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ALX-162-027 Revised 30-Jun-08
MALP-2
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SYNONYMS Macrophage-activating Lipopeptide-2
S-[2,3-bis(Palmityloxy)-(2R)-propyl-cysteinyl-GNNDESNISFKEK]
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Agonists Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-162-027-C050   50 µg 310.00 USD Add To Cart
Product Specification
FORMULA: C99H167N19O30S
MW: 2135.2
SOURCE/HOST: Synthetic.
QUANTITY: 1x107units.
CONCENTRATION: 0.1mg/ml
FORMULATION: Liquid. Sterile solution in PBS containing 2.5% (v/v) 2-propanol, 25mM n-octyl-β-D-glucopyranoside and 1% (wt/v) human serum albumin.
ACTIVITY: Specific activity is ~2x108units/mg. One unit is defined as the dilution giving half maximal release of nitric oxide from C3H/HeJ mouse peritoneal exudate cells in the standard assay (see [1]).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 2 years when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. Avoid accidental injection, extreme care should be taken with hypodermic syringes. Avoid inhalation and prevent this compound from entering the bloodstream.
HAZARD: TOXIC.
Product Description
MALP-2 was originally isolated from Mycoplasma fermentans. This MALP-2 corresponds to the originally isolated isomer, which expresses potent endotoxin-like activity and approaches in certain experimental systems the toxicity of LPS. For description of the stereochemistry of MALP-2 (see [7]). MALP-2 signalling, unlike that of LPS, is not transduced via TLR4, but is induced via TLR2 and TLR6 signalling.
For more information about MALP-2 see www.malp-research.de.
Product Specific Literature References
[1] Purification and partial biochemical characterization of a Mycoplasma fermentans-derived substance that activates macrophages to release nitric oxide, tumor necrosis factor, and interleukin-6: P.F. Muhlradt and M. Frisch; Infect. Immun. 62, 3801 (1994) Abstract
[2] Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration: P.F. Mühlradt, et al.; J. Exp. Med. 185, 1951 (1997) Abstract; Full Text
[3] MALP-2, a Mycoplasma lipopeptide with classical endotoxic properties: end of an era of LPS monopoly?: C. Galanos, et al.; J. Endotox. Res. 6, 471 (2000) Abstract
[4] Discrimination of bacterial lipoproteins by Toll-like receptor 6: O. Takeuchi, et al.; Int. Immunol. 13, 933 (2001) Abstract
[5] In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application: A. Luhrmann, et al.; Infect. Immun. 70, 3785 (2002) Abstract; Full Text
[6] The Mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant: F. Rharbaoui, et al.; Eur. J. Immunol. 32, 2857 (2002) Abstract
[7] Differential recognition of structural details of bacterial lipopeptides by toll-like receptors: M. Morr, et al.; Eur. J. Immunol. 32, 3337 (2002) Abstract
[8] CD14 is required for MyD88-independent LPS signaling: Z. Jiang, et al.; Nat. Immunol. 6, 565 (2005) Abstract
[9] The tumor suppressor CYLD Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7: H. Yoshida, et al.; J. Biol. Chem. 280, 41111 (2005) Abstract; Full Text
[10] IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature 434, 772 (2005) Abstract
[11] The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract
[12] Induction of cytokines and chemokines in human monocytes by Mycoplasma fermentans-derived lipoprotein MALP-2: A. Kaufmann, et al.; Infect. Immun. 67, 6303 (1999) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION MALP-2 sticks avidly to glass or plastic. Since it is active at very low concentrations, i.e. at high dilutions, these low amounts of material tend to become adsorbed to pipette tips and plastic or glass containers. To avoid this, prepare several dilution steps of the MALP-2 stock solution with medium containing 5% autologous serum or buffers with 2% HSA. The presence of 50mM octyl glucoside in the first dilution step is often beneficial and gives rise to higher activity. Avoid small volumes in large vessels. Do not filter.
