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Receptors
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ALX-550-359 Revised 12-May-03
1-Benzyl-APDC . hydrochloride
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SYNONYMS 1-Benzyl-(2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-359-M001   1 mg 30.00 USD Add To Cart
ALX-550-359-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C13H16N2O4 . HCl
MW: 264.3 . 36.5
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
mGlu6 receptor selective ligand.
Product Specific Literature References
Synthesis, molecular modelling and biology of the 1-benzyl derivative of APDC - an apparent mGluR6 selective ligand: W. Tückmantel, et al.; Bioorg. Med. Chem. Lett. 7, 601 (1997)
Synthesis and metabotropic glutamate receptor antagonist activity of N1- substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid: M.J. Valli, et al.; Bioorg. Med. Chem. Lett. 8, 1985 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-360 Revised 19-Aug-02
α-Benzylquisqualic acid
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-360-M001   1 mg 30.00 USD Add To Cart
ALX-550-360-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C12H13N3O5
MW: 279.3
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective antagonist of group II mGluRs.
Product Specific Literature References
alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists: A.P. Kozikowski, et al.; Bioorg. Med. Chem. Lett. 8, 447 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-270-476 Revised 11-Mar-08
Bicalutamide
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SYNONYMS N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Androgens & Androgen Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-476-M100   100 mg 40.00 USD Add To Cart
ALX-270-476-M500   500 mg 140.00 USD Add To Cart
ALX-270-476-G001   1 g 220.00 USD Add To Cart
Product Specification
FORMULA: C18H14F4N2O4S
MW: 430.4
CAS NUMBER: 90357-06-5
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in acetone and tetrahydrofuran; slightly soluble in 100% ethanol or methanol; practically insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Nonsteroidal antiandrogen. Effective in the treatment of prostate cancer. Induces cell death by a pathway that is independent of changes in mitochondrial membrane potential and Bcl-2 action.
Product Specific Literature References
Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours: A. Maucher & E. von Angerer; J. Cancer Res. Clin. Oncol. 119, 669 (1993) Abstract
Antiandrogen-induced cell death in LNCaP human prostate cancer cells: E.C. Lee, et al.; Cell Death Differ. 10, 761 (2003) Abstract
Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B: P.K. Vayalil, et al.; Carcinogenesis 25, 987 (2004) Abstract; Full Text
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells: M. Verras, et al.; Cancer Res. 64, 8860 (2004) Abstract; Full Text
Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer: X. Liao, et al.; Endocrinology 145, 2941 (2004) Abstract; Full Text
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2’-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer: K.N. Chi, et al.; J. Natl. Cancer Inst. 97, 1287 (2005) Abstract; Full Text
The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers: K.M. Rau, et al.; Endocr. Relat. Cancer 12, 511 (2005), Review Abstract; Full Text
Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation: P.M. Ghosh, et al.; Endocr. Relat. Cancer 12, 119 (2005) Abstract; Full Text
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies: M. Mimeault & S.K. Batra; Carcinogenesis 27, 1 (2006), Review Abstract; Full Text
Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak: C. Castilla, et al.; Endocrinology 147, 4960 (2006) Abstract; Full Text
Androgen receptor corepressors and prostate cancer: C.J. Burd, et al.; Endocr. Relat. Cancer 13, 979 (2006), Review Abstract; Full Text
Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells: S. Srinivasan, et al.; Cancer Res. 67, 246 (2006) Abstract; Full Text
Androgen receptor structural and functional elements: role and regulation in prostate cancer: S.M. Dehm & D.J. Tindall; Mol. Endocrinol. 21, 2855 (2007), Review Abstract
Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains: B. Cinar, et al.; JBC 282, 29584 (2007) Abstract; Full Text
A novel class of pyranocoumarin anti-androgen receptor signaling compounds: J. Guo, et al.; Mol. Cancer Ther. 6, 907 (2007) Abstract; Full Text
Increased resistance to trail-induced apoptosis in prostate cancer cells selected in the presence of bicalutamide: M. Mitterberger, et al.; Prostate 67, 1194 (2007) Abstract
Interplay of nuclear factor-kappaB and B-myb in the negative regulation of androgen receptor expression by tumor necrosis factor alpha: S. Ko, et al.; Mol. Endocrinol. 22, 273 (2008) Abstract
Further Categories Containing This Product:
Antitumor Agents (Hormone-related) • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-152-001 Revised 26-Sep-08
Big Endothelin-1 (1-38) (human)
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SYNONYMS Big ET-1 (1-38) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-001-PC01   0.1 mg* 100.00 USD Add To Cart
ALX-152-001-PC05   0.5 mg* 400.00 USD Add To Cart
ALX-152-001-P001   1 mg* 650.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C189H282N48O56S5
MW: 4283.0
CAS NUMBER: 121014-53-7
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: 1mg/ml soluble in water; also soluble in 0.5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-007 Revised 14-Dec-04
Big Endothelin-1 (1-39) (bovine)
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SYNONYMS Big ET-1 (1-39) (bovine)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-007-PC01   0.1 mg* 140.00 USD Add To Cart
ALX-152-007-PC05   0.5 mg* 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C192H287N49O58S5
MW: 4370.0
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequencing of a bovine preproendothelin cDNA: G.J. Price & L. Malone; Nucl. Acid Res. 18, 3658 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-002 Revised 26-Nov-04
Big Endothelin-1 (1-39) (pig)
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SYNONYMS Big ET-1 (1-39) (pig)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-002-PC01   0.1 mg* 140.00 USD Add To Cart
ALX-152-002-PC05   0.5 mg* 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Ile-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C193H289N49O58S5
MW: 4384.1
CAS NUMBER: 121014-54-8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]: M. Yanagisawa, et al.; Nature 332, 411 (1988) Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-003 Revised 26-Nov-04
Big Endothelin-1 (1-39) (rat)
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SYNONYMS Big ET-1 (1-39) (rat)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-003-PC01   0.1 mg* 110.00 USD Add To Cart
ALX-152-003-PC05   0.5 mg* 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Arg-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C192H292N50O58S5
MW: 4389.1
CAS NUMBER: 135842-15-8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA: T. Sakurai, et al.; BBRC 175, 44 (1991) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-014 Revised 13-Jan-05
Big Endothelin-1 (19-37) (human), [Phe22]-
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SYNONYMS [Phe22]-Big ET-1 (19-37) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-014-MC05   0.5 mg 120.00 USD Add To Cart
ALX-152-014-M001   1 mg 190.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-OH
FORMULA: C100H152N26O26
MW: 2134.5
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of endothelin-converting enzyme (ECE).
Further Categories Containing This Product:
Peptides
 
 
ALX-152-012 Revised 14-Dec-04
Big Endothelin-1 (22-38) (human)
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SYNONYMS Big ET-1 (22-38) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-012-MC05   0.5 mg 100.00 USD Add To Cart
ALX-152-012-M001   1 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
FORMULA: C80H125N23O25
MW: 1809.0
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-004 Revised 12-May-03
Big Endothelin-2 (1-37) (human)
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SYNONYMS Big ET-2 (1-37) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-004-PC01   0.1 mg* 110.00 USD Add To Cart
ALX-152-004-PC05   0.5 mg* 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Gln-Thr-Ala-Pro-Tyr-Gly-Leu-Gly-Asn-Pro-Pro-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C188H269N45O56S4
MW: 4183.8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization: S. Ohkubo, et al.; FEBS Lett. 274, 136 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-201-204/1 Revised 06-Jun-08 New product
pro-Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS proBMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
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