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ALX-270-039
Revised 15-Nov-06
A-3 . hydrochloride
SYNONYMS
N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
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ALX-270-039-M010
10 mg
65.00 USD
ALX-270-039-M050
50 mg
260.00 USD
Product Specification
FORMULA:
C
12
H
13
ClN
2
O
2
S . HCl
MW:
284.8 . 36.5
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of cAMP- and cGMP-dependent protein kinase (PKA and PKG), protein kinase C (PKC), casein kinase I and II, and myosin light chain kinase.
Product Specific Literature References
Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors:
M. Inagaki, et al.; Mol. Pharmacol.
29
, 577 (1986)
Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors
•
PKC Inhibitors
•
PKG Inhibitors
•
Casein Kinase Inhibitors
ALX-420-030
Revised 24-Sep-08
BAY 41-2272
SYNONYMS
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1
H
-pyrazolo[3,4-b]pyridine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-420-030-M005
5 mg
92.00 USD
ALX-420-030-M025
25 mg
358.00 USD
Product Specification
FORMULA:
C
20
H
17
FN
6
MW:
360.4
CAS NUMBER:
256376-24-6
PURITY:
≥98%
APPEARANCE:
White to off-white needles.
SOLUBILITY:
Soluble in DMSO, dichloromethane, 100% ethanol or 2-pyrrolidone; practically insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
IRRITANT.
Product Description
NO-independent activator of soluble guanylyl cyclase (sGC) [1,2]. Activates both isoforms α
1
β
1
and α
1
β
2
of sGC [3]. While the related compound YC-1 (Prod. No.
ALX-420-025
) also acts as a non-specific phosphodiesterase inhibitor, BAY 41-2272 has no effect on phosphodiesterases. Stimulation of sGC is not blocked by high concentrations of NO scavengers (e.g. PTIO, Prod. No.
ALX-430-007
) and the combination of BAY 41-2272 with the NO donor DEA NONOate (Prod. No.
ALX-430-034
) potentiates the activation of sGC. Although BAY 41-2272 alone is not as strong a stimulator of sGC as NO, concentrations as low as 10-100nM stimulate sGC to a level that would be expected to cause biologically important increases in cGMP [1]. ODQ (Prod. No.
ALX-270-034
), a potent and selective inhibitor of sGC, completely inhibited the effect of BAY 41-2272 [1]. The activity of BAY 41-2272 is described in selected literature references [4-6].
Product Specific Literature References
[1]
NO-independent regulatory site on soluble guanylate cyclase
:
J.P. Stasch, et al.; Nature
410
, 212 (2001)
Abstract
[2]
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272
:
E.M. Becker, et al.; BMC Pharmacol.
1
, 13 (2001)
Abstract
;
Full Text
NO-independent stimulators of soluble guanylate cyclase:
A. Straub, et al.; Bioorg. Med. Chem. Lett.
11
, 781 (2001)
Abstract
[3]
BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase
:
M. Koglin, et al.; BBRC
292
, 1057 (2002)
Abstract
[4]
Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure:
G. Boerrigter, et al.; Circulation
107
, 686 (2003)
Abstract
[5]
BAY 41-2272: a stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo
:
E. Bischoff, et al.; Urology
61
, 464 (2003)
Abstract
[6]
Macrophage endothelial nitric oxide synthase auto-regulates cellular activation and pro-inflammatory protein expression
:
L. Connelly, et al.; J. Biol. Chem
278
, 26480 (2003)
Abstract
;
Full Text
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment:
A. Ahluwalia, et al.; PNAS
101
, 1386 (2004)
Abstract
;
Full Text
Identification of residues crucially involved in soluble guanylate cyclase activation:
C. Rothkegel, et al.; FEBS Lett.
580
, 4205 (2006)
Abstract
ALX-270-421
Revised 14-Feb-07
BAY 60-7550
SYNONYMS
2-(3,4-Dimethoxybenzyl)-7-[(1R)-1-[(1R)-1-hydroxyethyl]-4-phenylbutyl]-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphodiesterases / Related Products
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Product Numbers:
Format:
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ALX-270-421-M005
5 mg
98.00 USD
ALX-270-421-M025
25 mg
395.00 USD
Product Specification
FORMULA:
C
27
H
32
N
4
O
4
MW:
476.6
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in acetone, DMSO or 100% ethanol. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Inhibitor of human phosphodiesterase 2 (PDE2) (IC
50
=5nM). Selective (>50-fold) versus other human PDEs tested (1C,3A, 4B, 5A, 6, 7B, 8A, 9A, 10A, 11A) and does not affect adenosine deaminase. Raises cGMP levels in cell culture, particularly in combination with a suitable activator of soluble guanylyl cyclase (sGC). Raises cAMP in combination with forskolin (Prod. No.
