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Items 13 of 13
ALX-430-156 Revised 21-Apr-08
6BIO
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SYNONYMS (2’Z,3’E)-6-Bromoindirubin-3’-oxime
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY GSK-3 Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-156-M001   1 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C16H10BrN3O2
MW: 356.2
CAS NUMBER: 667463-62-9
PURITY: ≥98%
APPEARANCE: Dark red solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β).
Product Specific Literature References
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004) Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006) Abstract
Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol. 14, 1207 (2007) Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) Abstract
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Further Categories Containing This Product:
PI(3)K-Akt-mTOR Pathway Other Products
 
 
ALX-340-063 Revised 19-Apr-07
N-Arachidonoyl-L-serine
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SYNONYMS N-[(5Z,8Z,11Z,14Z)-1-Oxo-5,8,11,14-eicosatetraenyl)]-L-serine
ARA-S
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Endocannabinoids
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ALX-340-063-M010   10 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C23H37NO4
MW: 391.5
CAS NUMBER: 187224-29-9
PURITY: ≥98%
APPEARANCE: Waxy solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; sparingly soluble in water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C

Product Description
Endocannabinoid-like brain constituent with similar biological profile like abnormal cannabidiol. Binds weakly to CB1 and CB2 receptors and TRPV1. Produces endothelium-dependent vasodilation. Increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC.
Product Specific Literature References
N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties: G. Milman, et al.; PNAS 103, 2428 (2006) Abstract; Full Text
Further Categories Containing This Product:
MAPK Pathway Activators • Endovanilloids • PI(3)K-Akt-mTOR Pathway Other Products
 
 
ALX-804-852 Revised 28-Apr-08
Monoclonal Antibody to Omentin 1 (Saly-2)
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SYNONYMS anti-Intelectin-1 MAb (Saly-2)
anti-Intestinal Lactoferrin Receptor MAb (Saly-2)
anti-Galactofuranose-binding Lectin MAb (Saly-2)
anti-Endothelial Lectin HL-1 MAb (Saly-2)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Omentin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-852-C100   100 µg 360.00 USD Add To Cart
ALX-804-852B-C100 Biotin 100 µg 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
CLONE: Saly-2
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human omentin 1 (intelectin-1) (aa 17-231).
SPECIFICITY: Recognizes human omentin 1 and rat omentin. Cross-reacts with human omentin 2.
APPLICATION: ELISA (detection)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been recently identified as a novel visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38 kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006) Abstract
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Further Categories Containing This Product:
PI(3)K-Akt-mTOR Pathway Other Products • Monoclonal Antibodies
 
 
ALX-804-850 Revised 16-Aug-07
Monoclonal Antibody to Omentin 1 (human) (Saly-1)
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SYNONYMS anti-Intelectin-1 (human) MAb (Saly-1)
anti-Intestinal Lactoferrin Receptor (human) MAb (Saly-1)
anti-Galactofuranose-binding Lectin (human) MAb (Saly-1)
anti-Endothelial Lectin HL-1 (human) MAb (Saly-1)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Omentin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-850-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Saly-1
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human omentin 1 (intelectin-1) (aa 17-231).
SPECIFICITY: Recognizes human omentin 1.
APPLICATION: ELISA (capture)
Immunohistochemistry (paraffin sections)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been recently identified as a novel visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38 kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006) Abstract
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Further Categories Containing This Product:
PI(3)K-Akt-mTOR Pathway Other Products • Monoclonal Antibodies
 
 
APO-54N-026 Revised 16-Jul-08
Omentin 1 (human) Detection Set [For ELISA Application]
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SYNONYMS Intelectin-1 (human) Detection Set [For ELISA Application]
Intestinal Lactoferrin Receptor (human) Detection Set [For ELISA Application]
Galactofuranose-binding Lectin (human) Detection Set [For ELISA Application]
Endothelial Lectin HL-1 (human) Detection Set [For ELISA Application]
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Omentin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-026-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.4ng/ml (range 0.78 to 50ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human omentin 1 (intelectin-1) from biological fluids (serum and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008) Abstract
General Information

Obesity is strongly associated to the insulin resistance syndrome, which includes type 2 diabetes mellitus, and to an increased risk of atherosclerotic cardiovascular disease [1]. Several studies have reported that visceral obesity (fat located within omental and mesenteric fat depots) is more closely associated with insulin resitance, type 2 diabetes and cardiovascular disease than is peripheral obesity (subcutaneous) [2]. However, the underlying mechanism is still unclear. Recently, a new protein Omentin 1 (also named Omentin, Intelectin-1, Endothelial Lectin HL-1 and Intestinal Lactoferrin Receptor) has been identified as a major visceral (omental) fat secretory adipokine [3]. Omentin 1 is a secreted protein of ~38kDa containing a fibrinogen-related domain that is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant Omentin 1 in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin [3]. Omentin 1 plasma levels measured by western blotting are decreased in obesity [4].

BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8WWA0: Intelectin-1 (human) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Obesity wars: molecular progress confronts an expanding epidemic: J.S. Flier; Cell 116, 337 (2004) Abstract
[2] Abdominal obesity and metabolic syndrome: J.P. Després & I. Lemieux; Nature 444, 881 (2006) Abstract
[3] Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006) Abstract
[4] Omentin plasma levels and gene expression are decreased in obesity: C.M. de Souza Batista, et al.; Diabetes 56, 1655 (2007) Abstract
Omentin-1, a novel adipokine, is decreased in overweight insulin resistant women with the polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 804 (2008) Abstract
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ELISA Sets • PI(3)K-Akt-mTOR Pathway Other Products
 
 
APO-54N-034 Revised 07-Oct-08
Omentin 1 (human) ELISA Kit
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SYNONYMS Intelectin-1 (human) ELISA Kit
Intestinal Lactoferrin Receptor (human) ELISA Kit
Galactofuranose-binding Lectin (human) ELISA Kit
Endothelial Lectin HL-1 (human) ELISA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Omentin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-034-KI01   1 Kit 780.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.4ng/ml (range 0.5 to 32ng/ml).
QUANTITY: For 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human omentin 1 (intelectin-1) from biological fluids (serum, plasma and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008) Abstract; Full Text
General Information

Obesity is strongly associated to the insulin resistance syndrome, which includes type 2 diabetes mellitus, and to an increased risk of atherosclerotic cardiovascular disease [1]. Several studies have reported that visceral obesity (fat located within omental and mesenteric fat depots) is more closely associated with insulin resitance, type 2 diabetes and cardiovascular disease than is peripheral obesity (subcutaneous) [2]. However, the underlying mechanism is still unclear. Recently, a new protein Omentin 1 (also named Omentin, Intelectin-1, Endothelial Lectin HL-1 and Intestinal Lactoferrin Receptor) has been identified as a major visceral (omental) fat secretory adipokine [3]. Omentin 1 is a secreted protein of ~38kDa containing a fibrinogen-related domain that is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant Omentin 1 in vitro does not affect basal, but enhances insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin [3]. Omentin 1 plasma levels measured by western blotting are decreased in obesity [4]. Omentin 1 is decreased in patients with polycystic ovary syndrome (PCOS), a disease associated with insulin resistance and obesity [5]. Glucose and Insulin negatively regulate Omentin-1 levels ex vivo and in vivo [5].

BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8WWA0: Intelectin-1 (human) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Obesity wars: molecular progress confronts an expanding epidemic: J.S. Flier; Cell 116, 337 (2004) Abstract
[2] Abdominal obesity and metabolic syndrome: J.P. Després & I. Lemieux; Nature 444, 881 (2006) Abstract
[3] Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006) Abstract
[4] Omentin plasma levels and gene expression are decreased in obesity: C.M. de Souza Batista, et al.; Diabetes 56, 1655 (2007) Abstract
[5] Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008) Abstract
Omentin-1, a novel adipokine, is decreased in overweight insulin resistant women with the polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008) Abstract
Related Products
Further Categories Containing This Product:
PI(3)K-Akt-mTOR Pathway Other Products • ELISA & EIA Kits
 
 
ALX-522-108 Revised 27-Mar-08
Omentin 1 (human) (recombinant)
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SYNONYMS Intelectin-1 (human) (recombinant)
Intestinal Lactoferrin Receptor (human) (recombinant)
Galactofuranose-binding Lectin (human) (recombinant)
Endothelial Lectin HL-1 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Omentin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-108-C010   10 µg 300.00 USD Add To Cart
Product Specification
MW: ~30-40kDa
SOURCE/HOST: Produced in HEK 293 cells. Human omentin 1 (intelectin-1) (aa 17-313) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
BIOLOGICAL ACTIVITY: Enhances insulin-mediated glucose transport in 3T3-L1 adipocytes.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been recently identified as a novel visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8WWA0: Intelectin-1 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Human homologs of the Xenopus oocyte cortical granule lectin XL35: J.K. Lee, et al.; Glycobiology 11, 65 (2001) Abstract; Full Text
Molecular cloning and functional expression of a human intestinal lactoferrin receptor: Y.A. Suzuki, et al.; Biochemistry 40, 15771 (2001) Abstract
Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall: S. Tsuji, et al.; J. Biol. Chem. 276, 23456 (2001) Abstract; Full Text
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006) Abstract; Full Text
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • PI(3)K-Akt-mTOR Pathway Other Products
 
 
ALX-201-371 Revised 06-Feb-08
Omentin 1 (human) (recombinant) (His)
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SYNONYMS Intelectin-1 (human) (recombinant) (His)
Intestinal Lactoferrin Receptor (human) (recombinant) (His)
Galactofuranose-binding Lectin (human) (recombinant) (His)
Endothelial Lectin HL-1 (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Omentin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-371-C010   10 µg 310.00 USD Add To Cart
ALX-201-371-C050