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Signal Transduction
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ALX-480-038 Revised 18-Jun-08
IBMX
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SYNONYMS 3-Isobutyl-1-methylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-038-M500   500 mg 99.00 USD Add To Cart
ALX-480-038-G001   1 g 195.00 USD Add To Cart
Product Specification
FORMULA: C10H14N4O2
MW: 222.3
CAS NUMBER: 28822-58-4
RTECS: ZD8500000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or methanol (warm, 50mg/ml); almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.
IDENTITY: Identity determined by IR.

Product Description
Potent, non-specific inhibitor of phosphodiesterases. More potent than theophylline (Prod. No. ALX-480-062) at adenosine receptors. Accelerates conversion of mouse fibroblast cells into adipose cells.
Product Specific Literature References
Effects of xanthine derivatives on lipolysis and on adenosine 3',5'- monophosphate phosphodiesterase activity: J.A. Beavo, et al.; Mol. Pharmacol. 6, 597 (1970) Abstract
Adenosine 3':5'-cyclic monophosphate and insulin release: W. Montague & J.R. Cook; Biochem. J. 120, 9P (1970) Abstract
The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release by isolated rat islets of Langerhans: W. Montague & J.R. Cook; Biochem. J. 122, 115 (1971) Abstract
Cyclic nucleotide phosphodiesterase activity in normal mouse pancreatic islets: S.J. Ashcroft, et al.; FEBS Lett. 20, 263 (1972) Abstract
The mode of action of adenosine 3’:5’-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity: W. Montague & S.L. Howell; Biochem. J. 134, 321 (1973) Abstract
Effects of methylxanthines on adenosine 3’,5’-monophosphate and corticosterone in the rat adrenal: A. Peytremann, et al.; Endocrinology 92, 525 (1973) Abstract
Concentration of adenosine 3’:5’-cyclic monophosphate in mouse pancreatic islets measured by a protein-binding radioassay: R.H. Cooper, et al.; Biochem. J. 134, 599 (1973) Abstract
Determination of theophylline in plasma by electron capture gas chromatography: H.A. Schwertner, et al.; Anal. Chem. 48, 1875 (1976) Abstract
Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation: D.F. Horrobin, et al.; Prostaglandins 13, 33 (1977) Abstract
Selective inhibition of cyclic nucleotide phosphodiesterases by analogues of 1-methyl-3-isobutylxanthine: G.L. Kramer, et al.; Biochemistry 16, 3316 (1977) Abstract
Cyclic nucleotide phosphodiesterases of human and rat gastric mucosa: U. Klotz, et al.; Naunyn-Schmiedebergs Arch. Pharmacol. 296, 187 (1977) Abstract
Allergic reactions, cyclic AMP and histamine release: P.S. Skov, et al.; Experientia 33, 965 (1977) Abstract
Differentiation of 3T3-L2 fibroblasts into adipose cells in bromodeoxyuridine-suppressed cultures: T.R. Russell; PNAS 76, 4451 (1979) Abstract
Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine: P. Janik, et al.; Cancer Res. 40, 1950 (1980) Abstract
Induction of a transient elevation in intracellular levels of adenosine-3’,5’-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation: L. Simchowitz, et al.; J. Immunol. 124, 1482 (1980) Abstract
Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction: G.S. Ahluwalia & A.R. Rhoads; Biochem. Pharmacol. 31, 665 (1982) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
Methylxanthine inhibitors of phosphodiesterases: J.N. Wells & J.R. Miller; Methods Enzymol. 159, 489 (1988) Abstract
Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline: V.L. Coffin and R.D. Spealman; Eur. J. Pharmacol. 170, 35 (1989) Abstract
Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium: Y. Katano & M. Endoh; BBRC 167, 123 (1990) Abstract
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, Jr., et al.; Biochem. Pharmacol. 42, 679 (1991) Abstract
Effect of an antihypertensive hydrazine derivative on Ca2+ current of single frog cardiac cells: F. Scamps, et al.; Eur. J. Pharmacol. 244, 119 (1993) Abstract
Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity: C. Tomes, et al.; Cell. Signal. 5, 615 (1993) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
 
