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Ion Channels & Transporters / Related Products
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ALX-380-214 Revised 20-Feb-08
Monactin
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SYNONYMS Antibiotic AKD 1B
5-Demethyl-5-ethylnonactin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-214-M001   1 mg 370.00 USD Add To Cart
Product Specification
FORMULA: C41H66O12
MW: 751.0
CAS NUMBER: 7182-54-9
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5448.
PURITY: ≥95% (HPLC)
APPEARANCE: Colorless film.
SOLUBILITY: Soluble in ethyl acetate or DMSO, moderately soluble in 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Cation ionophore with high selectivity for ammonium and potassium. Inhibits T cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ.
Product Specific Literature References
The in vitro activity of nonactin and its homologs: monactin, dinactin and trinactin: E. Meyers, et al.; J. Antibiot. (Tokyo) 18, 128 (1965) Abstract
Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin: S.N. Graven, et al.; Biochemistry 5, 1735 (1966) Abstract
On the mechanism of sugar and amino acid interaction in intestinal transport: H. Murer, et al.; J. Biol. Chem. 250, 7392 (1975) Abstract
Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation: S.P. Umland, et al.; Am. J. Respir. Cell. Mol. Biol. 20, 481 (1999) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Antibiotics - Ionophores
 
 
ALX-380-026 Revised 26-Jun-08
Monensin . sodium salt
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Ionophores
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-026-M100   100 mg 25.00 USD Add To Cart
ALX-380-026-G001   1 g 63.00 USD Add To Cart
Product Specification
FORMULA: C36H61O11 . Na
MW: 669.9 . 23.0
CAS NUMBER: 22373-78-0
MERCK INDEX: 14: 6246
PURITY: ≥90%
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in chloroform or DMSO. Clear solution (5%) in methanol with heat. Slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Antibiotic that functions as Na+ ionophore. Blocks glycoprotein secretion. Inhibits proliferation of several lymphoma cell lines through cell cycle arrest and apoptosis.
Product Specific Literature References
Monensin, a new biologically active compound. I. Discovery and isolation: M. E. Haney, Jr. & M. M. Hoehn; Antimicrobial Agents Chemother. (Bethesda) 7, 349 (1967) Abstract
Solution chemistry of monensin and its alkali metal ion complexes. Potentiometric and spectroscopic studies
: P.G. Gertenbach & A.I. Popov; JACS 97, 4738 (1975)
Undersulfated proteoglycans are secreted by cultured chondrocytes in the presence of the ionophore monensin: K. Tajiri, et al.; J. Biol. Chem. 255, 6036 (1980) Abstract; Full Text
Expression of membrane IGM by a human B lymphoblastoid cell line in the presence of monensin: R.T. Kubo and M.L. Pigeon; Mol. Immunol. 20, 345 (1983) Abstract
Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity: H. H. Mollenhauer, et al.; Biochim. Biophys. Acta 1031, 225 (1990), Review Abstract
Monensin-mediated growth inhibition in human lymphoma cells through cell cycle arrest and apoptosis: W. H. Park, et al.; Br. J. Haematol. 119, 400 (2002) Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products • Vesicles & Membrane Trafficking Other Products • Natural Products for Cell Cycle Research • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-804-084 Revised 15-Sep-08
Monoclonal Antibody to H+/ K+ ATPase-β (2G11)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY H+-ATPase / Related Products
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ALX-804-084-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Pig
Others
CLONE: 2G11
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. PBS-diluted ascites containing 0.05% sodium azide.
IMMUNOGEN: Purified 34kDa core peptide from deglycosylated pig gastric microsomes.
SPECIFICITY: Recognizes the β subunit of human, mouse, rat, bovine, pig, dog, rabbit and ferret H+/K+ ATPase.
