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Signal Transduction
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ALX-550-132 Revised 24-Jun-08
Histamine . dihydrochloride
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SYNONYMS 1H-Imidazole-4-ethanamine . 2HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Histaminergics & Histamine Receptors / Related Products
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ALX-550-132-G005   5 g 40.00 USD Add To Cart
Product Specification
FORMULA: C5H9N3 . 2HCl
MW: 111.1 . 73.0
CAS NUMBER: 56-92-8
MERCK INDEX: 14: 4719
RTECS: MS1575000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.
IDENTITY: Identity determined by IR.

Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-550-141 Revised 17-Jan-05
4-Aminopyridine
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SYNONYMS Fampridine
4-Pyridylamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
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ALX-550-141-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C5H6N2
MW: 94.1
CAS NUMBER: 504-24-5
MERCK INDEX: 14: 3933
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Induces depolarization of GABA neurons. Non-selective K+ channel blocker. Reverses saxitoxin- and tetrodotoxin-induced cardiorespiratory depression. Increases stimulation-induced release of acetylcholine.
Product Specific Literature References
Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres: R.M. Sherratt, et al.; Nature 283, 570 (1980) Abstract
The origin, structure, and pharmacological activity of botulinum toxin: L.L. Simpson; Pharmacol. Rev. 33, 155 (1981) Abstract
Further Categories Containing This Product:
GABA-ergics & GABA Receptors / Related Products
 
 
ALX-550-143 Revised 19-Aug-02
Benztropine . mesylate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Muscarinic) / Related Products
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ALX-550-143-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C21H25NO . CH3SO3H
MW: 307.4 . 96.1
CAS NUMBER: 132-17-2
MERCK INDEX: 14: 1121
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Muscarinic acetylcholine receptor antagonist. Inhibits the dopamine transporter.
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products
 
 
ALX-550-144 Revised 09-Dec-04
Buspirone . hydrochloride
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SYNONYMS 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-144-G001   1 g 48.00 USD Add To Cart
Product Specification
FORMULA: C21H31N5O2 . HCl
MW: 385.5 . 36.5
CAS NUMBER: 33386-08-2
MERCK INDEX: 14: 1504
PURITY: ≥96%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
5-HT1A serotonin receptor agonist.
Product Specific Literature References
The discovery and development of buspirone: a new approach to the treatment of anxiety: J.S. New; Med. Res. Rev. 10, 283 (1990), (Review) Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products • Benzodiazepines / Related Products • Adrenergics & Adrenergic Receptors / Related Products
 
 
ALX-550-145 Revised 08-Feb-08
Capsazepine
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SYNONYMS N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-550-145-M005   5 mg 60.00 USD Add To Cart
ALX-550-145-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C19H21ClN2O2S
MW: 376.9
CAS NUMBER: 138977-28-3
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Analog of capsaicin (Prod. No. ALX-550-066) that acts as a capsaicin antagonist. Increases intracellular Ca2+ levels.
Product Specific Literature References
Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro: L. Urban & A. Dray; Neurosci. Lett. 134, 9 (1991) Abstract
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin: S. Bevan, et al.; Br. J. Pharmacol. 107, 544 (1992) Abstract
A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens: C.A. Maggi, et al.; Br. J. Pharmacol. 108, 801 (1993) Abstract
Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea: J.L. Ellis & B.J. Undem; J. Pharmacol. Exp. Ther. 268, 85 (1994) Abstract
The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin: C.S. Walpole, et al.; J. Med. Chem. 37, 1942 (1994) Abstract
Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h): A.M. Ray, et al.; J. Neurosci. 23, 10146 (2003) Abstract
Characterization of the human HCN1 channel and its inhibition by capsazepine: C.H. Gill, et al.; Br. J. Pharmacol. 143, 411 (2004) Abstract
Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel: H. Yamamura, et al.; J. Biol. Chem. 279, 44483 (2004) Abstract
Effect of capsazepine on cytosolic Ca(2+) levels and proliferation of human prostate cancer cells: J.K. Huang, et al.; Toxicol. In Vitro 20, 567 (2006) Abstract
Further Categories Containing This Product:
TRPV1 Agonists and Antagonists / Related Products
 
