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Ligand-gated Ion Channels
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ALX-550-027 Revised 26-Nov-04
D-AP7
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SYNONYMS D(-)-2-Amino-7-phosphonoheptanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-027-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C7H16NO5P
MW: 225.2
CAS NUMBER: 81338-23-0
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or very soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
More active form of DL-AP7 (Prod. No. ALX-550-028).
Product Specific Literature References
Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants: M.N. Perkins, et al.; Neurosci. Lett. 32, 65 (1982) Abstract
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist: T. Wieloch; Science 230, 681 (1985) Abstract
Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restriction: M. Benveniste & M.L. Mayer; Br. J. Pharmacol. 104, 207 (1991) Abstract
 
 
ALX-550-028 Revised 25-Nov-04
DL-AP7
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SYNONYMS DL-2-Amino-7-phosphonoheptanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-028-M005   5 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C7H16NO5P
MW: 225.2
CAS NUMBER: 78966-69-5
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent NMDA receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist: T. Wieloch; Science 230, 681 (1985) Abstract
 
 
ALX-101-010 Revised 11-Sep-07
L-Aspartic acid
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SYNONYMS H-L-Asp-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-010-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C4H7NO4
MW: 133.1
CAS NUMBER: 56-84-8
MERCK INDEX: 14: 840
RTECS: CI9098500
PURITY: ≥99.5%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids
 
 
ALX-101-011 Revised 22-Nov-06
D-Aspartic acid
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SYNONYMS H-D-Asp-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY D-Amino Acids
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ALX-101-011-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C4H7NO4
MW: 133.1
CAS NUMBER: 1783-96-6
MERCK INDEX: 14: 840
RTECS: CI9097500
PURITY: ≥99%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Excitatory Amino Acids • NMDA Receptors / Related Products
 
 
ALX-550-354 Revised 13-Dec-04
(S)-ATPA
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SYNONYMS (S)-α-Amino-3-hydroxy-5-t-butyl-4-isoxazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Kainate Receptors / Related Products
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ALX-550-354-M001   1 mg 35.00 USD Add To Cart
ALX-550-354-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C10H16N2O4
MW: 228.3
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Active isomer of (RS)-ATPA (Prod. No. ALX-550-352).
Product Specific Literature References
Pharmacological profile of the isomers of the GluR-specific agonist ATPA: K. Curry & H. Pajouhesh; Can. J. Physiol. Pharmacol. 76, 690 (1998) Abstract
 
 
ALX-550-352 Revised 17-Dec-04
(R,S)-ATPA
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SYNONYMS (R,S)-α-Amino-3-hydroxy-5-t-butyl-4-isoxazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Kainate Receptors / Related Products
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ALX-550-352-M001   1 mg 30.00 USD Add To Cart
ALX-550-352-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C10H16N2O4
MW: 228.3
CAS NUMBER: 140158-50-5
PURITY: ≥97%
APPEARANCE: White crystalline powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent and selective agonist of the GluR5 subtype of the kainate receptor.
Product Specific Literature References
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors: J. Lauridsen, et al.; J. Med. Chem. 28, 668 (1985) Abstract
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission: V.R. Clarke, et al.; Nature 389, 599 (1997) Abstract
Pharmacological profile of the isomers of the GluR-specific agonist ATPA: K. Curry & H. Pajouhesh; Can. J. Physiol. Pharmacol. 76, 690 (1998) Abstract
Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord: M.J. Procter, et al.; Neuropharmacology 37, 1287 (1998) Abstract
The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus: M. Vignes, et al.; Neuropharmacology 37, 1269 (1998) Abstract
 
