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Signal Transduction
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ALX-152-002 Revised 26-Nov-04
Big Endothelin-1 (1-39) (pig)
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SYNONYMS Big ET-1 (1-39) (pig)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-002-PC01   0.1 mg* 140.00 USD Add To Cart
ALX-152-002-PC05   0.5 mg* 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Ile-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C193H289N49O58S5
MW: 4384.1
CAS NUMBER: 121014-54-8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]: M. Yanagisawa, et al.; Nature 332, 411 (1988) Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-003 Revised 26-Nov-04
Big Endothelin-1 (1-39) (rat)
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SYNONYMS Big ET-1 (1-39) (rat)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-003-PC01   0.1 mg* 110.00 USD Add To Cart
ALX-152-003-PC05   0.5 mg* 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Arg-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C192H292N50O58S5
MW: 4389.1
CAS NUMBER: 135842-15-8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA: T. Sakurai, et al.; BBRC 175, 44 (1991) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-004 Revised 12-May-03
Big Endothelin-2 (1-37) (human)
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SYNONYMS Big ET-2 (1-37) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-004-PC01   0.1 mg* 110.00 USD Add To Cart
ALX-152-004-PC05   0.5 mg* 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Gln-Thr-Ala-Pro-Tyr-Gly-Leu-Gly-Asn-Pro-Pro-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C188H269N45O56S4
MW: 4183.8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization: S. Ohkubo, et al.; FEBS Lett. 274, 136 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
 
 
ALX-152-007 Revised 14-Dec-04
Big Endothelin-1 (1-39) (bovine)
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SYNONYMS Big ET-1 (1-39) (bovine)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-007-PC01   0.1 mg* 140.00 USD Add To Cart
ALX-152-007-PC05   0.5 mg* 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C192H287N49O58S5
MW: 4370.0
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequencing of a bovine preproendothelin cDNA: G.J. Price & L. Malone; Nucl. Acid Res. 18, 3658 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-012 Revised 14-Dec-04
Big Endothelin-1 (22-38) (human)
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SYNONYMS Big ET-1 (22-38) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-012-MC05   0.5 mg 100.00 USD Add To Cart
ALX-152-012-M001   1 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
FORMULA: C80H125N23O25
MW: 1809.0
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-014 Revised 13-Jan-05
Big Endothelin-1 (19-37) (human), [Phe22]-
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SYNONYMS [Phe22]-Big ET-1 (19-37) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-014-MC05   0.5 mg 120.00 USD Add To Cart
ALX-152-014-M001   1 mg 190.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-OH
FORMULA: C100H152N26O26
MW: 2134.5
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of endothelin-converting enzyme (ECE).
Further Categories Containing This Product:
Peptides
 
 
ALX-152-022 Revised 04-Jul-03
BPDEtide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG Substrates
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ALX-152-022-M001   1 mg 60.00 USD Add To Cart
ALX-152-022-M005   5 mg 240.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH
FORMULA: C68H115N23O20
MW: 1574.8
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for cGMP-dependent protein kinase corresponding to a peptide sequence surrounding the phosphorylation site of cGMP-binding cGMP-specific phosphodiesterase.
Product Specific Literature References
Studies of two different intrachain cGMP-binding sites of cGMP- dependent protein kinase: J.D Corbin & S.O. Døskeland; J. Biol. Chem. 258, 11391 (1983) Abstract; Full Text
A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases: J.L. Colbran, et al.; J. Biol. Chem. 267, 9589 (1992) Abstract; Full Text
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related ProductsPeptides
 
 
ALX-152-031 Revised 17-Nov-08
(Des-Arg1)-Bradykinin
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SYNONYMS Bradykinin (2-9)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-031-M001   1 mg 15.00 USD Add To Cart
ALX-152-031-M005   5 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 16875-11-9
PEPTIDE CONTENT: ≥85%
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
QUALITY CONTROL: Identity determined by MS.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
 
 
ALX-152-032 Revised 08-Dec-06
(Des-Arg9)-Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-032-M005   5 mg 75.00 USD Add To Cart
ALX-152-032-M025   25 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 15958-92-6
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
 
 
ALX-153-001 Revised 26-Nov-04
Calcitonin (salmon)
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PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Calcitonin & Calcitonin Receptors / Related Products
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ALX-153-001-MC05   0.5 mg 90.00 USD Add To Cart
ALX-153-001-M001   1 mg 140.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2
(Disulfide bond between Cys1-Cys7)
FORMULA: C145H240N44O48S2
MW: 3431.9
CAS NUMBER: 47931-85-1
MERCK INDEX: 14: 1643
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 0.05M acetic acid.
BIOLOGICAL ACTIVITY: ≥5000IU/mg.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-153-003 Revised 03-Feb-05
Casein Kinase II Substrate