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Serotonergics & Serotonin Receptors / Related Products
You are here: Product Lines > Signal Transduction > Serotonergics & Serotonin Receptors / Related Products
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Items 19 of 19
ALX-550-208 Revised 17-Dec-04
N-Acetyl-5-hydroxytryptamine
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SYNONYMS N-Acetylserotonin
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-208-M010   10 mg 10.00 USD Add To Cart
ALX-550-208-M050   50 mg 25.00 USD Add To Cart
ALX-550-208-M500   500 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C12H14N2O2
MW: 218.3
CAS NUMBER: 1210-83-9; 17994-17-1
PURITY: ≥99%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Metabolite of serotonin (Prod. No. ALX-550-328). Precursor of melatonin (Prod. No. ALX-550-071). Inhibitor of hydroxyindole-O-methyltransferase.
Product Specific Literature References
The metabolism of serotonin (5-hydroxytryptamine): W.M. McIsaac and I.H. Page; J. Biol. Chem. 234, 858 (1959) Full Text
Hydroxyindole-O-methyltransferase. I. Substrate binding: B.T. Ho, et al.; J. Pharm. Sci. 58, 130 (1969) Abstract
Hydroxyindole-O-methyltransferase. II. Inhibitory activities of some N- acyltryptamines: B.T. Ho, et al.; J. Pharm. Sci. 57, 1998 (1968) Abstract
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Serotonergics & Serotonin Receptors / Related Products
 
 
ALX-350-326 Revised 29-May-07
Agelongine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-326-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C13H11BrN2O4
MW: 339.1
CAS NUMBER: 163564-84-9
SOURCE/HOST: Isolated from the sponge Agelas longissima.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Alkaloid exhibiting antagonistic activity on serotonin receptors.
Product Specific Literature References
A novel bromopyrrole alkaloid from the sponge agelas longissima with antiserotonergic activity: F. Cafieri, et al.; Bioorg. Med. Chem. Lett. 5, 799 (1995)
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent: L. Meijer, et al.; Chem. Biol. 7, 51 (2000) Abstract
Further Categories Containing This Product:
Alkaloids • Serotonergics & Serotonin Receptors / Related Products
 
 
ALX-550-159 Revised 16-Dec-04
4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine . oxalate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-159-M005   5 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C20H25N5O . C2H2O4
MW: 351.5 . 90.0
PURITY: ≥96%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent pre- and postsynaptic 5-HT1A receptor antagonist.
Product Specific Literature References
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2- methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs: J.L. Mokrosz, et al.; J. Med. Chem. 37, 2754 (1994) Abstract
 
 
ALX-550-375 Revised 28-Jan-05
BRL 15572 . hydrochloride
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SYNONYMS 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-375-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C25H27ClN2O . HCl
MW: 406.9 . 36.5
CAS NUMBER: 193611-72-2
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective human 5-HT1D antagonist.
Product Specific Literature References
Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig: J.J. Hagan, et al.; Eur. J. Pharmacol. 331, 169 (1997) Abstract
SB-216641 and BRL-15572-compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors: G.W. Price, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 356, 312 (1997) Abstract
Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors: E. Schlicker, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 356, 321 (1997) Abstract
5-HT1-like receptors: a time to bid goodbye: P.R. Saxena, et al.; TIPS 19, 311 (1998), (Review) Abstract
The canine external carotid vasoconstrictor 5-HT1 receptor: blockade by 5-HT1B (SB224289), but not by 5-HT1D (BRL15572) receptor antagonists: P. De Vries, et al.; Eur. J. Pharmacol. 362, 69 (1998) Abstract
5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression: R. Verheggen, et al.; Br. J. Pharmacol. 124, 1345 (1998) Abstract
Pharmacological diversity between native human 5-HT1B and 5-HT1D receptors sited on different neurons and involved in different functions: M. Marcoli, et al.; Br. J. Pharmacol. 126, 607 (1999) Abstract
 
 
ALX-550-161 Revised 14-Dec-04
N-(4-Bromobenzyl)-5-methoxytryptamine . oxalate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-161-M001   1 mg 20.00 USD Add To Cart
ALX-550-161-M005   5 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C18H19N2OBr . C2H2O4
MW: 359.3 . 90.0
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Very potent and selective ligand for 5-HT2A receptors.
Product Specific Literature References
Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines: R.A. Glennon, et al.; J. Med. Chem. 37, 1929 (1994) Abstract
 
 
ALX-550-144 Revised 09-Dec-04
Buspirone . hydrochloride
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SYNONYMS 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-144-G001   1 g 48.00 USD Add To Cart
Product Specification
FORMULA: C21H31N5O2 . HCl
MW: 385.5 . 36.5
CAS NUMBER: 33386-08-2
MERCK INDEX: 14: 1504
PURITY: ≥96%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
5-HT1A serotonin receptor agonist.
Product Specific Literature References
The discovery and development of buspirone: a new approach to the treatment of anxiety: J.S. New; Med. Res. Rev. 10, 283 (1990), (Review) Abstract
Further Categories Containing This Product:
Benzodiazepines / Related Products • Dopaminergics & Dopamine Receptors / Related Products • Adrenergics & Adrenergic Receptors / Related Products
 