 
ALX-550-147 Revised 13-Jun-03
Tropanyl 2-(4-chlorophenoxy)propionate . maleate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics / Related Products
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ALX-550-147-M010   10 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C17H22ClNO3 . C4H4O4
MW: 323.8 . 116.1
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent analgesic and nootropic agent. Causes increased release of acetylcholine at central muscarinic synapses.
Product Specific Literature References
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters: F. Gualtieri, et al.; J. Med. Chem. 37, 1704 (1994) Abstract
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters: F. Gualtieri, et al.; J. Med. Chem. 37, 1712 (1994) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products • Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-550-148 Revised 13-Jun-03
Tropanyl 2-(4-bromophenoxy)propionate . oxalate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics / Related Products
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ALX-550-148-M010   10 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C17H22BrNO3 . C2H2O4
MW: 368.3 . 90.0
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent analgesic and nootropic agent. Causes increased release of acetylcholine at central muscarinic synapses.
Product Specific Literature References
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters: F. Gualtieri, et al.; J. Med. Chem. 37, 1704 (1994) Abstract
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2- (phenylamino)alkanoic acid esters: F. Gualtieri, et al.; J. Med. Chem. 37, 1712 (1994) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products • Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-550-150 Revised 13-Jun-03
Tropanyl 2-(4-chlorophenylthio)butanoate . oxalate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics / Related Products
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ALX-550-150-M010   10 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C18H24ClNO2S . C2H2O4
MW: 353.9 . 90.0
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent analgesic and nootropic agent. Causes increased release of acetylcholine at central muscarinic synapses.
Product Specific Literature References
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters: F. Gualtieri, et al.; J. Med. Chem. 37, 1704 (1994) Abstract
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters: F. Gualtieri, et al.; J. Med. Chem. 37, 1712 (1994) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products • Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-550-151 Revised 13-Jun-03
Tropanyl 2-naphthoxypropionate . maleate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics / Related Products
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ALX-550-151-M010   10 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C21H25NO3 . C4H4O4
MW: 339.4 . 116.1
PURITY: ≥98%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent analgesic and nootropic agent. Causes increased release of acetylcholine at central muscarinic synapses.
Product Specific Literature References
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters: F. Gualtieri, et al.; J. Med. Chem. 37, 1704 (1994) Abstract
Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters: F. Gualtieri, et al.; J. Med. Chem. 37, 1712 (1994) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products • Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-550-152 Revised 20-Sep-07
Domoic acid
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SYNONYMS [2S-[2α,3β,4β(1Z,3E,5R)]]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-550-152-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H21NO6
MW: 311.3
CAS NUMBER: 14277-97-5
MERCK INDEX: 14: 3417
SOURCE/HOST: Isolated from Nitzschia pungens f. multiseries.
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 8mg/ml soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HAZARD: HARMFUL. POTENT NEUROTOXIN.

Product Description
Glutamate/kainate excitatory amino acid agonist with highest affinity for the kainate receptor of all known kainic acid analogs.
Product Specific Literature References
Structure-activity relations of excitatory amino acids on frog and rat spinal neurones: T.J. Biscoe, et al.; Br. J. Pharmacol. 58, 373 (1976) Abstract
A kainic acid receptor from frog brain purified using domoic acid affinity chromatography: D.R. Hampson & R.J. Wenthold; J. Biol. Chem. 263, 2500 (1988) Abstract; Full Text
Domoic acid, the alleged "mussel toxin," might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the dorsal hippocampus: G. Debonnel, et al.; Can. J. Physiol. Pharmacol. 67, 29 (1989) Abstract
Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern Prince Edward Island: P. Wright, et al.; Can. J. Chem. 67, 481 (1989)
Domoic acid: a dementia-inducing excitotoxic food poison with kainic acid receptor specificity: G.R. Stewart, et al.; Exp. Neurol. 110, 127 (1990) Abstract
Pharmacology of systemically administered domoic acid in mice: R.A. Tasker, et al.; Can. J. Physiol. Pharmacol. 69, 378 (1991) Abstract
Transfer constants for blood-brain barrier permeation of the neuroexcitatory shellfish toxin, domoic acid: E. Preston & I. Hynie; Can. J. Neurol. Sci. 18, 39 (1991) Abstract
Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain: D.R. Hampson, et al.; Eur. J. Pharmacol. 218, 1 (1992) Abstract
Parenteral domoic acid impairs spatial learning in mice: B.F. Petrie, et al.; Pharmacol. Biochem. Behav. 41, 211 (1992) Abstract
Evidence for hybrid NMDA/kainate receptors from protein reconstitution studies and expression of vertebrate CNS RNAs in Xenopus oocytes: P.N. Usherwood & E.A. Barnard; Comp. Biochem. Physiol. [C] 103, 19 (1992) Abstract
Domoic acid induced release of [3H]GABA in cultured chick retina cells: M. Alfonso, et al.; Neurochem. Int. 24, 267 (1994) Abstract
Domoic acid inhibits adenylate cyclase activity in rat brain membranes: M.S. Nijjar & B. Grimmelt; Mol. Cell. Biochem. 136, 105 (1994) Abstract
The activation of glutamate receptors by kainic acid and domoic acid: D.R. Hampson & J.L. Manalo; Nat. Toxins 6, 153 (1998), Review Abstract
Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid: A.C. Scallet, et al.; Neurotoxicol. Teratol. 27, 745 (2005) Abstract
Further Categories Containing This Product:
Neurotoxins • Kainate Receptors / Related Products • Excitatory Amino Acids • Marine Natural Products
 
 
ALX-550-154 Revised 20-Dec-02
5-Methoxy-N-cyclopropanoyltryptamine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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