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Neurobiology
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ALX-630-053 Revised 14-Oct-08
ω-Conotoxin SVIB
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-053-C500   500 µg 640.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Lys-Leu-Lys-Gly-Gln-Ser-Cys-Arg-Lys-Thr-Ser-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Ser-Gly-Lys-Cys-NH2
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys26)
FORMULA: C105H176N38O36S6
MW: 2739.2
SOURCE/HOST: Synthetic. Originally isolated from Conus striatus.
PURITY: ≥97%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.
Product Description
Neurotoxin. N-Type Ca2+ channel blocker. Not for sale in U.S.A.
Product Specific Literature References
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
Novel alpha- and omega-conotoxins from Conus striatus venom: C.A. Ramilo, et al.; Biochemistry 31, 9919 (1992) Abstract
Effects of diverse omega-conopeptides on the in vivo release of glutamic and gamma-aminobutyric acids: R. Newcomb & A. Palma; Brain Res. 638, 95 (1994) Abstract
Novel omega-conopeptides reduced field potential amplitudes in the rat hippocampal slice: J.A. Fox; Neurosci. Lett. 165, 157 (1994) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Ann. Rev. Biochem. 63, 823 (1994), (Review) Abstract
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202: K.J. Nielsen, et al.; J. Mol. Biol. 263, 297 (1996) Abstract
Further Categories Containing This Product:
Peptides • Ca2+ Channels (N-type) • Marine Natural Products
 
 
ALX-270-242 Revised 21-Feb-08
CP 55,940
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SYNONYMS (-)-cis-3-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-270-242-M005   5 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C24H40O3
MW: 376.6
CAS NUMBER: 83002-04-4
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: 30mg/ml soluble in DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Cannabinoid receptor (CB) agonist which is considerably more potent than Δ9-THC in both behavioural tests and receptor binding assays. Displays high and about equal affinity for both CB1 (Ki=0.6-5.0nM) and CB2 (Ki=0.7-2.6nM) receptors.
Product Specific Literature References
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats: J.L. Wiley, et al.; Neuropharmacology 34, 669 (1995) Abstract
Comparative receptor binding analyses of cannabinoid agonists and antagonists: B.F. Thomas, et al.; J. Pharmacol. Exp. Ther. 285, 285 (1998) Abstract
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells: Y. Waksman, et al.; J. Pharmacol. Exp. Ther. 288, 1357 (1999) Abstract
 
 
ALX-550-120 Revised 26-May-03
(S)-4C-PG
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SYNONYMS (S)-4-Carboxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-120-M001   1 mg 40.00 USD Add To Cart
ALX-550-120-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C9H9NO4
MW: 195.2
CAS NUMBER: 134052-73-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Competitve group I mGluR antagonist, with selectivity for mGlu1 over mGlu5 receptor.
Product Specific Literature References
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine: S.A. Eaton, et al.; Eur. J. Pharmacol. 244, 195 (1993) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999) Abstract
 
 
ALX-550-231 Revised 13-Aug-04
(R)-CPP
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SYNONYMS 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-231-M001   1 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C8H17N2O5P
MW: 252.2
CAS NUMBER: 126453-07-4
PURITY: ≥97%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Highly potent NMDA receptor antagonist.
Product Specific Literature References
CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity: J. Davies, et al.; Brain Res. 382, 169 (1986) Abstract
Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-posphonoprop2-enyl)piperazine-2-carboxylic acid (CPP-ene): B. Aebischer, et al.; Helv. Chim. Acta 72, 1043 (1989)
 
 
ALX-550-325 Revised 26-May-03
(RS)-CPPG
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SYNONYMS (RS)-α-Cyclopropyl-4-phosphonophenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-325-M001   1 mg 35.00 USD Add To Cart
ALX-550-325-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C11H14NO5P
MW: 271.2
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Most potent group II/III mGluR antagonist, with approx. 20-fold selectivity for group III over group II.
Product Specific Literature References
The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist: N.J. Toms, et al.; Br. J. Pharmacol. 119, 851 (1996) Abstract
Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord: D.E. Jane, et al.; Neuropharmacology 35, 1029 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999) Abstract
 
