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Polyclonal Antibodies
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ALX-210-803 Revised 09-Feb-05
Polyclonal Antibody to Ataxia telangiectasia Mutated (human)
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SYNONYMS anti-ATM (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Ataxia telangiectasia Mutated / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-803-C100   100 µg 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.1mg/ml
FORMULATION: 100µg of purified antibody in 1.0ml of 0.05M sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
IMMUNOGEN: Synthetic peptide corresponding to aa 819-844 of human ATM (ataxia-telangiectasia mutated).
SPECIFICITY: Recognizes human ATM.
APPLICATION: Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Product Description
Ataxia telangiectasia is a recesive childhood disease by mutations in the ATM (AT-mutated) gene. ATM protein and Ataxia telangiectasia and Rad3-related protein (ATR) belongs to a family of protein kinases that share similarities at their C-terminal region with the catalytic domain of PI(3)K (phosphoinositide 3-kinase). ATM and ATR function in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATM and ATR directly phosphorylate the breast/ovarian cancer susceptibility gene BRCA1 following DNA damage and also regulate Chk1, which is required for the G2/M checkpoint. Like DNA-PK ATR phosphorylates p53 on serine 15. ATM has also been shown to phosphorylate murine double minute 2 (MDM2) and to interact with histone deacetylase. ATM, but not ATR is cleaved during apoptosis very similar to PARP.
Product Specific Literature References
Ataxia-telangiectasia and cellular responses to DNA damage: M.S. Meyn; Cancer Res. 55, 5991 (1995) Abstract
Defective G2 checkpoint function in cells from individuals with familial cancer syndromes: R.S. Paules, et al.; Cancer Res. 55, 1763 (1995) Abstract
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia: M.B. Kastan, et al.; Cell 71, 587 (1992) Abstract
Radiosensitivity in ataxia-telangiectasia: a new explanation: R.B. Painter & B.R. Young; PNAS 77, 7315 (1980) Abstract
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species: K. Savitsky, et al.; Hum. Mol. Genet. 4, 2025 (1995) Abstract
A single ataxia telangiectasia gene with a product similar to PI-3 kinase: K. Savitsky, et al.; Science 268, 1749 (1995) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Recommendations for Western blotting

