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PKG Activators
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ALX-480-006 Revised 22-Oct-08
8-Bromoguanosine-3',5'-cyclic Monophosphate . sodium salt
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SYNONYMS 8-Br-cGMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-006-M010   10 mg 48.00 USD Add To Cart
ALX-480-006-M050   50 mg 145.00 USD Add To Cart
Product Specification
FORMULA: C10H10BrN5O7P . Na
MW: 423.1 . 23.0
CAS NUMBER: 51116-01-9
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
PURITY DETAIL: Low in fluorescent and colored impurities.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR, MS and UV.

Product Description
Activator of cGMP-dependent protein kinases (PKGs) 1α, 1β and type II and cGMP-gated ion channels (cGMP agonist). Has increased metabolic stability and membrane permeability compared to cGMP (Prod. No. ALX-480-059).
Product Specific Literature References
Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP: R.M. Rapoport, et al.; PNAS 79, 6470 (1982) Abstract
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton, et al.; Eur. J. Neurosci. 6, 1528 (1994) Abstract
Nitric oxide in skeletal muscle: L. Kobzik, et al.; Nature 372, 546 (1994) Abstract
Nitric oxide. More jobs for that molecule: S. Snyder; Nature 372, 504 (1994) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
ALX-480-027 Revised 25-Jun-08
8-Bromoguanosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt (high purity)
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SYNONYMS Sp-8-Br-cGMPS . Na
8-Br-cGMPS . Na, Sp-isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-027-M001   1 mg 80.00 USD Add To Cart
ALX-480-027-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C10H10BrN5O6PS . Na
MW: 439.2 . 23.0
CAS NUMBER: 153660-03-8
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS, 1H-NMR and UV.

Product Description
Unspecific activator of both cGMP-dependent protein kinase (PKG) 1α and cAMP-dependent protein kinase (PKA). Resistant to cyclic nucleotide phosphodiesterases. Much more lipophilic and membrane permeant as compared to cyclic GMP (Prod. No. ALX-480-059) or Sp-cGMPS (Prod. No. ALX-480-073).
Product Specific Literature References
Evidence for two intracellular calcium pools in Dictyostelium: the cAMP- induced calcium influx is directed into a NBD-Cl- and 2,5-di-(tert- butyl)1,4-hydroquinone-sensitive pool: H. Flaadt, et al.; J. Cell Sci. 105, 1131 (1993) Abstract
Further Categories Containing This Product:
PKG Activators • PKA Activators
 
 
ALX-480-030 Revised 07-Jun-06
8-(4-Chlorophenylthio)adenosine 3',5'-cyclic Monophosphate . sodium salt
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SYNONYMS 8-pCPT-cAMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
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ALX-480-030-M010   10 mg 25.00 USD Add To Cart
ALX-480-030-M025   25 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C16H14ClN5O6PS . Na
MW: 470.8 . 23.0
CAS NUMBER: 93882-12-3
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.

Product Description
Lipophilic, membrane permeable activator of both cAMP- and cGMP-dependent protein kinases (PKA, PKG). More potent than cAMP and more resistant to phosphodiesterases, with good selectivity for site B of PKA. For specific activation of the cAMP pathway the highly membrane permeable Sp-5,6-DCl-cBIMPS (Prod. No. ALX-480-047) is a recommended.
Product Specific Literature References
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor: R.E. Rydel & L.A. Greene; PNAS 85, 1257 (1988) Abstract
Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs: D. Ogreid, et al.; Eur. J. Biochem. 181, 19 (1989) Abstract
8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA): B.J. Connolly, et al.; Biochem. Pharmacol. 44, 2303 (1992) Abstract
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger, et al.; PNAS 89, 1031 (1992) Abstract
The role of protein kinase A anchoring via the RII alpha regulatory subunit in the murine immune system: R.V. Schillace, et al.; J. Immunol. 174, 6847 (2005) Abstract; Full Text
Further Categories Containing This Product:
PKG Activators • PKA Activators
 
