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ALX-210-277
Revised 14-Feb-07
Polyclonal Antibody to Glucocorticoid Receptor α
SYNONYMS
anti-GRα PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-277-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Lyophilized. Contains 0.05% sodium azide.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 755-771 (C
755
EIITNQIPKYSN
GNIKK
771
) of human GRα (glucocorticoid receptor α
)
.
SPECIFICITY:
Recognizes human, mouse and rat GRα. Detects a band of ~94kDa by Western blot.
APPLICATION:
Immunoprecipitation, Chromatin Immunoprecipitation
Western Blot (4µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-283
Revised 06-Apr-06
Polyclonal Antibody to SRC-1
SYNONYMS
anti-Steroid Receptor Coactivator-1 PAb
anti-NCOA1 PAb
anti-Nuclear Receptor Coactivator 1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Receptor Coactivators / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-283-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 8-24 (S
8
SDPANPDSHKRK
GSPC
24
) of human SRC-1 (steroid receptor coactivator-1).
SPECIFICITY:
Recognizes human and mouse SRC-1. Detects a band of ~165kDa and an unspecific band of ~40kDa by Western blot.
APPLICATION:
Immunocytochemistry (1µg/ml)
Immunohistochemistry (frozen sections (1µg/ml))
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-167-020
.
Product Images
Please click on thumbnails to enlarge.
Product Description
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-286
Revised 15-Jun-06
Polyclonal Antibody to Glucocorticoid Receptor Interacting Protein 1
SYNONYMS
anti-GRIP1 PAb
anti-TIF2 PAb
anti-Transcriptional Intermediatory Factor 2 PAb
anti-SRC-2 PAb
anti-Steroid Receptor Coactivator-2 PAb
anti-NCOA2 PAb
anti-Nuclear Receptor Coactivator 2 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-286-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 206-217 (P
206
LPDSEEEGHDS
217
C) of human GRIP1 (glucocorticoid receptor interacting protein-1).
SPECIFICITY:
Recognizes human and hamster GRIP1.
APPLICATION:
Immunocytochemistry (1:1’000)
Immunohistochemistry (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-157-019
.
Product Images
Please click on thumbnails to enlarge.
Product Description
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. GRIP1 (Glucocorticoid Receptor Interacting Protein-1), or TIF2 (Transcription Intermediary Factor 2), is a member of a growing family of transcriptional coactivator proteins which includes SRC-1 and AIB1. GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.
Further Categories Containing This Product:
Nuclear Receptor Coactivators / Related Products
•
Polyclonal Antibodies
ALX-210-314
Revised 22-Sep-08
Polyclonal Antibody to Cannabinoid Receptor 1
SYNONYMS
anti-CB
1
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-314-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human CB
1
(cannabinoid receptor 1) (aa 1-99).
SPECIFICITY:
Recognizes human and rat CB
1
. Detects a band of ~52kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:1’000)
Immunohistochemistry (paraffin sections, frozen sections)
Western Blot (1:250)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Immunocytochemical staining of CB
1
in AtT20 cells transfected with the rat CB1 gene with Prod. No.
ALX-210-314
yields a pattern consistent with plasma membrane staining (see Figure).
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-315
Revised 30-Jun-08
Polyclonal Antibody to Cannabinoid Receptor 2
SYNONYMS
anti-CB
2
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-315-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human CB
2
(cannabinoid receptor 2) (aa 1-33).
SPECIFICITY:
Recognizes human and rat CB
2
. By Western blot detects bands of ~60kDa from human spinal cord homogenate and ~40kDa from RBL2H3 cells, representing different glycosylated forms of CB
2
.
APPLICATION:
Flow Cytometry (1:50)
Immunocytochemistry (1:100)
Immunohistochemistry (frozen sections, paraffin sections (1:100))
Western Blot (1:250)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status
:
N. Rayman, et al.; J. Immunol.
172
, 2111 (2004)
Abstract
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner:
M. Alberich Jorda, et al.; Blood
104
, 526 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-316
Revised 28-Mar-08
Polyclonal Antibody to Cannabinoid Receptor 1
SYNONYMS
anti-CB
1
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-316-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
3.3mg/ml
PURITY DETAIL:
Affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant rat CB
1
(cannabinoid receptor 1) (aa 1-77).
