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ALX-804-851
Revised 03-May-07
Monoclonal Antibody to RGMC (human) (Fery-1)
SYNONYMS
anti-Repulsive Guidance Molecule C (human) MAb (Fery-1)
anti-Hemojuvelin (human) MAb (Fery-1)
anti-Hemochromatosis Type 2 Protein (human) MAb (Fery-1)
anti-HFE2 (human) MAb (Fery-1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-851-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Fery-1
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RGMC (aa 36-398) (Prod. No.
ALX-522-104
).
SPECIFICITY:
Recognizes human RGMC.
APPLICATION:
Flow Cytometry
Immunoprecipitation
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
ALX-522-104
RGMC, Soluble (human) (recombinant)
Further Categories Containing This Product:
Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
•
Polyclonal Antibodies
ALX-804-139
Revised 09-May-07
Monoclonal Antibody to RIP2 (human) (Nick-1)
SYNONYMS
anti-Receptor-interacting Protein 2 (human) MAb (Nick-1)
anti-CARDIAK (human) MAb (Nick-1)
anti-CARD-containing Interleukin-1β Converting Enzyme Associated Kinase (human) MAb (Nick-1)
anti-RICK (human) MAb (Nick-1)
anti-RIPK2 (human) MAb (Nick-1)
anti-Receptor-interacting Serine/Threonine Protein Kinase 2 (human) MAb (Nick-1)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
RIP Kinases
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-139-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Nick-1
ISOTYPE:
Rat IgG2a
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RIP2 (receptor-interacting protein 2) (aa 1-322).
SPECIFICITY:
Recognizes human RIP2.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-604
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Participation of Rip2 in LPS signaling is independent of its kinase activity
:
C. Lu, et al.; J. Biol. Chem.
280
, 16278 (2005)
Abstract
;
Full Text
PIDD mediates NF-kB activation in Response to DNA damage:
Janssens, et al.; Cell
123
, 1079 (2005)
Abstract
Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity:
C. Lu, et al.; J. Biol. Chem.
280
, 16278 (2005)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Nod-complex / Related Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Monoclonal Antibodies
ALX-804-155
Revised 27-Feb-07
Monoclonal Antibody to RIP3 (human) (Rippy-3)
SYNONYMS
anti-Receptor-interacting Protein 3 (human) MAb (Rippy-3)
anti-Receptor-interacting Serine/Threonine Protein Kinase 3 (human) MAb (Rippy-3)
anti-RIP-like Protein Kinase 3 (human) MAb (Rippy-3)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
RIP Kinases
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-155-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Rippy-3
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RIP3 (receptor-interacting protein 3).
SPECIFICITY:
Recognizes human RIP3.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-608
.
Product Images
Please click on thumbnails to enlarge.
General Information
Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNF-R1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3 [1-3]. RIP3 contains an N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNF-R1, mediates TNF-R1 induced apoptosis, and attenuates RIP and TNF-R1 induced NF-κB activation. Overexpression of RIP3 induces apoptosis and NF-κB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues [2,3]. Meanwhile RIP4 has been identified and initially characterized. These recent data suggest that RIP4 is involved in NF-κB and JNK signalling and that caspase-dependent processing of RIP4 may negatively regulate NF-κB-dependent pro-survival or pro-inflammatory signals [4].
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
[1]
Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB
:
P.W. Yu, et al.; Curr. Biol.
9
, 539 (1999)
Abstract
[2]
RIP3, a novel apoptosis-inducing kinase
:
X. Sun, et al.; J. Biol. Chem.
274
, 16871 (1999)
Abstract
;
Full Text
[3]
Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB
:
N.J. Pazdernik, et al.; Mol. Cell. Biol.
19
, 6500 (1999)
Abstract
;
Full Text
[4]
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis
:
E. Meylan, et al.; EMBO Rep.
3
, 1201 (2002)
Abstract
;
Full Text
Related Products
ALX-804-139
Monoclonal Antibody to RIP2 (human) (Nick-1)
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-358
Revised 18-Jul-08
Monoclonal Antibody to Shc (phosphorylated) (pSer36) (6E10)
SYNONYMS
anti-Shc Transforming Protein 1 (phosphorylated) (pSer
36
) MAb (6E10)
anti-SH2 Domain Protein C1 (phosphorylated) (pSer
36
) MAb (6E10)
anti-Shc1 (phosphorylated) (pSer
36
) MAb (6E10)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-358-C100
100 µg
453.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE:
6E10
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION:
Reconstitute with 1ml distilled water (15 min, RT).
IMMUNOGEN:
Synthetic peptide corresponding to aa 33-39 (E
33
LPpSPSA
39
) of shc phosphorylated at Ser
36
.
SPECIFICITY:
Recognizes human, mouse and dog shc phosphorylated at Ser
36
. Does not cross-react with non-phosphorylated shc.
APPLICATION:
Western Blot
(1µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
Immunoprecipitation of shc prior to detection with MAb to Shc (phosphorylated) (pSer36) (6E10) is recommended.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL INCLUDED:
yes
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Shc & Other Ras Adaptors / Related Products
•
Monoclonal Antibodies
ALX-804-357
Revised 30-May-08
Monoclonal Antibody to Shc (phosphorylated) (pTyr239/240) (1E3)
SYNONYMS
anti-Shc Transforming Protein 1 (phosphorylated) (pTyr
239/240
) MAb (1E3)
anti-SH2 Domain Protein C1 (phosphorylated) (pTyr
239/240
) MAb (1E3)
anti-Shc1 (phosphorylated) (pTyr
239/240
) MAb (1E3)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-357-C100
100 µg
453.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE:
1E3
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION:
Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN:
Synthetic peptide corresponding to aa 236-243 (D
236
HQpYpYNDF
243
) of shc phosphorylated at Tyr
239
and Tyr
240
.
