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ALX-505-005
Revised 23-Jul-08
KillerTRAIL™ Storage and Dilution Buffer
PRODUCT LINE
Molecular Biology
PRODUCT CATEGORY
Buffers / Detergents / Solutions
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-505-005-R500
500 µl
60.00 USD
Product Specification
PURITY DETAIL:
Sterile filtered.
FORMULATION:
Liquid. 20mM HEPES, pH 7.4, containing 300mM NaCl, 0.01% Tween 20, 1% sucrose and 1mM DTT.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Storage and dilution buffer for use with the following products:
Killer
TRAIL™, Soluble (human) (recombinant) (Prod. No.
ALX-201-073
)
Super
Killer
TRAIL™, Soluble (human) (recombinant) (Prod. No.
ALX-201-115
)
Super
Killer
TRAIL™, Soluble (mouse) (recombinant) (Prod. No.
ALX-201-130
)
Useful for prediluting the above mentioned products before preparing aliquots or performing experiments. Predilution with
Killer
TRAIL™ Storage and Dilution Buffer allows for easier handling of small working concentrations (sometimes only 0.1µl of the
Killer
TRAIL™ or Super
Killer
TRAIL™ stock solution is necessary because of their high activity). Predilution with
Killer
TRAIL™ Storage and Dilution Buffer instead of medium or PBS prevents loss of biological activity. Can also be used as negative control.
General Information
BACKGROUND/TECHNICAL INFORMATION
Prepare a 1:10 dilution of
Killer
TRAIL™ or Super
Killer
TRAIL™ with
Killer
TRAIL™ Storage and Dilution Buffer. For immediate use, keep prediluted
Killer
TRAIL™ or Super
Killer
TRAIL™ on ice until adding to cells. For storage, prepare aliquots and freeze at -80°C.
Related Products
ALX-201-115
Super
Killer
TRAIL™, Soluble (human) (recombinant)
ALX-201-073
Killer
TRAIL™, Soluble (human) (recombinant)
ALX-201-130
Super
Killer
TRAIL™, Soluble (mouse) (recombinant)
Further Categories Containing This Product:
TRAIL [Apo-2L]
ALX-350-335
Revised 14-Nov-07
Cochlioquinone A
SYNONYMS
Luteoleersin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-335-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
30
H
44
O
8
MW:
532.7
CAS NUMBER:
32450-25-2
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites:
J.M. Schaeffer, et al.; J. Antibiot. (Tokyo)
43
, 1179 (1990)
Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi:
T. Fujioka, et al.; J. Antibiot. (Tokyo)
49
, 409 (1996)
Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola:
H.J. Jung, et al.; Bioorg. Med. Chem.
11
, 4743 (2003)
Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1:
H.B. Lee, et al.; J. Antibiot. (Tokyo)
56
, 967 (2003)
Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
NAD+ Metabolism / Related Products
•
Vitamins
ALX-350-341
Revised 14-Nov-07
Cochlioquinone B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-341-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
28
H
40
O
6
MW:
472.6
CAS NUMBER:
32450-26-3
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
NAD+ Metabolism / Related Products
•
Vitamins
ALX-270-478
Revised 30-Jul-08
SB 225002
SYNONYMS
N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CXC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-478-M001
1 mg
30.00 USD
ALX-270-478-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
10
BrN
3
O
4
MW:
352.1
CAS NUMBER:
182498-32-4
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by MS,
1
H-NMR and
13
C-NMR.
Product Description
Potent and selective antagonist of CXCR2 chemokine receptor (IC
50
=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC
50
=8nM) and GROα-mediated (IC
50
=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
Product Specific Literature References
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration:
J.R. White, et al.; J. Biol. Chem.
273
, 10095 (1998)
Abstract
;
Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2:
J. Catusse, et al.; Biochem. Pharmacol.
65
, 813 (2003)
Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer:
B. Wang, et al.; Cancer Res.
66
, 3071 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
HIV / AIDS / Related Products
ALX-350-119
Revised 20-Feb-08
Fumagillin
SYNONYMS
Fumidil B
Fumadil B
TNP-470
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-119-MC05
0.5 mg
65.00 USD
ALX-350-119-M001
1 mg
105.00 USD
Product Specification
FORMULA:
C
26
H
34
O
7
MW:
458.6
CAS NUMBER:
23110-15-8
MERCK INDEX:
14:
4286
SOURCE/HOST:
Isolated from
Aspergillus fumigatus.
PURITY:
≥95%
APPEARANCE:
Light yellow solid
SOLUBILITY:
Soluble in chloroform or diluted aqueous bases. Slightly soluble in methanol and other alcoholic solvents. Insoluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in aqueous solutions with pH >9.0 or pH <5.0.
HANDLING:
Packaged under inert gas. Protect from light.
HAZARD:
HARMFUL.
Product Description
Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II). Antineoplastic. Anti-infective.
Product Specific Literature References
Fumagillin (H-3), a new antibiotic with amebicidal properties
:
C.M. Mc, et al.; Science
113
, 202 (1951)
Abstract
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
:
D. Ingber, et al.; Nature
348
, 555 (1990)
Abstract
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase
:
W.T. Lowther, et al.; PNAS
95
, 12153 (1998)
Abstract
;
Full Text
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2:
E.C. Griffith, et al.; PNAS
95
, 15183 (1998)
Abstract
Fumagillin treatment of intestinal microsporidiosis:
J.M. Molina, et al.; N. Engl. J. Med.
346
, 1963 (2002)
Abstract
Whirling disease of salmonid fish: life cycle, biology, and disease:
M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol.
89
, 658 (2003)
Abstract
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis:
I.S. Sheen, et al.; World J. Gastroenterol.
