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Oxovanadates
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ALX-270-204 Revised 11-Nov-08
bpV(phen)
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SYNONYMS Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-204-M005   5 mg 53.00 USD Add To Cart
ALX-270-204-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: K[VO(O2)2C12H8N2] . 3H2O
MW: 350.3 . 54.0
PURITY: ≥98% (51V-NMR)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR (D2O) and 51V-NMR (D2O)

Product Description
Potent protein phosphotyrosine phosphatase inhibitor. Also shown to be a potent insulin receptor kinase activator; excellent insulin mimetic in vitro and in vivo.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling: A.P. Bevan, et al.; J. Biol. Chem. 270, 10784 (1995) Abstract; Full Text
In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency: A.P. Bevan, et al.; Am. J. Physiol. 268, E60 (1995) Abstract
Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats: J.F. Yale, et al.; Diabetes 44, 1274 (1995) Abstract
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo: P.G. Drake, et al.; Endocrinology 137, 4960 (1996) Abstract
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ: C.J. Band & B.I. Posner; J. Biol. Chem. 272, 138 (1997) Abstract; Full Text
Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1: K.J. Serio, et al.; J. Immunol. 170, 2121 (2003) Abstract; Full Text
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products
 
 
ALX-270-205 Revised 12-Sep-08
bpV(pic)
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SYNONYMS Dipotassium bisperoxo (picolinato) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-205-M005   5 mg 75.00 USD Add To Cart
ALX-270-205-M025   25 mg 275.00 USD Add To Cart
Product Specification
FORMULA: K2 [VO(O2)2C6H4NO2] . 2 H2O
MW: 331.2 . 36.0
PURITY: ≥95% (51V-NMR)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Unstable in solution; reconstitute just prior to use.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H- and 51V-NMR.

Product Description
Potent protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
 
 
ALX-270-206 Revised 07-Dec-04
bpV(HOpic)
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SYNONYMS Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-206-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: K2[VO(O2)2C6H4NO3]
MW: 347.2
PURITY: ≥90%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
 
 
ALX-270-207 Revised 24-Jun-05
bpV(bipy)
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SYNONYMS Potassium bisperoxo (bipyridine) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-207-M005   5 mg 65.00 USD Add To Cart
ALX-270-207-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: K[VO(O2)2C10H8N2]
MW: 326.2
PURITY: ≥95%
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
 
 
ALX-400-032 Revised 14-May-08
Sodium orthovanadate
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SYNONYMS Decavandate
Sodium vanadate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-400-032-G005   5 g 15.00 USD Add To Cart
ALX-400-032-G025   25 g 60.00 USD Add To Cart
Product Specification
FORMULA: Na3VO4
MW: 183.9
CAS NUMBER: 13721-39-6
RTECS: YW1120000
PURITY: ≥90% (on dry basis)
APPEARANCE: White to light blue powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.
Product Description
Potent inhibitor of alkaline phosphatase and tyrosine phosphates. Regarding decavandate: across the pH range of 1-13, simple aqueous solutions of [VO4]3- ion involve a dozen or more ionic species, both monomeric and oligomeric, whose abundances depend strongly on pH and [VO4]3- concentration. At pH 3.75 a stable complex can be prepared (see below in Fohr et al.) which contains ten vanadium atoms and hence is a decavanadate ion. When diluted to pH 7.2, the decavandate species has a half-life time of about 2 hours. Fohr et al., also provide directions for generating control solutions of mixed vanadate complexes in which decavandate is absent and monomeric orthovanadate is present. Decavandate inhibits inositol 1,4,5-trisphosphate- (IP3) induced calcium release from permeabilized endocrine cells and the binding of [3H]IP3 to its receptor in cerebellar and adrenal cortical membranes.
Product Specific Literature References
3rd Edition of interscience (New York): F.A. Cotton & G. Wilkinson; Adv. Inorg. Chem. 3, 820 (1972)
Inhibition of human alkaline phosphatases by vanadate: L.E. Seargeant and R.A. Stinson; Biochem. J. 181, 247 (1979) Abstract
Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate: G. Swarup, et al.; BBRC 107, 1104 (1982) Abstract
Characterization of the inositol 1,4,5-trisphosphate-induced calcium release from permeabilized endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoate: K.J. Fohr, et al.; Biochem. J. 262, 83 (1989) Abstract
Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist? [letter]: J. Strupish, et al.; Biochem J. 277, 294 (1991) Abstract
 
 
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