• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL] / Related Products
You are here: Product Lines > Signal Transduction > Lipid Signalling Pathways > Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL] / Related Products
Toolbar - View Selection
 
Items 4 of 4
ALX-270-172 Revised 04-Dec-07
RHC-80267
Add to Clipboard
SYNONYMS U-57908
1,6-bis(Cyclohexyloximinocarbonylamino)hexane
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-172-M005   5 mg 40.00 USD Add To Cart
ALX-270-172-M010   10 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C20H34N4O4
MW: 394.5
CAS NUMBER: 83654-05-1
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective inhibitor of diacylglycerol lipase activity. Also inhibits glucose- and carbachol-induced insulin release from intact islets.
Product Specific Literature References
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267: C.A. Southerland & D. Amin; J. Biol. Chem. 257, 14006 (1982) Abstract; Full Text
RHC 80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes: S. Levasseur, et al.; Prostaglandins 27, 673 (1984) Abstract
Inhibitors of diacylglycerol lipase and diacylglycerol kinase inhibit carbamylcholine-stimulated responses in guinea pig pancreatic minilobules: M. Chandra Sekar & L.E. Hokin; Arch. Biochem. Biophys. 256, 509 (1987) Abstract
Diacylglycerol provides arachidonic acid for lipoxygenase products that mediate angiotensin II-induced aldosterone synthesis: R. Natarajan, et al.; BBRC 156, 717 (1988) Abstract
Arachidonic acid liberated by diacylglycerol lipase is essential for the release mechanism in chromaffin cells from bovine adrenal medulla: B. Rindlisbacher, et al.; J. Neurochem. 54, 1247 (1990) Abstract
Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation: J. Balsinde, et al.; J. Biol. Chem. 266, 15638 (1991) Abstract; Full Text
 
 
ALX-550-410 Revised 01-Jun-06
URB754
Add to Clipboard
SYNONYMS 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-410-M001   1 mg 15.00 USD Add To Cart
ALX-550-410-M005   5 mg 25.00 USD Add To Cart
ALX-550-410-M025   25 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C16H14N2O2
MW: 266.3
CAS NUMBER: 86672-58-4
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO and dimethyl formamide. Also soluble in aqueous solutions.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light.

Product Description

Potent, noncompetitive inhibitor of monoacylglycerol lipase (MGL), which hydrolyzes 2-arachidonoylglycerol (2-AG) to arachidonic acid and glycerol. IC50=200nM for the recombinant rat brain enzyme. Inhibits rat brain fatty acid amide hydrolase (FAAH) less effectively (IC50=32µM) and binds weakly to the rat CB1 receptor (IC50=3.8µM).
Product Specific Literature References
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci. 8, 1139 (2005) Abstract
Related Products
Further Categories Containing This Product:
Fatty Acid Amide Hydrolase [FAAH] / Related Products
 
 
ALX-550-519 Revised 03-Jul-07
URB602
Add to Clipboard
SYNONYMS [1,1’-Biphenyl]-3-yl-carbamic acid cyclohexyl ester
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-519-M005   5 mg 34.00 USD Add To Cart
ALX-550-519-M025   25 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C19H21NO2
MW: 295.4
CAS NUMBER: 565460-15-3
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (10mg/ml), DMSO (30mg/ml) or dimethyl formamide (30mg/ml); also soluble in a 1:1 solution in DMSO:PBS, pH 7.2 (0.25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Sparingly soluble in aqueous buffers. For maximum solubility dissolve first in DMSO and then dilute with the aqeous buffer of choice. We do not recommend storing the aqueous solution for more than one day.

Product Description
Selective noncompetitive inhibitor of monoacylglycerol lipase (MGL) (IC50=28µM). Does not inhibit FAAH, DAG lipase or COX-2.
Product Specific Literature References
An endocannabinoid mechanism for stress-induced analgesia: A.G. Hohmann, et al.; Nature 435, 1108 (2005) Abstract
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla: R.L. Suplita, 2nd, et al.; Neuropharmacology 49, 1201 (2005) Abstract
 
 
ALX-215-054 Revised 20-Oct-08
Polyclonal Antibody to Monoacylglycerol Lipase
Add to Clipboard
SYNONYMS anti-MGL PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-054-1   1 vial 357.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST: From rabbit
PURITY DETAIL: Affinity-purified IgG.
FORMULATION: Liquid. In TBS, pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-14 (M1PEESSPRRTPQSI14) of human monoacylglycerol lipase (MAGL).
SPECIFICITY: Recognizes human, mouse, rat and bovine MAGL. Detects a band of ~35kDa by Western blot.
APPLICATION: Immunohistochemistry (formalin-fixed paraffin sections)
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
© 2008 ALEXIS Corporation, Privacy Policy, Disclaimer, Feedbackheader picture © micronaut.ch, another CS2 website

Catalogs / Brochures

E-Newsletter

 

Shopping Cart [0]

 

Distributors

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.