 
ALX-550-314 Revised 03-Feb-05
N-Cyclobutanecarbonyl-2-phenyltryptamine
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SYNONYMS N-[2-(2-Phenylindol-3-yl)ethyl] cyclobutanecarboxyamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-314-M001   1 mg 60.00 USD Add To Cart
ALX-550-314-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C21H22N2O
MW: 318.4
PURITY: ≥98%
APPEARANCE: Oil.
SOLUBILITY: Soluble in chloroform or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Melatonin receptor antagonist. More potent than Luzindole (Prod. No. ALX-550-184) in the Xenopus melanophore assay.
Product Specific Literature References
Radioligand binding affinity and biological activity of the enantiomers of a chiral melatonin analogue: D. Sugden, et al.; Eur. J. Pharmacol. 287, 239 (1995) Abstract
Mapping the melatonin receptor. 3. Design and synthesis of melatonin agonists and antagonists derived from 2-phenyltryptamines: P.J. Garratt, et al.; J. Med. Chem. 38, 1132 (1995) Abstract
Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles: D.J. Davies, et al.; J. Med. Chem. 41, 451 (1998) Abstract
 
 
ALX-430-159 Revised 19-Aug-08 New product
Cyclopamine
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SYNONYMS 11-Deoxyjervine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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ALX-430-159-M001   1 mg 80.00 USD Add To Cart
ALX-430-159-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C27H41NO2
MW: 411.6
CAS NUMBER: 4449-51-8
MERCK INDEX: 14: 10201
RTECS: GY0750000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol (20mg/ml), DMF (10mg/ml), methanol (7mg/ml) or DMSO (4mg/ml). Heating to 50-60°C may be necessary. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE TERATOGENIC. HARMFUL.

Product Description
Steroidal alkaloid. Blocks activation of the Hedgehog (Hh) response pathway. Binds to the heptahelical protein bundle of Smoothened. Induces expression of the transcription factor Pdx-1. Disrupts cholesterol biosynthesis. Displays anti-tumor properties. Induces apoptosis. Causes cyclopia.
Product Specific Literature References
The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction: J.P. Incardona, et al.; Development 125, 3553 (1998) Abstract; Full Text
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor: S.K. Kim & D.A. Melton; PNAS 95, 13036 (1998) Abstract; Full Text
Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper, et al.; Science 280, 1603 (1998) Abstract
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine: J. Taipale, et al.; Nature 406, 1005 (2000) Abstract
Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport: J.P. Incardona, et al.; Dev. Biol. 224, 440 (2000) Abstract
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened: J.K. Chen, et al.; Genes Dev. 16, 2743 (2002) Abstract; Full Text
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002) Abstract; Full Text
Medulloblastoma growth inhibition by hedgehog pathway blockade: D.M. Berman, et al.; Science 297, 1559 (2002) Abstract
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer: D.N. Watkins, et al.; Nature 422, 313 (2003) Abstract
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours: D.M. Berman, et al.; Nature 425, 846 (2003) Abstract
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis: S.P. Thayer, et al.; Nature 425, 851 (2003) Abstract
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment: D. Qualtrough, et al.; Int. J. Cancer 110, 831 (2004) Abstract
Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity: S. Tabs & O. Avci; Eur. J. Dermatol. 14, 96 (2004) Abstract; Full Text
In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells: T. Leon-Quinto, et al.; Diabetologia 47, 1442 (2004) Abstract
Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells: A. Skoudy, et al.; Biochem. J. 379, 749 (2004) Abstract; Full Text
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway: X. Wu, et al.; Chem. Biol. 11, 1229 (2004) Abstract
Related Products
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Alkaloids
 