 
ALX-550-088 Revised 28-Jan-05
Clozapine
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SYNONYMS 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Dopaminergics & Dopamine Receptors / Related Products
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ALX-550-088-M005   5 mg 15.00 USD Add To Cart
ALX-550-088-M025   25 mg 35.00 USD Add To Cart
ALX-550-088-M100   100 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C18H19ClN4
MW: 326.8
CAS NUMBER: 5786-21-0
MERCK INDEX: 14: 2423
PURITY: ≥98%
APPEARANCE: Pale yellow powder.
SOLUBILITY: Soluble in DMSO or dilute aqueous acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective antagonist for D4-dopamine receptor. Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.
Product Specific Literature References
Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites: H. Canton, et al.; Eur. J. Pharmacol. 191, 93 (1990) Abstract
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine: B.A. Ellenbroek, et al.; Eur. J. Pharmacol. 196, 103 (1991) Abstract
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine: H.H. Van Tol, et al.; Nature 350, 610 (1991) Abstract
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993) Abstract
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 255, 91 (1994) Abstract
Clozapine is a potent and selective muscarinic M4 receptor agonist: S.H. Zorn, et al.; Eur. J. Pharmacol. 269, R1 (1994) Abstract
Interaction of clozapine with the histamine H3 receptor in rat brain: A.A. Rodrigues, et al.; Br. J. Pharmacol. 114, 1523 (1995) Abstract
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Serotonergics & Serotonin Receptors / Related Products
 
 
ALX-550-195 Revised 09-Dec-04
8-Hydroxy-DPAT . hydrobromide
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SYNONYMS (±)-8-Hydroxy-2-dipropylaminotetralin . HBr
8-OH-DPAT . HBr
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-195-M005   5 mg 20.00 USD Add To Cart
ALX-550-195-M025   25 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C16H25NO . HBr
MW: 247.4 . 80.9
CAS NUMBER: 78950-78-4
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Standard selective 5-HT1A serotonin receptor agonist.
Product Specific Literature References
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site: D.N. Middlemiss & J.R. Fozard; Eur. J. Pharmacol. 90, 151 (1983) Abstract
Anticonflict effect of the putative serotonin receptor agonist 8- hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT): J.A. Engel, et al.; Eur. J. Pharmacol. 105, 365 (1984) Abstract
 
 
ALX-106-023 Revised 13-Dec-02
5-Hydroxy-L-tryptophan
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-106-023-M500   500 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C11H12N2O3
MW: 220.2
CAS NUMBER: 56-69-9
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Serotonin precursor.
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-350-291 Revised 19-Oct-07
Hymenidin
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SYNONYMS 2-Debromooroidin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cell Cycle Research
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ALX-350-291-M001   1 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C11H12BrN5O
MW: 310.2
CAS NUMBER: 107019-95-4
SOURCE/HOST: Isolated from Hymeniacidon sp.
PURITY: ≥95%
APPEARANCE: Amorphous solid.
SOLUBILITY: Soluble in DMSO or 100 % ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC. CYTOTOXIC.

Product Description
Antagonist of serotonergic receptors. Inhibitor of CDK5/p25 (IC50=4µM) and GSK-3β (IC50=12µM). 
Product Specific Literature References
A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp: J. Kobayashi, et al.; Experientia 42, 1176 (1986) Abstract
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent: L. Meijer, et al.; Chem. Biol. 7, 51 (2000)
Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation: U. Bickmeyer, et al.; Toxicon. 44, 45 (2004) Abstract
Marine compounds for the therapeutic treatment of neurological disorders: D. Alonso, et al.; Expert Opininon on Therapeutic Patents 15, 1377 (2005)
Further Categories Containing This Product:
CDK & Cyclin Inhibitors • Natural Products for Neurological Research • Serotonergics & Serotonin Receptors / Related Products • Alkaloids
 
 
ALX-550-051 Revised 27-Aug-07
Ketanserin . tartrate
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SYNONYMS 3-[2-[4-(4-Fluorobenzoyl)-1-piperdinyl)ethyl]-2,4(1H,3H)-quinazolinedione tartrate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-051-M010   10 mg 35.00 USD Add To Cart
ALX-550-051-M050   50 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C22H22FN3O3 . C4H6O6
MW: 395.4 . 150.1
CAS NUMBER: 83846-83-7
MERCK INDEX: 14: 5296
RTECS: VA1411195
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO; slightly soluble in water (4mg/ml) or 100% ethanol (3mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
HAZARD: TOXIC.