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Natural Products with Antibiotic Activity
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ALX-350-110 Revised 08-Apr-08
Nidulal
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-110-MC05   0.5 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C15H16O5
MW: 276.3
SOURCE/HOST: Isolated from Nidula candida.
PURITY: ≥95%
APPEARANCE: Lyophilized
SOLUBILITY: Soluble in 100% ethanol, methanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Keep cool and dry. Protect from light.
HAZARD: TOXIC.

Product Description
Induces differentiation of human promyelocytic leukemia cells. In COS-7 cells selectively activates AP-1 dependent signal transduction in a manner similar to TPA/PMA (Prod. No. ALX-445-004).
Product Specific Literature References
Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida: G. Erkel, et al.; J. Antibiot. 49, 1189 (1996) Abstract
Further Categories Containing This Product:
Natural Products with Antibiotic Activity • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-270-109 Revised 14-Apr-08
Ophiobolin A
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SYNONYMS Cochliobolin A
Ophiobalin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-109-MC01   0.1 mg 50.00 USD Add To Cart
ALX-270-109-M001   1 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C25H36O4
MW: 400.6
CAS NUMBER: 4611-05-6
RTECS: RL1576000
SOURCE/HOST: Isolated from Bipolaris leersia MST-FP107.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Cell permeable antagonist of calmodulin. Inhibits Ca2+/calmodulin-dependent phosphodiesterase. Inhibits P-glycoprotein-mediated transport. Exhibits antibacterial, antitumor and nematocidal activities. Phytotoxic.
Product Specific Literature References
The structure of ophiobolin, a C25 terpenoid having a novel skeleton: S. Nozoe, et al.; JACS 87, 4968 (1965) Abstract
The constitution of cochliobolin: L. Canonica, et al.; THL 7, 1211 (1966)
Ophiobolin A. A natural product inhibitor of calmodulin: P.C. Leung, et al.; J. Biol. Chem. 259, 2742 (1984) Abstract; Full Text
Role of Calmodulin Inhibition in the Mode of Action of Ophiobolin A: P.C. Leung, et al.; Plant Physiol. 77, 303 (1985) Abstract; Full Text
Characterization of the interaction of ophiobolin A and calmodulin: P.C. Leung, et al.; Int. J. Biochem. 20, 1351 (1988) Abstract
Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins: E. Li, et al.; J. Nat. Prod. 58, 74 (1995) Abstract
The biology of ophiobolins: T.K. Au, et al.; Life Sci. 67, 733 (2000), Review Abstract
Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis: S. Quetglas, et al.; EMBO J. 21, 3970 (2002) Abstract; Full Text
Herbicidal potential of ophiobolins produced by Drechslera gigantea: A. Evidente, et al.; J. Agric. Food Chem. 54, 1779 (2006) Abstract
Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products: N. Yoshida, et al.; Food Chem. Toxicol. 44, 2033 (2006) Abstract
Further Categories Containing This Product:
Calmodulin Inhibitors • Phosphodiesterases / Related Products • Natural Products with Antibiotic Activity • MDR Inhibitors • P-glycoprotein [Pgp] / Related Products • Other Toxins • Natural Products - Antitumor Reagents
 
 
ALX-350-338 Revised 16-Jun-08
Ophiobolin B
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SYNONYMS Cochliobolin B
Zizanin B
Ophiobolsin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-338-M001   1 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C25H38O4
MW: 402.6
CAS NUMBER: 5601-74-1
SOURCE/HOST: Isolated from Bipolaris leersia MST-FP107.
APPEARANCE: White to off-white solid.
FORMULATION: ≥95% (HPLC)
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Originally isolated from Helminthosporium sp. Inhibitor of calmodulin action in calcium regulation. Exhibits antibacterial, antitumor and nematocidal activities.
Product Specific Literature References
The structure of ophiobolin, a C25 terpenoid having a novel skeleton: S. Nozoe, et al.; JACS 87, 4968 (1965) Abstract
Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins: E. Li, et al.; J. Nat. Prod. 58, 74 (1995) Abstract
The biology of ophiobolins: T.K. Au, et al.; Life Sci. 67, 733 (2000), (Review) Abstract
Further Categories Containing This Product:
Calmodulin Inhibitors • Natural Products - Antitumor Reagents • Natural Products - Antitumor Reagents • Natural Products with Antibiotic Activity
 
