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Items 12 of 12
ALX-480-006
Revised 17-Sep-08
8-Bromoguanosine-3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
8-Br-cGMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-006-M010
10 mg
48.00 USD
ALX-480-006-M050
50 mg
145.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
7
P . Na
MW:
423.1 . 23.0
CAS NUMBER:
51116-01-9
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
PURITY DETAIL:
Low in fluorescent and colored impurities.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Activator of cGMP-dependent protein kinases (PKGs) 1α, 1β and type II and cGMP-gated ion channels (cGMP agonist). Has increased metabolic stability and membrane permeability compared to cGMP (Prod. No.
ALX-480-059
).
Product Specific Literature References
Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP:
R.M. Rapoport, et al.; PNAS
79
, 6470 (1982)
Abstract
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices:
C.L. Boulton, et al.; Eur. J. Neurosci.
6
, 1528 (1994)
Abstract
Nitric oxide in skeletal muscle:
L. Kobzik, et al.; Nature
372
, 546 (1994)
Abstract
Nitric oxide. More jobs for that molecule:
S. Snyder; Nature
372
, 504 (1994)
Abstract
Further Categories Containing This Product:
PKG Activators
ALX-480-026
Revised 03-Aug-06
8-Bromoguanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt (high purity)
SYNONYMS
Rp-8-Br-cGMPS . Na
8-Br-cGMPS . Na, Rp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-026-MC05
0.5 mg
90.00 USD
ALX-480-026-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
PS . Na
MW:
439.2 . 23.0
CAS NUMBER:
150418-07-8
PURITY:
≥99% (HPLC)
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of cGMP-dependent protein kinase (PKG) 1α and 1β. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases; no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to cyclic GMP (Prod. No.
ALX-480-059
) or Rp-cGMPS (Prod. No.
ALX-480-072
).
Product Specific Literature References
Nitric oxide regulates luteinizing hormone-releasing hormone secretion:
M. Moretto, et al.; Endocrinology
133
, 2399 (1993)
Abstract
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation:
M. Zhuo, et al.; Nature
368
, 635 (1994)
Abstract
Further Categories Containing This Product:
PKG Inhibitors
ALX-480-027
Revised 25-Jun-08
8-Bromoguanosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt (high purity)
SYNONYMS
Sp-8-Br-cGMPS . Na
8-Br-cGMPS . Na, Sp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-027-M001
1 mg
80.00 USD
ALX-480-027-M005
5 mg
320.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
PS . Na
MW:
439.2 . 23.0
CAS NUMBER:
153660-03-8
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by MS,
1
H-NMR and UV.
Product Description
Unspecific activator of both cGMP-dependent protein kinase (PKG) 1α and cAMP-dependent protein kinase (PKA). Resistant to cyclic nucleotide phosphodiesterases. Much more lipophilic and membrane permeant as compared to cyclic GMP (Prod. No.
ALX-480-059
) or Sp-cGMPS (Prod. No.
ALX-480-073
).
Product Specific Literature References
Evidence for two intracellular calcium pools in Dictyostelium: the cAMP- induced calcium influx is directed into a NBD-Cl- and 2,5-di-(tert- butyl)1,4-hydroquinone-sensitive pool:
H. Flaadt, et al.; J. Cell Sci.
105
, 1131 (1993)
Abstract
Further Categories Containing This Product:
PKG Activators
•
PKA Activators
ALX-480-088
Revised 31-Oct-06
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
8-pCPT-cGMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-088-M001
1 mg
50.00 USD
ALX-480-088-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
16
H
14
ClN
5
O
7
PS . Na
MW:
486.8 . 23.0
CAS NUMBER:
51239-26-0
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Selective activator of cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
Product Specific Literature References
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets
:
J. Geiger, et al.; PNAS
89
, 1031 (1992)
Abstract
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP
:
E. Butt, et al.; Biochem. Pharmacol.
43
, 2591 (1992)
Abstract
Further Categories Containing This Product:
PKG Activators
ALX-480-031
Revised 08-Oct-08
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . triethylammonium salt
SYNONYMS
8-pCPT-cGMP . TEA
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-031-M001
1 mg
42.00 USD
ALX-480-031-M005
5 mg
168.00 USD
Product Specification
FORMULA:
C
16
H
14
ClN
5
O
7
PS . C
6
H
15
N
MW:
486.8 . 101.2
CAS NUMBER:
54364-02-2
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by MS, UV and
1
H-NMR.
Product Description
Selective activator of cGMP-dependent protein kinase Iα, Iβ and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
Product Specific Literature References
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para- chlorophenylthio-cGMP:
E. Butt, et al.; Biochem. Pharmacol.
43
, 2591 (1992)
Abstract
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets:
J. Geiger, et al.; PNAS
89
, 1031 (1992)
Abstract
Further Categories Containing This Product:
PKG Activators
ALX-480-087
Revised 21-Dec-06
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS
Rp-8-pCPT-cGMPS . Na
8-pCPT-cGMPS . Na, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-087-C100
100 µg
50.00 USD
ALX-480-087-M001
1 mg
280.00 USD
Product Specification
FORMULA:
C
16
H
14
ClN
5
O
6
PS
2
. Na
MW:
502.9 . 23.0
CAS NUMBER:
153660-09-9
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent selective inhibitor of cGMP-dependent protein kinase (PKG) 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. No metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS (Prod. No.
