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Items 13 of 13
ALX-480-007
Revised 16-Feb-05
8-Bromoadenosine-3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
cAMP, 8-Br-, . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-007-M010
10 mg
42.00 USD
ALX-480-007-M050
50 mg
125.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
P . Na
MW:
407.1 . 23.0
CAS NUMBER:
76939-46-3
PURITY:
≥99% (low in fluorescent and colored impurities)
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Has increased metabolic stability and membrane permeability compared with cAMP (Prod. No.
ALX-480-011
).
Further Categories Containing This Product:
PKA Activators
ALX-480-011
Revised 17-Jan-05
Adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
Cyclic AMP . Na
cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-011-M100
100 mg
38.00 USD
ALX-480-011-M250
250 mg
70.00 USD
ALX-480-011-G001
1 g
195.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
6
P . Na
MW:
328.2 . 23.0
CAS NUMBER:
37839-81-9
MERCK INDEX:
14:
2708
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Key regulator of many cellular reactions. Naturally occurring activator of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes:
J. Lomo, et al.; J. Immunol.
154
, 1634 (1995)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-012
Revised 27-Apr-06
Adenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt
SYNONYMS
Rp-cAMPS . TEA
cAMPS . TEA, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-012-M001
1 mg
110.00 USD
ALX-480-012-M005
5 mg
460.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
5
PS . C
6
H
16
N
MW:
345.5 . 101.0
CAS NUMBER:
151837-09-1
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Competitive inhibitor of protein cAMP-dependent protein kinase type I and II (cAMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic as compared to cAMP and thus membrane permeable in many biological systems.
Product Specific Literature References
A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase:
J.D. Rothermel; Biochem. J.
251
, 757 (1988)
Abstract
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates:
E. Butt, et al.; FEBS Lett.
263
, 47 (1990)
Abstract
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases
:
L.Y. Wang, et al.; Science
253
, 1132 (1991)
Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells:
T. Bouschet, et al.; J. Biol. Chem.
278
, 4778 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-013
Revised 10-Feb-05
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . triethylammonium salt
SYNONYMS
Sp-cAMPS . TEA
cAMPS . TEA, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-013-M001
1 mg
75.00 USD
ALX-480-013-M005
5 mg
298.00 USD
ALX-480-013-M010
10 mg
580.00 USD
Product Specification
FORMULA:
C
16
H
27
N
6
O
5
PS
MW:
446.5
CAS NUMBER:
93602-66-5
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Considerably higher resistance against cyclic nucleotide-dependent phosphodiesterases as compared to N
6
,O
2'
-dibutyryladenosine 3',5'-cyclic monophosphate (dibutyryl-cAMP) (Prod. No.
ALX-480-045
) or 8-bromoadenosine-3',5'-cyclic monophosphate (8-Br-cAMP) (Prod. No.
ALX-480-007
). No metabolic side effects. Membrane permeable in many biological systems.
Product Specific Literature References
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Cyclic AMP antagonist Rp-cAMPS inhibits amylase exocytosis from saponin- permeabilized parotid acini:
T. Takuma & T. Ichida; J. Biochem.
110
, 292 (1991)
Abstract
Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: role of Na+/H+ exchange:
T. Sugimoto, et al.; J. Cell Physiol.
152
, 28 (1992)
Abstract
The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone:
H. Kaji, et al.; BBRC
182
, 1356 (1992)
Abstract
Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging:
P.J. Sammak, et al.; J. Cell. Biol.
117
, 57 (1992)
Abstract
Effects of activators and inhibitors of protein kinase A on increases in quantal size at the frog neuromuscular junction:
W. Van Der Kloot & D.D. Branisteanu; Pfluegers Arch.
420
, 336 (1992)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-024
Revised 18-Jun-08
8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS
Rp-8-Br-cAMPS . Na
8-Br-cAMPS . Na, Rp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
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ALX-480-024-MC05
0.5 mg
95.00 USD
ALX-480-024-M001
1 mg
175.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
5
PS . Na
MW:
423.2 . 23.0
CAS NUMBER:
129735-00-8
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
250 mM soluble in water, aqueous solutions, DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS (Prod. No.
ALX-480-012
, and Prod. No.
ALX-480-085
). Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP (Prod. No.
ALX-480-007
).
Product Specific Literature References
Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase:
A.C. Chao, et al.; EMBO J.
13
, 1065 (1994)
Abstract
Novel (Rp)-cAMPS analogs as tool for inhibition of cAMP-kinase in cell culture:
B.T. Gjertsen, et al.; J. Biol. Chem.
270
, 20599 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-025
Revised 26-Jul-06
8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-8-Br-cAMPS . Na
8-Br-cAMPS . Na, Sp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-025-M001
1 mg
140.00 USD
ALX-480-025-M005
5 mg
560.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
5
PS . Na
MW:
423.2 . 23.0
CAS NUMBER:
127634-20-2
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or aqueous buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Metabolically resistant activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). No metabolic side effects as observed with dibutyryl-cAMP (N
6
,O
2'
-Dibutyryladenosine 3',5'-cyclic monophosphate, Prod. No.
