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G-Protein Coupled Receptors & Ligands Other Products
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ALX-380-264 Revised 04-Jun-08
EM574
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SYNONYMS Motilide
Idremcinal
8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-264-M001   1 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C39H69NO12
MW: 744.0
CAS NUMBER: 110480-13-2
SOURCE/HOST: Semisynthetic from erythromycin A.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

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Product Description
Agonist of the motilin receptor. Shows antimicrobial and gastrointestinal motor stimulating activity in vitro and in vivo. Stimulates contractions of muscle strips in a concentration-dependent manner (10-7-10-5M) and this contractile effect is unaffected by pretreatment with atropine or tetrodotoxin (Prod. No. ALX-630-002). Binds to smooth muscle homogenates wit a Kd value of 7.8 x 10-9. Has orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, Ghrelin Receptor).
Product Specific Literature References
Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship: S. Omura, et al.; J. Antibiot. 38, 1631 (1985) Abstract
Macrolides with gastrointestinal motor stimulating activity: S. Omura, et al.; J. Med. Chem. 30, 1941 (1987) Abstract
Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal: K. Tsuzuki, et al.; Chem. Pharm. Bull. 37, 2687 (1989) Abstract
EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M. Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994) Abstract
Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. 49, 794 (1996) Abstract
Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs: N. Inatomi, et al.; Jpn. J. Pharmacol. 71, 29 (1996) Abstract
EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit: F. Sato, et al.; Eur. J. Pharmacol. 322, 63 (1997) Abstract
Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs: T. Tanaka, et al.; J. Pharmacol. Exp. Ther. 287, 712 (1998) Abstract
EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs: F. Sato, et al.; Eur. J. Pharmacol. 395, 165 (2000) Abstract
General Information
MANUFACTURER Manufactured by the Kitasato Institute, Tokyo.
Related Products
Further Categories Containing This Product:
Accessory Proteins & Motor Proteins Other Products • G-Protein Coupled Receptors & Ligands Other Products • Neuropeptides & Receptors Other Products
 
 
ALX-210-143/1 Revised 23-Jun-08
Polyclonal Antibody to Ca2+-Sensing Receptor
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SYNONYMS anti-CASR PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY G-Protein Coupled Receptors & Ligands Other Products
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ALX-210-143/1-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1.4mg/ml  
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 12-27 (A12LAWHSSAYGPDQRAQ27) of rat CASR (Ca2+-sensing receptor).
SPECIFICITY: Recognizes human and rat CASR. Detects a band of ~120kDa by Western blot.
APPLICATION: Western Blot (1:100)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-167-010.
Product Specific Literature References
Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium: S.E. McNeil, et al.; J. Biol. Chem. 273, 1114 (1998) Abstract; Full Text
General Information
The calcium sensing receptor (CASR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CASR is similar to the 7-transmembrane-domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CASR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
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