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Inflammasome
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ALX-210-958 Revised 07-May-08
Polyclonal Antibody to NALP12 (human) (AL236)
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SYNONYMS anti-NLRP12 PAb (human) (AL236)
anti-NACHT-, LRR- and PYD-containing Protein 12 PAb (human) (AL236)
anti-PYRIN-containing APAF1-like Protein 7 PAb (human) (AL236)
anti-Monarch-1 PAb (human) (AL236)
anti-Regulated by Nitric Oxide PAb (human) (AL236)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-958-C100   100 µg 350.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa near the N-terminus of human NALP12.
SPECIFICITY: Recognizes human NALP12.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-904 Revised 25-Jan-08
Polyclonal Antibody to NALP1 (human) (AL176)
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SYNONYMS anti-NACHT-, LRR- and PYD-containing Protein 1 (human) PAb (AL176)
anti-DEFCAP (human) PAb (AL176)
anti-NAC (human) PAb (AL176)
anti-CARD7 (human) PAb (AL176)
anti-Caspase Recruitment Domain-containing Protein 7 (human) PAb (AL176)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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ALX-210-904-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
PURITY: Affinity purified.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) of N-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY: Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: For Positive Control (Western blot) see Prod. No. ALX-840-603.
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Product Specific Literature References
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon; Mol. Cell. 10, 417 (2002) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Signalling: Initiation of pro-IL-1beta processing: E. Bell; Nat. Rev. Immunol. 2, 719 (2002), (Review) Abstract
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1: S.M. Srinivasula, et al.; J. Biol. Chem. 277, 21119 (2002) Abstract
NALPS: a novel protein family involved in inflammation: J. Tschopp, et al.; Nat. Rev. Mol. Cell Biol. 4, 95 (2003), (Review) Abstract; Full Text
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products • Polyclonal Antibodies
 
 
ALX-210-017 Revised 12-Apr-07
Polyclonal Antibody to NALP1 (human) (CT) (Bur 242)
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SYNONYMS anti-NACHT-, LRR- and PYD-containing Protein 1 (human) (CT) PAb (Bur 242)
anti-DEFCAP (human) (CT) PAb (Bur 242)
anti-NAC (human) (CT) PAb (Bur 242)
anti-CARD7 (human) (CT) PAb (Bur 242)
anti-Caspase Recruitment Domain-containing Protein 7 (human) (CT) PAb (Bur 242)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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ALX-210-017-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1058-1077 (C1058VPSPASQGDLHTKPLGTDD1077) of C-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY: Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION: Immunohistochemistry (paraffin sections)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: For Positive Control (Western blot) see Prod. No. ALX-840-603.
Product Specific Literature References
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis: Z.L. Chu, et al.; J. Biol. Chem. 276, 9239 (2001) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products • Polyclonal Antibodies
 
 
ALX-210-018 Revised 12-Apr-07
Polyclonal Antibody to NALP1 (human) (NT) (Bur 241)
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SYNONYMS anti-NACHT-, LRR- and PYD-containing Protein 1 (human) (NT) PAb (Bur 241)
anti-DEFCAP (human) (NT) PAb (Bur 241)
anti-NAC (human) (NT) PAb (Bur 241)
anti-CARD7 (human) (NT) PAb (Bur 241)
anti-Caspase Recruitment Domain-containing Protein 7 (human) (NT) PAb (Bur 241)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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ALX-210-018-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 161-180 (P161SSPDHESPSQESPNAPTST180) of N-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY: Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION: Immunohistochemistry (paraffin sections)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: For Positive Control (Western blot) see Prod. No. ALX-840-603.
Product Specific Literature References
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis: Z.L. Chu, et al.; J. Biol. Chem. 276, 9239 (2001) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products • Polyclonal Antibodies
 
 
ALX-210-949 Revised 29-Oct-07
Polyclonal Antibody to Pannexin-1 (human) (AT124)
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SYNONYMS anti-Pannexin-1 (human) PAb (AT124)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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ALX-210-949-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to 15 aa near the C-terminus of human pannexin-1.
SPECIFICITY: Recognizes human pannexin-1.
APPLICATION: Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
Pannexin-1 belongs to a new family of membrane proteins with homology to invertebrate gap junction proteins innexins. Pannexin-1 has recently been involved in the NALP (inflammasome)-mediated caspase-1 activation and IL-1β secretion.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling: T.D. Kanneganti, et al.; Immunity 26, 433 (2007) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-946 Revised 10-Oct-07
Polyclonal Antibody to Pyrin (human) (AL196)
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SYNONYMS anti-MEFV (human) PAb (AL196)
anti-Mediterranean Fever Protein (AL196)
anti-Marenostrin (human) PAb (AL196)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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ALX-210-946-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-29 (A2KTPSDHLLSTLEELVPYDFEKFKFKLQ29) of human pyrin (MEFV; mediterranean fever protein).
SPECIFICITY: Recognizes human pyrin.
APPLICATION: Immunoprecipitation
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing: S. Papin, et al.; Cell Death Differ. 14, 1457 (2007) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-420-038 Revised 09-May-07
R-848
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SYNONYMS 4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol
S 28463
Resiquimod
PRODUCT LINE Immunology
PRODUCT CATEGORY Immunomodulators Other Products
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ALX-420-038-M005   5 mg 50.00 USD Add To Cart
ALX-420-038-M025   25 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C17H22N4O2
MW: 314.4
CAS NUMBER: 144875-48-9
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% methanol or 5% methanol in dichloromethane. Poorly soluble in acetonitrile or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Potent antitumor and antiviral compound. Stimulates antibody secretion, cytokine production, protection from apoptosis and CD80 upregulation.
Product Specific Literature References
The immune response modifier resiquimod mimics CD40-induced B cell activation: G.A. Bishop, et al.; Cell. Immunol. 208, 9 (2001) Abstract
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway: H. Hemmi, et al.; Nat. Immunol. 3, 196 (2002) Abstract
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848: M. Jurk, et al.; Nat. Immunol. 3, 499 (2002) Abstract
Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses: J.J. Wu, et al.; Antiviral Res. 64, 79 (2004) Abstract
TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848): R.D. Weeratna, et al.; Vaccine 23, 5263 (2005) Abstract
Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells: G. Caron, et al.; J. Immunol. 175, 1551 (2005) Abstract; Full Text
Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848): M.J. McCluskie, et al.; Antiviral Res. 69, 77 (2006) Abstract
Further Categories Containing This Product:
CD40 & CD40L [CD154] / Related Products • Inflammasome • TLR Agonists Other Products
 
 
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