ATM is a high MW protein of ~350kDa and as such, conditions may require optimization. 100-150µg of cell lysate is loaded on 5% acrylamide gels (until 200kDa marker is halfway through the gel) and transferred to nitrocellulose using semi-dry transfer at 9V constant voltage for 2 hours. Detection should be done using HRP-conjugated anti-rabbit IgG. This antibody may detect several smaller non-specific bands present in both ATM mutant and wild type cells. Therefore, careful titering of antibody concentrations is recommended.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-798 Revised 27-Dec-06
Polyclonal Antibody to ATR (human)
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SYNONYMS anti-Ataxia telangiectasia and Rad3-related Protein (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Ataxia telangiectasia Mutated / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-798-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 4mg/ml
FORMULATION: Liquid. Affinity purified IgG in PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human ATR (ataxia telangiectasia and Rad3-related protein) (aa 400-460).
SPECIFICITY: Recognizes human ATR. Detects a band of ~305kDa by Western blot.
APPLICATION: Immunoprecipitation
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-066 Revised 30-Oct-06
Polyclonal Antibody to ATRIP (human)
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SYNONYMS anti-ATR-interacting Protein (human) PAb
anti-ATM and Rad3-related Interacting Protein (human) PAb
anti-Ataxia telangiectasia and Rad3-related Interacting Protein (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Ataxia telangiectasia Mutated / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-066-C050   50 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: ~3.8mg/ml
FORMULATION: Liquid. Protein G purified antibody in PBS containing 10% glycerol and 0.02% sodium azide.
IMMUNOGEN: Recombinant human ATRIP (Ataxia telangiectasia and Rad3-related interacting protein) (aa 1-182).
SPECIFICITY: Recognizes human ATRIP.
APPLICATION: Immunohistochemistry
Immunoprecipitation (0.1-0.5µg)
Western Blot (0.75µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
ATR and ATRIP: partners in checkpoint signaling: D. Cortez, et al.; Science 294, 1713 (2001) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-799 Revised 16-Apr-07
Polyclonal Antibody to BAFF (CT)
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SYNONYMS anti-BLyS (CT) PAb
anti-TALL-1 (CT) PAb
anti-THANK (CT) PAb
anti-zTNF4 (CT) PAb
anti-TNFSF 13B/20 (CT) PAb
anti-CD257 (CT) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
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ALX-210-799-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Ion exchange chromatography purified IgG.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to C-terminal aa 254-269 of human BAFF.
SPECIFICITY: Recognizes human, mouse and rat BAFF.
APPLICATION: Western Blot (0.25-1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1 year after receipt when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-011 Revised 22-Apr-08
Polyclonal Antibody to BAG-1 (Bur 1680)
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SYNONYMS anti-Bcl-2 Associated Athanogene-1 PAb (Bur 1680)
anti-BAG Family Molecular Chaperone Regulator 1 (Bur 1680) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-011-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant mouse BAG-1 (Bcl-2 associated athanogene-1) (aa 8-219).
SPECIFICITY: Recognizes mouse and rat BAG-1.
APPLICATION: Immunocytochemistry (1:100)
Immunohistochemistry (paraffin sections (1:5'000))
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Bag1 is a regulator and marker of neuronal differentiation: P. Kermer, et al.; Cell Death Differ. 9, 405 (2002) Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions: S. Alberti, et al.; Cell Stress Chaperones 8, 225 (2003) Abstract; Full Text
BAG-1: a multi-functional pro-survival molecule: P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol. 37, 251 (2005) Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • Chaperone-mediated Autophagy [CMA] • Polyclonal Antibodies • Ubiquitin Ligases [E3]
 
 
ALX-210-009 Revised 22-Apr-08
Polyclonal Antibody to BAG-1 (mouse) (CT) (Bur 1702)
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SYNONYMS anti-Bcl-2 Associated Athanogene-1 (mouse) (CT) PAb (Bur 1702)
anti-BAG Family Molecular Chaperone Regulator 1 (mouse) (CT) (Bur 1702) PAb
anti-RAP46 (mouse) (CT) (Bur 1702) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
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ALX-210-009-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 204-219 (C204QETERLQSTNLALAE219) of mouse BAG-1 (Bcl-2 associated athanogene-1).
SPECIFICITY: Recognizes mouse BAG-1.
APPLICATION: Immunohistochemistry (paraffin sections (1:2'500))
Immunoprecipitation (transfected cells)
Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity: S. Takayama, et al.; Cell 80, 279 (1995) Abstract
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain: M. Adachi, et al.; Blood 88, 4118 (1996) Abstract; Full Text
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1: H.G. Wang, et al.; PNAS 93, 7063 (1996) Abstract; Full Text
Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2: C.V. Clevenger, et al.; Mol. Endocrinol. 11, 608 (1997) Abstract; Full Text
Bag1 is a regulator and marker of neuronal differentiation: P. Kermer, et al.; Cell Death Differ. 9, 405 (2002) Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions: S. Alberti, et al.; Cell Stress Chaperones 8, 225 (2003) Abstract; Full Text
BAG-1: a multi-functional pro-survival molecule: P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol. 37, 251 (2005) Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • Chaperone-mediated Autophagy [CMA] • Polyclonal Antibodies • Ubiquitin Ligases [E3]
 