ALX-480-045
) or 8-Br-cAMP (8-Bromoadenosine-3',5'-cyclic monophosphate, Prod. No.
ALX-480-007
). Significantly more lipophilic and membrane permeant as compared to Sp-cAMPS (Adenosine 3',5'-cyclic monophosphothioate, Sp isomer, Prod. No.
ALX-480-013
).
Product Specific Literature References
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium:
P. Schaap, et al.; J. Biol. Chem.
268
, 6323 (1993)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Activators
ALX-480-029
Revised 26-Sep-08
8-Chloroadenosine 3',5'-Cyclic Monophosphate . sodium salt
SYNONYMS
8-Cl-cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
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ALX-480-029-M001
1 mg
27.00 USD
ALX-480-029-M005
5 mg
108.00 USD
Product Specification
FORMULA:
C
10
H
11
ClN
5
O
6
P . Na
MW:
363.7 . 23.0
CAS NUMBER:
41941-56-4
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water and aqueous buffers. May produce hazy solutions.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
cAMP analog with high selectivity for cAMP-dependent protein kinase type I. Induces growth inhibition and differentiation in cultured cancer cell lines.
Product Specific Literature References
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth:
S. Ally, et al.; PNAS
85
, 6319 (1988)
Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
ALX-480-030
Revised 07-Jun-06
8-(4-Chlorophenylthio)adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
8-pCPT-cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-030-M010
10 mg
25.00 USD
ALX-480-030-M025
25 mg
50.00 USD
Product Specification
FORMULA:
C
16
H
14
ClN
5
O
6
PS . Na
MW:
470.8 . 23.0
CAS NUMBER:
93882-12-3
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
Product Description
Lipophilic, membrane permeable activator of both cAMP- and cGMP-dependent protein kinases (PKA, PKG). More potent than cAMP and more resistant to phosphodiesterases, with good selectivity for site B of PKA. For specific activation of the cAMP pathway the highly membrane permeable Sp-5,6-DCl-cBIMPS (Prod. No.
ALX-480-047
) is a recommended.
Product Specific Literature References
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor:
R.E. Rydel & L.A. Greene; PNAS
85
, 1257 (1988)
Abstract
Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs:
D. Ogreid, et al.; Eur. J. Biochem.
181
, 19 (1989)
Abstract
8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA):
B.J. Connolly, et al.; Biochem. Pharmacol.
44
, 2303 (1992)
Abstract
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets:
J. Geiger, et al.; PNAS
89
, 1031 (1992)
Abstract
The role of protein kinase A anchoring via the RII alpha regulatory subunit in the murine immune system:
R.V. Schillace, et al.; J. Immunol.
174
, 6847 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
PKG Activators
•
PKA Activators
ALX-480-045
Revised 23-Jan-08
N6,O2’-Dibutyryladenosine 3’,5’-cyclic Monophosphate . sodium salt
SYNONYMS
Dibutyryl-cAMP . Na
cAMP, DB-, . Na
Bucladesine . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-045-M005
5 mg
25.00 USD
ALX-480-045-M025
25 mg
75.00 USD
Product Specification
FORMULA:
C
18
H
23
N
5
O
8
P . Na
MW:
468.4 . 23.0
CAS NUMBER:
16980-89-5
PURITY:
≥97%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water (200mM), DMSO (200mM) or 96% ethanol (25mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions must be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
Product Description
Membrane permeable activator of cAMP-dependent protein kinase (cAMP agonist). The product releases butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects.
Product Specific Literature References
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity:
R.B. Meyer & J.P. Miller; Life Sci.
14
, 1019 (1974)
Abstract
The preparation of acylated derivatives of cyclic nucleotides:
T. Posternak & G. Weimann; Meth. Enzymol.
38
, 399 (1974)
Abstract
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs:
Y.-J. Hei, et al.; Mol. Pharmacol.
39
, 233 (1991)
Abstract
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3',5'- monophosphate:
A. Hinko and M.S. Soloff; Endocrinology
132
, 126 (1993)
Abstract
Transcription of the gene for parathyroid hormone-related peptide from the human is activated through a cAMP-dependent pathway by prostaglandin E1 in HTLV-I-infected T cells:
K. Ikeda, et al.; J. Biol. Chem.
268
, 1174 (1993)
Abstract
;
Full Text
Apoptosis of vascular smooth muscle cells. Protein kinase C and oncoprotein Bcl-2 are involved in regulation of apoptosis in non- transformed rat vascular smooth muscle cells:
D. Leszczynski, et al.; Am. J. Pathol.
145
, 1265 (1994)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-085
Revised 05-Sep-07
Adenosine-3’,5’-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS
Rp-cAMPS . Na
cAMPS . Na, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-085-M001
1 mg
120.00 USD
ALX-480-085-M005
5 mg
490.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
NaO
5
PS
