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Cell Death / Apoptosis / Autophagy
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ALX-270-461 Revised 25-May-07
AS-604850
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SYNONYMS 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-461-M001   1 mg 35.00 USD Add To Cart
ALX-270-461-M005   5 mg 130.00 USD Add To Cart
ALX-270-461-M025   25 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C11H5F2NO4S
MW: 285.2
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in acetonitrile (6mg/ml), DMSO (50mg/ml), methanol (9mg/ml) or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.
MELTINGPOINT: 200-202°C

Product Description
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.
Product Specific Literature References
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med. 11, 936 (2005) Abstract
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells: A. Bilancio, et al.; Blood 107, 642 (2006) Abstract; Full Text
 
 
ALX-270-462 Revised 09-Oct-07
AS-605240
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SYNONYMS 5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-462-M001   1 mg 25.00 USD Add To Cart
ALX-270-462-M005   5 mg 80.00 USD Add To Cart
ALX-270-462-M025   25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C12H7N3O2S
MW: 257.3
PURITY: ≥95% (1H-NMR)
APPEARANCE: Pink to reddish brown solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Packaged under inert gas.

Product Description
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.
Product Specific Literature References
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med. 11, 936 (2005) Abstract
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus: D.F. Barber, et al.; Nat. Med. 11, 933 (2005) Abstract
 
 
ALX-840-602 Revised 24-Nov-05
Positive Control (Cell Lysate) for Antibodies to Asc (human)
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SYNONYMS Positive Control (Cell Lysate) for Antibodies to Pycard (human)
PRODUCT LINE Immunology
PRODUCT CATEGORY Positive Controls (Cell Lysates & Extracts)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-840-602-R100   100 µl 70.00 USD Add To Cart
Product Specification
SOURCE/HOST: Whole cell lysate of HEK 293T cells transfected with an expression plasmid for human Asc (aa 1-195) fused at the C-terminus to a FLAG®-tag.
QUANTITY: 100µl corresponding to 2x105 cells.
FORMULATION: Liquid. In 5x sample buffer (312.5mM TRIS, pH 6.8, containing 10% SDS, 6% glycerol, 0.075% bromophenol blue, 10% β-mercaptoethanol and 10mM DTT).
APPLICATION: Positive control in Western blot for PAb to Asc (human) (AL177) (Prod. No. ALX-210-905). Add 13µl sterile water and 2µl DTT (100mM) to 5µl of cell lysate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related ProductsInflammasome
 
 
ALX-460-001 Revised 13-Mar-06
L-(+)-Ascorbic acid
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SYNONYMS Vitamin C
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-001-G010   10 g 20.00 USD Add To Cart
Product Specification
FORMULA: C6H8O6
MW: 176.1
CAS NUMBER: 50-81-7
MERCK INDEX: 14: 830
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Aqueous solutions are easily oxidized. Stable at pH 5.0-6.0.

 
 
ALX-430-064 Revised 15-Sep-08
Auranofin
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-064-M025   25 mg 35.00 USD Add To Cart
ALX-430-064-M100   100 mg 68.00 USD Add To Cart
Product Specification
FORMULA: C20H34AuO9PS
MW: 678.5
CAS NUMBER: 34031-32-8
MERCK INDEX: 14: 878
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (5mg/ml) or 100% ethanol (4mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20 °C.
HAZARD: TOXIC.

Product Description
Gold derivative in clinical use as an anti-arthritic. Acts as an inhibitor of several leukocyte activation pathways. Inhibits release of inflammatory mediators from human macrophages, pulmonary mast cell and basophils. Also inhibits human neutrophil 5-lipoxygenase. Efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions, potentially referable to its inhibition of mitochondrial thioredoxin reductase.
Product Specific Literature References
Antiarthritic gold compounds effectively quench electronically excited singlet oxygen: E.J. Corey, et al.; Science 236, 68 (1987) Abstract
Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin: M. Columbo, et al.; Biochem. Pharmacol. 39, 285 (1990) Abstract
Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils: W.H. Betts, et al.; Biochem. Pharmacol. 39, 1233 (1990) Abstract
Auranofin inhibits the activation pathways of polymorphonuclear leukocytes at multiple sites: R. Rudkowski, et al.; Biochem. Pharmacol. 41, 1921 (1991) Abstract
Induction of mitochondrial permeability transition by auranofin, a Gold(I)-phosphine derivative: M.P. Rigobello, et al.; Br. J. Pharmacol. 136, 1162 (2002) Abstract
General Literature References
Auranofin: W.F. Kean, et al.; Br. J. Theumatol. 36, 560 (1997), (Review) Abstract; Full Text
 
 
ALX-350-361 Revised 17-Mar-08
Auraptene
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SYNONYMS 7-Geranyloxycoumarin
7-[(2E)-3,7-Dimethylocta-2,6-dienoxy]chromen-2-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-361-M005   5 mg 25.00 USD Add To Cart
ALX-350-361-M025   25 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C19H22O3
MW: 298.4
CAS NUMBER: 495-02-3
SOURCE/HOST: Isolated from citrus fruit.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by NMR.