11
, 771 (2005)
Abstract
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors:
B. Lefkove, et al.; Expert Rev. Anti Infect. Ther.
5
, 573 (2007), Review
Abstract
FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470):
G.J. Chen, et al.; J. Cell Biochem.
101
, 1492 (2007)
Abstract
Further Categories Containing This Product:
Aminopeptidases / Related Products
•
Fibroblast Growth Factors [FGFs] & Receptors / Related Products
•
Natural Products - Other Anti-infective Agents
•
Antitumor Antibiotics
•
Antitumor Agents (Anti-proliferative)
ALX-270-204
Revised 11-Nov-08
bpV(phen)
SYNONYMS
Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Oxovanadates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-204-M005
5 mg
53.00 USD
ALX-270-204-M025
25 mg
195.00 USD
Product Specification
FORMULA:
K[VO(O
2
)
2
C
12
H
8
N
2
] . 3H
2
O
MW:
350.3 . 54.0
PURITY:
≥98% (
51
V-NMR)
APPEARANCE:
Yellow to orange powder.
SOLUBILITY:
Soluble in water (10mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR (D
2
O) and
51
V-NMR (D
2
O)
Product Description
Potent protein phosphotyrosine phosphatase inhibitor. Also shown to be a potent insulin receptor kinase activator; excellent insulin mimetic
in vitro
and
in vivo
.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics:
B.I. Posner, et al.; J. Biol. Chem.
269
, 4596 (1994)
Abstract
;
Full Text
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling:
A.P. Bevan, et al.; J. Biol. Chem.
270
, 10784 (1995)
Abstract
;
Full Text
In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency:
A.P. Bevan, et al.; Am. J. Physiol.
268
, E60 (1995)
Abstract
Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats:
J.F. Yale, et al.; Diabetes
44
, 1274 (1995)
Abstract
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo:
P.G. Drake, et al.; Endocrinology
137
, 4960 (1996)
Abstract
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ:
C.J. Band & B.I. Posner; J. Biol. Chem.
272
, 138 (1997)
Abstract
;
Full Text
Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1:
K.J. Serio, et al.; J. Immunol.
170
, 2121 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products
ALX-270-112
Revised 16-Jun-08
Pentoxifylline
SYNONYMS
Trental
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-
1H
-purine-2,6-dione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
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Quantity:
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ALX-270-112-G001
1 g
15.00 USD
ALX-270-112-G005
5 g
35.00 USD
Product Specification
FORMULA:
C
13
H
18
N
4
O
3
MW:
278.3
CAS NUMBER:
6493-05-6
MERCK INDEX:
14:
7136
SOURCE/HOST:
Isolated from
Penicillium expansum
.
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Phosphodiesterase inhibitor. Blocks the synthesis of TNF-α. Improves blood flow by decreasing blood viscosity.
Product Specific Literature References
Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality:
P. Noel, et al.; Life Sci.
47
, 1023 (1990)
Abstract
Pentoxifylline inhibits the expression of tissue factor mRNA in endotoxin-activated human monocytes:
V. Ollivier, et al.; FEBS Lett.
322
, 231 (1993)
Abstract
Pentoxifylline:
C.P. Samlaska & E.A. Winfield; J. Am. Acad. Dermatol.
30
, 603 (1994), Review
Abstract
Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism:
K. Prasad & P. Lee; Atherosclerosis
192
, 313 (2007)
Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
•
TNF-alpha & TNF Receptors Other Products
•
Nitric Oxide Pathway Other Products
ALX-270-171
Revised 30-Jun-08
Chlorpromazine . hydrochloride
SYNONYMS
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-171-G001
1 g
22.00 USD
ALX-270-171-G005
5 g
66.00 USD
Product Specification
FORMULA:
C
17
H
19
ClN
2
S . HCl
MW:
318.9 . 36.5
CAS NUMBER:
69-09-0
MERCK INDEX:
14:
2185
RTECS:
SO1750000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D
2
antagonist. H
1
antagonist. Inhibits TNF-α production. Potent PLA
2
inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity:
H.B. Collier; Clin. Biochem.
7
, 331 (1974)
Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins:
D.R. Marshak, et al.; Biochemistry
24
, 144 (1985)
Abstract
Selective inhibition of group II phospholipase A2 by quercetin:
M. Lindahl & C. Tagesson; Inflammation
17
, 573 (1993)
Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge:
M. Palacios, et al.; BBRC
196
, 280 (1993)
Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice:
H. Yamamoto; Toxicol. Lett.
66
, 73 (1993)
Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice:
M.G. Netea, et al.; J. Infect. Dis.
171
, 393 (1995)
Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase:
A. Boveris, et al.; Methods Enzymol.
359
, 328 (2002)
Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine:
S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys.
430
, 170 (2004)
Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
•
TNF-alpha & TNF Receptors Other Products
•
Chemopreventive Agents Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
PLA2 Inhibitors
•
Dopaminergics & Dopamine Receptors / Related Products
ALX-270-235
Revised 04-Feb-05
JM 42
SYNONYMS
N-(4,6-Dimethylpyridin-2-yl)-5-bromofurane-2-carboxamide
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
TNF-alpha & TNF Receptors Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-235-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
12
H
11
BrN
2
O
2
MW:
295.1
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
For biological studies, solubilize as a maleate salt just before use.
HANDLING:
Keep under inert gas. Protect from light.
Product Description
Anti-inflammatory pyridinylamide that inhibits TNF-α production, probably by interacting with a protein kinase C (PKC)-dependent pathway. May serve as an alternative to classical cyclooxygenase (COX) inhibitors in TNF-α involved pathogenesis.
Product Specific Literature References
New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation
:
F. Lang, et al.; J. Pharmacol. Exp. Ther.
275
, 171 (1995)
Abstract
ALX-270-236
Revised 04-Feb-05
JM 34
