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Caspase Inhibitors
You are here: Product Lines > Cell Death / Apoptosis / Autophagy > Caspases / Related Products > Caspase Inhibitors
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ALX-260-166 Revised 21-Oct-08
Z-VRPR-FMK
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SYNONYMS Z-Val-Arg-Pro-DL-Arg-FMK . TFA
MALT1 Inhibitor
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-166-MC05   0.5 mg 280.00 USD Add To Cart
ALX-260-166-M001   1 mg 520.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Arg-Pro-DL-Arg-fluoromethylketone
FORMULA: C31H49FN10O6 . C2HF3O2
MW: 676.8 . 114.0
PURITY: ≥90% (HPLC)
APPEARANCE: White to slightly yellow powder.
SOLUBILITY: Soluble in water (1mg/ml).
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Description
The proteolytic activity of the paracaspase MALT1 is key to NF-κB and T cell activation. Z-VRPR-FMK is a selective MALT1 inhibitor of such proteolytic activity.
Product Specific Literature References
The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008) Abstract
Further Categories Containing This Product:
T Cell Signalling Other Products • NF-kB Pathway Inhibitors
 
 
ALX-260-140 Revised 01-Sep-05
Z-WEHD-FMK (Ready-to-Use)
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SYNONYMS Caspase-1 Inhibitor (Fluoromethylketone) (Ready-to-Use)
Caspase-5 Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-140-R100 2mM 100 µl 161.00 USD Add To Cart
ALX-260-140-R020 10mM 20 µl 161.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Trp-Glu-His-Asp-fluoromethylketone
MW: 877.0
PURITY: ≥99% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Irreversible, cell permeable inhibitor of caspase-1 and -5. Inhibits also caspase-4. Designed as a methyl ester to facilitate cell permeability.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 
 
ALX-260-154 Revised 09-Aug-05
Z-YVAD-FMK (Ready-to-Use)
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SYNONYMS Caspase-1 Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-154-R100 2mM 100 µl 161.00 USD Add To Cart
ALX-260-154-R020 10mM 20 µl 161.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Tyr-Val-Ala-Asp-fluoromethylketone
MW: 630.0
PURITY: ≥99% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2-10µM for inhibiting caspase-1 activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 
 
ALX-260-074 Revised 04-Nov-05
Z-YVAD(OMe)-FMK
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SYNONYMS Caspase-1 Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-074-M001   1 mg 331.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA: C31H39FN4O9
MW: 630.7
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING: Packaged under inert gas.
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.
Product Specific Literature References
The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells: B.A. Eldadah, et al.; J. Neurosci. 17, 6105 (1997) Abstract; Full Text
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells: X.M. Zhang, et al.; Biochem. J. 340, 127 (1999) Abstract; Full Text
Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo: C. Wiessner, et al.; Cell Mol. Biol. (Noisy-Le-Grand) 46, 53 (2000) Abstract
 
 
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