ALX-350-001
). Increases memory performance in rodents
in vivo
.
Product Specific Literature References
Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance:
F.G. Boess, et al.; Neuropharmacology
47
, 1081 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Please also see our Product Flyer
"BAY 60-7550 - A Novel Potent & Selective PDE2 Inhibitor"
.
General Literature References
Dynamic regulation of cAMP signaling by cGMP in the cardiovascular system: roles of phosphodiesterase 2 and phosphodiesterase 3 enzymes:
D.H. Maurice; Proc. West. Pharmacol. Soc.
46
, 32 (2003)
Abstract
Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors:
A. Castro, et al.; Med. Res. Rev.
25
, 229 (2005)
Abstract
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases:
D.T. Manallack, et al.; J. Med. Chem.
48
, 3449 (2005)
Abstract
Related Products
ALX-350-001
Forskolin
Further Categories Containing This Product:
Phosphodiesterases / Related Products
ALX-152-022
Revised 04-Jul-03
BPDEtide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKG Substrates
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ALX-152-022-M001
1 mg
60.00 USD
ALX-152-022-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH
FORMULA:
C
68
H
115
N
23
O
20
MW:
1574.8
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for cGMP-dependent protein kinase corresponding to a peptide sequence surrounding the phosphorylation site of cGMP-binding cGMP-specific phosphodiesterase.
Product Specific Literature References
Studies of two different intrachain cGMP-binding sites of cGMP- dependent protein kinase:
J.D Corbin & S.O. Døskeland; J. Biol. Chem.
258
, 11391 (1983)
Abstract
;
Full Text
A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases:
J.L. Colbran, et al.; J. Biol. Chem.
267
, 9589 (1992)
Abstract
;
Full Text
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
•
Peptides
ALX-480-006
Revised 22-Oct-08
8-Bromoguanosine-3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
8-Br-cGMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
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ALX-480-006-M010
10 mg
48.00 USD
ALX-480-006-M050
50 mg
145.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
7
P . Na
MW:
423.1 . 23.0
CAS NUMBER:
51116-01-9
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
PURITY DETAIL:
Low in fluorescent and colored impurities.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Activator of cGMP-dependent protein kinases (PKGs) 1α, 1β and type II and cGMP-gated ion channels (cGMP agonist). Has increased metabolic stability and membrane permeability compared to cGMP (Prod. No.
ALX-480-059
).
Product Specific Literature References
Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP:
R.M. Rapoport, et al.; PNAS
79
, 6470 (1982)
Abstract
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices:
C.L. Boulton, et al.; Eur. J. Neurosci.
6
, 1528 (1994)
Abstract
Nitric oxide in skeletal muscle:
L. Kobzik, et al.; Nature
372
, 546 (1994)
Abstract
Nitric oxide. More jobs for that molecule:
S. Snyder; Nature
372
, 504 (1994)
Abstract
Further Categories Containing This Product:
PKG Activators
ALX-480-026
Revised 03-Aug-06
8-Bromoguanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt (high purity)
SYNONYMS
Rp-8-Br-cGMPS . Na
8-Br-cGMPS . Na, Rp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
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ALX-480-026-MC05
0.5 mg
90.00 USD
ALX-480-026-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
PS . Na
MW:
439.2 . 23.0
CAS NUMBER:
150418-07-8
PURITY:
≥99% (HPLC)
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of cGMP-dependent protein kinase (PKG) 1α and 1β. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases; no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to cyclic GMP (Prod. No.
ALX-480-059
) or Rp-cGMPS (Prod. No.
ALX-480-072
).
Product Specific Literature References
Nitric oxide regulates luteinizing hormone-releasing hormone secretion:
M. Moretto, et al.; Endocrinology
133
, 2399 (1993)
Abstract
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation:
M. Zhuo, et al.; Nature
368
, 635 (1994)
Abstract
Further Categories Containing This Product:
PKG Inhibitors
ALX-480-027
Revised 25-Jun-08
8-Bromoguanosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt (high purity)
SYNONYMS
Sp-8-Br-cGMPS . Na
8-Br-cGMPS . Na, Sp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
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Product Numbers:
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ALX-480-027-M001
1 mg
80.00 USD
ALX-480-027-M005
5 mg
320.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
PS . Na
MW:
439.2 . 23.0
CAS NUMBER:
153660-03-8
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by MS,
1
H-NMR and UV.
