• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Signal Transduction
You are here: Product Lines > Signal Transduction
Toolbar - View Selection
 
 Items 600-700 of 2948 Page 7 of 30 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-480-014 Revised 25-Oct-06
Adenosine 5'-monophosphate . disodium salt
Add to Clipboard
SYNONYMS AMP . 2Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-014-G005   5 g 68.00 USD Add To Cart
Product Specification
FORMULA: C10H12N5O7P . 2Na
MW: 345.2 . 46.0
CAS NUMBER: 4578-31-8
MERCK INDEX: 14: 158
RTECS: AU7481600
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water and aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture.

 
 
ALX-480-026 Revised 03-Aug-06
8-Bromoguanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt (high purity)
Add to Clipboard
SYNONYMS Rp-8-Br-cGMPS . Na
8-Br-cGMPS . Na, Rp-isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-026-MC05   0.5 mg 90.00 USD Add To Cart
ALX-480-026-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C10H10BrN5O6PS . Na
MW: 439.2 . 23.0
CAS NUMBER: 150418-07-8
PURITY: ≥99% (HPLC)
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of cGMP-dependent protein kinase (PKG) 1α and 1β. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases; no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to cyclic GMP (Prod. No. ALX-480-059) or Rp-cGMPS (Prod. No. ALX-480-072).
Product Specific Literature References
Nitric oxide regulates luteinizing hormone-releasing hormone secretion: M. Moretto, et al.; Endocrinology 133, 2399 (1993) Abstract
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation: M. Zhuo, et al.; Nature 368, 635 (1994) Abstract
Further Categories Containing This Product:
PKG Inhibitors
 
 
ALX-480-028 Revised 16-Dec-04
8-Chloroadenosine
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-028-M001   1 mg 40.00 USD Add To Cart
ALX-480-028-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C10H12ClN5O4
MW: 301.7
CAS NUMBER: 34408-14-5
PURITY: ≥98%
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Cytotoxic metabolite of 8-Cl-cAMP (Prod. No. ALX-480-029).
Product Specific Literature References
Site-selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation: Y.S. Cho-Chung, et al.; Cancer Invest. 7, 161 (1989) Abstract
 
 
ALX-480-032 Revised 03-Feb-05
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt (high purity)
Add to Clipboard
SYNONYMS Rp-8-pCPT-cGMPS . TEA
8-pCPT-cGMPS . TEA, Rp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-032-C100   100 µg 45.00 USD Add To Cart
ALX-480-032-M001   1 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C16H15ClN5O6PS2 . C6H15N
MW: 504.1 . 101.0
CAS NUMBER: 153660-04-9
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent selective inhibitor of cGMP-dependent protein kinase 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS (Prod. No. ALX-480-072) or Rp-8-Br-cGMPS (Prod. No. ALX-480-026).
Product Specific Literature References
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor: E. Butt, et al.; Eur. J. Pharmacol. 269, 265 (1994) Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms: D.M. Gamm, et al.; J. Biol. Chem. 270, 27380 (1995) Abstract; Full Text
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action: R.H. Kramer & G.R. Tibbs; J. Neurosci. 16, 1285 (1996) Abstract
Further Categories Containing This Product:
PKG Inhibitors
 
 
ALX-480-038 Revised 18-Jun-08
IBMX
Add to Clipboard
SYNONYMS 3-Isobutyl-1-methylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-038-M500   500 mg 99.00 USD Add To Cart
ALX-480-038-G001   1 g 195.00 USD Add To Cart
Product Specification
FORMULA: C10H14N4O2
MW: 222.3
CAS NUMBER: 28822-58-4
RTECS: ZD8500000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or methanol (warm, 50mg/ml); almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.
IDENTITY: Identity determined by IR.