ALX-480-072
) or Rp-8-Br-cGMPS (Prod. No.
ALX-480-026
).
Product Specific Literature References
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor
:
E. Butt, et al.; Eur. J. Pharmacol.
269
, 265 (1994)
Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms
:
D.M. Gamm, et al.; J. Biol. Chem.
270
, 27380 (1995)
Abstract
;
Full Text
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action
:
R.H. Kramer & G.R. Tibbs; J. Neurosci.
16
, 1285 (1996)
Abstract
Further Categories Containing This Product:
PKG Inhibitors
ALX-480-032
Revised 03-Feb-05
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt (high purity)
SYNONYMS
Rp-8-pCPT-cGMPS . TEA
8-pCPT-cGMPS . TEA, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-032-C100
100 µg
45.00 USD
ALX-480-032-M001
1 mg
230.00 USD
Product Specification
FORMULA:
C
16
H
15
ClN
5
O
6
PS
2
. C
6
H
15
N
MW:
504.1 . 101.0
CAS NUMBER:
153660-04-9
PURITY:
≥99%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent selective inhibitor of cGMP-dependent protein kinase 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS (Prod. No.
ALX-480-072
) or Rp-8-Br-cGMPS (Prod. No.
ALX-480-026
).
Product Specific Literature References
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor:
E. Butt, et al.; Eur. J. Pharmacol.
269
, 265 (1994)
Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms:
D.M. Gamm, et al.; J. Biol. Chem.
270
, 27380 (1995)
Abstract
;
Full Text
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action:
R.H. Kramer & G.R. Tibbs; J. Neurosci.
16
, 1285 (1996)
Abstract
Further Categories Containing This Product:
PKG Inhibitors
ALX-480-070
Revised 05-Dec-04
8-(4-Chlorophenylthio)guanosine-3',5'-cyclic-Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-8-pCPT-cGMPS . Na
8-pCPT-cGMPS . Na, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-070-MC05
0.5 mg
80.00 USD
ALX-480-070-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
16
H
14
N
5
ClO
6
S
2
P . Na
MW:
502.9 . 23.0
CAS NUMBER:
160385-87-5
PURITY:
≥99%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent activator of both cGMP-dependent protein kinase 1α, 1β and type II and cAMP-dependent protein kinase II. Excellent cell membrane permeability and phosphodiesterase stability.
Product Specific Literature References
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor:
E. Butt, et al.; Eur. J. Pharmacol.
269
, 265 (1994)
Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms:
D.M. Gamm, et al.; J. Biol. Chem.
270
, 27380 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Activators
•
PKG Activators
ALX-480-046
Revised 17-Sep-08
N2,2'-O-Dibutyrylguanosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
Dibutyryl-cGMP . Na
DBcGMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-046-M005
5 mg
40.00 USD
ALX-480-046-M025
25 mg
160.00 USD
Product Specification
FORMULA:
C
18
H
23
N
5
O
9
P . Na
MW:
484.4 . 23.0
CAS NUMBER:
51116-00-8
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water, 100% ethanol, DMSO, dimethyl formamide or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Activates cGMP-dependent protein kinase (PKG). Cell permeable. For a better and more selective agonist, use 8-pCPT-cGMP (Prod. No.
ALX-480-031
or Prod. No.
ALX-480-088
).
Product Specific Literature References
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity:
R.B. Meyer & J.P. Miller; Life Sci.
14
, 1019 (1974)
Abstract
Relaxation of hormonally stimulated smooth muscular tissues by the 8- bromo derivative of cyclic GMP:
K.D. Schultz, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol.
306
, 1 (1979)
Abstract
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase:
S.G. Francis, et al.; Mol. Pharmacol.
34
, 506 (1988)
Abstract
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets:
D.C. Sane, et al.; BBRC
165
, 708 (1989)
Abstract
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP:
E. Butt, et al.; Biochem. Pharmacol.
43
, 2591 (1992)
Abstract
Further Categories Containing This Product:
PKG Activators
ALX-480-059
Revised 09-Mar-06
Guanosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
cGMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-059-M025
25 mg
25.00 USD
ALX-480-059-M100
100 mg
95.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
7
P . Na
MW:
344.2 . 23.0
CAS NUMBER:
40732-48-7
MERCK INDEX:
14:
2709
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Intracellular messenger implicated in mediating action of nitric oxide (NO) in many cell types. Target receptors for the second messenger guanosine 3',5'-cyclic monophosphate (cGMP) include protein kinase G (PKG) isozymes, cGMP-dependent ion channels as well as cGMP-responsive phosphodiesterases. In presence of corresponding phosphodiesterases cGMP is metabolized rapidly. Suppresses apoptosis.
Product Specific Literature References
Cyclic GMP metabolism and involvement in biological regulation:
N.D. Goldberg & M.K. Haddox; Ann. Rev. Biochem.
46
, 823 (1977)