SPECIFICITY:
Recognizes human, mouse and dog p46shc, p52shc and p66shc when phosphorylated at Tyr
239/240
. Does not cross-react with non-phosphorylated shc.
APPLICATION:
Immunohistochemistry
Western Blot
(0.5µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
POSITIVE CONTROL:
Included (Prod. No. ALX-840-025).
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Shc & Other Ras Adaptors / Related Products
•
Monoclonal Antibodies
ALX-804-316
Revised 04-Jun-08
Monoclonal Antibody to Src (phosphorylated) (pTyr416) (9A6)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-316-C100
100 µg
453.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE:
9A6
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION:
Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN:
Synthetic peptide corresponding to a portion of src phosphorylated at Tyr
416
.
SPECIFICITY:
Recognizes human, mouse and rat src phosphorylated at Tyr
416
. Does not cross-react with non-phosphorylated form of src nor with unrelated tyrosine-phosphorylated proteins.
APPLICATION:
Flow Cytometry
Immunocytochemistry
Western Blot
(1µg/ml for AP/BCIP/NBT (MTT) detection; 0.1µg/ml for HRPO/ECL detection).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
Product Specific Literature References
Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases
:
B. Viviani, et al.; J. Neurosci.
23
, 8692 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Monoclonal Antibodies
ALX-804-577
Revised 03-May-06
Monoclonal Antibody to STAT1 (human) (phosphorylated) (pSer727) (PSM1)
SYNONYMS
anti-Signal Transducer and Activator of Transcription 1-α/β (human) (phosphorylated) (pSer
727
) MAb (PSM1)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
STATs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-577-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
PSM1
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY:
>95% (SDS-PAGE).
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 721-733 (D
721
NLLPMpSP
EEFDE
733
) of human STAT1 phosphorylated at Ser
727
.
SPECIFICITY:
Recognizes human STAT1. Cross-reactivity with other species has not been tested.
APPLICATION:
Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation
:
J. Kovarik, et al.; Int. J. Mol. Med.
12
, 335 (2003)
Abstract
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Monoclonal Antibodies
ALX-804-180
Revised 05-Jun-07
Monoclonal Antibody to STAT3 (phosphorylated) (pTyr705) (9E12)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
STATs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-180-C100
100 µg
453.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE:
9E12
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION:
Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN:
Synthetic peptide corresponding to a portion of STAT3 phosphorylated at Tyr
705
.
SPECIFICITY:
Recognizes the -AAPpYLKT-motif of activated human, mouse and dog STAT3 phosphorylated at Tyr
705
. Does not cross-react with the non-phosphorylated form of STAT3 nor with unrelated tyrosine-phosphorylated proteins.
APPLICATION:
Immunocytochemistry
Immunohistochemistry
Immunoprecipitation
Western Blot
(0.1µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Included (Prod. No. ALX-840-025).
General Information
The STAT proteins serve as both cytoplasmic
s
ignal
t
ransducers and nuclear
a
ctivators of
t
ranscription. STAT3 is activated by tyrosine phosphorylation at residue Y705 in cells treated with interleukin-6 or EGF. Activated STAT3 can bind to DNA either as homodimer or as heterodimer with STAT1.
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Monoclonal Antibodies
ALX-804-272
Revised 13-Jun-08
Monoclonal Antibody to STAT6 (phosphorylated) (pTyr641) (16E12)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
STATs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-272-C100
100 µg
453.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
16E12
ISOTYPE:
Mouse IgG1
PURITY DETAIL:
Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION:
Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION:
Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN:
Synthetic peptide corresponding to a portion of human STAT6 phophorylated at Tyr
641
.
SPECIFICITY:
Recognizes the GRGpYVPA motif of human, mouse (weak) and rat (weak) activated STAT6 phosphorylated at Tyr
641
. Does not cross-react with the non-phosphorylated form of STAT6 nor with unrelated tyrosine-phosphorylated proteins.
APPLICATION:
Immunohistochemistry
Western Blot
(1HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING:
After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Included (Prod. No. ALX-840-018).
Product Specific Literature References
IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-Fos:
A. Lorentz, et al.; J. Immunol.
174
, 6751 (2005)
Abstract
;
Full Text
General Information
STATs (signal transducing activators of transcription) are mediators involved in cytokine signalling. In response to a specific cytokine signal, STATs move to the nucleus and induce transcription. STAT6 is activated primarily by IL-4 and IL-13. Upon activation, STAT6 is phosphorylated at tyrosine 641 by Janus Kinases (JAKs). Phosphorylated STAT6 forms head-to-tail heterodimers and translocates to the nucleus where it participates in transcriptional control.
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Monoclonal Antibodies
•
Autophagy Other Products
ALX-804-480
Revised 09-May-07
Monoclonal Antibody to Syk (SYK-01)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Kinases in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-480-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE:
SYK-01
ISOTYPE:
Mouse IgG1
CO