 
ALX-550-269 Revised 27-Oct-06
8-Cyclopentyl-1,3-dipropylxanthine
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SYNONYMS DPCPX
PD 116,948
1,3-Dipropyl-8-cyclopentylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-550-269-M010   10 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C16H24N4O2
MW: 304.4
CAS NUMBER: 102146-07-6
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow.
SOLUBILITY: Soluble in 100% ethanol or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Potent and very selective A1 adenosine receptor antagonist, both in vitro and in vivo.
Product Specific Literature References
1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N- ethylcarboxamidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors: K.S. Lee & M. Reddington; Brain Res. 368, 394 (1986) Abstract
Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3- dipropylxanthine to rat brain membranes: R.F. Bruns, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 59 (1987) Abstract
PD 116,948, a highly selective A1 adenosine receptor antagonist: S.J. Haleen, et al.; Life Sci. 40, 555 (1987) Abstract
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations: H. von der Leyen, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 204 (1989) Abstract
Characterization of the adenosine receptors mediating hypothermia in the conscious mouse: Anderson, et al.; Br. J. Pharmacol. 113, 1386 (1994) Abstract
 
 
ALX-350-023 Revised 03-Jun-08
Cyclopiazonic acid
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SYNONYMS CPA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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ALX-350-023-M005   5 mg 42.00 USD Add To Cart
ALX-350-023-M025   25 mg 145.00 USD Add To Cart
ALX-350-023-M100   100 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C20H20N2O3
MW: 336.4
CAS NUMBER: 18172-33-3
RTECS: UY8587000
SOURCE/HOST: Isolated from Penicillium griseofulvum.
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO (50mg/ml), methylene chloride or methanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Mycotoxin. Cell permeable, reversible inhibitor of Ca2+-ATPases.
Product Specific Literature References
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum: N.W. Seidler, et al.; J. Biol. Chem. 264, 17816 (1989) Abstract; Full Text
Acetylcholine Ca2+ stores refilling directly involves a dihydropyridine- sensitive channel in dog trachea: J.P. Bourreau, et al.; Am. J. Physiol. 261, C497 (1991) Abstract
Discrimination of Ca(2+)-ATPase activity of the sarcoplasmic reticulum from actomyosin-type ATPase activity of myofibrils in skinned mammalian skeletal muscle fibres: distinct effects of cyclopiazonic acid on the two ATPase activities: N. Kurebayashi & Y. Ogawa; J. Muscle Res. Cell Motility 12, 355 (1991) Abstract
Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di- (tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes: M.J. Mason, et al.; J. Biol. Chem. 266, 20856 (1991) Abstract; Full Text
Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells: N. Demaurex, et al.; J. Biol. Chem. 267, 2318 (1992) Abstract; Full Text
Cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca(2+)- pump, reduces Ca(2+)-dependent K+ currents in guinea-pig smooth muscle cells: M. Suzuki, et al.; Br. J. Pharmacol. 107, 134 (1992) Abstract
Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle: Y. Uyama, et al.; Br. J. Pharmacol. 106, 208 (1992) Abstract
Effects of cyclopiazonic acid and ryanodine on cytosolic calcium and contraction in vascular smooth muscle: F. Abe, et al.; Br. J. Pharmacol. 118, 1711 (1996) Abstract
Natural and in vitro coproduction of cyclopiazonic acid and aflatoxins: M.L. Martins & H.M. Martins; J. Food Prot. 62, 292 (1999) Abstract
Recent advances in analytical methodology for cyclopiazonic acid: J.W. Dorner; Adv. Exp. Med. Biol. 504, 107 (2002), Review Abstract
Cyclopiazonic acid reduces the coupling factor of the Ca2+-ATPase acting on Ca2+ binding: F. Martinez-Azorin; FEBS Lett. 576, 73 (2004) Abstract
Further Categories Containing This Product:
Ca2+-ATPase / Related Products • Neurotoxins • Mycotoxins
 
 
ALX-106-028 Revised 03-Apr-08
D-Cycloserine