 
ALX-480-088 Revised 31-Oct-06
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . sodium salt
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SYNONYMS 8-pCPT-cGMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-088-M001   1 mg 50.00 USD Add To Cart
ALX-480-088-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C16H14ClN5O7PS . Na
MW: 486.8 . 23.0
CAS NUMBER: 51239-26-0
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Selective activator of cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
Product Specific Literature References
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger, et al.; PNAS 89, 1031 (1992) Abstract
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
ALX-480-031 Revised 08-Oct-08
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . triethylammonium salt
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SYNONYMS 8-pCPT-cGMP . TEA
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-031-M001   1 mg 42.00 USD Add To Cart
ALX-480-031-M005   5 mg 168.00 USD Add To Cart
Product Specification
FORMULA: C16H14ClN5O7PS . C6H15N
MW: 486.8 . 101.2
CAS NUMBER: 54364-02-2
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS, UV and 1H-NMR.

Product Description
Selective activator of cGMP-dependent protein kinase Iα, Iβ and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
Product Specific Literature References
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para- chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992) Abstract
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger, et al.; PNAS 89, 1031 (1992) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
ALX-480-070 Revised 05-Dec-04
8-(4-Chlorophenylthio)guanosine-3',5'-cyclic-Monophosphothioate, Sp-Isomer . sodium salt
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SYNONYMS Sp-8-pCPT-cGMPS . Na
8-pCPT-cGMPS . Na, Sp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-070-MC05   0.5 mg 80.00 USD Add To Cart
ALX-480-070-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C16H14N5ClO6S2P . Na
MW: 502.9 . 23.0
CAS NUMBER: 160385-87-5
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent activator of both cGMP-dependent protein kinase 1α, 1β and type II and cAMP-dependent protein kinase II. Excellent cell membrane permeability and phosphodiesterase stability.
Product Specific Literature References
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor: E. Butt, et al.; Eur. J. Pharmacol. 269, 265 (1994) Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms: D.M. Gamm, et al.; J. Biol. Chem. 270, 27380 (1995) Abstract; Full Text
Further Categories Containing This Product:
PKA Activators • PKG Activators
 
 
ALX-480-046 Revised 17-Sep-08
N2,2'-O-Dibutyrylguanosine 3',5'-cyclic Monophosphate . sodium salt
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SYNONYMS Dibutyryl-cGMP . Na
DBcGMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-046-M005   5 mg 40.00 USD Add To Cart
ALX-480-046-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C18H23N5O9P . Na
MW: 484.4 . 23.0
CAS NUMBER: 51116-00-8
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, 100% ethanol, DMSO, dimethyl formamide or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR, MS and UV.

Product Description
Activates cGMP-dependent protein kinase (PKG). Cell permeable. For a better and more selective agonist, use 8-pCPT-cGMP (Prod. No. ALX-480-031 or Prod. No. ALX-480-088).
Product Specific Literature References
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer & J.P. Miller; Life Sci. 14, 1019 (1974) Abstract
Relaxation of hormonally stimulated smooth muscular tissues by the 8- bromo derivative of cyclic GMP: K.D. Schultz, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 306, 1 (1979) Abstract
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.G. Francis, et al.; Mol. Pharmacol. 34, 506 (1988) Abstract
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane, et al.; BBRC 165, 708 (1989) Abstract
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
ALX-480-073 Revised 06-Dec-04
Guanosine-3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
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SYNONYMS Sp-cGMPS . Na
cGMPS . Na, Sp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-073-MC05   0.5 mg 95.00 USD Add To Cart
ALX-480-073-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5O6SP . Na
MW: 360.3 . 23.0
CAS NUMBER: 86562-10-9 (free acid)
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Metabolically resistant activator of cGMP-dependent protein kinases (PKGs). Low membrane permeability.
Product Specific Literature References
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990) Abstract
Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase: S.L. Archer, et al.; PNAS 91, 7583 (1994) Abstract
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
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