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ALX-101-010
Revised 11-Sep-07
L-Aspartic acid
SYNONYMS
H-L-Asp-OH
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
L-Amino Acids
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ALX-101-010-G001
1 g
12.00 USD
Product Specification
FORMULA:
C
4
H
7
NO
4
MW:
133.1
CAS NUMBER:
56-84-8
MERCK INDEX:
14:
840
RTECS:
CI9098500
PURITY:
≥99.5%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
NMDA Receptors / Related Products
•
Excitatory Amino Acids
ALX-101-011
Revised 22-Nov-06
D-Aspartic acid
SYNONYMS
H-D-Asp-OH
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
D-Amino Acids
Ordering Information
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ALX-101-011-G001
1 g
12.00 USD
Product Specification
FORMULA:
C
4
H
7
NO
4
MW:
133.1
CAS NUMBER:
1783-96-6
MERCK INDEX:
14:
840
RTECS:
CI9097500
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
Excitatory Amino Acids
•
NMDA Receptors / Related Products
ALX-445-006
Revised 03-Dec-07
4α-Phorbol 12,13-didecanoate
SYNONYMS
4α-PDD
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-006-M001
1 mg
35.00 USD
ALX-445-006-M005
5 mg
110.00 USD
Product Specification
FORMULA:
C
40
H
64
O
8
MW:
672.9
CAS NUMBER:
27536-56-7
PURITY:
≥98% (HPLC)
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solution cannot be made in aqueous media. Compound must be dissolved in an organic solvent prior to dilution into aqueous media. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous media.
HANDLING:
Protect from light.
HAZARD:
HIGHLY IRRITANT. VERY TOXIC. MAY BE CARCINOGENIC.
Product Description
Activator of TRPV4. Negative control for phorbol 12,13-didecanoate (PDD) (Prod. No.
ALX-445-002
).
Product Specific Literature References
TRPV4 calcium entry channel: a paradigm for gating diversity
:
B. Nilius, et al.; Am. J. Physiol. Cell Physiol.
286
, C195 (2004)
Abstract
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
:
H. Watanabe, et al.; J. Biol. Chem.
277
, 13569 (2002)
Abstract
Related Products
ALX-445-002
Phorbol 12,13-didecanoate
Further Categories Containing This Product:
TRPV2, TRPV3, TRPV4 / Related Products
•
Natural Products for Neurological Research
ALX-106-023
Revised 13-Dec-02
5-Hydroxy-L-tryptophan
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-106-023-M500
500 mg
20.00 USD
Product Specification
FORMULA:
C
11
H
12
N
2
O
3
MW:
220.2
CAS NUMBER:
56-69-9
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Serotonin precursor.
Further Categories Containing This Product:
Special Amino Acids
•
Glutamate Receptors (Metabotropic) / Related Products
ALX-106-024
Revised 14-Oct-08
O-Phospho-L-serine
SYNONYMS
L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
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ALX-106-024-G001
1 g
10.00 USD
Product Specification
FORMULA:
C
3
H
8
NO
6
P
MW:
185.1
CAS NUMBER:
407-41-0
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Store tightly sealed. Use fresh solutions.
Product Description
L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor.
Product Specific Literature References
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes:
W.E. Klunk, et al.; J. Neurochem.
56
, 1997 (1991)
Abstract
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor:
C. Thomsen & P.D. Suzdak; Neuroreport
4
, 1099 (1993)
Abstract
Agonists and antagonists for metabotropic glutamate receptors:
P.L. Ornstein, et al.; Curr. Pharm. Design
1
, 355 (1995), (Review)
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis:
K. Borodezt & S.R. D'Mello; J. Neurosci. Res.
53
, 531 (1998)
Abstract
Further Categories Containing This Product:
Special Amino Acids
•
Glutamate Receptors (Metabotropic) / Related Products
ALX-106-028
Revised 03-Apr-08
D-Cycloserine
SYNONYMS
R(+)-4-Amino-3-isoxazolidinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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ALX-106-028-M050
50 mg
20.00 USD
ALX-106-028-M250
250 mg
80.00 USD
Product Specification
FORMULA:
C
3
H
6
N
2
O
2
MW:
102.1
CAS NUMBER:
68-41-7
RTECS:
NY2975000
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Excitatory amino acid. Partial agonist at the glycine modulatory site of the NMDA receptor.