APPLICATION: Immunocytochemistry (1:2’000)
Immunohistochemistry (paraffin and frozen sections (1:2’000))
Immunoprecipitation, Chromatin Immunoprecipitation
Western Blot (1:4’000)
Functional Application: Inhibits enzymatic activity of H+/ K+ ATPase and alters affinity of its cytoplasmic potassium binding site.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase: J.G. Duman, et al.; Am. J. Physiol. 277, C361 (1999) Abstract; Full Text
Functionally distinct pools of actin in secretory cells: D.A. Ammar, et al.; Am. J. Physiol. Cell Physiol. 281, C407 (2001) Abstract; Full Text
Localization and function of soluble N-ethylmaleimide-sensitive factor attachment protein-25 and vesicle-associated membrane protein-2 in functioning gastric parietal cells: S. Karvar, et al.; J. Biol. Chem. 277, 50030 (2002) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-214 Revised 18-Feb-08
Monoclonal Antibody to CFTR (CF3)
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SYNONYMS anti-Cystic Fibrosis Transmembrane Conductance Regulator MAb (CF3)
anti-ABCC7 MAb (CF3)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Cl- Channels
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ALX-804-214-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: CF3
ISOTYPE: Mouse IgM
FORMULATION: Liquid. Diluted ascites containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 103-117(G103RIIASYDPDNKEER117) in the first extracellular loop of human and mouse CFTR (cystic fibrosis transmembrane conductance regulator). This sequence is highly conserved in mouse, sheep, bovine and Xenopus laevis CFTR.
SPECIFICITY: Recognizes human and mouse CFTR. Detects a band of ~170kDa by Western blot.
APPLICATION: Immunocytochemistry: 1:500. Staining of CFTR in mouse epithelial cells results in cell surface staining, consistent with localization at the plasma membrane. Antibody also detects one or more immunologically related proteins in murine cell line Heb7a that does not contain CFTR mRNA.
Immunoprecipitation
Western Blot: 1:500
Functional Application: inhibits epithelial uptake of S. typhi in some mouse cell lines.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Production and characterisation of monoclonal and polyclonal antibodies to different regions of thy cystic fibrosis transmembrane conductance regulator: detection of immunologically related proteins: J. Walker, et al.; J. Cell Sci. 108, 2433 (1995) Abstract
Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility: W.M. Xu, et al.; PNAS 104, 9816 (2007) Abstract
General Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (δ F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-090 Revised 30-Jan-06
Monoclonal Antibody to Dihydropyrine Receptor α1 (1A)
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SYNONYMS anti-DHP Receptor α1 MAb (1A)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Channels (L-type)
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ALX-804-090-R400   400 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: 1A
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Contains 0.05% sodium azide.
IMMUNOGEN: Purified rabbit muscle T-tubule DHP receptor (dihydropyridine receptor).
SPECIFICITY: Recognizes the α1 subunit of human, mouse, rat, guinea pig and rabbit DHP receptor. Detects a band of ~200kDa by Western blot.
APPLICATION: Immunohistochemistry (frozen sections (1:200))
Immunoprecipitation
Western Blot (1:500)
Functional Application (inhibits DHP-sensitive calcium current in certain cell lines)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-091 Revised 28-Feb-08
Monoclonal Antibody to Dihydropyrine Receptor α2 (20A)
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SYNONYMS anti-DHP Receptor α2 MAb (20A)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Channels (L-type)
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ALX-804-091-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: 20A
ISOTYPE: Mouse IgG2a
FORMULATION: Liquid. Diluted ascites containing 0.05% sodium azide.
IMMUNOGEN: Purified rabbit DHP receptor (dihydropyridine receptor).
SPECIFICITY: Recognizes the α2 subunit of human, mouse, rat, guinea pig and rabbit DHP receptor. Detects a band of ~220kDa (non-reducing conditions) or ~143kDa (reducing conditions) by Western blot.
APPLICATION: Immunocytochemistry: 1:250
Immunohistochemistry (paraffin or frozen): 1:500. Staining of DHP in rabbit skeletal muscle results in double rows of discrete punctate staining representing pairs of triads on the opposing sides of the Z-lines
Western Blot: 1:500
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-652 Revised 22-Feb-07
Monoclonal Antibody to HERG1 (human) (A12)
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SYNONYMS anti-Erg1 (human) MAb (A12)
anti-Ether-a-go-go Related Protein 1 (human) MAb (A12)
anti-KCNH2 (human) MAb (A12)
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (human) MAb (A12)
anti-Voltage-gated Potassium Channel Kv11.1 (human) MAb (A12)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
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ALX-804-652-R300   300 µl 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: A12
ISOTYPE: Mouse IgG2b
FORMULATION: Liquid. Ascites.
