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ALX-380-102
Revised 03-Apr-08
Borrelidin
SYNONYMS
2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid
Treponemycin
U 78548
C2989
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Cell Cycle Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-102-MC05
0.5 mg
160.00 USD
ALX-380-102-M001
1 mg
240.00 USD
Product Specification
FORMULA:
C
28
H
43
NO
6
MW:
489.7
CAS NUMBER:
7184-60-3
RTECS:
ED8750000
SOURCE/HOST:
Isolated from
Streptomyces
sp.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
IRRITANT.
Product Description
Antibiotic. Inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS). Inhibitor of cyclin-dependent kinase (CDK). Shows angiogenesis inhibiting and antiviral activity.
Product Specific Literature References
Isolation of a cDNA clone for human threonyl-tRNA synthetase: amplification of the structural gene in borrelidin-resistant cell lines:
K.J. Kontis and S.M. Arfin; Mol. Cell. Biol.
9
, 1832 (1989)
Abstract
Genetic analysis of mutations causing borrelidin resistance by overproduction of threonyl-transfer ribonucleic acid synthetase:
J. Frohler, et al.; J. Bacteriol.
143
, 1135 (1980)
Abstract
;
Full Text
Increased levels of threonyl-tRNA synthetase in a borrelidin-resistant Chinese hamster ovary cell line:
J.S. Gantt, et al.; PNAS
78
, 5367 (1981)
Abstract
;
Full Text
Chinese hamster ovary cells resistant to borrelidin overproduce threonyl-tRNA synthetase:
S.C. Gerken and S.M. Arfin; J. Biol. Chem.
259
, 9202 (1984)
Abstract
;
Full Text
Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae:
E. Tsuchiya, et al.; J. Antibiot.
54
, 84 (2001)
Abstract
Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway:
E.L. Eastwood and S.E. Schaus; Bioorg. Med. Chem. Lett.
13
, 2235 (2003)
Abstract
Isolation of vivomycin and borrelidin, two antibiotics with anti-viral activity, from a species of Streptomyces (C2989):
M. Lumb, et al.; Nature
206
, 263 (1965)
Abstract
A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases:
B. Ruan, et al.; J. Biol. Chem.
280
, 571 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
•
tRNA / Related Products
•
Antibiotics - Antiviral / Anti-HIV
•
Antibiotics for Angiogenesis Research
ALX-152-022
Revised 04-Jul-03
BPDEtide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKG Substrates
Ordering Information
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ALX-152-022-M001
1 mg
60.00 USD
ALX-152-022-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH
FORMULA:
C
68
H
115
N
23
O
20
MW:
1574.8
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for cGMP-dependent protein kinase corresponding to a peptide sequence surrounding the phosphorylation site of cGMP-binding cGMP-specific phosphodiesterase.
Product Specific Literature References
Studies of two different intrachain cGMP-binding sites of cGMP- dependent protein kinase:
J.D Corbin & S.O. Døskeland; J. Biol. Chem.
258
, 11391 (1983)
Abstract
;
Full Text
A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases:
J.L. Colbran, et al.; J. Biol. Chem.
267
, 9589 (1992)
Abstract
;
Full Text
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
•
Peptides
ALX-270-313
Revised 03-Mar-05
BPIQ-I
SYNONYMS
8-[(3-Bromophenyl)amino]-3-methyl-3
H
-imidazo[4,5-γ]-quinazoline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
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Product Numbers:
Format:
Size:
Unit Price:
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ALX-270-313-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
16
H
12
BrN
5
MW:
354.2
PURITY:
≥95%
APPEARANCE:
Off white to yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC
50
=25 pM).
Product Specific Literature References
Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor:
G.W. Rewcastle, et al.; J. Med. Chem.
39
, 918 (1996)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
ALX-270-338
Revised 03-Mar-05
BPIQ-II
SYNONYMS
8-[(3-Bromophenyl)amino]-1
H
-imidazo[4,5-γ]-quinazoline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
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ALX-270-338-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
15
H
10
BrN
5
MW:
340.2
PURITY:
≥98%
APPEARANCE:
Pale pink solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC
50
=8pM).
Product Specific Literature References
Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor
:
G.W. Rewcastle, et al.; J. Med. Chem.
39
, 918 (1996)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
ALX-270-207
Revised 24-Jun-05
bpV(bipy)
SYNONYMS
Potassium bisperoxo (bipyridine) oxovanadate (V)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Oxovanadates
Ordering Information
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ALX-270-207-M005
5 mg
65.00 USD
ALX-270-207-M025
25 mg
195.00 USD
Product Specification
FORMULA:
K[VO(O
2
)
2
C
10
H
8
N
2
]
MW:
326.2
PURITY:
≥95%
APPEARANCE:
Yellow to orange powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics:
B.I. Posner, et al.; J. Biol. Chem.
