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Adaptor Proteins & Interaction Domains / Related Products
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ALX-210-347 Revised 28-Jul-08
Polyclonal Antibody to Caveolin-1
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-347-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Dog
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-17 (M1SGGKYVDSEGHLYTVP17C) of human caveolin-1. This sequence is completely conserved in mouse, rat, dog and bovine caveolin-1.
SPECIFICITY: Recognizes mouse, rat, dog and hamster caveolin-1. Detects a band of ~22kDa by Western blot.
APPLICATION: Immunoprecipitation
Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-054.
Further Categories Containing This Product:
NOS Regulation • Polyclonal Antibodies
 
 
ALX-210-240 Revised 16-Mar-07
Polyclonal Antibody to Caveolin-2
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-240-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-19 (M1GLETEKADVQLF
MADDAY19C) of rat caveolin-2.
SPECIFICITY: Recognizes mouse and rat caveolin-2. Detects a band of ~21kDa by Western blot. Does not cross-react with caveolin-1 or -3.
APPLICATION: Immunoprecipitation
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-029.
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Further Categories Containing This Product:
NOS Regulation • Polyclonal Antibodies
 
 
ALX-210-888 Revised 25-May-07
Polyclonal Antibody to Caveolin-2 (mouse) (phosphorylated) (pTyr19)
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
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ALX-210-888-C100   100 µg 385.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 14-25 (M14ADDApYSHHSGC25) of mouse caveolin-2 phosphorylated at Tyr19.
SPECIFICITY: Recognizes mouse phosphorylated caveolin-2. Detects a band of ~21kDa by Western blot.
APPLICATION: Immunocytochemistry (5µg/ml)
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-060.
Related Products
Further Categories Containing This Product:
Phospho-specific Antibodies • NOS Regulation • Polyclonal Antibodies
 
 
ALX-210-241 Revised 24-Apr-08
Polyclonal Antibody to Caveolin-3
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
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ALX-210-241-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope affinity-purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-18 (M1MTEEHTDLEARIIKDIH18C) of rat caveolin-3.
SPECIFICITY: Recognizes mouse and rat caveolin-3. Detects a band of ~21kDa by Western blot. Does not cross-react with caveolin-1 or -2.
APPLICATION: Immunocytochemistry
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-030.
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Further Categories Containing This Product:
NOS Regulation • Polyclonal Antibodies
 
 
ALX-210-564 Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (human)
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SYNONYMS anti-LIME (human) PAb
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-210-564-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant intracellular fragment corresponding to aa 141-295 of human LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes human LIME. Does not cross-react with mouse LIME.
APPLICATION: Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Src Family Kinases / Related Products • Polyclonal Antibodies
 
 
ALX-210-565 Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (mouse)
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SYNONYMS anti-LIME (mouse) PAb
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-210-565-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant fragment of mouse LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes mouse LIME. Does not cross-react with human LIME.
APPLICATION: Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Src Family Kinases / Related Products • Polyclonal Antibodies
 
 
ALX-210-935 Revised 20-Feb-08
Polyclonal Antibody to MDA5 (human) (AT113)
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SYNONYMS anti-Melanoma Differentiation-associated Gene 5 (human) PAb (AT113)
anti-Helicard (human) PAb (AT113)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases / Related Products
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ALX-210-935-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555).
SPECIFICITY: Recognizes human MDA5.
APPLICATION: Immunoprecipitation (1:100)
Western Blot (1:1‘000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity: Y.M. Loo, et al.; J. Virol. 82, 335 (2008) Abstract
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002) Abstract
Related Products
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products • NF-kB Pathway Other Products • Interferons & Interferon Receptors Other Products • Antiviral Signalling / Related Products • Polyclonal Antibodies
 
 
ALX-210-352 Revised 30-Oct-06
Polyclonal Antibody to MDA5 (mouse) (AL180)
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SYNONYMS anti-Melanoma Differentiation-associated Gene 5 (mouse) PAb (AL180)
anti-Helicard (mouse) PAb (AL180)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases / Related Products
Ordering Information
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ALX-210-352-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Contains 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse MDA5 (melanoma differentiation-associated gene 5) (aa 2-208).
SPECIFICITY: Recognizes mouse MDA5.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation: M. Kovacsovics, et al.; Curr. Biol. 12, 838 (2002) Abstract
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002) Abstract
Related Products
Further Categories Containing This Product:
NF-kB Pathway Other Products • Antiviral Signalling / Related Products • Caspase Recruitment Domain [CARD] Proteins / Related Products • Interferons & Interferon Receptors Other Products • Polyclonal Antibodies
 
 
ALX-210-900 Revised 25-Jan-08
Polyclonal Antibody to MyD88
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SYNONYMS anti-Myeloid Differentiation Primary Response Protein PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY Toll-IL-1 Receptor Adaptors / Related Products
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ALX-210-900-R100   100 µl 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Recombinant human MyD88 (myeloid differentiation primary response protein) (aa 1-172).
SPECIFICITY: Recognizes the death domain of human and mouse MyD88.
APPLICATION: Western Blot (1:5'000-1:8'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING: Do not freeze/thaw.
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Product Specific Literature References
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor: K. Burns, et al.; Nat. Cell Biol. 2, 346 (2000) Abstract
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells: N. Tsuboi, et al.; J. Immunol. 169, 2026 (2002) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL- 1 signaling  : M. Muzio, et al.; Science 278, 1612 (1997) Abstract
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function : O. Adachi, et al.; Immunity 9, 143 (1998) Abstract
MyD88, an adapter protein involved in interleukin-1 signaling : K. Burns, et al.; J. Biol. Chem. 273, 12203 (1998) Abstract; Full Text
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways: R. Medzhitov, et al.; Mol. Cell 2, 253 (1998) Abstract
Unresponsiveness of MyD88-deficient mice to endotoxin: T. Kawai, et al.; Immunity 11, 115 (1999) Abstract
The apoptotic signaling pathway activated by toll-like receptor-2: A.O. Aliprantis, et al.; EMBO J. 19, 3325 (2000) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-904 Revised 25-Jan-08
Polyclonal Antibody to NALP1 (human) (AL176)
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SYNONYMS anti-NACHT-, LRR- and PYD-containing Protein 1 (human) PAb (AL176)
anti-DEFCAP (human) PAb (AL176)
anti-NAC (human) PAb (AL176)
anti-CARD7 (human) PAb (AL176)
anti-Caspase Recruitment Domain-containing Protein 7 (human) PAb (AL176)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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ALX-210-904-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
PURITY: Affinity purified.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) of N-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY: Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: For Positive Control (Western blot) see Prod. No. ALX-840-603.
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Product Specific Literature References
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon; Mol. Cell. 10, 417 (2002) Abstract