IMMUNOGEN: Synthetic peptide corresponding to aa 575-588 (E575QPHMDSRIGWLHN588) of the extracellular loop S5-P of HERG1 (human ether-a-go-go related protein 1).
SPECIFICITY: Recognizes the extracellular loop S5-P of HERG1.
APPLICATION: Flow Cytometry (1:2-1:50)
Immunocytochemistry (1:50-1:200)
Immunohistochemistry (paraffin sections) (1:50-1:200)
Immunoprecipitation (3-5µl)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Monoclonal Antibodies
 
 
ALX-804-081 Revised 28-Jul-08
Monoclonal Antibody to Na+/K+ ATPase-α (M7-PB-E9)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
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ALX-804-081-R200   200 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Pig
Others
CLONE: M7-PB-E9
ISOTYPE: Mouse IgG1
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Purified sheep kidney Na+/K+ ATPase-α.
SPECIFICITY: Recognizes human, mouse, rat (α3 isoform only), sheep, bovine, pig, dog and chicken Na+/K+ ATPase-α. Detects a band of ~110kDa by Western blot.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry (1:100)
Immunoprecipitation
Western Blot (1:250)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-082 Revised 12-Nov-07
Monoclonal Antibody to Na+/K+ ATPase-α1 (M8-P1-A3)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
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ALX-804-082-R200   200 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
Sheep
Dog
Pig
CLONE: M8-P1-A3
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Sheep kidney Na+/K+ ATPase-α1.
SPECIFICITY: Recognizes the α1 subunit of rat, sheep, pig and dog Na+/K+ ATPase-α. Detects a band of ~110kDa by Western blot. Does not cross-react with Xenopus and chicken Na+/K+ ATPase-α1 or with rat Na+/K+ ATPase-α2 and -α3. Recognizes an epitope between aa 496-506 of sheep kidney Na+/K+ ATPase-α.
APPLICATION: Immunohistochemistry (frozen sections (1:100))
Western Blot (1:250)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-080 Revised 04-Mar-05
Monoclonal Antibody to Na+/K+ ATPase-α1 (9-A5)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
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ALX-804-080-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Dog
Others
CLONE: 9-A5
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified rat kidney Na+/K+ ATPase.
SPECIFICITY: Recognizes an intracellular region near Asp369 of the α1 subunit of human, rat, dog and chicken Na+/K+ ATPase-α.
APPLICATION: ELISA
Immunohistochemistry (1:1'000)
Immunoprecipitation (can be used for affinity purification of the α subunit of Na+/K+ ATPase from dog kidney extracts)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
The Na+/K+ ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The Na+ / K+ ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the a subunit, and an associated smaller glycoprotein, termed the b subunit. Studies indicate that there are three isoforms of the α subunit (α1, α2, α3) and two isoforms of the β subunit (β1 and β2) encoded by two multigene families.The different isoforms of the Na+/K+ ATPase exhibit tissue-specific and developmental patterns of expression. The α1 and β mRNAs are present in all cell types examined, whereas the α2 and α3 mRNAs exhibit a more restricted pattern of cell-specific expression. The α subunit has been found in kidney, brain, heart, and to a lesser extent liver, skeletal and smooth muscle.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-083 Revised 28-Apr-08
Monoclonal Antibody to Na+/K+ ATPase-α3 (XVIF9-G10)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
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ALX-804-083-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Sheep
Dog
Monkey
Others
CLONE: XVIF9-G10
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Dog cardiac microsomes.
SPECIFICITY: Recognizes the a3 subunit of human, rat, sheep, guinea pig, dog, rabbit and monkey Na+/K+ ATPase-α. Detects a band of ~110kDa by Western blot.
APPLICATION: Immunocytochemistry (5μg/ml)
Immunohistochemistry (frozen sections) (3μg/ml)
Western Blot (1μg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.