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ALX-804-084
Revised 15-Sep-08
Monoclonal Antibody to H+/ K+ ATPase-β (2G11)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
H+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-084-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Pig
Others
CLONE:
2G11
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. PBS-diluted ascites containing 0.05% sodium azide.
IMMUNOGEN:
Purified 34kDa core peptide from deglycosylated pig gastric microsomes.
SPECIFICITY:
Recognizes the β subunit of human, mouse, rat, bovine, pig, dog, rabbit and ferret H
+
/K
+
ATPase.
APPLICATION:
Immunocytochemistry
(1:2’000)
Immunohistochemistry
(paraffin and frozen sections (1:2’000))
Immunoprecipitation
,
Chromatin Immunoprecipitation
Western Blot
(1:4’000)
Functional Application
: Inhibits enzymatic activity of H
+
/ K
+
ATPase and alters affinity of its cytoplasmic potassium binding site.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase:
J.G. Duman, et al.; Am. J. Physiol.
277
, C361 (1999)
Abstract
;
Full Text
Functionally distinct pools of actin in secretory cells:
D.A. Ammar, et al.; Am. J. Physiol. Cell Physiol.
281
, C407 (2001)
Abstract
;
Full Text
Localization and function of soluble N-ethylmaleimide-sensitive factor attachment protein-25 and vesicle-associated membrane protein-2 in functioning gastric parietal cells:
S. Karvar, et al.; J. Biol. Chem.
277
, 50030 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-081
Revised 28-Jul-08
Monoclonal Antibody to Na+/K+ ATPase-α (M7-PB-E9)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-081-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Pig
Others
CLONE:
M7-PB-E9
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Purified sheep kidney Na
+
/K
+
ATPase-α.
SPECIFICITY:
Recognizes human, mouse, rat (α3 isoform only), sheep, bovine, pig, dog and chicken Na
+
/K
+
ATPase-α. Detects a band of ~110kDa by Western blot.
APPLICATION:
ELISA
Immunocytochemistry
Immunohistochemistry (1:100)
Immunoprecipitation
Western Blot (1:250)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-082
Revised 12-Nov-07
Monoclonal Antibody to Na+/K+ ATPase-α1 (M8-P1-A3)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-082-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
Sheep
Dog
Pig
CLONE:
M8-P1-A3
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Sheep kidney Na
+
/K
+
ATPase-α1.
SPECIFICITY:
Recognizes the α1 subunit of rat, sheep, pig and dog Na
+
/K
+
ATPase-
α
. Detects a band of ~110kDa by Western blot. Does not cross-react with Xenopus and chicken Na
+
/K
+
ATPase-
α
1 or with rat Na
+
/K
+
ATPase-α
2 and -α3. Recognizes an epitope between aa 496-506 of sheep kidney Na
+
/K
+
ATPase-α.
APPLICATION:
Immunohistochemistry (frozen sections (1:100))
Western Blot (1:250)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-080
Revised 04-Mar-05
Monoclonal Antibody to Na+/K+ ATPase-α1 (9-A5)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-080-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Dog
Others
CLONE:
9-A5
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified rat kidney Na
+
/K
+
ATPase.
SPECIFICITY:
Recognizes an intracellular region near Asp
369
of the α1 subunit of human, rat, dog and chicken Na
+
/K
+
ATPase-α.
APPLICATION:
ELISA
Immunohistochemistry (1:1'000)
Immunoprecipitation (can be used for affinity purification of the α subunit of Na
+
/K
+
ATPase from dog kidney extracts)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
The Na
+
/K
+
ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The Na
+
/ K
+
ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the a subunit, and an associated smaller glycoprotein, termed the b subunit. Studies indicate that there are three isoforms of the α subunit (α1, α2, α3) and two isoforms of the β subunit (β1 and β2) encoded by two multigene families.The different isoforms of the Na
+
/K
+
ATPase exhibit tissue-specific and developmental patterns of expression. The α1 and β mRNAs are present in all cell types examined, whereas the α2 and α3 mRNAs exhibit a more restricted pattern of cell-specific expression. The α subunit has been found in kidney, brain, heart, and to a lesser extent liver, skeletal and smooth muscle.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-083
Revised 28-Apr-08
Monoclonal Antibody to Na+/K+ ATPase-α3 (XVIF9-G10)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-083-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Sheep
Dog
Monkey
Others
CLONE:
XVIF9-G10
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Dog cardiac microsomes.
SPECIFICITY:
Recognizes the a3 subunit of human, rat, sheep, guinea pig, dog, rabbit and monkey Na
+
/K
+
ATPase-α. Detects a band of ~110kDa by Western blot.
APPLICATION:
Immunocytochemistry (5μg/ml)
Immunohistochemistry (frozen sections) (3μg/ml)
Western Blot (1μg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-085
Revised 02-Apr-07
Monoclonal Antibody to Na+/K+ ATPase-β1 (M17-P5-F11)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-085-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Sheep
Dog
Pig
CLONE:
M17-P5-F11
ISOTYPE:
Mouse IgG2a
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified sheep kidney Na
+
/K
+
ATPase-
β.
SPECIFICITY:
Recognizes the β1 subunit of human, sheep, pig and dog Na
+
/K
+
ATPase-β
.