Because of the ester-bound fatty acids, MALP-2 is sensitive to alkali or acid. The medium should be preconditioned in the CO2 incubator in order to ensure that the pH does not become alkaline. Add cells in preconditioned medium as soon as possible and incubate.
MANUFACTURER Licensed from GBF Braunschweig, Germany.
General Literature References
Synergic effects of mycoplasmal lipopeptides and extracellular ATP on activation of macrophages: T. Into, et al.; Infect. Immun. 70, 3586 (2002) Abstract; Full Text
Site-specific proteolysis of the MALP-404 lipoprotein determines the release of a soluble selective lipoprotein-associated motif-containing fragment and alteration of the surface phenotype of Mycoplasma fermentans: K.L. Davis & K.S. Wise; Infect. Immun. 70, 1129 (2002) Abstract; Full Text
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Further Categories Containing This Product:
Peptides
 
 
ALX-162-034 Revised 03-Jul-08 New product
MALP-2 (BULK)
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SYNONYMS Macrophage-activating Lipopeptide-2
S-[2,3-bis(Palmityloxy)-(2R)-propyl-cysteinyl-GNNDESNISFKEK]
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Agonists Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-162-034-C500   500 µg 1'250.00 USD Add To Cart
Product Specification
FORMULA: C99H167N19O30S
MW: 2135.2
SOURCE/HOST: Synthetic.
CONCENTRATION: 1mg/ml
PURITY DETAIL: HPLC purified
FORMULATION: Liquid. Pyrogen-free, sterile solution in 33% (v/v) 2-propanol/water.
BIOLOGICAL ACTIVITY: Stimulates macrophages, monocytes and other TLR2 and TLR6 expressing cells in vitro at pg/ml concentrations (e.g. mouse macrophages: 50pg/ml; fibroblasts: 2ng/ml) to release various mediators. Human monocytes require about 10-100x higher concentrations for optimal cytokine or chemokine release than mouse PECS (see [12]). In vivo active at 0.5-5μg (e.g 0.5μg/20g mouse). The presence of 50mM octyl glucoside as carrier gives rise to a higher activity.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 3 years when stored at -20°C. This stock solution is stable for many months when kept in the refrigerator. MALP-2 solutions in the presene of carrier (50mM octyl glucoside, see Background/Technical Information below) are stable at +4°C at least 6 weeks. Some (10%) decrease of activity may occur shortly after transfer into new vessels. This is not due to decomposition but to adsorption (see below). Storage at room temperature for short periods of time does not influence bioactivity. When deep-frozen, MALP-2 does not loose activity within years.
HANDLING: Avoid freeze/thaw cycles. Avoid accidental injection, extreme care should be taken with hypodermic syringes. Avoid inhalation and prevent this compound from entering the bloodstream.
HAZARD: TOXIC.
Product Description
MALP-2 was originally isolated from Mycoplasma fermentans. This MALP-2 corresponds to the originally isolated isomer, which expresses potent endotoxin-like activity and approaches in certain experimental systems the toxicity of LPS. For description of the stereochemistry of MALP-2 (see [7]). MALP-2 signalling, unlike that of LPS, is not transduced via TLR4, but is induced via TLR2 and TLR6 signalling.
For more information about MALP-2 see www.malp-research.de.
New BULK size (500μg) of biologically active, pyrogen-free and sterile MALP-2 for in vitro and animal in vivo studies.