Product Description
Potent, non-specific inhibitor of phosphodiesterases. More potent than theophylline (Prod. No. ALX-480-062) at adenosine receptors. Accelerates conversion of mouse fibroblast cells into adipose cells.
Product Specific Literature References
Effects of xanthine derivatives on lipolysis and on adenosine 3',5'- monophosphate phosphodiesterase activity: J.A. Beavo, et al.; Mol. Pharmacol. 6, 597 (1970) Abstract
Adenosine 3':5'-cyclic monophosphate and insulin release: W. Montague & J.R. Cook; Biochem. J. 120, 9P (1970) Abstract
The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release by isolated rat islets of Langerhans: W. Montague & J.R. Cook; Biochem. J. 122, 115 (1971) Abstract
Cyclic nucleotide phosphodiesterase activity in normal mouse pancreatic islets: S.J. Ashcroft, et al.; FEBS Lett. 20, 263 (1972) Abstract
The mode of action of adenosine 3’:5’-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity: W. Montague & S.L. Howell; Biochem. J. 134, 321 (1973) Abstract
Effects of methylxanthines on adenosine 3’,5’-monophosphate and corticosterone in the rat adrenal: A. Peytremann, et al.; Endocrinology 92, 525 (1973) Abstract
Concentration of adenosine 3’:5’-cyclic monophosphate in mouse pancreatic islets measured by a protein-binding radioassay: R.H. Cooper, et al.; Biochem. J. 134, 599 (1973) Abstract
Determination of theophylline in plasma by electron capture gas chromatography: H.A. Schwertner, et al.; Anal. Chem. 48, 1875 (1976) Abstract
Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation: D.F. Horrobin, et al.; Prostaglandins 13, 33 (1977) Abstract
Selective inhibition of cyclic nucleotide phosphodiesterases by analogues of 1-methyl-3-isobutylxanthine: G.L. Kramer, et al.; Biochemistry 16, 3316 (1977) Abstract
Cyclic nucleotide phosphodiesterases of human and rat gastric mucosa: U. Klotz, et al.; Naunyn-Schmiedebergs Arch. Pharmacol. 296, 187 (1977) Abstract
Allergic reactions, cyclic AMP and histamine release: P.S. Skov, et al.; Experientia 33, 965 (1977) Abstract
Differentiation of 3T3-L2 fibroblasts into adipose cells in bromodeoxyuridine-suppressed cultures: T.R. Russell; PNAS 76, 4451 (1979) Abstract
Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine: P. Janik, et al.; Cancer Res. 40, 1950 (1980) Abstract
Induction of a transient elevation in intracellular levels of adenosine-3’,5’-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation: L. Simchowitz, et al.; J. Immunol. 124, 1482 (1980) Abstract
Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction: G.S. Ahluwalia & A.R. Rhoads; Biochem. Pharmacol. 31, 665 (1982) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
Methylxanthine inhibitors of phosphodiesterases: J.N. Wells & J.R. Miller; Methods Enzymol. 159, 489 (1988) Abstract
Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline: V.L. Coffin and R.D. Spealman; Eur. J. Pharmacol. 170, 35 (1989) Abstract
Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium: Y. Katano & M. Endoh; BBRC 167, 123 (1990) Abstract
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, Jr., et al.; Biochem. Pharmacol. 42, 679 (1991) Abstract
Effect of an antihypertensive hydrazine derivative on Ca2+ current of single frog cardiac cells: F. Scamps, et al.; Eur. J. Pharmacol. 244, 119 (1993) Abstract
Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity: C. Tomes, et al.; Cell. Signal. 5, 615 (1993) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
 
 
ALX-480-021 Revised 16-Dec-04
Adenosine 5'-triphosphate . disodium salt
Add to Clipboard
SYNONYMS ATP . 2Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-021-G001   1 g 15.00 USD Add To Cart
ALX-480-021-G005   5 g 45.00 USD Add To Cart
Product Specification
FORMULA: C10H14N5O13P3. 2Na
MW: 505.2 . 46.0
CAS NUMBER: 51963-61-2
MERCK INDEX: 14: 155
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture. Keep cool and dry.