 
ALX-550-049 Revised 09-Oct-08
(±)-Ibotenic acid
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SYNONYMS (±)α-Amino-3-hydroxy-5-isoxazoleacetic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-049-M001   1 mg 55.00 USD Add To Cart
ALX-550-049-M005   5 mg 220.00 USD Add To Cart
ALX-550-049-M025   25 mg 690.00 USD Add To Cart
Product Specification
FORMULA: C5H6N2O4
MW: 158.1
CAS NUMBER: 2552-55-8
MERCK INDEX: 14: 4877
RTECS: NY2100000
SOURCE/HOST: Synthetic.
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
HAZARD: TOXIC.

Product Description
Potent glutamate receptor agonist. Neurotoxic agent.
Product Specific Literature References
Central actions of ibotenic acid and muscimol: G.A. Johnston, et al.; Biochem. Pharmacol. 17, 2488 (1968) Abstract
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid: G.A. Johnston, et al.; Nature 248, 804 (1974) Abstract
Excitatory amino acid transmitters: J.C. Watkins and R.H. Evans; Annu. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
 
 
ALX-550-384 Revised 24-Feb-05
IBTU
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SYNONYMS N-(4-Chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl)thiourea
PRODUCT LINE Neurobiology
PRODUCT CATEGORY TRPV1 Agonists and Antagonists / Related Products
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ALX-550-384-M001   1 mg 110.00 USD Add To Cart
ALX-550-384-M005   5 mg 440.00 USD Add To Cart
Product Specification
FORMULA: C16H16ClIN2O2S
MW: 462.7
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, acetone, 100% ethanol, DMSO or Tween 20.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent vanilloid receptor 1 [TRPV1] antagonist with marked selectivity for the calcium entry-linked receptor subpopulation of TRPV1.
Product Specific Literature References
Design of a high-affinity competitive antagonist of the vanilloid receptor selective for the calcium entry-linked receptor population: A. Toth, et al.; Mol. Pharmacol. 65, 282 (2004) Abstract
 
 
ALX-550-249 Revised 27-May-03
Ibuprofen
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SYNONYMS α-Methyl-4-(2-methylpropyl)benzeneacetic acid
(±)-2-(4-Isobutylphenyl)propionic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-249-G001   1 g 17.00 USD Add To Cart
ALX-550-249-G005   5 g 48.00 USD Add To Cart
Product Specification
FORMULA: C13H18O2
MW: 206.3
CAS NUMBER: 15687-27-1
MERCK INDEX: 14: 4881
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in methanol or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective cyclooxygenase (COX) inhibitor.
Product Specific Literature References
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction: R.F. Myers & M.I. Siegel; BBRC 112, 586 (1983) Abstract
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition: M. Rampart & T.J. Williams; Biochem. Pharmacol. 35, 581 (1986) Abstract
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-420-037 Revised 11-Feb-08
Icilin
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SYNONYMS AG 3-5
3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuroactive Agents Other Products
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ALX-420-037-M001   1 mg 10.00 USD Add To Cart
ALX-420-037-M005   5 mg 32.00 USD Add To Cart
ALX-420-037-M025   25 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C16H13N3O4
MW: 311.3
CAS NUMBER: 36945-98-9
PURITY: ≥98% (1H-NMR)
APPEARANCE: Light yellow solid.
SOLUBILITY: Soluble in DMSO (100mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1 (at 10- to 100-fold higher concentration). Induces currents in TRPM8 expressing HEK 293 cells (EC50=0.36mM) more potently than menthol (Prod. No. ALX-420-042) or low temperatures.
Product Specific Literature References
AG-3-5: a chemical producing sensations of cold: E.T. Wei and D.A. Seid; J. Pharm. Pharmacol. 35, 110 (1983) Abstract
Identification of a cold receptor reveals a general role for TRP channels in thermosensation: D.D. McKemy, et al.; Nature 416, 52 (2002) Abstract
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH: D.A. Andersson, et al.; J. Neurosci. 24, 5364 (2004) Abstract; Full Text
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel: H.H. Chuang, et al.; Neuron 43, 859 (2004) Abstract
Icilin activates the {delta}-subunit of the human epithelial Na+ channel.: H. Yamamura; Mol. Pharmacol. 68, 1142 (2005) Abstract
Sensing with TRP channels: T. Voets, et al.; Nat. Chem. Biol. 1, 85 (2005), Review Abstract
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain: C.J. Proudfoot, et al.; Curr. Biol. 16, 1591 (2006) Abstract
Related Products
Further Categories Containing This Product:
TRP Channels Other Products
 
