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Items 13 of 13
ALX-290-001
Revised 29-Nov-04
N-Acetyl-S-farnesyl-L-cysteine
SYNONYMS
AFC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-290-001-M005
5 mg
50.00 USD
ALX-290-001-M025
25 mg
150.00 USD
Product Specification
FORMULA:
C
20
H
33
NO
3
S
MW:
367.6
CAS NUMBER:
135304-07-3
PURITY:
≥97%
APPEARANCE:
Clear oil.
SOLUBILITY:
Soluble in DMSO, methanol or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific inhibitor of S-farnesylcysteine methyl transferase.
Related Products
ALX-290-007
N-Acetyl-S-geranyl-L-cysteine
ALX-290-010
Revised 20-Apr-07
N-Acetyl-S-farnesyl-L-cysteine-methyl ester
SYNONYMS
AFCME
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-290-010-M010
10 mg
40.00 USD
Product Specification
FORMULA:
C
21
H
35
NO
3
S
MW:
381.6
CAS NUMBER:
135304-08-4
PURITY:
≥95%
APPEARANCE:
White to slightly yellow powder.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Substrate for studying the reversibility of carboxyl methylation in signal-transducing G-proteins.
Product Specific Literature References
Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments:
D. Pérez-Sala, et al.; PNAS
88
, 3043 (1991)
Abstract
Identifying the recognition unit for G protein methylation:
E.W. Tan, et al.; J. Biol. Chem.
266
, 10719 (1991)
Abstract
;
Full Text
ALX-270-064
Revised 14-Jul-03
Chaetomellic acid A . disodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
Ordering Information
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Format:
Size:
Unit Price:
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ALX-270-064-M001
1 mg
30.00 USD
ALX-270-064-M005
5 mg
70.00 USD
ALX-270-064-M010
10 mg
130.00 USD
Product Specification
FORMULA:
C
19
H
32
O
4
. 2Na
MW:
324.5 . 46.0
PURITY:
≥
98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in warm water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent inhibitor of farnesyltransferase in isolated enzyme assays but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II.
Product Specific Literature References
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo:
J.B. Gibbs, et al.; J. Biol. Chem.
268
, 7617 (1993)
Abstract
;
Full Text
Inhibitors of Ras farnesyltransferases:
F. Tamanoi; TIBS
18
, 349 (1993), (Review)
Abstract
ALX-260-021
Revised 17-Sep-02
H-Cys-4-Abz-Met-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
Ordering Information
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ALX-260-021-M001
1 mg
40.00 USD
ALX-260-021-M005
5 mg
160.00 USD
Product Specification
FORMULA:
C
15
H
21
N
3
O
4
S
2
MW:
371.5
PURITY:
≥92%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent inhibitor of Ras farnesyltransferase.
Product Specific Literature References
Inhibitors of Ras Farnesyltransferase as Novel Antitumor Agents
:
A.D. Hamilton & S.M. Sebti; Drug News Perspect.
8
, 138 (1995)
ALX-290-002
Revised 13-Dec-04
S-Farnesylated Cysteine Tetrapeptide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
Ordering Information
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ALX-290-002-M001
1 mg
45.00 USD
ALX-290-002-M005
5 mg
150.00 USD
Product Specification
SEQUENCE:
Ac-Cys(farnesyl)-Val-Ile-Met-OH
FORMULA:
C
36
H
62
N
4
O
6
S
2
MW:
711.0
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic. Protect from light and oxygen.
Product Description
Tetrapeptide substrate for the protein endoprotease that cleaves the modified protein at the isoprenylated cysteine residue.
Product Specific Literature References
Inhibitors of the isoprenylated protein endoprotease:
Y.-T. Ma, et al.; Biochemistry
32
, 2386 (1993)
Abstract
ALX-290-003
Revised 30-Jun-08
Farnesylpyrophosphate . triammonium salt
SYNONYMS
FPP . 3NH
4
3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol pyrophosphate . 3NH
4
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
Ordering Information
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ALX-290-003-C200
200 µg
62.00 USD
Product Specification
FORMULA:
C
15
H
25
O
7
P
2
. 3NH
4
MW:
379.3 . 54.1
CAS NUMBER:
13058-04-3
PURITY:
≥98% (TLC)
APPEARANCE:
Liquid. Solution in 0.25M ammonium bicarbonate containing 70% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Store solutions at -20°C for up to 3 months.
HANDLING:
Protect from light and moisture.
Product Description
Farnesyl donor in enzymatic protein farnesylation catalyzed by farnesyltransferase.
Product Specific Literature References
Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A:
C. MacKintosh & S. Klumpp; FEBS Lett.
277
, 137 (1990)
Abstract
M. Ubukata, et al.; J. C. S. Chem. Commun. 244 (1990)
Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme:
Y. Reiss, et al.; J. Biol. Chem.
267
, 6403 (1992)
Abstract
;
Full Text
Inhibitors of Ras farnesyltransferases:
F. Tamanoi; TIBS
18
, 349 (1993), (Review)
Abstract
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic:
J.B. Gibbs, et al.; Cell
77
, 175 (1994)
Abstract
ALX-290-004
Revised 25-Oct-06
Farnesylthioacetic acid
SYNONYMS
FTA
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
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ALX-290-004-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
17
H
28
O
2
S
MW:
296.5
CAS NUMBER:
135784-48-4
PURITY:
≥98%
APPEARANCE:
Yellow viscous oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions are stable for up to 6 months when stored at -20°C. Product is not sterile.
HANDLING:
Protect from light.
Product Description
Potent and specific inhibitor of methyl esterification of farnesylated proteins (e.g. the γ subunit of transducin). This compound is not a methyltransferase substrate.
Product Specific Literature References
Identifying the recognition unit for G protein methylation:
E.W. Tan, et al.; J. Biol. Chem.