269
, 4596 (1994)
Abstract
;
Full Text
ALX-270-204
Revised 11-Nov-08
bpV(phen)
SYNONYMS
Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Oxovanadates
Ordering Information
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Format:
Size:
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ALX-270-204-M005
5 mg
53.00 USD
ALX-270-204-M025
25 mg
195.00 USD
Product Specification
FORMULA:
K[VO(O
2
)
2
C
12
H
8
N
2
] . 3H
2
O
MW:
350.3 . 54.0
PURITY:
≥98% (
51
V-NMR)
APPEARANCE:
Yellow to orange powder.
SOLUBILITY:
Soluble in water (10mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR (D
2
O) and
51
V-NMR (D
2
O)
Product Description
Potent protein phosphotyrosine phosphatase inhibitor. Also shown to be a potent insulin receptor kinase activator; excellent insulin mimetic
in vitro
and
in vivo
.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics:
B.I. Posner, et al.; J. Biol. Chem.
269
, 4596 (1994)
Abstract
;
Full Text
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling:
A.P. Bevan, et al.; J. Biol. Chem.
270
, 10784 (1995)
Abstract
;
Full Text
In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency:
A.P. Bevan, et al.; Am. J. Physiol.
268
, E60 (1995)
Abstract
Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats:
J.F. Yale, et al.; Diabetes
44
, 1274 (1995)
Abstract
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo:
P.G. Drake, et al.; Endocrinology
137
, 4960 (1996)
Abstract
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ:
C.J. Band & B.I. Posner; J. Biol. Chem.
272
, 138 (1997)
Abstract
;
Full Text
Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1:
K.J. Serio, et al.; J. Immunol.
170
, 2121 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products
ALX-270-205
Revised 12-Sep-08
bpV(pic)
SYNONYMS
Dipotassium bisperoxo (picolinato) oxovanadate (V)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Oxovanadates
Ordering Information
Product Numbers:
Format:
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ALX-270-205-M005
5 mg
75.00 USD
ALX-270-205-M025
25 mg
275.00 USD
Product Specification
FORMULA:
K
2
[VO(O
2
)
2
C
6
H
4
NO
2
] . 2 H
2
O
MW:
331.2 . 36.0
PURITY:
≥95% (
51
V-NMR)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in water (10mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Unstable in solution; reconstitute just prior to use.
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H- and
51
V-NMR.
Product Description
Potent protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics:
B.I. Posner, et al.; J. Biol. Chem.
269
, 4596 (1994)
Abstract
;
Full Text
ALX-270-206
Revised 07-Dec-04
bpV(HOpic)
SYNONYMS
Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Oxovanadates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-206-M005
5 mg
75.00 USD
Product Specification
FORMULA:
K
2
[VO(O
2
)
2
C
6
H
4
NO
3
]
MW:
347.2
PURITY:
≥90%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics:
B.I. Posner, et al.; J. Biol. Chem.
269
, 4596 (1994)
Abstract
;
Full Text
ALX-480-007
Revised 16-Feb-05
8-Bromoadenosine-3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
cAMP, 8-Br-, . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
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ALX-480-007-M010
10 mg
42.00 USD
ALX-480-007-M050
50 mg
125.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
P . Na
MW:
407.1 . 23.0
CAS NUMBER:
76939-46-3
PURITY:
≥99% (low in fluorescent and colored impurities)
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Has increased metabolic stability and membrane permeability compared with cAMP (Prod. No.
ALX-480-011
).
Further Categories Containing This Product:
PKA Activators
ALX-480-024
Revised 18-Jun-08
8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS
Rp-8-Br-cAMPS . Na
8-Br-cAMPS . Na, Rp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
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ALX-480-024-MC05
0.5 mg
95.00 USD
ALX-480-024-M001
1 mg
175.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
5
PS . Na
MW:
423.2 . 23.0
CAS NUMBER:
129735-00-8
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
250 mM soluble in water, aqueous solutions, DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS (Prod. No.
ALX-480-012
, and Prod. No.
ALX-480-085
). Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP (Prod. No.
ALX-480-007
).
Product Specific Literature References
Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase:
A.C. Chao, et al.; EMBO J.
13
, 1065 (1994)
Abstract
Novel (Rp)-cAMPS analogs as tool for inhibition of cAMP-kinase in cell culture:
B.T. Gjertsen, et al.; J. Biol. Chem.
270
, 20599 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-025
Revised 26-Jul-06
8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
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