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JAK / STAT Signalling Pathway
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ALX-210-634 Revised 25-Sep-07
Polyclonal Antibody to IL-22 Receptor (human)
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SYNONYMS anti-Interleukin-22 Receptor (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptor Antibodies
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ALX-210-634-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 42-70 (D42SGPEGTPDTV
YSIEYKTYGERDWVAKKG70) of human IL-22 (interleukin-22) receptor.
SPECIFICITY: Recognizes human IL-22 receptor.
APPLICATION: ELISA (peptide (1:100'000))
Immunohistochemistry (1:300)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-159-016.
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General Literature References
Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R: M.H. Xie, et al.; J. Biol. Chem. 275, 31335 (2000) Abstract; Full Text
Identification of the functional interleukin-22 (IL-22) receptor complex: S.V. Kotenko, et al.; J. Biol. Chem. 276, 2725 (2001) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-633 Revised 31-Oct-06
Polyclonal Antibody to IL-22 Receptor-α 2 (human)
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SYNONYMS anti-Interleukin-22 Receptor-α 2 (human) PAb
anti-IL-22RA2 (human) PAb
anti-Interleukin 22-binding Protein CRF2-10 (human) PAb
anti-Class II Cytokine Receptor (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptor Antibodies
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ALX-210-633-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 33-60 (R33VQFQSRNFHNIL
QWQPGRALTGNSSVY60C) of human IL-22 (interleukin-22) receptor-α 2.
SPECIFICITY: Recognizes N-terminus of human IL-22 Receptor-α 2.
APPLICATION: ELISA (peptide (1:100'000))
Immunohistochemistry (1:300)
QUALITY CONTROL: Immunohistochemistry on human spleen and/or tonsil.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-159-015.
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General Literature References
A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist: W. Xu, et al.; PNAS 98, 9511 (2001) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies • Polyclonal Antibodies
 
 
ALX-210-635 Revised 25-Sep-07
Polyclonal Antibody to IL-28 Receptor-α (mouse)
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SYNONYMS anti-Interleukin-28 Receptor-α (mouse) PAb
anti-IL-28RA (mouse) PAb
anti-Cytokine Receptor Class II CRF2-12 (mouse) PAb
anti-Cytokine Receptor Family 2 Member 12 (mouse) PAb
anti-IFN-λ R1 (mouse) PAb
anti-Interferon λ Receptor 1 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptor Antibodies
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ALX-210-635-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 44-72 (L44PGLGSPPNVT
YFVTYQSYIKTGWRPVEH72) of mouse IL-28 (interleukin-28) receptor-α.
SPECIFICITY: Recognizes N-terminus of mouse IL-28 Receptor-α.
APPLICATION: ELISA (peptide (1:100'000))
Immunohistochemistry (1:300)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-159-017.
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General Literature References
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex: S.V. Kotenko, et al.; Nat. Immunol. 4, 69 (2003) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • Polyclonal Antibodies
 
 
ALX-210-392 Revised 12-Jul-06
Polyclonal Antibody to SOCS-1
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SYNONYMS anti-Suppressor of Cytokine Signalling-1 PAb
anti-JAB PAb
anti-SSI-1 PAb
anti-TIP-3 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SOCS / Related Products
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ALX-210-392-R200   200 µl 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide containing aa residues of human SOCS-1 (suppressor of cytokine signalling-1).
SPECIFICITY: Recognizes human and mouse SOCS-1.
APPLICATION: Western Blot (1:500 - 1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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General Information
SOCS-1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signalling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin. SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signalling.
General Literature References
SOCS proteins: negative regulators of cytokine signaling: D.L. Krebs and D.J. Hilton; Stem Cells 19, 378 (2001) Abstract
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation: I. Kinjyo, et al.; Immunity 17, 583 (2002) Abstract
A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts: S. Ilangumaran, et al.; J. Immunol. 169, 5010 (2002) Abstract
Further Categories Containing This Product:
Toll-IL-1 Receptor Adapters & TLR Downstream Signalling Other Products • Polyclonal Antibodies
 
