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Natural Products for Neurological Research
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ALX-350-264 Revised 17-Dec-07
Sceptrin . dihydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-264-M001   1 mg 98.00 USD Add To Cart
Product Specification
FORMULA: C22H24Br2N10O2 . 2HCl
MW: 620.3 . 73.0
CAS NUMBER: 79703-25-6
SOURCE/HOST: Isolated from the sponge Agelas nakamurai.
PURITY: ≥97% (HPLC)
APPEARANCE: Amorphous powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibits the growth of several Gram-positive and Gram-negative bacteria. Competitively inhibits muscarinic acetylcholine receptors.
Product Specific Literature References
Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges: R. Rosa, et al.; Experientia 48, 885 (1992) Abstract
A study on the mechanism of action of sceptrin, an antimicrobial agent isolated from the South Pacific sponge Agelas mauritiana: V.S. Bernan, et al.; J. Antimicrob. Chemother. 32, 539 (1993) Abstract
New bromopyrrole alkaloids from the Indopacific sponge Agelas nakamurai: C. Eder, et al.; J. Nat. Prod. 62, 1295 (1999) Abstract
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica: R. Mohammed, et al.; J. Nat. Prod. 69, 1739 (2006) Abstract
Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton: D.P. O’Malley, et al.; J. Am. Chem. Soc. 129, 4762 (2007) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products • Natural Products for Neurological Research • Alkaloids • Marine Natural Products
 
 
ALX-550-094 Revised 13-Dec-06
(-)-Scopolamine . hydrobromide
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-550-094-G001   1 g 60.00 USD Add To Cart
Product Specification
FORMULA: C17H21NO4 . HBr
MW: 303.4 . 80.9
CAS NUMBER: 114-49-8
MERCK INDEX: 14: 8406
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or 100% ethanol; insoluble in organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Solutions may be stored for several hours at +4°C if protected from light.
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Cholinergic antagonist.
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products • Cholinergics / Related Products • Alkaloids
 
 
ALX-480-061 Revised 15-Mar-06
Theobromine
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SYNONYMS 3,7-Dimethylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-480-061-G005   5 g 10.00 USD Add To Cart
ALX-480-061-G025   25 g 45.00 USD Add To Cart
Product Specification
FORMULA: C7H8N4O2
MW: 180.2
CAS NUMBER: 83-67-0
MERCK INDEX: 14: 9282
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in 0.5M sodium hydroxide; insoluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Weak phosphodiesterase inhibitor and adenosine receptor blocker. Diuretic and smooth-muscle relaxant.
Product Specific Literature References
Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines: J.W. Daly, et al.; Cell Mol. Neurobiol. 3, 69 (1983) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
Further Categories Containing This Product:
Natural Products for Neurological Research • Active Substances from Fruit and Vegetables • Alkaloids • Phosphodiesterases / Related Products
 
 
ALX-350-374 Revised 10-Jul-08 New product
Thiocolchicoside
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SYNONYMS 2-Demethoxy-2-glucosidoxythiocolchicine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-374-M001   1 mg 40.00 USD Add To Cart
ALX-350-374-M005   5 mg 120.00 USD Add To Cart
ALX-350-374-M025   25 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C27H33NO10S
MW: 563.6
CAS NUMBER: 602-41-5
MERCK INDEX: 14: 9324
SOURCE/HOST: Semisynthetic.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Potent competitive antagonist of GABAAR function. Muscle relaxant. Displays anti-inflammatory and analgesic properties. Shows strong epileptogenic and convulsant activity.
Product Specific Literature References
Review of the toxicology, pharmacodynamics and pharmacokineticss of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions: J.M. Janbroers; Acta Ther. 13, 221 (1987)
Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat: G. Sechi, et al.; Seizure 12, 508 (2003) Abstract
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system: M. Carta, et al.; Neuropharmacology 51, 805 (2006) Abstract
Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes: M.P. Mascia, et al.; Eur. J. Pharmacol. 558, 37 (2007) Abstract
Further Categories Containing This Product:
Alkaloids
 
 
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