266
, 10719 (1991)
Abstract
;
Full Text
ALX-290-005
Revised 10-Aug-05
Farnesyltransferase Inhibitor
SYNONYMS
B581
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
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ALX-290-005-M001
1 mg
85.00 USD
ALX-290-005-M005
5 mg
320.00 USD
Product Specification
SEQUENCE:
N-[(2S)-((2R)-Amino-3-mercaptopropylamino)-3-methylbutyl]-Phe-Met-OH
FORMULA:
C
22
H
38
N
4
O
3
S
2
MW:
470.7
PURITY:
≥96%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Stable, membrane permeable inhibitor of farnesyltransferase. Has 30-fold higher selectivity for farnesyltransferase over geranylgeranyltransferase. Potential anticancer drug.
Product Specific Literature References
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells:
A.M. Garcia, et al.; J. Biol. Chem.
268
, 18415 (1993)
Abstract
;
Full Text
ALX-290-009
Revised 02-Apr-04
α-Hydroxyfarnesylphosphonic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
Ordering Information
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ALX-290-009-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
15
H
27
O
4
P
MW:
302.4
PURITY:
≥96%
FORMULATION:
Liquid. 1mg dissolved in 500µl ethanol.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Product decomposes rapidly when not in solution. Do not evaporate to dryness.
Product Description
Potent inhibitor of farnesyltransferase in cell-free enzyme preparations (IC
50
=30nM) and in whole cells. Selectively inhibits farnesyltransferase over geranylgeranyltransferases I and II (IC
50
=35.8µM and IC
50
=67.0µM).
Product Specific Literature References
Steady-state kinetic mechanism of Ras farnesyl:protein transferase:
D.L. Pompliano, et al.; Biochemistry
31
, 3800 (1992)
Abstract
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo:
J.B. Gibbs, et al.; J. Biol. Chem.
268
, 7617 (1993)
Abstract
;
Full Text
Inhibitors of Ras farnesyltransferases:
F. Tamanoi; TIBS
18
, 349 (1993), (Review)
Abstract
ALX-350-241
Revised 07-Dec-07
Manumycin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-241-M001
1 mg
58.00 USD
ALX-350-241-M005
5 mg
170.00 USD
ALX-350-241-M010
10 mg
260.00 USD
Product Specification
FORMULA:
C
31
H
38
N
2
O
7
MW:
550.7
CAS NUMBER:
52665-74-4
SOURCE/HOST:
Isolated from
Streptomyces parvulus
.
PURITY:
≥96% (HPLC)
APPEARANCE:
Yellow to brown powder.
SOLUBILITY:
Soluble in methanol or DMSO; insoluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR.
Product Description
Potent, selective and competitive inhibitor of Ras farnesyltransferase. Does not affect geranylgeranyltransferase. Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Inhibits neutral sphingomyelinase.
Product Specific Literature References
Inhibitors of Ras farnesyltransferases:
F. Tamanoi; TIBS
18
, 349 (1993), (Review)
Abstract
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic:
J.B. Gibbs, et al.; Cell
77
, 175 (1994)
Abstract
Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells:
A. Di Paolo, et al.; Br. J. Cancer
82
, 905 (2000)
Abstract
Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase:
C. Arenz, et al.; ChemBioChem
2
, 141 (2001)
Abstract
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells:
M. She, et al.; Leukemia
19
, 595 (2005)
Abstract
Binding of manumycin A inhibits IkappaB kinase beta activity:
M. Bernier, et al.; J. Biol. Chem.
281
, 2551 (2006)
Abstract
Further Categories Containing This Product:
Farnesylation / Isoprenylation Reagents
•
Ceramides / Cerebrosides / Sphingolipids / Related Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
ALX-270-111
Revised 31-Jul-08
Patulin
SYNONYMS
4-Hydroxy-4
H
-furo[3,2-
c
]pyran-2(6
H
)-one
Clairformin
Clavacin
Clavatin
Claviformin
Leucopin
Mycoin C3
Mycosin
Penicidin
Terinin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-270-111-M001
1 mg
20.00 USD
ALX-270-111-M005
5 mg
80.00 USD
ALX-270-111-M025
25 mg
320.00 USD
Product Specification
FORMULA:
C
7
H
6
O
4
MW:
154.1
CAS NUMBER:
149-29-1
MERCK INDEX:
14:
7053
RTECS:
LV2625000
SOURCE/HOST:
Isolated from
Penicillium expansum
.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water, 100% ethanol, ethyl acetate or DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
MAY BE CARCINOGENIC. TOXIC.
Product Description
Inhibitor of protein farnesylation in a cell free assay. Inhibits incorporation of tritiated mevalonate into proteins in whole cells. Mycotoxin with anti-bacterial, potassium uptake inhibitory and possibly carcinogenic activities. Known contaminant of spoiled apples.
Product Specific Literature References
M. Birkinshaw, et al.; Lancet
245
, 625 (1943)
J. Kahn; J. Pharmacol. Exp. Ther.
121
, 234 (1957)
IARC Monographs
10
, 205 (1976)
Chronology of patulin-induced alterations in membrane function of cultured renal cells, LLC-PK:
R.T. Riley, et al.; Toxicol. Appl. Pharmacol.
102
, 128 (1990)
Abstract
Inhibition of protein prenylation by patulin:
S. Miura, et al.; FEBS Lett.
318
, 88 (1993)
Abstract
Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin:
E. Pfeiffer, et al.; Carcinogenesis
19
, 1313 (1998)
Abstract
Hplc detection of patulin in apple juice with GC/MS confirmation of patulin identity:
J.A. Roach, et al.; Adv. Exp. Med. Biol.
504
, 135 (2002), Review
Abstract
Further Categories Containing This Product:
