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Caveolae / Related Products
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ALX-153-064 Revised 31-Aug-07
Caveolin-1 Scaffolding Domain Peptide
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SYNONYMS Cavtratin
AP-Cav
Pen-C1-SD
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-064-M001   1 mg 140.00 USD Add To Cart
ALX-153-064-M005   5 mg 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
FORMULA: C228H335N61O49S
MW: 4746.6
APPEARANCE: ≥97% (HPLC)
SOLUBILITY: Soluble in DMSO or acentonitrile:water (50:50).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Hygroscopic. Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.
Product Description
Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release in vitro and reduces inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.
Product Specific Literature References
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane: T. Okamoto, et al.; J. Biol. Chem. 273, 4519 (1998) Abstract; Full Text
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation: M. Bucci, et al.; Nat. Med. 6, 1362 (2000) Abstract; Full Text
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice: J.P. Gratton, et al.; Cancer Cell 4, 31 (2003) Abstract; Full Text
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion: T.M. Williams, et al.; J. Biol. Chem. 279, 51630 (2004) Abstract; Full Text
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides: P.N. Bernatchez, et al.; PNAS 102, 761 (2005) Abstract; Full Text
Further Categories Containing This Product:
Peptides • NOS Inhibitors (NOS Induction & Enzyme Activity) • NOS Regulation • Cancer Other Products
 
 
ALX-210-347 Revised 28-Jul-08
Polyclonal Antibody to Caveolin-1
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-347-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Dog
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-17 (M1SGGKYVDSEGHLYTVP17C) of human caveolin-1. This sequence is completely conserved in mouse, rat, dog and bovine caveolin-1.
SPECIFICITY: Recognizes mouse, rat, dog and hamster caveolin-1. Detects a band of ~22kDa by Western blot.
APPLICATION: Immunoprecipitation
Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-054.
Further Categories Containing This Product:
NOS Regulation • Polyclonal Antibodies
 
 
ALX-210-240 Revised 16-Mar-07
Polyclonal Antibody to Caveolin-2
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-240-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-19 (M1GLETEKADVQLF
MADDAY19C) of rat caveolin-2.
SPECIFICITY: Recognizes mouse and rat caveolin-2. Detects a band of ~21kDa by Western blot. Does not cross-react with caveolin-1 or -3.
APPLICATION: Immunoprecipitation
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-029.
Product Images
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Further Categories Containing This Product:
NOS Regulation • Polyclonal Antibodies
 
 
ALX-210-888 Revised 25-May-07
Polyclonal Antibody to Caveolin-2 (mouse) (phosphorylated) (pTyr19)
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-888-C100   100 µg 385.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 14-25 (M14ADDApYSHHSGC25) of mouse caveolin-2 phosphorylated at Tyr19.
SPECIFICITY: Recognizes mouse phosphorylated caveolin-2. Detects a band of ~21kDa by Western blot.
APPLICATION: Immunocytochemistry (5µg/ml)
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-060.
Related Products
Further Categories Containing This Product:
Phospho-specific Antibodies • NOS Regulation • Polyclonal Antibodies
 
 
ALX-210-241 Revised 24-Apr-08
Polyclonal Antibody to Caveolin-3
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-241-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope affinity-purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-18 (M1MTEEHTDLEARIIKDIH18C) of rat caveolin-3.
SPECIFICITY: Recognizes mouse and rat caveolin-3. Detects a band of ~21kDa by Western blot. Does not cross-react with caveolin-1 or -2.
APPLICATION: Immunocytochemistry
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-030.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
NOS Regulation • Polyclonal Antibodies
 
 
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