Product Specific Literature References
[1] Purification and partial biochemical characterization of a Mycoplasma fermentans-derived substance that activates macrophages to release nitric oxide, tumor necrosis factor, and interleukin-6: P.F. Muhlradt and M. Frisch; Infect. Immun. 62, 3801 (1994) Abstract
[2] Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration: P.F. Mühlradt, et al.; J. Exp. Med. 185, 1951 (1997) Abstract; Full Text
[3] MALP-2, a Mycoplasma lipopeptide with classical endotoxic properties: end of an era of LPS monopoly?: C. Galanos, et al.; J. Endotox. Res. 6, 471 (2000) Abstract
[4] Discrimination of bacterial lipoproteins by Toll-like receptor 6: O. Takeuchi, et al.; Int. Immunol. 13, 933 (2001) Abstract
[5] In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application: A. Luhrmann, et al.; Infect. Immun. 70, 3785 (2002) Abstract; Full Text
[6] The Mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant: F. Rharbaoui, et al.; Eur. J. Immunol. 32, 2857 (2002) Abstract
[7] Differential recognition of structural details of bacterial lipopeptides by toll-like receptors: M. Morr, et al.; Eur. J. Immunol. 32, 3337 (2002) Abstract
[8] CD14 is required for MyD88-independent LPS signaling: Z. Jiang, et al.; Nat. Immunol. 6, 565 (2005) Abstract
[9] The tumor suppressor CYLD Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7: H. Yoshida, et al.; J. Biol. Chem. 280, 41111 (2005) Abstract; Full Text
[10] IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature 434, 772 (2005) Abstract
[11] The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract
[12] Induction of cytokines and chemokines in human monocytes by Mycoplasma fermentans-derived lipoprotein MALP-2: A. Kaufmann, et al.; Infect. Immun. 67, 6303 (1999) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION MALP-2 sticks avidly to glass or plastic. Since it is active at very low concentrations, i.e. at high dilutions, these low amounts of material tend to become adsorbed to pipette tips and plastic or glass containers. To avoid this, prepare several dilution steps of the MALP-2 stock solution with medium containing 5% autologous serum or buffers with 2% HSA. The presence of 50mM octyl glucoside in the first dilution step is often beneficial and gives rise to higher activity. Avoid small volumes in large vessels. Do not filter.
Because of the ester-bound fatty acids, MALP-2 is sensitive to alkali or acid. The medium should be preconditioned in the CO2 incubator in order to ensure that the pH does not become alkaline. Add cells in preconditioned medium as soon as possible and incubate.
MANUFACTURER Licensed from GBF Braunschweig, Germany.
General Literature References
Synergic effects of mycoplasmal lipopeptides and extracellular ATP on activation of macrophages: T. Into, et al.; Infect. Immun. 70, 3586 (2002) Abstract; Full Text
Site-specific proteolysis of the MALP-404 lipoprotein determines the release of a soluble selective lipoprotein-associated motif-containing fragment and alteration of the surface phenotype of Mycoplasma fermentans: K.L. Davis & K.S. Wise; Infect. Immun. 70, 1129 (2002) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Peptides
 
 
ALX-165-066 Revised 08-Mar-07
Pam3Cys-Ser-(Lys)4 . trihydrochloride
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SYNONYMS Pam3CSK4 . 3HCl
(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys- (S)-Ser-(S)-Lys4-OH . 3HCl
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Agonists Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-066-M002   2 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C81H156N10O13S . 3HCl
MW: 1510.3 . 109.4
CAS NUMBER: 112208-00-1
CONCENTRATION: 1mg/ml after reconstitution.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in water, saline or aqueous buffers at pH <7.5.
RECONSTITUTION: Reconstitute in 2ml distilled water. Use a homogeniser or sonicator to prepare a homogenous solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

Product Description
Selective agonist of Toll-like receptor 1 (TLR1) complexed with TLR2. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Activates/represses an array of at least 140 genes partly involved in signal transduction and regulation of the immune response.