Further Categories Containing This Product:
Excitatory Amino Acids
•
Special Amino Acids
•
NMDA Receptors / Related Products
ALX-106-037
Revised 09-Oct-07
L-Cycloserine
SYNONYMS
S(-)-4-Amino-3-isoxazolidinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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ALX-106-037-M025
25 mg
50.00 USD
ALX-106-037-M100
100 mg
150.00 USD
Product Specification
FORMULA:
C
3
H
6
N
2
O
2
MW:
102.1
CAS NUMBER:
339-72-0; 4834-58-6
MERCK INDEX:
14:
2751
RTECS:
NY2976000
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Specific Literature References
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo:
K.S. Sundaram & M. Lev; J. Neurochem.
42
, 577 (1984)
Abstract
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine
:
R.D. Williams, et al.; J. Lipid Res.
28
, 1478 (1987)
Abstract
;
Full Text
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes:
G.B. Watson, et al.; Brain Res.
510
, 158 (1990)
Abstract
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain:
I.P. Chessell, et al.; Brain Res.
565
, 345 (1991)
Abstract
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor:
G.S. Shukla, et al.; Biochim. Biophys. Acta
1083
, 101 (1991)
Abstract
Further Categories Containing This Product:
Special Amino Acids
•
Excitatory Amino Acids
•
NMDA Receptors / Related Products
ALX-480-002
Revised 12-Apr-07
Adenosine 5'-diphosphate . potassium salt
SYNONYMS
ADP . K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
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ALX-480-002-G001
1 g
45.00 USD
ALX-480-002-G005
5 g
180.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
10
P
2
. K
MW:
426.2 . 39.1
CAS NUMBER:
72696-48-1
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during prolonged storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-550-010
Revised 16-Feb-05
(1R,3R)-homo-ACPD
SYNONYMS
(1R,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-010-M005
5 mg
95.00 USD
Product Specification
FORMULA:
C
8
H
13
NO
4
MW:
187.2
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Active isomer of
cis
-1,3-
homo
-ACPD (Prod. No.
ALX-550-009
) Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors:
H. Bräuner-Osborne, et al.; Eur. J. Pharmacol.
332
, 327 (1997)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
ALX-301-010
Revised 18-Feb-08
PAF (C16), Carbamyl-
SYNONYMS
1-O-Hexadecyl-2-N-methylcarbamyl-
sn
-glycero-3-phosphocholine
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-301-010-M001
1 mg
35.00 USD
ALX-301-010-M005
5 mg
140.00 USD
Product Specification
FORMULA:
C
26
H
55
N
2
O
7
P
MW:
538.7
CAS NUMBER:
91575-58-5
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, acetone, DMSO or acetonitrile purged with an inert gas.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Very hygroscopic.
Product Description
Biologically potent, non-metabolizable analog of platelet-activating factor (PAF).
Product Specific Literature References
1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor:
J.T. O'Flaherty, et al.; BBRC
147
, 18 (1987)
Abstract
Synthesis and evidence for the stability of a glycerophosphochloridate: rac-1-O-hexadecyl-2-O-(methylcarbamyl)-sn-glycero-3-phosphorochloridocholine:
J.R. Surles, et al.; J. Org. Chem.
53
, 899 (1988)
Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites:
T.G. Tessner, et al.; J. Biol. Chem.
264
, 4794 (1989)
Abstract
;
Full Text
PAF-acether transfer activity in HL-60 cells is induced during differentiation:
R.H. Lumb, et al.; BBRC
171
, 548 (1990)
Abstract
Further Categories Containing This Product:
Phospholipids / Related Products
ALX-430-156
Revised 21-Apr-08
6BIO
SYNONYMS
(2’Z,3’E)-6-Bromoindirubin-3’-oxime
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
GSK-3 Inhibitors
Ordering Information
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ALX-430-156-M001
1 mg
40.00 USD