 
ALX-210-010 Revised 22-Apr-08
Polyclonal Antibody to BAG-1 (NT) (Bur 1735)
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SYNONYMS anti-Bcl-2 Associated Athanogene-1 (NT) PAb (Bur 1735)
anti-BAG-family Molecular Chaperone Regulator 1 (NT) (Bur 1735) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-010-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 26-46 (N26ERYDLLVTPQQGNSEPVVQD46) of mouse BAG-1 (Bcl-2 associated athanogene-1).
SPECIFICITY: Recognizes mouse and rat BAG-1.
APPLICATION: Immunocytochemistry (1:1'000)
Immunohistochemistry (paraffin sections (1:3'500))
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Bag1 is a regulator and marker of neuronal differentiation: P. Kermer, et al.; Cell Death Differ. 9, 405 (2002) Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions: S. Alberti, et al.; Cell Stress Chaperones 8, 225 (2003) Abstract; Full Text
BAG-1: a multi-functional pro-survival molecule: P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol. 37, 251 (2005) Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • Chaperone-mediated Autophagy [CMA] • Polyclonal Antibodies • Ubiquitin Ligases [E3]
 
 
ALX-210-538 Revised 22-Apr-08
Polyclonal Antibody to BAG-3 (TOS-2)
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SYNONYMS anti-Bcl-2-binding Athanogene-3 PAb (TOS-2)
anti-Docking Protein CAIR-1 PAb (TOS-2)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
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ALX-210-538-R050   50 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human BAG-3 (Bcl-2-binding athanogene-3).
SPECIFICITY: Recognizes human, mouse and rat BAG-3.
APPLICATION: Immunocytochemistry
Immunohistochemistry (frozen sections; paraffin sections (1:100-1:200))
Immunoprecipitation
Western Blot (1:1’000-1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Specific Literature References
The anti- apoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor- related apoptosis-inducing ligand (TRAIL): G. Chiappetta, et al.; J. Clin. Endocrinol. Metab. 92, 1159 (2007) Abstract; Full Text
Evidence for BAG3 modulation of HIV-1 gene transcription: A. Rosati, et al.; J. Cell. Physiol. 210, 676 (2007) Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-3 (CAIR-1; Bis) forms a complex with HSC70 and assists in polypeptide folding. In addition, this complex can mediate protein delivery to proteasome and is able to downregulate apoptosis by interfering with cytochrome c release, apoptosome assembly and other events. In human cancer cell lines, BAG-3 expression sustains cell survival and underlies resistance to therapy through downmodulation of apoptosis.
General Literature References
BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis: M.F. Romano, et al.; Cell Death Differ. 10, 383 (2003) Abstract; Full Text
Apoptosis inhibition in cancer cells: a novel molecular pathway that involves BAG3 protein: A. Rosati, et al.; Int. J. Biochem. Cell Biol. 39, 1337 (2007), (Review) Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • Polyclonal Antibodies
 
 
ALX-210-002 Revised 29-Jun-05
Polyclonal Antibody to Bak
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SYNONYMS anti-BCL2L7 PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-002-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 14-36 (C14GEPALPSASEEQVAQDTEEVFR36) of human Bak.
SPECIFICITY: Recognizes human, mouse and rat Bak. Detects a band of ~24kDa by Western blot.
APPLICATION: Immunohistochemistry (paraffin sections)
Western Blot (1-2µl/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
Product Specific Literature References
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas: M. Krajewska, et al.; Cancer Res. 56, 2422 (1996) Abstract
Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family: S. Krajewski, et al.; Cancer Res. 56, 2849 (1996) Abstract
Increased intestinal Bak expression results in apoptosis: S.F. Moss, et al.; BBRC 223, 199 (1996) Abstract
Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teeth: S. Krajewski, et al.; Cell Death Differ. 5, 408 (1998) Abstract
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1: I.M. Pedersen, et al.; Blood 100, 1795 (2002) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-016 Revised 02-Feb-07
Polyclonal Antibody to BAR (human) (AR-48)
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SYNONYMS anti-Bifunctional Apoptosis  Regulator (human) PAb (AR-48)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-016-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Contains PBS and 0.05% sodium azide.