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Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
You are here: Product Lines > Signal Transduction > cGMP Pathways > Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-804-649 Revised 25-May-07
Monoclonal Antibody to Guanylyl Cyclase (β1), Soluble (5A5)
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SYNONYMS anti-sGCβ1 MAb (5A5)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-649-R200   200 µl 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 5A5
ISOTYPE: Mouse IgG2
FORMULATION: Liquid. In undiluted cell culture supernatant containing RPMI and 10% FBS.
IMMUNOGEN: Recombinant human soluble guanylyl cyclase β1 subunit (sGCβ1) (aa 1-348).
SPECIFICITY: Recognizes human, mouse and rat sGCβ1 N-terminal epitope (aa 1-60).
APPLICATION: Immunocytochemistry
Immunohistochemistry
Immunoprecipitation (1:25-1:50)
Western Blot (1:50-1:200)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 4 weeks when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-270-210 Revised 06-Feb-05
NS-2028
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SYNONYMS 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-210-M001   1 mg 30.00 USD Add To Cart
ALX-270-210-M005   5 mg 90.00 USD Add To Cart
ALX-270-210-M025   25 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C9H5N2O3Br
MW: 269.1
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent and selective inhibitor of nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC). Inhibits also the basal, the YC-1 and the coenhanced sGC activity.
Product Specific Literature References
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase: S.P. Olesen, et al.; Br. J. Pharmacol. 123, 299 (1998) Abstract
Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production: L. Bang, et al.; Scand. Cardiovasc. J. 33, 33 (1999) Abstract
Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase: I. Fleming, et al.; PNAS 96, 1123 (1999) Abstract
 
 
ALX-270-034 Revised 10-Jun-08
ODQ
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SYNONYMS 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-270-034-M010   10 mg 46.00 USD Add To Cart
ALX-270-034-M050   50 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C9H5N3O2
MW: 187.2
CAS NUMBER: 41443-28-1
PURITY: ≥98%
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO (5mg/ml), ethyl acetate or 100% ethanol (1.2mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Solutions may decompose slowly.
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase.
Product Specific Literature References
Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase: C.L. Boulton, et al.; Neuroscience 69, 699 (1995) Abstract
Novel guanylyl cyclase inhibitor, ODQ reveals role of nitric oxide, but not of cyclic GMP in endothelin-1 secretion: F. Brunner, et al.; FEBS Lett. 376, 262 (1995) Abstract
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one: J. Garthwaite, et al.; Mol. Pharmacol. 48, 184 (1995) Abstract
cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase: M.A. Moro, et al.; PNAS 93, 1480 (1996) Abstract
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase: A. Schrammel, et al.; Mol. Pharmacol. 50, 1 (1996) Abstract
The nitric oxide-cyclic GMP pathway and synaptic plasticity in the rat superior cervical ganglion: E. Southam, et al.; Br. J. Pharmacol. 119, 527 (1996) Abstract
A comparative study of the effects of three guanylyl cyclase inhibitors on the L-type Ca2+ and muscarinic K+ currents in frog cardiac myocytes: N. Abi-Gerges, et al.; Br. J. Pharmacol. 121, 1369 (1997) Abstract
Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation: L.J. Olson, et al.; Hypertension 29, 254 (1997) Abstract
Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles: C.G. Sobey & F.M. Faraci; Stroke 28, 837 (1997) Abstract
Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea: T.L. Hwang, et al.; Br. J. Pharmacol 125, 1158 (1998) Abstract
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000) Abstract; Full Text
 
