• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Cell Death / Apoptosis / Autophagy
You are here: Product Lines > Cell Death / Apoptosis / Autophagy
 
Toolbar - View Selection
 
 Items 60-80 of 1132 Page 4 of 57 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-380-084 Revised 30-Oct-07
Actinomycin X0δ
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-084-C200   200 µg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H86N12O17
MW: 1271.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (contains traces of ethyl acetate or cyclohexane)
APPEARANCE: Red crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry: S. Cho, et al.; Arch. Pharm. Res. 17, 424 (1994) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors / Related Products
 
 
ALX-380-080 Revised 03-Apr-08
Actinomycin X2
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-080-M001   1 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H84N12O17
MW: 1269.4
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥95% (solvent free)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic. Has higher cytotoxicity toward cultured human leukemia (HL-60) cells than actinomycin D (Prod. No. ALX-380-009). Induces cell death via apoptosis.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Correlation of actinomycin X2 to the lipid profile in static and shaken cultures of Streptomyces nasri strain YG62: M.Y. el-Naggar, et al.; Microbios. 100, 117 (1999) Abstract
Characterization of Streptomyces MITKK-103, a newly isolated actinomycin X2-producer: K. Kurosawa, et al.; Appl. Microbiol. Biotechnol. 72, 145 (2006) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors / Related Products
 
 
ALX-260-128 Revised 03-Apr-08
Actinonin
Add to Clipboard
SYNONYMS 3[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]-carbonyl]-2-methylpropyl]-carbamoyl]-octanohydroxamic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-128-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C19H35N3O5
MW: 385.5
CAS NUMBER: 13434-13-4
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of aminopeptidase M, leucine aminopeptidase and deformylase. Shows antitumor activity. Apoptosis inducer.
Product Specific Literature References
Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes: H. Umezawa, et al.; J. Antibiot. (Tokyo) 38, 1629 (1985) Abstract
Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes: M. Hachisu, et al.; Life Sci. 41, 235 (1987) Abstract
Effects of an antibiotic protease inhibitor, actinonin on the growth within collagen gels of non-metastatic and metastatic mouse mammary tumors of the same origin: K. Sayama, et al.; Cancer Lett 94, 171 (1995) Abstract
Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299: U. Lendeckel, et al.; BBRC 252, 5 (1998) Abstract
Antitumor activity of actinonin in vitro and in vivo: Y. Xu, et al.; Clin. Cancer Res. 4, 171 (1998) Abstract
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor: D.Z. Chen, et al.; Biochemistry 39, 1256 (2000) Abstract
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics: M.D. Lee, et al.; J. Clin. Invest. 114, 1107 (2004) Abstract
Actinonin induces apoptosis in U937 leukemia cells: M. Grujic, et al.; Cancer Lett. 223, 211 (2005) Abstract
Further Categories Containing This Product:
Aminopeptidases / Related Products • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-480-094 Revised 07-Oct-08
ADP-HPD . ammonium salt . dihydrate
Add to Clipboard
SYNONYMS Adenosine 5'-diphosphate (hydroxymethyl) pyrrolidinediol . NH4 . 2H2O
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-094-C060   60 µg 188.00 USD Add To Cart
Product Specification
FORMULA: C15H23N6O12P2 . NH4 . 2H2O
MW: 541.3 . 18.0 . 36.0
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white amorphous solid.
SOLUBILITY: Soluble in water (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Hygroscopic.

Product Description
Potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50=120nM) versus ADP-ribose (IC50=120µM). Does not affect the activities of either PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1mM concentration.
Product Specific Literature References
Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 389 (1995) Abstract
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 4332 (1995) Abstract
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage: S. Vispe, et al.; PNAS 97, 9886 (2000) Abstract; Full Text
Further Categories Containing This Product:
DNA Repair Other Products • PARG / Related Products
 
 
ALX-630-093 Revised 23-Jul-08
Aflatoxin B1
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-093-M001   1 mg 28.00 USD Add To Cart
ALX-630-093-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C17H12O6
MW: 312.3
CAS NUMBER: 1162-65-8
MERCK INDEX: 14: 180
RTECS: GY1925000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in DMSO (20mg/ml) or methylene chloride (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description
Naturally occuring mycotoxin produced by many species of Aspergillus. Metabolized by the liver to the reactive intermediate aflatoxin M1. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage.
Product Specific Literature References
Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus: C.P. Wild, et al.; Environ. Health Perspect. 99, 115 (1993) Abstract
A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China: G.S. Qian, et al.; Cancer Epidemiol. Biomarkers Prev. 3, 3 (1994) Abstract
Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone: H. Autrup, et al.; Mutagenesis 11, 69 (1996) Abstract
Activation and detoxication of aflatoxin B1: F.P. Guengerich, et al.; Mutat. Res. 402, 121 (1998), (Review) Abstract
Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B1: B.D. Roebu; J. Cell. Biochem. 91, 242 (2004), (Review) Abstract
Aflatoxin B1-induced DNA damage and its repair: L. L. Bedard & T. E. Massey; Cancer Lett. 241, 174 (2006), (Review) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis • Plant Research Reagents / Related Products
 