 
ALX-550-360 Revised 19-Aug-02
α-Benzylquisqualic acid
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-360-M001   1 mg 30.00 USD Add To Cart
ALX-550-360-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C12H13N3O5
MW: 279.3
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective antagonist of group II mGluRs.
Product Specific Literature References
alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists: A.P. Kozikowski, et al.; Bioorg. Med. Chem. Lett. 8, 447 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-550-155 Revised 28-Jan-05
(RS)-4-Bromo-homo-ibotenic acid
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SYNONYMS Br-HIBO
(RS)-α-Amino-4-bromo-3-hydroxy-5-isoazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-155-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C6H7N2O4Br
MW: 251.0
CAS NUMBER: 71366-32-0
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent AMPA receptor agonist. Selective but relatively non-potent group I mGluR agonist.
Product Specific Literature References
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid: J.J. Hansen, et al.; J. Med. Chem. 32, 2254 (1989) Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS 11, 25 (1990) Abstract
4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane- 1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices: D.S. Chung, et al.; J. Neurochem. 63, 133 (1994) Abstract
Effects of bromohomoibotenate on metabotropic glutamate receptors: C. Thomsen, et al.; Neuroreport 5, 2417 (1994) Abstract
4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis: D.S. Chung, et al.; J. Pharmacol. Exp. Ther. 283, 742 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-630-075 Revised 10-Oct-08
α-Bungarotoxin
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SYNONYMS α-BuTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-075-M001   1 mg 65.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Val-Cys-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys-Pro-Pro-Gly-Glu-Asn-Leu-Cys-Tyr-Arg-Lys-Met-Trp-Cys-Asp-Ala-Phe-Cys-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys-Cys-Ser-Thr-Asp-Lys-Cys-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH
(Disulfide bonds between Cys3-Cys23, Cys16-Cys44, Cys29-Cys33, Cys48-Cys59 and Cys60-Cys65)
MW: 7984.2
CAS NUMBER: 11032-79-4
MERCK INDEX: 14: 1488
RTECS: EI6201400
SOURCE/HOST: Isolated from Bungarus multicinctus.
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.
Product Description
Post-synaptic neurotoxin that binds irreversibly to acetylcholine receptor sites, producing neuromuscular blockade and skeletal muscle paralysis. Prevents opening of nicotinic receptor-associated ion channels.
Product Specific Literature References
Use of a snake venom toxin to characterize the cholinergic receptor protein: J.P. Changeux, et al.; PNAS 67, 1241 (1970) Abstract
Amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al.; BBRC 44, 711 (1971) Abstract
Elapid neurotoxins. Purification, characterization, and immunochemical studies of alpha-bungarotoxin: D.G. Clark, et al.; Biochemistry 11, 1663 (1972) Abstract
Purification, properties and amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al.; Hoppe Seylers Z. Physiol. Chem. 353, 243 (1972) Abstract
alpha-Bungarotoxin binding sites in the CNS: B.J. Morley, et al.; Life Sci. 24, 859 (1979) Abstract
Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors: R.E. Oswald & J.A. Freeman; Neuroscience 6, 1 (1981) Abstract
Determination of the primary amino acid sequence specifying the alpha-bungarotoxin binding site on the alpha subunit of the acetylcholine receptor from Torpedo californica: P.T. Wilson, et al.; PNAS 82, 8790 (1985) Abstract
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor: R.A. Love & R.M. Stroud; Protein Eng. 1, 37 (1986) Abstract
Neuronal nicotinic alpha-bungarotoxin sites: M. Quik & S. Geertsen; Can. J. Physiol. Pharmacol. 66, 971 (1988) Abstract
The fall and rise of neuronal alpha-bungarotoxin binding proteins: P.B. Clarke; TIPS 13, 407 (1992), (Review) Abstract
Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina: K.T. Keyser, et al.; J. Neurosci. 13, 442 (1993) Abstract
Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner: P.C. Pugh and D.K. Berg; J. Neurosci. 14, 889 (1994) Abstract
The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library: M. Balass, et al.; PNAS 94, 6054 (1997) Abstract
Nicotine blocks TNF-alpha-mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway: N.G. Carlson, et al.; J. Neurobiol. 35, 29 (1998) Abstract
Alpha-Bungarotoxin binding to human muscle acetylcholine receptor measurement of affinity, delineation of AChR subunit residues crucial to binding, and protection of AChR function by synthetic peptide: A. Vincent, et al.; Neurochem. Int. 32, 427 (1998) Abstract
Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction: H.S. Young, et al.; Biophys. J. 83, 943 (2003) Abstract
Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors: Y. Sekine-Aizawa & R. L. Huganir; PNAS 101, 17114 (2004) Abstract
The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors: C.M. McCann, et al.; PNAS 103, 5149 (2006) Abstract
MD and NMR studies of alpha-bungarotoxin surface accessibility: V. Venditti, et al.; Biochem. Biophys. Res. Commun . 356, 114 (2007) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Nicotinic) / Related Products
 
 
ALX-550-313 Revised 06-Dec-04
t-CAA
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SYNONYMS (+)-trans-2-Carboxyazetidine-3-acetic acid
(2S,3S)-trans-3-(Carboxymethyl)azetidine-2-carboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-313-M001   1 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C6H9NO4
MW: 159.1
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
A potent in vivo inhibitor of glutamate uptake. Kainate receptor agonist.
Product Specific Literature References
Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA): A.P. Kozikowski, et al.; Bioorg. Med. Chem. Lett. 6, 2559 (1996)
Further Categories Containing This Product:
Kainate Receptors / Related Products
 
 
ALX-550-083 Revised 28-Jan-05
L-CCG-IV
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SYNONYMS (2S,1'R,2S)-2-(Carboxycyclopropyl)glycine
(2S,3R,4S)-CCG
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-083-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C6H9NO4
MW: 159.1
CAS NUMBER: 117857-95-1
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in dilute aqueous base.