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Items 16 of 16
ALX-155-021
Revised 29-Jun-05
EGF Receptor (human) (651-658)
SYNONYMS
Epidermal Growth Factor Receptor (human) (651-658)
EGFR (human) (651-658)
HER-1 (human) (651-658)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGF / EGF Receptor [EGFR] Kinase Other Products
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ALX-155-021-M001
1 mg
50.00 USD
ALX-155-021-M005
5 mg
200.00 USD
Product Specification
SEQUENCE:
H-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA:
C
46
H
91
N
21
O
10
MW:
1098.4
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin:
C.A. O'Brian, et al.; Invest. New Drugs
9
, 169 (1991)
Abstract
Further Categories Containing This Product:
Peptides
•
PKC Substrates
ALX-155-023
Revised 29-Jun-05
EGF Receptor (human) (652-657)
SYNONYMS
Epidermal Growth Factor Receptor (human) (652-657)
EGFR (human) (652-657)
HER-1 (human) (652-657)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGF / EGF Receptor [EGFR] Kinase Other Products
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ALX-155-023-M001
1 mg
45.00 USD
ALX-155-023-M005
5 mg
180.00 USD
Product Specification
SEQUENCE:
H-Lys-Arg-Thr-Leu-Arg-Arg-OH
FORMULA:
C
34
H
68
N
16
O
8
MW:
829.0
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific substrate (aa 652-657 of mature EGF receptor, without signal peptide (aa 1-24)) for protein kinase C (PKC).
Product Specific Literature References
Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells:
L. Heasley & G.L. Johnson; J. Biol. Chem.
264
, 8646 (1989)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
•
PKC Substrates
ALX-157-013
Revised 04-Jul-03
[Ala9,10, Lys11,12]-Glycogen Synthase (1-12)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
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ALX-157-013-M001
1 mg
80.00 USD
ALX-157-013-M005
5 mg
320.00 USD
Product Specification
SEQUENCE:
H-Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys-OH
FORMULA:
C
56
H
103
N
17
O
16
MW:
1270.5
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein kinase C (PKC). Peptide comprising the amino acid sequence of the glycogen synthase phosphorylation site.
Product Specific Literature References
The influence of basic residues on the substrate specificity of protein kinase C:
C. House, et al.; J. Biol. Chem.
262
, 772 (1987)
Abstract
;
Full Text
A tandem chromatographic column method for assaying cAMP-dependent protein kinase and protein kinase C with synthetic peptide substrates:
J.J. Egan, et al.; Anal. Biochem.
175
, 552 (1988)
Abstract
A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes:
D.R. Alexander, et al.; Biochem. J.
260
, 893 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-159-001
Revised 01-Mar-06
IL-2 Receptor Fragment (human)
SYNONYMS
Interleukin-2 Receptor Fragment (human)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukin Receptors
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ALX-159-001-M001
1 mg
80.00 USD
Product Specification
SEQUENCE:
H-Gln-Arg-Arg-Gln-Arg-Lys-Ser-Arg-Arg-Thr-Ile-OH
FORMULA:
C
59
H
113
N
29
O
16
MW:
1484.7
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein kinase C (PKC). The peptide is derived from the cytoplasmic C-terminus of the human interleukin-2 receptor.
Product Specific Literature References
Phosphorylation of the human interleukin-2 receptor and a synthetic peptide identical to its C-terminal, cytoplasmic domain:
B. Gallis, et al.; J. Biol. Chem.
261
, 5075 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Substrates
•
CD25 [IL-2Ralpha] / Related Products
•
Peptides
ALX-162-004
Revised 05-Feb-05
MARCKS Protein (151-175) (bovine brain)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
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ALX-162-004-MC05
0.5 mg
120.00 USD
ALX-162-004-M001
1 mg
210.00 USD
Product Specification
SEQUENCE:
H-Lys-Lys-Lys-Lys-Lys-Arg-Phe-Ser-Phe-Lys-Lys-Ser-Phe-Lys-Leu-Ser-Gly-Phe-Ser-Phe-Lys-Lys-Asn-Lys-Lys-OH
FORMULA:
C
147
H
243
N
41
O
31
MW:
3081.8
CAS NUMBER:
125267-21-2
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Excellent substrate for protein kinase C (PKC). The peptide consists of residues 151-175 of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein phosphorylation site. Protein kinase C isotypes (including PKCε) phosphorylate serines 8, 12 and 19 of this peptide. It is a very weak substrate for cAMP- and cGMP-dependent protein kinase and CaM kinases I, II and III.
Product Specific Literature References
Protein kinase C substrate and inhibitor characteristics of peptides derived from the myristoylated alanine-rich C kinase substrate (MARCKS) protein phosphorylation site domain:
J.M. Graff, et al.; J. Biol. Chem.
266
, 14390 (1991)
Abstract
;
Full Text
The MARCKS family of cellular protein kinase C substrates:
P.J. Blackshear; J. Biol. Chem.