Product Specific Literature References
Induction of tumor cytotoxicity in murine bone marrow-derived macrophages by two synthetic lipopeptide analogues: P. Hoffmann, et al.; Biol. Chem. Hoppe Seyler 370, 575 (1989) Abstract
Lipopeptide derivatives of bacterial lipoprotein constitute potent immune adjuvants combined with or covalently coupled to antigen or hapten: A. Reitermann, et al.; Biol. Chem. Hoppe Seyler 370, 343 (1989) Abstract
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides: R. Seifert, et al.; Biochem. J. 267, 795 (1990) Abstract
Synthesis of novel immunologically active tripalmitoyl-S-glycerylcysteinyl lipopeptides as useful intermediates for immunogen preparations: J. Metzger, et al.; Int. J. Pept. Protein Res. 37, 46 (1991) Abstract
The influence of various adjuvants on antibody synthesis following immunization with an hapten: J. Kellner, et al.; Biol. Chem. Hoppe Seyler 373, 51 (1992) Abstract
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells: S. Offermanns, et al.; Biochem. J. 282, 551 (1992) Abstract
Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. Requirement of NF-kappaB activation after stimulation with bacterial cell wall products and phorbol esters: M.J. Diaz-Guerra, et al.; J. Biol. Chem. 271, 30114 (1996) Abstract; Full Text
Adjuvant lipopeptide interaction with model membranes: J. Gonzalez-Christen; Biochim. Biophys. Acta 1368, 97 (1998) Abstract
Alteration of the lateral organization of the plasma membrane of Chinese hamster ovary cells by synthetic lipopeptide, Pam3Cys-Ser-Lys4: I. Vergne & L. Cezanne; Eur. J. Biochem. 264, 369 (1999) Abstract; Full Text
Adjuvant effects of various lipopeptides and interferon-gamma on the humoral immune response of chickens: M.H. Erhard, et al.; Poult. Sci. 79, 1264 (2000) Abstract
Immunostimulation by the synthetic lipopeptide P3CSK4: TLR4-independent activation of the ERK1/2 signal transduction pathway in macrophages: M.R. Muller, et al.; Immunology 103, 49 (2001) Abstract
TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages: V. Toshchakov, et al.; Nat. Immunol. 3, 392 (2002) Abstract
The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract
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Further Categories Containing This Product:
Peptides
 
 
ALX-165-069 Revised 22-Jul-08
Pam3Cys-Ser-(Lys)4 (Aca-Aca-Biotin) . 2 trifluoroacetate
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SYNONYMS Pam3CSK4 (Aca-Aca-Biotin) . 2TFA
(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH (Aca-Aca-Biotin) . 2TFA
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Agonists Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-069-M001   1 mg 1'300.00 USD Add To Cart
Product Specification
FORMULA: C103H192N14O17S2 . 2C2HF3O2
MW: 1962.9 . 228.1
APPEARANCE: Colorless powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in water, saline or aqueous buffers at pH <7.5.
RECONSTITUTION: Reconstitute with water to 1mg/ml stock solution. Through the use of either a homogeniser or sonicator, a homogenous solution can be prepared.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Description
Selective, biotin-labelled ligand of Toll-like receptor 1 (TLR1) complexed with TLR2. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Activates/represses an array of at least 140 genes partly involved in signal transduction and regulation of the immune response.
Related Products
Further Categories Containing This Product:
Peptides
 
 
ALX-201-131 Revised 15-May-07
LBP (human) (recombinant) (His)
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SYNONYMS Lipopolysaccharide Binding Protein (human) (recombinant) (His)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharide Binding Protein [LBP] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-131-C010   10 µg 295.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in CHO cells.
CONCENTRATION: 0.25mg/ml after reconstitution.
PURITY: ~90-95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.00015EU/µg protein (LAL test; Chromogenix).
RECONSTITUTION: Reconstitute with 40µl distilled water.
BIOLOGICAL ACTIVITY: Mediates binding of LPS to CD14 (up to 0.2µg/ml LBP mediates binding of FITC-LPS (0.5µg/ml) to CD14+ CHO transfectants (FACS)).
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Will precipitate by rapid changes of pH or temperature. Best working temperature is ice bath.