Product Description
Unspecific activator of both cGMP-dependent protein kinase (PKG) 1α and cAMP-dependent protein kinase (PKA). Resistant to cyclic nucleotide phosphodiesterases. Much more lipophilic and membrane permeant as compared to cyclic GMP (Prod. No.
ALX-480-059
) or Sp-cGMPS (Prod. No.
ALX-480-073
).
Product Specific Literature References
Evidence for two intracellular calcium pools in Dictyostelium: the cAMP- induced calcium influx is directed into a NBD-Cl- and 2,5-di-(tert- butyl)1,4-hydroquinone-sensitive pool:
H. Flaadt, et al.; J. Cell Sci.
105
, 1131 (1993)
Abstract
Further Categories Containing This Product:
PKG Activators
•
PKA Activators
ALX-350-246
Revised 07-Oct-08
Butein
SYNONYMS
2',3,4,4'-Tetrahydroxychalcone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
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ALX-350-246-M010
10 mg
190.00 USD
Product Specification
FORMULA:
C
15
H
12
O
5
MW:
272.3
CAS NUMBER:
487-52-5
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (>50mg/ml) or methanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep cool and dry under inert gas.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Plant polyphenol. Specific tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor and p60
c-
src
. Potent antioxidant and anti-inflammatory agent. Inhibits glutathione reductase and rat liver glutathione S-transferase. Activator of human deacetylase SIRT1. Inhibits aromatase, showing chemopreventive properties. Directly inhibits IKK.
Product Specific Literature References
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects:
E. Aizu, et al.; Carcinogenesis
7
, 1809 (1986)
Abstract
Protective effects of hydroxychalcones on free radical-induced cell damage:
S. Sogawa, et al.; Biol. Pharm. Bull.
17
, 251 (1994)
Abstract
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation:
C.C. Yit & N.P. Das; Cancer Lett.
82
, 65 (1994)
Abstract
Inhibitory effects of plant polyphenols on rat liver glutathione S-transferase:
K. Zhang & N.P. Das; Biochem. Pharmacol.
47
, 2063 (1994)
Abstract
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor:
S.M. Yu, et al.; Eur. J. Pharmacol.
280
, 69 (1995)
Abstract
Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimantal anti-glomerular basement membrane antibody-associated glomerulonephritis (3):
K. Hayashi, et al.; Eur. J. Pharmacol.
316
, 297 (1996)
Abstract
Inhibition of glutathione reductase by plant polyphenols:
K. Zhang, et al.; Biochem. Pharmacol
54
, 1047 (1997)
Abstract
Butein, a specific protein tyrosine kinase inhibitor:
E.-B. Yang, et al.; BBRC
245
, 435 (1998)
Abstract
Antioxidant properties of butein isolated from Dalbergia odorifera:
Z.J. Cheng, et al.; Biochim. Biophys. Acta
1392
, 291 (1998)
Abstract
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells:
K. Iwashita, et al.; Biosci. Biotechnol. Biochem.
64
, 1813 (2000)
Abstract
Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells:
N.Y. Kim, et al.; Pharmacol. Toxicol.
88
, 261 (2001)
Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
:
K.T. Howitz, et al.; Nature
425
, 191 (2003)
Abstract
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase:
Y. Wang, et al.; Life Sci.
77
, 39 (2005)
Abstract
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue:
M.K. Pandey, et al.; J. Biol. Chem.
282
, 17340 (2007)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
EGFR Kinase Inhibitors
•
Glutathione / Related Products
•
Chalcones
•
Phosphodiesterases / Related Products
•
Natural Products - Chemopreventive Agents
•
Glutathione S-Transferase
•
Sirtuins / Related Products
•
Natural Products - Antioxidants
•
IkB Kinases [IKKs] / Related Products
ALX-550-322
Revised 11-Nov-08
Caffeine
SYNONYMS
1,3,7-Trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
Ordering Information
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ALX-550-322-G005
5 g
10.00 USD
Product Specification
FORMULA:
C
8
H
10
N
4
O
2
MW:
194.2
CAS NUMBER:
58-08-2
MERCK INDEX:
14:
1636
SOURCE/HOST:
Found in tea leaves, coffee beans, cocoa beans, maté leaves, guarana paste and kola nuts.
