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NMDA Receptors / Related Products
You are here: Product Lines > Neurobiology > Excitatory Amino Acids & Receptors > Glutamate Receptors (Ionotropic) / Related Products > NMDA Receptors / Related Products
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ALX-550-033 Revised 07-Aug-07
D-AP5
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SYNONYMS D(-)-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-033-M005   5 mg 65.00 USD Add To Cart
ALX-550-033-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C5H12NO5P
MW: 197.1
CAS NUMBER: 79055-68-8
PURITY: ≥97%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (acidify for better solubility).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
More active form of DL-AP5 (Prod. No. ALX-550-034). Widely used competitive NMDA receptor antagonist.
Product Specific Literature References
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids: T.W. Stone, et al.; Neuroscience 6, 2249 (1981) Abstract
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation: J. Davies, et al.; Neurosci. Lett. 21, 77 (1981) Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord: J. Davies & J.C. Watkins; Brain Res. 235, 378 (1982) Abstract
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro: J. Davis; J. Neurosci. 12, 21 (1992) Abstract
 
 
ALX-550-034 Revised 25-Jul-08
DL-AP5
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SYNONYMS DL-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-034-M005   5 mg 30.00 USD Add To Cart
ALX-550-034-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C5H12NO5P
MW: 197.1
CAS NUMBER: 76326-31-3
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 1M NaOH or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Potent and selective NMDA receptor antagonist.
Product Specific Literature References
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation: J. Davies, et al.; Neurosci. Lett. 21, 77 (1981) Abstract
Excitatory amino acid transmitters: J.C. Watkins and R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord: J. Davies and J.C. Watkins; Brain Res. 235, 378 (1982) Abstract
 
 
ALX-550-035 Revised 26-Nov-04
L-AP5
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SYNONYMS L(+)-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-035-M001   1 mg 40.00 USD Add To Cart
ALX-550-035-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C5H12NO5P
MW: 197.1
CAS NUMBER: 79055-67-7
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Specific Literature References
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord: J. Davies and J.C. Watkins; Brain Res. 235, 378 (1982) Abstract
 
 
ALX-550-037 Revised 17-Jan-05
DL-AP3
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SYNONYMS DL-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-037-M050   50 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C3H8NO5P
MW: 169.1
CAS NUMBER: 20263-06-3
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.

Product Description
NMDA receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase: J.E. Hawkinson, et al.; Eur. J. Pharmacol. 307, 219 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-043 Revised 15-May-03
5,7-Dichlorokynurenic acid . sodium salt
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SYNONYMS 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid . Na
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-043-M005   5 mg 25.00 USD Add To Cart
ALX-550-043-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C10H5Cl2NO3 . Na
MW: 258.1 . 23.0
CAS NUMBER: 131123-76-7
PURITY: ≥98%
APPEARANCE: Light yellow solid.
SOLUBILITY: Soluble in DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Potent antagonist at the glycine site of the NMDA receptor.
Product Specific Literature References
Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site: B.M. Baron, et al.; Mol. Pharmacol. 38, 554 (1990) Abstract
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors: D. McNamara, et al.; Neurosci. Lett. 120, 17 (1990) Abstract
Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate: P.D. Leeson, et al.; J. Med. Chem. 34, 1243 (1991) Abstract
 
 
ALX-550-049 Revised 09-Oct-08
(±)-Ibotenic acid
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SYNONYMS (±)α-Amino-3-hydroxy-5-isoxazoleacetic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-049-M001   1 mg 55.00 USD Add To Cart
ALX-550-049-M005   5 mg 220.00 USD Add To Cart
ALX-550-049-M025   25 mg 690.00 USD Add To Cart
Product Specification
FORMULA: C5H6N2O4
MW: 158.1
CAS NUMBER: 2552-55-8
MERCK INDEX: 14: 4877
RTECS: NY2100000
SOURCE/HOST: Synthetic.
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
HAZARD: TOXIC.

