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Lipid Signalling Pathways
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ALX-301-005 Revised 09-Dec-04
PAF (C16), Enantio-
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SYNONYMS 3-O-Hexadecyl-2-acetyl-sn-glycero-1-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-301-005-M001   1 mg 15.00 USD Add To Cart
ALX-301-005-M005   5 mg 45.00 USD Add To Cart
ALX-301-005-M025   25 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C26H54NO7P
MW: 523.7
CAS NUMBER: 117985-57-6
SOURCE/HOST: Synthetic.
PURITY: ≥99%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Further Categories Containing This Product:
Phospholipids / Related Products
 
 
ALX-301-007 Revised 09-Dec-04
PAF (C16), Propionyl-
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SYNONYMS 1-O-Hexadecyl-2-propionyl-sn-glycero-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-301-007-M001   1 mg 30.00 USD Add To Cart
ALX-301-007-M005   5 mg 90.00 USD Add To Cart
ALX-301-007-M025   25 mg 270.00 USD Add To Cart
Product Specification
FORMULA: C27H56NO7P
MW: 537.7
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Lyophilized solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Slightly hygroscopic.

Product Description
2-fold more potent analog than PAF.
Further Categories Containing This Product:
Phospholipids / Related Products
 
 
ALX-301-008 Revised 09-Dec-04
PAF (C18), Propionyl-
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SYNONYMS 1-O-Octadecyl-2-propionyl-sn-glycero-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
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ALX-301-008-M001   1 mg 30.00 USD Add To Cart
ALX-301-008-M005   5 mg 90.00 USD Add To Cart
ALX-301-008-M025   25 mg 270.00 USD Add To Cart
Product Specification
FORMULA: C29H60NO7P
MW: 565.8
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Lyophilized solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
2-fold more potent analog than PAF.
Further Categories Containing This Product:
Phospholipids / Related Products
 
 
ALX-301-009 Revised 09-Dec-04
1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
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ALX-301-009-M005   5 mg 45.00 USD Add To Cart
ALX-301-009-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C30H62NO7P
MW: 579.8
CAS NUMBER: 99103-16-9
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in chloroform, 100% ethanol or methanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Slightly hygroscopic.

Product Description
PAF antagonist. Shows inhibitory behavior on platelet aggregation, secretion and phospholipid turnover.
Product Specific Literature References
Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation: A. Tokumura, et al.; J. Biol. Chem. 260, 12710 (1985) Abstract; Full Text
Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages: M. Rouis, et al.; BBRC 156, 1293 (1988) Abstract
Further Categories Containing This Product:
Phospholipids / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
 
 
ALX-301-010 Revised 18-Feb-08
PAF (C16), Carbamyl-
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SYNONYMS 1-O-Hexadecyl-2-N-methylcarbamyl-sn-glycero-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
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ALX-301-010-M001   1 mg 35.00 USD Add To Cart
ALX-301-010-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C26H55N2O7P
MW: 538.7
CAS NUMBER: 91575-58-5
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, acetone, DMSO or acetonitrile purged with an inert gas.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.

Product Description
Biologically potent, non-metabolizable analog of platelet-activating factor (PAF).
Product Specific Literature References
1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor: J.T. O'Flaherty, et al.; BBRC 147, 18 (1987) Abstract
Synthesis and evidence for the stability of a glycerophosphochloridate: rac-1-O-hexadecyl-2-O-(methylcarbamyl)-sn-glycero-3-phosphorochloridocholine: J.R. Surles, et al.; J. Org. Chem. 53, 899 (1988)
Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites: T.G. Tessner, et al.; J. Biol. Chem. 264, 4794 (1989) Abstract; Full Text
PAF-acether transfer activity in HL-60 cells is induced during differentiation: R.H. Lumb, et al.; BBRC 171, 548 (1990) Abstract
Further Categories Containing This Product:
Phospholipids / Related Products
 
 
ALX-301-013 Revised 08-Jul-08
Azelaoyl-PAF
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SYNONYMS 1-O-Hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-301-013-M001   1 mg 58.00 USD Add To Cart
ALX-301-013-M005   5 mg 261.00 USD Add To Cart
Product Specification
FORMULA: C33H66NO9P
MW: 651.9
SOURCE/HOST: Synthetic.
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO (8mg/ml) or dimethyl formamide (33mg/ml) or PBS, pH 7.2 (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description
Potent PPARγ agonist which competes for the thiazoladinedione binding site. More potent than 15-deoxy-Δ12,14-prostaglandin J2 (Prod. No. ALX-340-022) and equipotent with rosiglitazone (Prod. No. ALX-350-125) as a ligand for this receptor.
Product Specific Literature References
Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists: S.S. Davies, et al.; J. Biol. Chem. 276, 16015 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Phospholipids / Related Products • PPAR Agonists
 