 
ALX-210-878 Revised 03-Apr-08
Polyclonal Antibody to Guanylyl Cyclase (α Subunit),  Soluble
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SYNONYMS anti-sGCα PAb
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-210-878-1   1 Vial 269.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.3mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In 500µl TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 418-436 (E418QARAQDGLKK
RLGKLKAT436) of human sGCα (soluble guanylyl cyclase α subunit).
SPECIFICITY: Recognizes human, mouse and bovine sGCα. Other species not tested.
APPLICATION: Western Blot (1.5µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt when stored at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-157-024.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-786 Revised 25-May-07
Polyclonal Antibody to Guanylyl Cyclase (α1β1), Soluble
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SYNONYMS anti-sGCα1β1 PAb
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-210-786-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From chicken.
CONCENTRATION: 6.8mg/ml
PURITY: Liquid. In 10mM TRIS-HCl, pH 7.5, containing 150mM sodium chloride and 0.02% thimerosal.
PURITY DETAIL: Purified IgY from egg yolk.
IMMUNOGEN: Purified rat lung soluble guanylyl cylase α1β1 (sGCα1β1) (native protein).
SPECIFICITY: Recognizes endogenous rat sGCα1β1. Recognizes human and mouse sGCβ1. Does not cross-react with human and mouse sGCα1.
APPLICATION: Western Blot (works on endogenous (1:500))
Note: Not recommended for the detection of human and mouse sGCα1 subunits, because of the lack of sensitivity.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Specific Literature References
Soluble guanylate cyclase purified from bovine lung contains heme and copper: R. Gerzer, et al.; FEBS Lett. 132, 71 (1981) Abstract
Intracellular cyclic GMP receptor proteins: T.M. Lincoln and T.L. Cornwell; FASEB J. 7, 328 (1993) Abstract; Full Text
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action: H.H. Schmidt, et al.; Biochim. Biophys. Acta 1178, 153 (1993) Abstract
cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts: A. Shimouchi, et al.; Am. J. Physiol. 265, L456 (1993) Abstract
Homologous and heterologous desensitization of a guanylyl cyclase-linked nitric oxide receptor in cultured rat medullary interstitial cells: K. Ujiie, et al.; J. Pharmacol. Exp. Ther. 270, 761 (1994) Abstract
Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA, and protein levels by cAMP-elevating agents: A. Papapetropoulos, et al.; Hypertension 26, 696 (1995) Abstract; Full Text
Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase: J.R. Stone, et al.; BBRC 207, 572 (1995) Abstract
Functional domains of soluble guanylyl cyclase: B. Wedel, et al.; J. Biol. Chem. 270, 24871 (1995) Abstract; Full Text
Human soluble guanylate cyclase: functional expression and revised isoenzyme family: U. Zabel, et al.; Biochem. J. 335, 51 (1998) Abstract
Tissue distribution of the human soluble guanylate cyclases: J. Budworth, et al.; BBRC 263, 6967 (1999) Abstract
Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta: S. Kloss, et al.; J. Biol. Chem. 278, 2377 (2003) Abstract; Full Text
Down-regulation of soluble guanylyl cyclase expression by cyclic AMP is mediated by mRNA-stabilizing protein HuR: S. Kloss, et al.; Mol. Pharmacol. 65, 1440 (2004) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-868 Revised 04-Mar-05
Polyclonal Antibody to Guanylyl Cyclase (α1), Soluble (human)
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SYNONYMS anti-sGCα1 (human) PAb
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-210-868-R200   200 µl 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid (undiluted serum).
IMMUNOGEN: Regulatory domain (aa 1-419) of human sGCα1 (soluble guanylyl cyclase α1 subunit).
SPECIFICITY: Recognizes human sGCα1.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1'000)
Not recommended for immunohistochemistry or functional applications (e.g. inhibition of soluble guanylyl cyclase).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: +4°C
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-867 Revised 30-Sep-08
Polyclonal Antibody to Guanylyl Cyclase (β1), Soluble
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SYNONYMS anti-sGCβ1 PAb
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-867-1   1 Vial 313.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: ~0.5mg/ml
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In 500μl TBS, pH 7.4, containing 0.5mg/ml BSA, 50% glycerol and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 188-207 (E188DFYEDLDRFEENGTQDSR207) of rat sGCβ1 (soluble guanylyl cyclase β1 subunit).
SPECIFICITY: Recognizes human, rat and bovine sGCβ1. Does not cross-react with sGCα1. Detects a band of ~70kDa by Western blot.
APPLICATION: Immunohistochemistry (1:1´000)
Western Blot (1:200-1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-157-023.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-870 Revised 04-Mar-05
Polyclonal Antibody to Guanylyl Cyclase (β1), Soluble (human)
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SYNONYMS anti-sGCβ1 (human) PAb
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-210-870-R200   200 µl 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid (undiluted serum).
IMMUNOGEN: Catalytic domain (aa 404-619) of human sCGβ1 (soluble guanylyl cyclase β1 subunit).
SPECIFICITY: Recognizes human sCGβ1.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1'000-1:5'000).
Not recommended for immunohistochemistry or functional applications (e.g. inhibition of soluble guanylyl cyclase).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: +4°C
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-430-041 Revised 17-Sep-08
Protoporphyrin IX (free acid)
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SYNONYMS 8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-041-M300   300 mg 50.00 USD Add To Cart
ALX-430-041-G001   1 g 90.00 USD Add To Cart
Product Specification
FORMULA: C34H34N4O4
MW: 562.6
CAS NUMBER: 553-12-8
MERCK INDEX: 14: 7897
PURITY: ≥97% (HPLC)
APPEARANCE: Purple to dark brown solid.
SOLUBILITY: Soluble in conc. HCl, DMSO (10mg/ml) or 100% ethanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.
IDENTITY: Identity determined by NMR.

Product Description
Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable.
Product Specific Literature References
H. Verweij & J. Van Steveninck; Photochem. Photobiol. 35, 265 (1982)
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme: M.S. Wolin, et al.; J. Biol. Chem. 257, 13312 (1982) Abstract; Full Text
Porphyrins and chlorophylls as probes for fluoroimmunoassays [letter]: J.L. Hendrix; Clin. Chem. 29, 1003 (1983) Abstract
Photodynamic intramolecular crosslinking of myoglobin: J. van Steveninck and T.M.A.R. Dubbelman; Biochim. Biophys. Acta 791, 98 (1984)
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
 
 
ALX-420-025 Revised 26-Jun-08
YC-1
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SYNONYMS 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-420-025-M001   1 mg 20.00 USD Add To Cart
ALX-420-025-M005   5 mg 65.00 USD Add To Cart
ALX-420-025-M025   25 mg 260.00 USD Add To Cart
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Product Specification
FORMULA: C19H16N2O2
MW: 304.4
CAS NUMBER: 170632-47-0
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale yellow powder.
SOLUBILITY: Soluble in DMSO, methanol or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Nitric oxide (NO) independent, superoxide-sensitive stimulator of soluble guanylyl cyclase (sGC). Inhibits platelet adhesion to collagen. Non-specific phosphodiesterase inhibitor. YC-1 inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth.
Inhibits Na+ channel.
Binds to [3H]BW202W92.
Product Specific Literature References
YC-1, a novel activator of platelet guanylate cyclase: F.N. Ko, et al.; Blood 84, 4226 (1994) Abstract
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase: C.C. Wu, et al.; Br. J. Pharmacol 116, 1973 (1995) Abstract
Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators: A. Mülsch, et al.; Br. J. Pharmacol. 120, 681 (1997) Abstract
Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat: J.W. Wegener, et al.; Br. J. Pharmacol. 122, 1523 (1997) Abstract
Differential effects of isoliquiritigenin and