 
ALX-201-333 Revised 18-Mar-08
IDO (human) (recombinant) (His)
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SYNONYMS Indoleamine 2,3-dioxygenase (human) (recombinant) (His)
PRODUCT LINE Immunology
PRODUCT CATEGORY Indoleamine 2,3-dioxygenase [IDO] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-333-C050   50 µg 395.00 USD Add To Cart
Product Specification
EC: 1.13.11.42
SOURCE/HOST: Produced in E. coli. Mature human IDO (indoleamine 2,3-dioxygenase) (aa 1-403) is fused at the C-terminus to a His-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 50mM TRIS, pH 7.4, containing 1mM EDTA.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL test; Bio Whittaker).
SPECIFIC ACTIVITY: >80’000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P14902: Indoleamine 2,3-dioxygenase (human)

Note: Heme content was not determined for the end product. 7µM hemin was added for protein induction.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-335 Revised 18-Mar-08
IDO (mouse) (recombinant) (His)
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SYNONYMS Indoleamine 2,3-dioxygenase (mouse) (recombinant) (His)
PRODUCT LINE Immunology
PRODUCT CATEGORY Indoleamine 2,3-dioxygenase [IDO] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-335-C050   50 µg 395.00 USD Add To Cart
Product Specification
EC: 1.13.11.42
SOURCE/HOST: Produced in E. coli. Mature mouse IDO (indoleamine 2,3-dioxygenase) (aa 1-407) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 50mM TRIS, pH 7.4, containing 1mM EDTA.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SPECIFIC ACTIVITY: >100’000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P28776: Indoleamine 2,3-dioxygenase (mouse)

Note: Heme content was not determined for the end product. 7µM hemin was added for protein induction.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-550-062 Revised 11-Jan-07
IDRA 21
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SYNONYMS 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-062-M005   5 mg 60.00 USD Add To Cart
ALX-550-062-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C8H9ClN2O2S
MW: 232.7
CAS NUMBER: 22503-72-6
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Analog of cyclothiazide (Prod. No. ALX-550-338). Inhibits AMPA receptor desensitization. Crosses the blood-brain barrier more readily than cyclothiazide (Prod. No. ALX-550-338) and diazoxide (Prod. No. ALX-550-260) and is a more potent cognitive enhancing drug.
Product Specific Literature References
Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus: M. Bertolino, et al.; Receptors Channels 1, 267 (1993) Abstract
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys: D.M. Thompson, et al.; PNAS 92, 7667 (1995) Abstract
7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazol: I. Zivkovic, et al.; J. Pharmacol. Exp. Ther. 272, 300 (1995) Abstract
Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices: A. Arai, et al.; Neuroreport 7, 2211 (1996) Abstract
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity: F. Impagnatiello, et al.; PNAS 94, 7053 (1997) Abstract
The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide augments AMPA- and GABA-mediated synaptic responses in cultured hippocampal neurons: K.A. Yamada, et al.; Neurobiol. Dis. 5, 196 (1998) Abstract
The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury: K.A. Yamada, et al.; Ann. Neurol. 43, 664 (1998) Abstract
 
 
ALX-522-057 Revised 01-Oct-08
IL-1 Receptor Type I (human):Fc (human) (recombinant)
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SYNONYMS IL-1RI (human):Fc (human) (recombinant)
Interleukin-1 Receptor Type I (human):Fc (human) (recombinant)
CD121a (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-057-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~83kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water.
SPECIFICITY: Binds to human IL-1 (interleukin-1).
BIOLOGICAL ACTIVITY: Blocks IL-1 activity.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.