ALEXIS Biochemicals: Sodium fluoride

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ALX-420-008

Revised 04-Dec-07

Compound 48/80 . trihydrochloride
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calmodulin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-008-M100		100 mg	95.00 USD

Product Specification

FORMULA:	C₃₂H₄₆N₃O₃. 3HCl
MW:	520.7 . 109.4
CAS NUMBER:	94724-12-6
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water (100mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 3 months when stored at -20°C.
HAZARD:	TOXIC.

Product Description

Oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde. The trimer is the most abundant oligomere in the mixture. Blocks calmodulin and human platelet phospholipase C and ADP ribosylation. Activates G-proteins in a manner similar to G-protein-coupled receptors.

Product Specific Literature References

Activation of bovine rod outer segment phosphatidylinositol-4,5- bisphosphate phospholipase C by calmodulin antagonists does not depend on calmodulin: B.D. Gehm, et al.; Biochemistry 30, 11302 (1991) Abstract
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol. 44, 45 (1992) Abstract
Phosphorylation of smg p21B in rat peritoneal mast cells in association with histamine release inhibition by dibutyryl-cAMP: K. Izushi, et al.; FEBS Lett. 314, 241 (1992) Abstract
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992) Abstract
Activation of the Na+/K(+)-pump in rat peritoneal mast cells following histamine release: a possible role in cell recovery: T. Knudsen, et al.; Br. J. Pharmacol. 108, 120 (1993) Abstract
Eclosion hormone activates phosphatidylinositol hydrolysis in silkworm abdominal ganglia during adult metamorphosis: Y. Shibanaka, et al.; Eur. J. Biochem. 211, 427 (1993) Abstract

Further Categories Containing This Product:

Phospholipase C / Related Products • G-proteins & GTPases Other Products

ALX-162-001

Revised 22-Oct-08

Mastoparan
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-162-001-M001		1 mg	50.00 USD
ALX-162-001-M005		5 mg	200.00 USD

Product Specification

SEQUENCE:	H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂
FORMULA:	C₇₀H₁₃₁N₁₉O₁₅
MW:	1478.9
CAS NUMBER:	72093-21-1
SOURCE/HOST:	Synthetic. Originally isolated from wasp venom.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water (1 mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Mast cell degranulating peptide. Stimulates glycogenolysis. Stimulates phospholipase D₂ (PLD₂) activity. Alters G-proteins in brain membranes.

Product Specific Literature References

A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull. 27, 1942 (1979) Abstract
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem. 263, 6491 (1988) Abstract; Full Text
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett. 260, 179 (1990) Abstract
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta 1027, 185 (1990) Abstract
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol. 121, 1406 (1997) Abstract
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem. 278, 12039 (2003) Abstract
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol. 174, 4252 (2005) Abstract
Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci. 7, 501 (2006), Review Abstract

Further Categories Containing This Product:

G-proteins & GTPases Other Products • Peptides

ALX-400-031

Revised 13-Apr-07

Sodium fluoride
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	G-proteins & GTPases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-031-G025		25 g	20.00 USD

Product Specification

FORMULA:	NaF
MW:	42.0
CAS NUMBER:	7681-49-4
MERCK INDEX:	14: 8618
PURITY:	≥99%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	TOXIC.

Product Description

Fluoride ion (F^-) induces a variety of effects thought to be initiated by stimulation of both stimulatory and inhibitory guanine nucleotide binding proteins (G-proteins) followed by effects of those G-proteins on adenylyl cyclase and other targets. The action of F^- is thought to involve the species [AlF₄]^-, formed by reaction of F^- with aluminium ions leached from glass vessels and/or otherwise present as contaminants in virtually all aqueous media and buffers used in routine biological research. Many studies report an increase in the effects of NaF, or in its potency, when it is supplemented with aluminum salts. Occasional studies report no increase in NaF effects when Al³⁺ is added, presumably due to an already saturating level of aluminium ions in the experimental media.

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