268
, 1501 (1993), (Minireview)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-162-005
Revised 04-Jul-03
MARCKS Protein (159-165) amide (bovine brain)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
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ALX-162-005-M001
1 mg
105.00 USD
ALX-162-005-M005
5 mg
420.00 USD
Product Specification
SEQUENCE:
H-Phe-Lys-Lys-Ser-Phe-Lys-Leu-NH
2
FORMULA:
C
45
H
73
N
11
O
8
MW:
896.1
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
The peptide consists of residues 159-165 of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein. It is sufficiently selective for protein kinase C (PKC) to permit specific assay of this enzyme in crude cell extracts and permeabilized cells.
Product Specific Literature References
The MARCKS family of cellular protein kinase C substrates
:
P.J. Blackshear; J. Biol. Chem.
268
, 1501 (1993)
Abstract
;
Full Text
:
T. Spencker, et al.; Liebigs Ann. Chem.
237
, (1993)
Further Categories Containing This Product:
Peptides
ALX-162-009
Revised 04-Jul-07
Myelin Basic Protein (4-14) (bovine)
SYNONYMS
MBP (4-14) (bovine)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
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ALX-162-009-M001
1 mg
85.00 USD
ALX-162-009-M005
5 mg
330.00 USD
Product Specification
SEQUENCE:
H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA:
C
60
H
103
N
21
O
17
MW:
1390.6
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific and convenient substrate for protein kinase C (PKC). Very poor substrate for phosphorylase kinase, CaM kinase II, casein kinases I and II and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts:
Y.J.K. Farrar, et al.; BBRC
180
, 694 (1991)
Abstract
A synthetic peptide substrate for selective assay of protein kinase C:
I. Yasuda, et al.; BBRC
166
, 1220 (1990)
Abstract
Further Categories Containing This Product:
PKC Substrates
•
Peptides
ALX-162-016
Revised 04-Jul-07
[Pyr4]-Myelin Basic Protein (4-14) (bovine)
SYNONYMS
[Pyr
4
]-MBP (4-14) (bovine)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
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ALX-162-016-M001
1 mg
95.00 USD
ALX-162-016-M005
5 mg
380.00 USD
Product Specification
SEQUENCE:
Pyr-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA:
C
60
H
100
N
20
O
17
MW:
1373.6
CAS NUMBER:
136132-68-8
PURITY:
≥96%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Very selective substrate for protein kinase C (PKC).
Product Specific Literature References
A synthetic peptide substrate for selective assay of protein kinase C:
I. Yasuda, et al.; BBRC
166
, 1220 (1990)
Abstract
Peptide fragments of myelin basic protein as substrates of protein kinase C:
M. Eller, et al.; Biochem. Int.
27
, 625 (1992)
Abstract
Further Categories Containing This Product:
Peptides
•
PKC Substrates
ALX-162-010
Revised 28-Jul-08
Myelin Basic Protein (104-118) (bovine)
SYNONYMS
MBP (104-118) (bovine)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
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ALX-162-010-M001
1 mg
95.00 USD
ALX-162-010-M005
5 mg
380.00 USD
Product Specification
SEQUENCE:
H-Gly-Lys-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg-Phe-Ser-Trp-Gly-Ala-OH
FORMULA:
C
70
H
111
N
23
O
19
MW:
1578.8
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein:
R.S. Turner, et al.; J. Biol. Chem.
260
, 11503 (1985)
Abstract
;
Full Text
Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C):
H. Su, et al.; BBRC
134
, 78 (1986)
Abstract
Further Categories Containing This Product:
PKC Substrates
•
Peptides
ALX-163-004
Revised 06-Jun-03
Neurogranin (28-43)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
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ALX-163-004-M001
1 mg
120.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Lys-Ile-Gln-Ala-Ser-Phe-Arg-Gly-His-Met-Ala-Arg-Lys-Lys-OH
FORMULA:
C
78
H
134
N
28
O
19
S
MW:
1800.2
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Peptide derived from the neurogranin phosphorylation domain. Highly selective substrate for protein kinase C (PKC), but very poor substrate for Ca
2+
/calmodulin-dependent kinase II and cAMP-dependent kinase (PKA).
Product Specific Literature References
Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C:
S.-J. Chen, et al.; Biochemistry
32
, 1032 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-006
Revised 04-Jul-03
Peptide ε
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
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ALX-165-006-MC01
0.1 mg
30.00 USD
ALX-165-006-M001
1 mg
120.00 USD
ALX-165-006-M005
5 mg
420.00 USD
Product Specification
SEQUENCE:
H-Glu-Arg-Met-Arg-Pro-Arg-Lys-Arg-Gln-Gly-Ser-Val-Arg-Arg-Arg-Val-OH
FORMULA:
C
83
H
155
N
39
O
21
S
MW:
2067.5
PURITY:
≥99%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific substrate for PKCε, derived from the pseudosubstrate site of PKCε (residues 149-164), with Ala
159
replaced by Ser. This peptide is also phosphorylated by PKCξ.
Product Specific Literature References
Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity:
D. Schaap, et al.; FEBS Lett.
243
, 351 (1989)
Abstract
Expression, purification, and characterization of protein kinase C- epsilon:
D. Schaap & P.J. Parker; J. Biol. Chem.
265
, 7301 (1990)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-210-573
Revised 28-Sep-07
Polyclonal Antibody to Myelin Basic Protein
SYNONYMS
anti-Myelin Basic Protein PAb
Polyclonal Antibody to MBP
anti-MBP PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