 
ALX-210-461 Revised 07-Oct-08
Polyclonal Antibody to ST2 (human)
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SYNONYMS anti-IL-1 Receptor-like 1 (human) PAb
anti-Interleukin-1 Receptor-like 1 (human) PAb
anti-IL1RL1 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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ALX-210-461-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human ST2.
SPECIFICITY: Recognizes human ST2.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1-2 weeks when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-201-334 Revised 09-Jul-08
SOCS-3 (human) (recombinant) (His)
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SYNONYMS Suppressor of Cytokine Signalling-3 (human) (recombinant) (His)
CIS-3 (human) (recombinant) (His)
Cytokine-inducible SH2-containing Protein-3 (human) (recombinant) (His)
SSI-3 (human) (recombinant) (His)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SOCS / Related Products
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ALX-201-334-C050   50 µg 395.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Full length human SOCS-3 (suppressor of cytokine signalling-3) (aa 1-225) is fused at the C-terminus to a His-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 20mM sodium phosphate, pH 6.5, containing 20mM sodium chloride, 50mM glutamate, 50mM arginine, 2mM dithiothreitol, 1mM EDTA.
ENDOTOXIN CONTENT: <1.0EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O14543: Suppressor of Cytokine Signaling 3 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-370 Revised 07-Oct-08
ST2 (human) (recombinant)
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SYNONYMS IL-1 Receptor-like 1 (human) (recombinant)
Interleukin-1 Receptor-like 1 (human) (recombinant)
IL1RL1 (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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ALX-201-370-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the sequence of isoform 2 of human ST2 (IL1RL1) (aa 1-328) are fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q01638: Interleukin-1 receptor-like 1 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Interleukin-33 [IL-33] & Receptors / Related Products
 
 
ALX-201-367 Revised 07-Oct-08
ST2 (human):Fc (human) (recombinant)
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SYNONYMS IL-1 Receptor-like 1 (human):Fc (human) (recombinant)
Interleukin-1 Receptor-like 1 (human):Fc (human) (recombinant)
IL1RL1 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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ALX-201-367-C050   50 µg 410.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the sequence of isoform 2 of human ST2 (IL1RL1) (aa 1-328) are fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION: 0.25mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
BIOLOGICAL ACTIVITY: Interacts with human IL-33 as confirmed by pull-down assay (see figure 2).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q01638: Interleukin-1 receptor-like 1 (human) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Interleukin-33 [IL-33] & Receptors / Related Products
 
 
ALX-522-107 Revised 07-Oct-08
ST2 (mouse):Fc (human) (recombinant)
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SYNONYMS IL-1 Receptor-like 1 (mouse):Fc (human) (recombinant)
Interleukin-1 Receptor-like 1 (mouse):Fc (human) (recombinant)
IL1RL1 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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ALX-522-107-C050   50 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: Produced in CHO cells. Mouse ST2 (aa 27-332) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to mouse and human IL-33.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
ST2 is a transmembrane receptor of the new IL-1 family member IL-33. It induces the NF-κB pathway upon its activation and is involved in T helper type 2 response driving the production of Th2-associated cytokines. ST2 is predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P14719: Interleukin-1 Receptor-like 1 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Interleukin-33 [IL-33] & Receptors / Related Products
 
 
ALX-270-168 Revised 18-May-06
Tyrphostin AG 490
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SYNONYMS Tyrphostin B42
N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-]N-benzylcinnamamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-168-M005   5 mg 45.00 USD Add To Cart
ALX-270-168-M025   25 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C17H14N2O3
MW: 294.3
CAS NUMBER: 133550-30-8
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO and acetone; slightly soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosine kinase. Does not significantly inhibit other kinases, such as Lck, Lyn, Btk, Syk or Src. Blocks IL-7 induced JAK kinase activity in T cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. Valuable tool for studying the cellular role of JAK kinases in signal transduction.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989)