 
ALX-350-109 Revised 29-Nov-07
Panepoxydone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-109-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C11H14O4
MW: 210.2
SOURCE/HOST: Isolated from Lentinus crinitus.
PURITY: >95% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light. Keep cool and dry.
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.
Product Specific Literature References
Inhibition of NF-kappa B activation by panepoxydone: G. Erkel, et al.; BBRC 226, 214 (1996) Abstract
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways: H. Kleinert, et al.; Br. J. Pharmacol. 125, 193 (1998) Abstract
Naturally occurring and synthetic inhibitors of NF-kappaB functions: K. Umezawa, et al.; Anticancer Drug Des. 15, 239 (2000) Abstract
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett. 12, 3463 (2002) Abstract
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells 14, 163 (2002) Abstract
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol. 7, 612 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents • Natural Products with Antibiotic Activity • NF-kB Pathway Inhibitors
 
 
ALX-350-364 Revised 08-Apr-08
Psoralen
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SYNONYMS Ficusin
7H-Furo[3,2-g]benzopyran-7-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-364-M025   25 mg 95.00 USD Add To Cart
ALX-350-364-M100   100 mg 285.00 USD Add To Cart
Product Specification
FORMULA: C11H6O3
MW: 186.2
CAS NUMBER: 66-97-7
MERCK INDEX: 14: 7928
RTECS: LV0944000
SOURCE/HOST: Isolated from Psoralea corylifolia.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in ethyl acetate or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.

Product Description
Shows antiviral, antibacterial, antifungal and insecticidal properties. Binds DNA through single and double-stranded cross-linking after photoactivation. Used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.
Product Specific Literature References
Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig: A. Kornhauser, et al.; Science 217, 733 (1982) Abstract
Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry: G.D. Cimino, et al.; Annu. Rev. Biochem. 54, 1151 (1985), (Review) Abstract
Electron microscopic identification of supercoiled regions in complex DNA structures: R.B. Inman & M. Schnos; J. Mol. Biol. 193, 377 (1987) Abstract
Probing DNA structure with psoralen in vitro: D.W. Ussery, et al.; Meth. Enzymol. 212, 242 (1992) Abstract
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria: C. Cullinane & V.A. Bohr; Cancer Res. 58, 1400 (1998) Abstract; Full Text
Psoralen photocrosslinking, a tool to study the chromatin structure of RNA polymerase I--transcribed ribosomal genes: M. Toussaint, et al.; Biochem. Cell Biol. 83, 449 (2005) Abstract
Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells: S. Couve-Privat, et al.; Nucl. Acids Res. 35, 5672 (2007) Abstract; Full Text
Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids: K.H. Kim, et al.; Nucl. Acids Res. 35, 7604 (2007) Abstract; Full Text
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents • Natural Products - Antifungal Agents • DNA Intercalators & Crosslinkers • Pesticides / Related Products
 
 
ALX-350-323 Revised 20-Jun-08
Psoralidin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-323-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H16O5
MW: 336.3
CAS NUMBER: 18642-23-4
SOURCE/HOST: Isolated from Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antineoplastic compound. Cytotoxic against stomach cancer cell lines. Shows antibacterial activity against Shigella sonnei and S. flexneri. Shows strong antioxidant activity and inhibits tyrosine phosphatase 1B (PTP1B) activity. Was shown to possess potent antidepressant properties.
Product Specific Literature References
Influence of nitrogen on accumulation of isosojagol (a newly detected coumestan in soybean) and associated isoflavonoids in roots and nodules of mycorrhizal and non-mycorrhizal soybean: D. Morandi and J.L. Le Quere; New Phytol. 117, 75 (1991) Full Text
The cytotoxicity of psoralidin from Psoralea corylifolia: Y.M. Yang, et al.; Planta Med. 62, 353 (1996) Abstract
Coumarins: A. Estevez-Braun and A.G. Gonzalez; Nat. Prod. Rep. 14, 465 (1997) Abstract
Cytotoxic constituents of Psoralea corylifolia: W. Mar, et al.; Arch. Pharm. Res. 24, 211 (2001) Abstract
Antibacterial compounds from the seeds of Psoralea corylifolia: N.A. Khatune, et al.; Fitoterapia 75, 228 (2004) Abstract
Inducible flavone in oats (Avena sativa) is a novel defense against plant-parasitic nematodes: I. R. Soriano, et al.; Nematology 94, 1207 (2004) Full Text
Antioxidants from a Chinese medicinal herb - Psoralea corylifolia L.: G. Jiangning, et al.; Food Chem. 91, 287 (2005)
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice: L.T. Yi, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 510 (2008) Abstract
Further Categories Containing This Product:
Monoamine Neurotransmitters & Receptors Other Products • Antitumor Agents (Anti-proliferative) • Natural Products with Antibiotic Activity • Natural Products - Antioxidants • Natural Products - Other Signal Transduction Pathway Modulators • Protein Tyrosine Phosphatases Other Products
 