SPECIFICITY:
Recognizes human, mouse, rat, monkey, amphibian, chicken and fish CB
1
. Detects a band of ~60kDa by Western blot representing CB
1
;
also detects less intense bands of ~23kDa, ~72kDa and ~180kDa from rat brain homogenate.
APPLICATION:
Flow Cytometry
Immunocytochemistry (1:1’000)
Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-317/1
Revised 03-Jan-07
Polyclonal Antibody to Cannabinoid Receptor 2
SYNONYMS
anti-CB
2
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-317/1-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant rat CB
2
(cannabinoid receptor 2) (aa 1-32).
SPECIFICITY:
Recognizes human and rat CB
2
.
APPLICATION:
Flow Cytometry
Immunocytochemistry (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-335
Revised 29-Aug-06
Polyclonal Antibody to TNF-α
SYNONYMS
anti-Tumor Necrosis Factor-α PAb
anti-TNFSF 2 PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
TNF-alpha
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-335-C100
100 µg
259.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
≥99% (SDS-PAGE).
FORMULATION:
Liquid. In PBS.
ENDOTOXIN CONTENT:
≤0.0005EU/µg protein.
IMMUNOGEN:
Recombinant rat TNF-α (tumor necrosis factor-α).
SPECIFICITY:
Recognizes human, mouse and rat TNF-α.
APPLICATION:
ELISA
Western Blot
: 10ng recombinant rat TNF-α by 40-60µg/ml Prod. No. ALX-210-335.
Functional Application
: Neutralizes cytotoxic activity of recombinant rat TNF-α (Neutralizing activity: >2x10
5
U/mg. One unit is defined as the amount of antibody sufficient for neutralizing the cytotoxic activity of 1 unit recombinant rat TNF-α).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-346
Revised 10-Feb-05
Polyclonal Antibody to MD-1 (human)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Co-Receptors Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-346-C100
100 µg
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Purified. Contains 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 112-125 of human MD-1.
SPECIFICITY:
Recognizes human MD-1.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-349
Revised 09-Dec-04
Polyclonal Antibody to PICK1
SYNONYMS
anti-Protein Interacting with Protein Kinase C PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
AMPA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-349-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Purified. Contains 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
FADLDYDIEEDKLGIPT
18
) of mouse PICK1 (protein interacting with protein kinase C).
SPECIFICITY:
Recognizes mouse and rat PICK1. Detects a band of ~52kDa by Western blot.
APPLICATION:
Immunocytochemistry (1.7µg/ml)
Immunoprecipitation
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-051
.
Further Categories Containing This Product:
PKC Other Products
•
Polyclonal Antibodies
ALX-210-361
Revised 26-Feb-07
Polyclonal Antibody to PPARα (mouse) (phosphorylated) (pSer12)
SYNONYMS
anti-Peroxisome Proliferator Activated Receptor α (mouse (phosphorylated) (pSer
12
) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-361-C100
100 µg
385.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS contanining 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 8-19 (I
8
CPLpSPLEADDL
19
) of mouse PPARα (peroxisome proliferator activated receptor α) phosphorylated at Ser
12
.
SPECIFICITY:
Recognizes mouse PPARα phosphorylated at Ser
12
. Detects a band of ~52 kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-055
.
Product Specific Literature References
MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response
:
M.W. Kilgore, et al.; Mol. Cell Endocrinol.
129
, 229 (1997)
Abstract
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
:
R.M. Lavinsky, et al.; PNAS
95
, 2920 (1998)
Abstract
;
Full Text
Related Products
ALX-165-055
Blocking Peptide for PAb to PPARα (mouse) (phosphorylated) (pSer
12
) (Prod. No.
ALX-210-361
)
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Polyclonal Antibodies
ALX-210-362
Revised 09-Feb-05
Polyclonal Antibody to PPARα (mouse) (phosphorylated) (pSer21)
SYNONYMS
anti-Peroxisome Proliferator Activated Receptor α (mouse) (phosphorylated) (pSer
21
) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antibodies