 
ALX-303-001 Revised 03-Feb-05
Ceramide I (bovine brain)
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SYNONYMS N-Acylsphingosine (bovine brain)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides / Cerebrosides / Sphingolipids / Related Products
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ALX-303-001-M025   25 mg 65.00 USD Add To Cart
Product Specification
SOURCE/HOST: Semisynthetic (from bovine brain cerebrosides).
PURITY: ≥98%
APPEARANCE: White powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Contains saturated, unsaturated and α-hydroxy fatty acids. Modulator of cell growth and differentiation.
Product Specific Literature References
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3- induced HL-60 cell differentiation: T. Okazaki, et al.; J. Biol. Chem. 265, 15823 (1990) Abstract; Full Text
 
 
ALX-303-002 Revised 24-Feb-05
Ceramide II (bovine brain)
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SYNONYMS Ceramide HFA (bovine brain)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides / Cerebrosides / Sphingolipids / Related Products
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ALX-303-002-M025   25 mg 65.00 USD Add To Cart
Product Specification
SOURCE/HOST: Semisynthetic (from bovine brain cerebrosides).
PURITY: ≥98%
APPEARANCE: White powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Contains α-hydroxy fatty acids. Prepared from cerebrosides by a modified protocol of H.E. Carter et al.; J. Lipid Res. 2, 228 (1961)
 
 
ALX-303-003 Revised 29-Jan-05
D-erythro-Sphingosine, N-Hexanoyl-
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SYNONYMS N-Hexanoyl-D-erythro-sphingosine
C6-Ceramide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides / Cerebrosides / Sphingolipids / Related Products
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ALX-303-003-M001   1 mg 38.00 USD Add To Cart
ALX-303-003-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C24H47NO3
MW: 397.6
CAS NUMBER: 124753-97-5
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Cell permeable, biologically active, nonphysical ceramide analog. Activates protein phosphatase 2A and MAP kinase (MAPK/ERK). Induces an arrest at the G0/G1 transition of the cell cycle. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis.
Product Specific Literature References
Ceramide stimulates a cytosolic protein phosphatase: R.T. Dobrowsky & Y.A. Hannun; J. Biol. Chem. 267, 5048 (1992) Abstract; Full Text
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells: M. A. Raines, et al.; J. Biol. Chem. 268, 14572 (1993) Abstract; Full Text
Ceramide activates heterotrimeric protein phosphatase 2A: R.T. Dobrowsky, et al.; J. Biol. Chem. 268, 15523 (1993) Abstract; Full Text
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway: W.D. Jarvis, et al.; PNAS 91, 73 (1994) Abstract; Full Text
Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence: M.E. Venable, et al.; J. Biol. Chem. 269, 26040 (1994) Abstract; Full Text
Role for ceramide in cell cycle arrest: S. Jayadev, et al.; J. Biol. Chem. 270, 2047 (1995) Abstract; Full Text
Further Categories Containing This Product:
Phospholipase D / Related Products • MAPK Pathway Activators • Apoptosis Inducers & Inhibitors Other Products • Cell Cycle Blockers & Inhibitors / Related Products
 
 
ALX-303-005 Revised 06-Feb-05
MSDH-C
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SYNONYMS D-erythro-1-Methylthiohydroceramide
(2R,3R)-(2-N-Lauroyl)-amino-1-methylthio-3-hydroxy-nonan
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides / Cerebrosides / Sphingolipids / Related Products
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ALX-303-005-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C22H45NO2S
MW: 387.7
CAS NUMBER: 144474-37-3
PURITY: ≥95%
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent inhibitor of the glycosphingolipid biosynthesis [1]. At 10µM decreases de novo ceramide biosynthesis by about 90% [2].
Product Specific Literature References
[1] Synthesis of potential inhibitors of the glycosphingolipid biosynthesis: G. Brenner-Weiss, et al.; Tetrahedron 48, 5855 (1992)
[2] 1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis: G. van Echten-Deckert, et al.; J. Biol. Chem. 273, 1184 (1998) Abstract; Full Text
 
 
ALX-306-001 Revised 10-Dec-04
D-erythro-Sphingomyelin (bovine brain)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides / Cerebrosides / Sphingolipids / Related Products
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ALX-306-001-M250   250 mg 130.00 USD Add To Cart
ALX-306-001-G001   1 g 390.00 USD