH
FORMULA: C30H48N5O10PS
MW: 701.8
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Contains the PDGF β-receptor recognition sequence which specifically interacts with the SH2 domain of PI(3)K (phosphoinositide 3-kinase). In this phosphorylated form the peptide inhibits the binding of the 85kDa subunit of PI(3)K to the PDGF β-receptor.
Product Specific Literature References
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways: W.J. Fantl, et al.; Cell 69, 413 (1992) Abstract
Closing in on SH2 specificity: R.B. Birge & H. Hanafusa; Science 262, 1522 (1993) Abstract
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Peptides • Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
 
 
ALX-165-006 Revised 04-Jul-03
Peptide ε
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Substrates
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ALX-165-006-MC01   0.1 mg 30.00 USD Add To Cart
ALX-165-006-M001   1 mg 120.00 USD Add To Cart
ALX-165-006-M005   5 mg 420.00 USD Add To Cart
Product Specification
SEQUENCE: H-Glu-Arg-Met-Arg-Pro-Arg-Lys-Arg-Gln-Gly-Ser-Val-Arg-Arg-Arg-Val-OH
FORMULA: C83H155N39O21S
MW: 2067.5
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Specific substrate for PKCε, derived from the pseudosubstrate site of PKCε (residues 149-164), with Ala159 replaced by Ser. This peptide is also phosphorylated by PKCξ.
Product Specific Literature References
Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity: D. Schaap, et al.; FEBS Lett. 243, 351 (1989) Abstract
Expression, purification, and characterization of protein kinase C- epsilon: D. Schaap & P.J. Parker; J. Biol. Chem. 265, 7301 (1990) Abstract; Full Text
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Peptides
 
 
ALX-165-052 Revised 04-Mar-05
Peptide YY (3-36) (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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ALX-165-052-C500   500 µg 130.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
FORMULA: C180H279N53O54
MW: 4049.5
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized. TFA salt.
SOLUBILITY: 5mg/ml soluble in distilled water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Y2R agonist, inhibiting food intake and reducing weight gain in rats and humans after peripheral injection.
Product Specific Literature References
Gut hormone PYY(3-36) physiologically inhibits food intake: R.L. Batterham, et al.; Nature 418, 650 (2002) Abstract
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Peptides
 
 
ALX-165-007 Revised 05-Dec-04
Phospholipase A2 Activating Peptide
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SYNONYMS PLAP
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PLA2 Activators
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ALX-165-007-MC01   0.1 mg 40.00 USD Add To Cart
ALX-165-007-M001   1 mg 140.0