APPLICATION:
Immunohistochemistry (1:100)
Immunoprecipitation
Western Blot (1:250)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-803-050
Revised 07-Mar-06
Monoclonal Antibody to Ouabain (129/5E4)
SYNONYMS
anti-Strophanthin G MAb (129/5E4)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-050-C100
100 µg
388.00 USD
Product Specification
CLONE:
129/5E4
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Ammonium sulphate precipitation.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 0.9mg/ml sodium azide.
IMMUNOGEN:
Ouabain (Strophanthin G).
SPECIFICITY:
Recognizes ouabain. Cross-reacts with strophanthin K and ouabagenin. Does not cross-react with digoxin.
APPLICATION:
ELISA
Radioimmunoassay
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products
•
Monoclonal Antibodies
ALX-804-049
Revised 02-Oct-08
Monoclonal Antibody to PMCA ATPase (5F10)
SYNONYMS
anti-Plasma Membrane Calcium Pump ATPase MAb (5F10)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-049-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Monkey
Others
CLONE:
5F10
ISOTYPE:
Mouse IgG2a
FORMULATION:
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified human erythrocyte PMCA ATPase (plasma membrane calcium pump ATPase).
SPECIFICITY:
Recognizes all known (currently four) isoforms of human, rat, mouse, sheep, dog, monkey, rabbit, cat and chicken plasma membrane PMCA ATPase. Detects a band of ~140kDa by Western blot. Also detects bands at ~95kDa and ~180kDa which may represent aggregation and/or natural proteolytic products of PMCA ATPase. Recognizes an epitope between aa 724-783 of human PMCA ATPase.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (frozen sections (1:500), paraffin sections (1:500))
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Plasma membrane calcium pump and 28-kDa calcium binding protein in cells of rat kidney distal tubules:
J.L. Borke, et al.; Am. J. Physiol.
257
, F842 (1989)
Abstract
Plasma membrane Ca2+ pump in rat brain. Patterns of alternative splices seen by isoform-specific antibodies:
A.G. Filoteo, et al.; J. Biol. Chem.
272
, 23741 (1997)
Abstract
;
Full Text
Localization of alkaline phosphatase and Ca2+-ATPase in the cat placenta:
E.E. Champion, et al.; Placenta
24
, 453 (2003)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-086
Revised 26-Oct-04
Monoclonal Antibody to SERCA1 ATPase (IIH11)
SYNONYMS
anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1 MAb (IIH11)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-086-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Dog
Others
CLONE:
IIH11
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified rabbit skeletal muscle sarcoplasmic reticulum.
SPECIFICITY:
Recognizes SERCA1 ATPase (sarcoplasmic/endoplasmic reticulum calcium ATPase 1) in mouse, rat, dog, rabbit and guinea pig type II (fast) skeletal muscle. Detects a band of ~110kDa by Western blot. Does not cross-react with human SERCA1 ATPase.
APPLICATION:
Immunocytochemistry (1:500)
Western Blot (1:2'500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
A monoclonal antibody to the Ca2+ ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical study:
A.O. Jorgensen, et al.; Cell Motil. Cytoskeleton
9
, 164 (1988)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-087
Revised 11-Jan-05
Monoclonal Antibody to SERCA1 ATPase (VE121G9)
SYNONYMS
anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1 MAb (VE121G9)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-087-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
Others
CLONE:
VE121G9
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. Antibody in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified rabbit skeletal muscle sarcoplasmic reticulum.
SPECIFICITY:
Recognizes SERCA1 ATPase (sarcoplasmic/endoplasmic reticulum calcium ATPase 1) in human, mouse, dog and rabbit type II (fast) skeletal muscle. Detects a band of ~110kDa by Western blot.
APPLICATION:
Immunohistochemistry (1:500)
Western Blot (1:2'500)
Functional Application (inhibits the crystallization of SERCA1 ATPase induced by vanadate)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
A monoclonal antibody to the Ca2+ ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical study:
A.O. Jorgensen, et al.; Cell Motil. Cytoskeleton
9
, 164 (1988)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-088
Revised 26-Jan-05
Monoclonal Antibody to SERCA2 ATPase (2A7-A1)
SYNONYMS
anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 MAb (2A7-A1)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-088-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
CLONE:
2A7-A1
ISOTYPE:
Mouse IgG2a
FORMULATION:
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified dog cardiac sarcoplasmic reticulum vesicles.
SPECIFICITY:
Recognizes human, mouse, rat, dog, rabbit, and guinea pig SERCA2 ATPase (sarcoplasmic/endoplasmic reticulum calcium ATPase 2). Detects a band of ~110kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
A novel interaction mechanism accounting for different acylphosphatase effects on cardiac and fast twitch skeletal muscle sarcoplasmic reticulum calcium pumps
:
C. Nediani, et al.; FEBS Lett.
443
, 308 (1999)
Abstract
;
Full Text
General Information
ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are comprised of a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-048
Revised 29-Sep-05
Monoclonal Antibody to SERCA2 ATPase (IID8)
SYNONYMS
anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 MAb (IID8)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+-ATPase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-048-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Dog
Pig
Others