Product Description
Anti-inflammatory and chemopreventive compound. Exerts tumor preventive effects through apoptosis. Suppresses cell proliferation and lipid peroxidation. Acts as an agonist of PPARs. Induces phase II drug-metabolizing enzymes.
Product Specific Literature References
Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes: T. Tanaka, et al.; Cancer Res. 58, 2550 (1998) Abstract; Full Text
Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice: T. Tanaka, et al.; Carcinogenesis 20, 1471 (1999) Abstract; Full Text
Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells: H. Mori, et al.; Mutat. Res. 480-481, 201 (2001) Abstract
Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins: M. Curini, et al.; Bioorg. Med. Chem. Lett. 14, 2241 (2004) Abstract
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism: K. Kawabata, et al.; FEBS Lett. 580, 5288 (2006) Abstract
Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes: K. Kuroyanagi, et al.; BBRC 366, 219 (2008) Abstract
 
 
ALX-270-201 Revised 18-Sep-07
Aurintricarboxylic acid
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SYNONYMS ATA
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Topoisomerase Inhibitors Other Products
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ALX-270-201-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C22H14O9
MW: 422.4
CAS NUMBER: 4431-00-9
PURITY: ~85%
APPEARANCE: Red solid.
SOLUBILITY: Soluble in aqueous alkali.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Potent inhibitor of DNA topoisomerase II in vitro and protein-nucleic acid interactions. Stimulates the tyrosine phosphorylation of MAP kinases. Inhibits both major calpain isoforms. Potent and selective inhibitor of SARS coronavirus replication. Apoptosis inhibitor.
Product Specific Literature References
Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein--nucleic acid interactions: R.G. Gonzalez, et al.; Biochemistry 19, 4299 (1980) Abstract
Delayed application of aurintricarboxylic acid reduces glutamate- induced cortical neuronal injury: C.A. Csernansky, et al.; J. Neurosci. Res. 38, 101 (1994) Abstract
Inhibition of topoisomerase II by aurintricarboxylic acid: implications for mechanisms of apoptosis: D.R. Catchpoole & B.W. Stewart; Anticancer Res. 14, 853 (1994) Abstract
Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells: Y. Benchokroun, et al.; Biochem. Pharmacol. 49, 305 (1995) Abstract
A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells: N. Okada & S. Koizumi; J. Biol. Chem. 270, 16464 (1995) Abstract; Full Text
Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid: R. He, et al.; BBRC 320, 1199 (2004) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-350-366 Revised 03-Apr-08
Azaspiracid-1
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SYNONYMS AZA-1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-366-C001   1 µg 180.00 USD Add To Cart
Product Specification
FORMULA: C47H71NO12
MW: 842.1
CAS NUMBER: 214899-21-5
SOURCE/HOST: Islolated from marine mussel.
CONCENTRATION:

2μg/ml

PURITY: ≥95%
FORMULATION: Liquid. In methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC. MAY BE TERATOGENIC.

Product Description
Activator of JNK (c-Jun-N-terminal kinase). Cellular growth inhibitor and inducer of cytoskeletal alterations. Activator of caspases. Modulator of intracellular cAMP (cyclic adenosine monophosphate) and calcium levels. Inhibitor of cholesterol biosynthesis in human T lymphocyte cells. Potent teratogen to finfish. Cytotoxic to mammalian cells.
Product Specific Literature References
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland: E. Ito, et al.; Toxicon 38, 917 (2000) Abstract
Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets: Y. Roman, et al.; Cell. Signal. 14, 703 (2002) Abstract
Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos: J.R. Coleman, et al.; Toxicon 45, 881 (2005) Abstract
Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines: M.J. Twiner, et al.; Toxicon 45, 891 (2005) Abstract
Azaspiracids modulate intracellular pH levels in human lymphocytes: A. Alfonso, et al.; BBRC 346, 1091 (2006) Abstract
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies: N. Vilarino, et al.; Chem. Res. Toxicol. 19, 1459 (2006) Abstract
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1: C. Vale, et al.; Cell Physiol. Biochem. 20, 957 (2007) Abstract
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study: C. Vale, et al.; J. Med. Chem. 50, 356 (2007) Abstract
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells: N. Vilarino, et al.; Biochem. Pharmacol. 74, 327 (2007) Abstract
Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid: M.J. Twiner, et al.; Genomics 91, 289 (2008) Abstract
 
 
ALX-260-050 Revised 18-Jan-05
BAADT
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SYNONYMS Granzyme B Substrate (Chromogenic)
Boc-AAD-SBzl
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-050-M001   1 mg 110.00 USD Add To Cart
ALX-260-050-M005   5 mg 410.00 USD Add To Cart
Product Specification
SEQUENCE: Boc-Ala-Ala-Asp-SBzl
FORMULA: C22H31N3O7S
MW: 481.6
PURITY: ≥96% (HPLC).
Single spot (TLC)
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.
Product Description
Chromogenic substrate for granzyme B. λmax is at 405nm.
Product Specific Literature References
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins: S. Odake, et al.; Biochemistry 30, 2217 (1991) Abstract
Further Categories Containing This Product:
Granzyme Substrates
 
 
ALX-620-080 Revised 23-May-06
bADA
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SYNONYMS Dibenzyl-1-[(R)-biotin-6-aminohexanoyl-aziridine]-2,3-(S,S+R,R)-dicarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Proteases Other Products
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ALX-620-080-M002   2 mg 540.00 USD Add To Cart
Product Specifi