Further Categories Containing This Product:
Inflammasome
 
 
ALX-480-046 Revised 17-Sep-08
N2,2'-O-Dibutyrylguanosine 3',5'-cyclic Monophosphate . sodium salt
Add to Clipboard
SYNONYMS Dibutyryl-cGMP . Na
DBcGMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-046-M005   5 mg 40.00 USD Add To Cart
ALX-480-046-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C18H23N5O9P . Na
MW: 484.4 . 23.0
CAS NUMBER: 51116-00-8
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, 100% ethanol, DMSO, dimethyl formamide or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR, MS and UV.

Product Description
Activates cGMP-dependent protein kinase (PKG). Cell permeable. For a better and more selective agonist, use 8-pCPT-cGMP (Prod. No. ALX-480-031 or Prod. No. ALX-480-088).
Product Specific Literature References
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer & J.P. Miller; Life Sci. 14, 1019 (1974) Abstract
Relaxation of hormonally stimulated smooth muscular tissues by the 8- bromo derivative of cyclic GMP: K.D. Schultz, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 306, 1 (1979) Abstract
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.G. Francis, et al.; Mol. Pharmacol. 34, 506 (1988) Abstract
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane, et al.; BBRC 165, 708 (1989) Abstract
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
ALX-480-047 Revised 23-Jul-08
5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
Add to Clipboard
SYNONYMS Sp-5,6-DCl-cBIMPS . Na
5,6-DCI-cBIMPS . Na, Sp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Other Cyclic Nucleotides
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-047-C100   100 µg 30.00 USD Add To Cart
ALX-480-047-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C12H10Cl2N2O5PS . Na
MW: 396.2 . 23.0
CAS NUMBER: 120912-54-1
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (167 mM), dimethyl formamide (167 mM), 96 % ethanol (167 mM), methanol (25 mM), water (25 mM) and aqueous buffers such as PBS (pH 7.4; 1.4 mM), 25 mM TRIS (pH 7.4-; 25 mM), 25 mM HEPES (pH 7.2; 35.7 mM) and Na2HPO4 (pH 7.0; 2.8 mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent, specific and site selective activator of cAMP-dependent protein kinases especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian phosphodiesterases type I and III and only extremely slowly hydrolyzed by type II. Surpasses the widely used but problematic dibutyryl-cAMP (Prod. No. ALX-480-045) or 8-CPT-cAMP (Prod. No. ALX-480-030) in terms of metabolic stability, membrane permeability and potency.
Product Specific Literature References
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg, et al.; Biochem J. 279, 521 (1991) Abstract
Further Categories Containing This Product:
PKA Activators
 
 
ALX-480-048 Revised 06-Mar-07
2',3'-Dideoxyadenosine
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-048-M001   1 mg 15.00 USD Add To Cart
ALX-480-048-M005   5 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O2
MW: 235.2
CAS NUMBER: 4097-22-7
MERCK INDEX: 14: 3101
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Inhibitor of adenylate cyclase. Useful tool in antiviral and anticancer studies. Blocks viral reverse transcription from RNA to DNA. Inhibitor of adenosine deaminase.
Product Specific Literature References
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2',3'-dideoxyadenosine and 2',3'- dideoxyinosine: V. Nair & T.B. Sells; Biochim. Biophys. Acta 1119, 201 (1992) Abstract
Long-term inhibn. of human T-lymphotropic virus type III/lymphadenopathy-associated virus DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro: H. Mitsuya, et al.; PNAS 84, 2033 (1987) Abstract
Further Categories Containing This Product:
Adenylyl Cyclase InhibitorsAntiviral Agents Other Products
 
 
ALX-480-049 Revised 03-Jun-08
2',5'-Dideoxyadenosine
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-049-M001   1 mg 30.00 USD Add To Cart
ALX-480-049-M005   5 mg