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism: U. Grunwald, et al.; J. Immunol. 157, 4119 (1996) Abstract
General Information
LBP (lipopolysaccharide binding protein) is a ~58kDa acute phase glycoprotein and binds to the lipid A portion of lipopolysaccharide (LPS) with high affinity and catalyzes the CD14 dependent cellular activation by LPS.
BACKGROUND/TECHNICAL INFORMATION Note: His-tag at the C-terminal end of the LBP has no protease site and cannot be split off.
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-132 Revised 28-Jul-06
LBP (mouse) (recombinant) (His)
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SYNONYMS Lipopolysaccharide Binding Protein (mouse) (recombinant) (His)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharide Binding Protein [LBP] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-132-C010   10 µg 295.00 USD Add To Cart
Product Specification
MW: ~58kDa.
SOURCE/HOST: Produced in CHO cells.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: Affinity purified
FORMULATION: Lyophilized. Contains PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.00015EU/µg protein (LAL test; Chromogenix).
RECONSTITUTION: Reconstitute with 10µl distilled water.
BIOLOGICAL ACTIVITY: Mediates binding of LPS to CD14 (up to 2µg/ml LBP mediates binding of FITC-LPS (0.5µg/ml) to CD14+ CHO transfectants (2x106/ml)).
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: LBP will precipitate upon rapid changes of pH or temperature. Keep in ice bath during application.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism: U. Grunwald, et al.; J. Immunol. 157, 4119 (1996) Abstract
General Information
LBP (lipopolysaccharide binding protein) is a 58kDa acute phase glycoprotein and binds to the lipid A portion of lipopolysaccharide (LPS) with high affinity and catalyzes the CD14 dependent cellular activation by LPS.
BACKGROUND/TECHNICAL INFORMATION His-tag at C-terminal end of LBP has no protease site and cannot be split off.
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-133 Revised 19-Feb-08
CD14 (human) (recombinant)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-133-C010   10 µg 270.00 USD Add To Cart
Product Specification
MW: ~50kDa.
SOURCE/HOST: Produced in CHO cells.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ~90-95% (SDS-PAGE)
PURITY DETAIL: Affinity purified using MAb to CD14 (human) (biG 2/RoMo-1) (Prod. No. ALX-804-498).
FORMULATION: Lyophilized from PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.00015EU/µg protein (LAL test; Chromogenix).
RECONSTITUTION: Reconstitute with 10µl distilled water. Further dilutions should be made with PBS
BIOLOGICAL ACTIVITY: Inhibits binding of LPS to CD14. Up to 20µg/ml CD14 inhibit binding of FITC-LPS (0.5µg/ml) to 6x105 CD14+ CHO transfectants (FACS).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Both membrane-bound and soluble forms of CD14 bind to gram-negative bacteria: R.S. Jack, et al.; Eur. J. Immunol. 25, 1436 (1995) Abstract
The myeloid differentiation antigen CD14 is N- and O-glycosylated. Contribution of N-linked glycosylation to different soluble CD14 isoforms: F. Stelter, et al.; Eur. J. Biochem. 236, 457 (1996) Abstract
Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation: K. Le-Barillec, et al.; J. Clin. Invest. 103, 1039 (1999) Abstract; Full Text
General Information
The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wildtype CD14 ist the 50kDa protein.
The CD14 glycoprotein, gp 55, is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore it is present in a soluble form in mouse serum, urine and other body fluids.
MANUFACTURER Manufactured by Biometec.
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Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-134 Revised 25-Sep-08
CD14 (mouse) (recombinant) (His)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-134-C010   10 µg 370.00 USD Add To Cart
Product Specification
MW: ~45kDa
SOURCE/HOST: Produced in CHO cells.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: His-tag-affinity purified.
FORMULATION: Lyophilized from PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.00015EU/µg protein (LAL test; Chromogenix).
RECONSTITUTION: Reconstitute with 10µl distilled water.
BIOLOGICAL ACTIVITY: