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cGMP Pathways
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ALX-270-119 Revised 09-Mar-06
Rolipram
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SYNONYMS 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-119-M005   5 mg 30.00 USD Add To Cart
ALX-270-119-M025   25 mg 115.00 USD Add To Cart
Product Specification
FORMULA: C16H21NO3
MW: 275.4
CAS NUMBER: 61413-54-5
MERCK INDEX: 14: 8251
RTECS: UY5749237
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Selective inhibitor of phosphodiesterase 4 (PDE4).
Product Specific Literature References
Stereospecific binding of the antidepressant rolipram to brain protein structures: H.H. Schneider, et al.; Eur. J. Pharmacol. 127, 105 (1986) Abstract
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J. 241, 535 (1987) Abstract
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, et al.; Biochem. Pharmacol. 42, 679 (1991) Abstract
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther. 270, 250 (1994) Abstract
 
 
ALX-270-126 Revised 13-Dec-04
Trequinsin . hydrochloride
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SYNONYMS 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-[6,1a]-isoquinolin-4-one . HCl
HL 725 . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-126-M010   10 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C24H27N3O3 . HCl
MW: 405.5 . 36.5
CAS NUMBER: 79855-88-2
PURITY: ≥98%
APPEARANCE: White to pale yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from moisture.

Product Description
Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll) in vitro. Potentiates adenosine-stimulated cAMP accumulation.
Product Specific Literature References
HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro: D. Rupert & K.U. Weithmann; Life Sci. 31, 2037 (1982) Abstract
Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat: F. DeClerck, et al.; Blood Coag. Fibrinol. 1, 247 (1990) Abstract
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C- mediated pathways: B.A. Konkle, et al.; J. Biol. Chem. 265, 21867 (1990) Abstract; Full Text
Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells: M.E. Whalin, et al.; Mol. Pharmacol. 39, 711 (1991) Abstract
 
 
ALX-270-150 Revised 05-Oct-06
Vinpocetine
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SYNONYMS Eburnamenine-14-carboxylic acid-ethyl ester
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-150-M005   5 mg 30.00 USD Add To Cart
ALX-270-150-M025   25 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C22H26N2O2
MW: 350.5
CAS NUMBER: 42971-09-5
MERCK INDEX: 14: 9991
RTECS: JW4792000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: HARMFUL.

Product Description
Selective inhibitor of Ca2+/calmodulin-dependent phosphodiesterase 1 (PDE1).
Product Specific Literature References
Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle: M. Hagiwara, et al.; Biochem. Pharmacol. 33, 453 (1984) Abstract
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol. 38, 3331 (1989) Abstract
Regulation of cyclic AMP metabolism in bovine adrenal medullary cells: P.D. Marley & K.A. Thomsom; Biochem. Pharmacol. 44, 2105 (1992) Abstract
Cyclic 3',5'-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells: M. Yamaki, et al.; Am. J. Physiol. 262, F957 (1992) Abstract
Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors: K. Molnar-Kimber, et al.; Agents Actions 39, C77 (1993) Abstract
 
 
ALX-270-151 Revised 10-May-05
W-5 . hydrochloride
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SYNONYMS N-(6-Aminohexyl)-1-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-151-M005   5 mg 20.00 USD Add To Cart
ALX-270-151-M025   25 mg 60.00 USD Add To Cart
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Product Specification
FORMULA: C16H22N2O2S . HCl
MW: 306.4 . 36.5
CAS NUMBER: 61714-25-8
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water, DMSO, 100% ethanol (hot) or methanol (hot).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 years when stored at -20°C. Stock solutions are stable for up to  6 months when stored at +4°C.
HANDLING: Protect from light.

Product Description
Antagonist of calmodulin, inhibiting Ca2+/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
Hydrophobic regions function in calmodulin-enzyme(s) interactions: T. Tanaka & H. Hidaka; J. Biol. Chem. 255, 11078 (1980) Abstract; Full Text
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]: H. Hidaka; Prot. Nucl. Acid Enz. 26, 977 (1981) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • Myosin Light Chain Kinase Inhibitors
 
 
ALX-270-153 Revised 29-Feb-08
W-7 . hydrochloride
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SYNONYMS N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-153-M005   5 mg 20.00 USD Add To Cart
ALX-270-153-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C16H21ClN2O2S . HCl
MW: 340.9 . 36.5
CAS NUMBER: 61714-27-0
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (warm), methanol, 100% ethanol (warm), DMSO, dimethyl formamide or ethylene glycol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY:

Determined by H-NMR.

Product Description
Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981) Abstract
Calmodulin antagonists enhance calcium binding to calmodulin: M. Inagaki, et al.; Pharmacology 27, 125 (1983) Abstract
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase: H. Itoh & H. Hidaka; J. Biochem. 96, 1721 (1984) Abstract
Related Products
Further Categories Containing This Product:
Phosphodiesterases / Related Products • Myosin Light Chain Kinase Inhibitors
 
 
ALX-270-155 Revised 04-Mar-05
W-12 . hydrochloride
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SYNONYMS N-(4-Aminobutyl)-2-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-155-M005   5 mg 40.00 USD Add To Cart
ALX-270-155-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C14H18N2O2S . HCl
MW: 278.4 . 36.5
CAS NUMBER: 89108-46-3
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
T. Tanaka and H. Hidaka; J. Biol. Chem. 255, 11078 (1980) Abstract; Full Text
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]: H. Hidaka; Prot. Nucl. Acid Enz. 26, 977 (1981) Abstract
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • Myosin Light Chain Kinase Inhibitors
 
 
ALX-270-156 Revised 20-Feb-07
W-13 . hydrochloride
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SYNONYMS N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-156-M005   5 mg 60.00 USD Add To Cart
ALX-270-156-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C14H17ClN2O2S . HCl
MW: 312.8 . 36.5
CAS NUMBER: 88519-57-7
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (warm) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
Hydrophobic regions function in calmodulin-enzyme(s) interactions: T. Tanaka & H. Hidaka; J. Biol. Chem. 255, 11078 (1980) Abstract; Full Text
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]: H. Hidaka; Prot. Nucl. Acid Enz. 26, 977 (1981) Abstract
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981) Abstract
Naphthalenesulfonamides as calmodulin antagonists: H. Hidaka & T. Tanaka; Meth. Enzymol. 102, 185 (1983) Abstract
Calmodulin antagonists enhance calcium binding to calmodulin: M. Inagaki, et al.; Pharmacology 27, 125 (1983) Abstract
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase: H. Itoh & H. Hidaka; J. Biochem. 96, 1721 (1984) Abstract
Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13: J.S. Stroble & V.A. Peterson; J. Pharm. Exp. Ther. 263, 186 (1992) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • Myosin Light Chain Kinase Inhibitors
 
 
ALX-270-161 Revised 26-Nov-04
W-5 Isomer . hydrochloride
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SYNONYMS N-(6-Aminohexyl)-2-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-161-M001   1 mg 30.00 USD Add To Cart
ALX-270-161-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C16H22N2O2S . HCl
MW: 306.4 . 36.5
PURITY: ≥98%
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Isomer of W-5 (Prod. No. ALX-270-151).
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors • Phosphodiesterases / Related Products
 
 
ALX-270-171 Revised 30-Jun-08
Chlorpromazine . hydrochloride
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SYNONYMS 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-171-G001   1 g 22.00 USD Add To Cart
ALX-270-171-G005   5 g 66.00 USD Add To Cart
Product Specification
FORMULA: C17H19ClN2S . HCl
MW: 318.9 . 36.5
CAS NUMBER: 69-09-0
MERCK INDEX: 14: 2185
RTECS: SO1750000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. H1 antagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993) Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993) Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995) Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002) Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • Chemopreventive Agents Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • PLA2 Inhibitors • Dopaminergics & Dopamine Receptors / Related Products
 
 
ALX-270-208 Revised 04-Feb-05
J-8 . hydrochloride
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SYNONYMS