Product Description
Potent glutamate receptor agonist. Neurotoxic agent.
Product Specific Literature References
Central actions of ibotenic acid and muscimol: G.A. Johnston, et al.; Biochem. Pharmacol. 17, 2488 (1968) Abstract
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid: G.A. Johnston, et al.; Nature 248, 804 (1974) Abstract
Excitatory amino acid transmitters: J.C. Watkins and R.H. Evans; Annu. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Further Categories Containing This Product:
NMDA Receptors / Related Products • Glutamate Receptors (Metabotropic) / Related Products • Excitatory Amino Acids
 
 
ALX-550-052 Revised 09-Oct-08
Kynurenic acid
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SYNONYMS 4-Hydroxyquinoline-2-carboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-052-M250   250 mg 12.00 USD Add To Cart
ALX-550-052-G001   1 g 35.00 USD Add To Cart
Product Specification
FORMULA: C10H7NO3
MW: 189.2
CAS NUMBER: 492-27-3
MERCK INDEX: 14: 5327
PURITY: ≥98% (Titration, HPLC)
APPEARANCE: Off-white to tan powder.
SOLUBILITY: Soluble in water (~0.9% at 100°C) or 100% ethanol (warm); also soluble in 0.1N NaOH or DMSO; insoluble in ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for several days when stored at +4°C.
HAZARD: IRRITANT.

Product Description
Metabolite of tryptophan. Antagonist at both the NMDA and AMPA/kainate receptors. Blocks kainic acid neurotocixity.
Product Specific Literature References
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid: M.N. Perkins & T.W. Stone; Brain Res. 247, 184 (1982) Abstract
The N-methyl-D-aspartate receptor and burst firing of CA1 hippocampal pyramidal neurons: M.J. Peet, et al.; Neuroscience 22, 563 (1987) Abstract
Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors: J.J. Hansen & P. Krogsgaard-Larsen; Med. Res. Rev. 10, 55 (1990) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products • Kainate Receptors / Related Products
 
 
ALX-550-057 Revised 21-Feb-03
Quinolinic acid
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SYNONYMS Pyridine-2,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-057-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C7H5NO4
MW: 167.1
CAS NUMBER: 89-00-9
MERCK INDEX: 14: 8073
PURITY: ≥98%
APPEARANCE: White photosensitive solid.
SOLUBILITY: Soluble in water or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect form light.

Product Description
Metabolite of tryptophan. Putative NMDA receptor agonist.
Product Specific Literature References
Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS: T.W. Stone, et al.; Eur. J. Pharmacol. 72, 411 (1981) Abstract
The N-methyl-D-aspartate receptor and burst firing of CA1 hippocampal pyramidal neurons: M.J. Peet, et al.; Neuroscience 22, 563 (1987) Abstract
 
 
ALX-550-067 Revised 06-Dec-04
7-Chlorothiokynurenic acid . hydrochloride
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SYNONYMS 7-Chloro-4-mercaptoquinoline-2-carboxylic acid . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-067-M005   5 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C10H6ClNO2S . HCl
MW: 239.7 . 36.5
CAS NUMBER: 135025-56-8
PURITY: ≥99%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
NMDA receptor antagonist acting at the glycine site. More potent than the corresponding kynurenic acid analog (Prod. No. ALX-550-070).
Product Specific Literature References
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor: F. Moroni, et al.; Eur. J. Pharmacol. 199, 227 (1991) Abstract
A study of the dose dependency of a glycine receptor antagonist in focal ischemia: J. Chen, et al.; J. Pharmacol. Exp. Ther. 267, 937 (1993) Abstract
The glycine antagonist and free radical scavenger 7-Cl-thio-kynurenate reduces CA1 ischemic damage in the gerbil: D.E. Pellegrini-Giampietro, et al.; Neuroscience 63, 701 (1994) Abstract
 
 
ALX-550-068 Revised 20-May-03
5-Chlorokynurenic acid . hydrochloride
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SYNONYMS 5-Chloro-4-hydroxyquinoline-2-carboxylic acid . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-068-M005   5 mg 30.00 USD Add To Cart
ALX-550-068-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C10H6ClNO3 . HCl
MW: 223.6 . 36.5
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

 
 
ALX-550-070 Revised 10-Feb-05
7-Chlorokynurenic acid . hydrochloride
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SYNONYMS 7-Chloro-4-hydroxyquinoline-2-carboxylic acid . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-070-M005   5 mg 25.00 USD Add To Cart
ALX-550-070-M025   25 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C10H6ClNO3 . HCl
MW: 223.6 . 36.5
CAS NUMBER: 18000-24-3
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C