 
ALX-630-103 Revised 04-Sep-08
Aflatoxin B2
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-103-M001   1 mg 55.00 USD Add To Cart
ALX-630-103-M005   5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H14O6
MW: 314.3
CAS NUMBER: 7220-81-7
MERCK INDEX: 14: 180
RTECS: GY1722000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Aflatoxin B2: Chemical Identity and Biological Activity: S.B. Chang, et al.; Science 142, 1191 (1963) Abstract
Accumulation of only aflatoxin B2 by a strain of Aspergillus flavus: H.W. Schroeder & W.W. Carlton; Appl. Microbiol. 25, 146 (1973) Abstract
In vitro metabolism of aflatoxin B2 by animal and human liver: B.D. Roebuck, et al.; Cancer Res. 38, 999 (1978) Abstract
Interaction of aflatoxin B2 with rat liver DNA and histones in vivo: J.D. Groopman, et al.; Carcinogenesis 2, 1371 (1981) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis • Plant Research Reagents / Related Products
 
 
ALX-630-104 Revised 24-Sep-08
Aflatoxin G1
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-104-M001   1 mg 65.00 USD Add To Cart
ALX-630-104-M005   5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H12O7
MW: 328.3
CAS NUMBER: 1165-39-5
MERCK INDEX: 14: 181
RTECS: LV1720000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in DMSO (10mg/ml), methylene chloride (5mg/ml) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC. MAY BE CARCINOGENIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Mutagenic effect of aflatoxin G1 in comparison with B1: M.M. el-Zawahri, et al.; J. Environ. Pathol. Toxicol. Oncol. 10, 45 (1990) Abstract
Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins: G. Sabbioni & C.P. Wild; Carcinogenesis 12, 97 (1991) Abstract
Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro: X.M. Sun, et al.; Biomed. Environ. Sci. 15, 145 (2002) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Non-apoptotic Cell Death / Necrosis • Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Plant Research Reagents / Related Products
 
 
ALX-630-106 Revised 20-Jun-08
Aflatoxin G2
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-106-M001   1 mg 150.00 USD Add To Cart
ALX-630-106-M005   5 mg 600.00 USD Add To Cart
Product Specification
FORMULA: C17H14O7
MW: 330.3
CAS NUMBER: 7241-98-7
MERCK INDEX: 14: 181
RTECS: LV1700000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Combining Ability for Resistance to Field Aflatoxin Accumulation in Maize Grain: D.P. Gorman, et al.; Plant Breeding 109, 296 (1992)
Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential: J.J. Wong & D.P. Hsieh; PNAS 73, 2241 (1976) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Plant Research Reagents / Related Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis
 
 
ALX-630-095 Revised 29-Oct-08
Aflatoxin M1
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-095-MC01   0.1 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C17H12O7
MW: 328.3
CAS NUMBER: 6795-23-9
MERCK INDEX: 14: 182
RTECS: GY1880000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methylene chloride (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. MAY BE MUTAGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin. Hydroxylated metabolite of aflatoxin B1. Maximum absorbance (λmax) at 228, 264 and 360nm.
Product Specific Literature References
Production and characterization of monoclonal antibodies against aflatoxin M1: N.A. Woychik, et al.; Appl. Environ. Microbiol. 48, 1096 (1984) Abstract; Full Text
Comparative binding and sequence interaction specificities of aflatoxin B1, aflatoxicol, aflatoxin M1, and aflatoxicol M1 with purified DNA: K. Marien, et al.; J. Biol. Chem. 262, 7455 (1987) Abstract; Full Text
Presence of aflatoxin M1 in commercial ultra-high-temperature-treated milk.: J.L. Blanco, et al.; Appl. Environ. Microbiol. 54, 1622 (1988) Abstract; Full Text
Distribution and stability of aflatoxin M1 during processing, ripening and storage of Telemes cheese: A. Govaris, et al.; Food Addit. Contam. 18, 437 (2001) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis • Plant Research Reagents / Related Products