 
ALX-350-249 Revised 07-Oct-08
Puerarin
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SYNONYMS 8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one
NPI-031G
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-249-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C21H20O9
MW: 416.4
CAS NUMBER: 3681-99-0
RTECS: UO5216000
SOURCE/HOST: Isolated from Kudzu root.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Biologically active isoflavone. Affects serotonin levels and platelet aggregation in blood cells. 5-HT2c antagonist. Antibacterial. Displays cardioprotective effects. Induces apoptosis.
Product Specific Literature References
Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria: W.M. Keung & B.L. Vallee; PNAS 95, 2198 (1998) Abstract
Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity: D.H. Kim, et al.; Biol. Pharm. Bull. 21, 628 (1998) Abstract
NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists: D.H. Overstreet, et al.; Pharmacol. Biochem. Behav. 75, 619 (2003) Abstract
Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells: C.P. Mao & Z.L. Gu; Acta Pharmacol. Sin. 26, 982 (2005) Abstract
Contrasting effects of puerarin and daidzin on glucose homeostasis in mice: E. Meezan, et al.; J. Agric. Food Chem. 53, 8760 (2005) Abstract
Induction of apoptosis by puerarin in colon cancer HT-29 cells: Z. Yu & W. L; Cancer Lett. 238, 53 (2006) Abstract
Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin: 574, 179 (2007)
: Q. Gao, et al.; Eur. J. Pharmacol. 574, 179 (2007) Abstract
Further Categories Containing This Product:
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products with Antibiotic Activity • Natural Products for Neurological Research • Serotonergics & Serotonin Receptors / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Isoflavones
 
 
ALX-350-264 Revised 17-Dec-07
Sceptrin . dihydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-264-M001   1 mg 98.00 USD Add To Cart
Product Specification
FORMULA: C22H24Br2N10O2 . 2HCl
MW: 620.3 . 73.0
CAS NUMBER: 79703-25-6
SOURCE/HOST: Isolated from the sponge Agelas nakamurai.
PURITY: ≥97% (HPLC)
APPEARANCE: Amorphous powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibits the growth of several Gram-positive and Gram-negative bacteria. Competitively inhibits muscarinic acetylcholine receptors.
Product Specific Literature References
Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges: R. Rosa, et al.; Experientia 48, 885 (1992) Abstract
A study on the mechanism of action of sceptrin, an antimicrobial agent isolated from the South Pacific sponge Agelas mauritiana: V.S. Bernan, et al.; J. Antimicrob. Chemother. 32, 539 (1993) Abstract
New bromopyrrole alkaloids from the Indopacific sponge Agelas nakamurai: C. Eder, et al.; J. Nat. Prod. 62, 1295 (1999) Abstract
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica: R. Mohammed, et al.; J. Nat. Prod. 69, 1739 (2006) Abstract
Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton: D.P. O’Malley, et al.; J. Am. Chem. Soc. 129, 4762 (2007) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products • Natural Products for Neurological Research • Alkaloids • Marine Natural Products
 
 
ALX-350-231 Revised 30-Jun-08
L-Sulforaphene
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SYNONYMS S-Sulforaphene
(-)-4-Isothiocyanato-(1S)-(methylsulfinyl)-1-butene
Raphanin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-231-M010   10 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C6H9NOS2
MW: 175.3
CAS NUMBER: 592-95-0
SOURCE/HOST: Chiral natural product isolated from radish seeds (Raphanus sativus L.) and broccoli.
PURITY: ≥97% (GC)
APPEARANCE: Slightly yellowish liquid.
SOLUBILITY: Soluble in methanol or DMSO; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS and NMR.

Product Description
Shows antitumor activity.
Product Specific Literature References
Phytochemicals as modulators of cancer risk: H.L. Bradlow, et al.; Adv. Exp. Med. Biol. 472, 207 (1999), Review Abstract
Glucosinolates of seven medicinal plants from Thailand: T. Songsak & G.B. Lockwood; Fitoterapia 73, 209 (2002) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Natural Products with Antibiotic Activity • Active Substances from Fruit and Vegetables
 
 
ALX-350-077 Revised 30-Jun-08
Swainsonine
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SYNONYMS 8α,β-Octahydroindolizidine-1α,2α,8β-triol
PRODUCT LINE