PURITY:
≥99%
APPEARANCE:
White to colorless powder.
SOLUBILITY:
Soluble in chloroform, 100% alcohol or hot water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by NIR.
Product Description
CNS stimulant. Blocks adenosine A1 and A2A receptors. cAMP phosphodiesterase inhibitor. Interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by various chemicals. Inhibits cellular DNA repair mechanisms. Anti-inflammatory.
Product Specific Literature References
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors:
J.W. Daly, et al.; J. Med. Chem.
29
, 1305 (1986)
Abstract
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action:
J. Sawynok & T.L. Yaksh; Pharmacol. Rev.
45
, 43 (1993)
Abstract
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells:
F. Traganos, et al.; Cancer Res.
53
, 4613 (1993)
Abstract
Multiple effects of caffeine on calcium current in rat ventricular myocytes:
I. Zahradnik & P. Palade; Pfluegers Arch.
424
, 129 (1993)
Abstract
Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures:
T.G. Papaioannou, et al.; Am. J. Hypertens.
18
, 129 (2005), (Review)
Abstract
Caffeine and the dopaminergic system:
O. Cauli & M. Morelli; Behav. Pharmacol.
16
, 63 (2005), (Review)
Abstract
Immunomodulatory effects of caffeine: friend or foe:
L. A. Horrigan, et al.; Pharmacol. Ther.
111
, 877 (2006), (Review)
Abstract
Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson’s disease:
A. Kalda, et al.; J. Neurol. Sci.
248
, 9 (2006), (Review)
Abstract
The enigmatic effects of caffeine in cell cycle and cancer:
A. M. & Bode and Z. Dong; Cancer Lett.
247
, 26 (2007), (Review)
Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators
•
Ca2+ Modulators
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Chemopreventive Agents
•
Neuroactive Agents Other Products
•
Alkaloids
•
Active Substances from Fruit and Vegetables
•
Natural Products - Anti-inflammatory Agents
•
DNA Repair Other Products
•
Other Natural Products - DNA Regulation / Transcription
•
Natural Products for Cell Cycle Research
•
Phosphodiesterases / Related Products
ALX-430-026
Revised 12-Sep-06
Calmidazolium chloride
SYNONYMS
1-[
bis
(p-Chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl] imidazolium chloride
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-026-M010
10 mg
85.00 USD
ALX-430-026-M050
50 mg
340.00 USD
Product Specification
FORMULA:
C
31
H
23
Cl
7
N
2
O
MW:
687.7
CAS NUMBER:
57265-65-3
PURITY:
≥98%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in methanol, 100% ethanol, chloroform, DMSO or propylene glycol; almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Calmodulin antagonist. At least 150 times more potent than trifluoperazine (Prod. No.
ALX- 550-310
) as an inhibitor of brain calmodulin-dependent phosphodiesterase. Inhibitor of voltage-gated Ca
2+
channels. Blocks Ca
2+
-calmodulin binding to NOS.
Product Specific Literature References
Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta:
V.B. Schini & P.M. Vanhoutte; J. Pharmacol. Exp. Ther.
261
, 553 (1992)
Abstract
Calmidazolium, a calmodulin inhibitor, inhibits endothelium-dependent relaxations resistant to nitro-L-arginine in the canine coronary artery:
S. Illiano, et al.; Br. J. Pharmacol.
107
, 387 (1992)
Abstract
The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells:
J. Hu & E.E. el-Fakahany; Neuroreport
4
, 198 (1993)
Abstract
Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2:
K.S. Murthy & G.M. Makhlouf; J. Biol. Chem.
269
, 15977 (1994)
Abstract
Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia:
Z. Lacza, et al.; Free Radic. Biol. Med.
31
, 1609 (2001)
Abstract
Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells:
E.N. Dedkova, et al.; Am. J. Physiol. Cell Physiol.
286
, C406 (2004)
Abstract
;
Full Text
Neural tube closure depends on nitric oxide synthase activity:
A. Nachmany, et al.; J. Neurochem.
96
, 247 (2006)
Abstract
Further Categories Containing This Product:
NOS Other Products
•
Ca2+ Channels (L-type)
•
Phosphodiesterases / Related Products
ALX-350-027
Revised 19-Aug-08
