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Pyrethroids
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ALX-430-031 Revised 11-Jan-07
Allethrin
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SYNONYMS (R,S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,S)-cis,trans-chrysanthemate
Allylcinerin
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-031-M010   10 mg 30.00 USD Add To Cart
ALX-430-031-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 584-79-2
MERCK INDEX: 14: 260
RTECS: GZ1925000
PURITY: ≥95% (HPLC)
APPEARANCE: Clear or whitish film.
SOLUBILITY: Soluble in DMSO or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalis.
HAZARD: HARMFUL.

Product Description
Type I pyrethroid, useful as a very weakly active "negative" control for inhibition of calcineurin (protein phosphatase 2B) by type II pyrethroids.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-430-032 Revised 24-Feb-05
Bioallethrin
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SYNONYMS D-trans-Allethrin
(S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,3R)-2,2-dimethyl-3-(2-methyl-prop-1-enyl)cyclopropancarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-032-M025   25 mg 90.00 USD Add To Cart
ALX-430-032-M100   100 mg 270.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 22431-63-6
PURITY: ≥97%
SOLUBILITY: Soluble in hot water, diluted acids or alkaline solutions; hardly soluble in cold water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalies.
HAZARD: HARMFUL.

Product Description
Although bioallethrin is a type I pyrethroid, its effects on calcineurin (protein phosphatase 2B) resembles those of type II pyrethrins. Unlike most type I pyrethrins, which are very weak, bioallethrin is a potent calcineurin inhibitor.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-430-044 Revised 29-Feb-08
Cypermethrin
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SYNONYMS Alphamethrine
(R,S)-α-Cyano-(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
Pestanal
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-044-M010   10 mg 40.00 USD Add To Cart
ALX-430-044-M025   25 mg 80.00 USD Add To Cart
ALX-430-044-M100   100 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C22H19Cl2NO3
MW: 416.3
CAS NUMBER: 52315-07-8
MERCK INDEX: 14: 2767
RTECS: GZ1250000
PURITY: ≥95% (HPLC)
FORMULATION: Clear or whitish film adhered to inside of vial.
SOLUBILITY: Soluble in methanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. TOXIC.
IDENTITY: Determined by 1H-NMR.

Product Description
Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B).
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Inhibition of phosphatase 2B prevents expression of hippocampal long- term potentiation: J.H. Wang & A. Stelzer; Neuroreport 5, 2377 (1994) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-430-045 Revised 24-Feb-05
Deltamethrin
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SYNONYMS (S)-α-Cyano-(3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-045-M010   10 mg 45.00 USD Add To Cart
ALX-430-045-M025   25 mg 96.00 USD Add To Cart
Product Specification
FORMULA: C22H19Br2NO3
MW: 505.2
CAS NUMBER: 52918-63-5
MERCK INDEX: 14: 2883
PURITY: ≥98%
APPEARANCE: Whitish film.
SOLUBILITY: Soluble in DMSO, ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Type II pyrethrin, potent inhibitor of calcineurin (protein phosphatase 2B). Causes an increase in neurotransmitter release at synapses and also increases intrasynaptosomal Ca2+ levels.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Activation of phosphoinositide/protein kinase C pathway in rat brain tissue by pyrethroids: E. Enan & F. Matsumura; Biochem. Pharmacol. 45, 703 (1993) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-550-267 Revised 05-Feb-07
Fenvalerate
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SYNONYMS α-Cyano-3-phenoxybenzyl α-(4-chlorophenyl)isovalerate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-267-M025   25 mg 43.00 USD Add To Cart
ALX-550-267-M100   100 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C25H22ClNO3
MW: 419.9
CAS NUMBER: 51630-58-1
MERCK INDEX: 14: 4010
RTECS: CY1576350
PURITY: ≥98% (mixture of diastereoisomers)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B). May also have varied effects on ion channels. Induces depolarization by keeping Na+ channels in an open state.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Effect of fenvalerate, a pyrethroid insecticide on membrane fluidity: S.N. Sarkar, et al.; Biochim. Biophys. Acta 1147, 137 (1993) Abstract
Immobilization of sodium channel gating charge in crayfish giant axons by the insecticide fenvalerate: V.L. Salgado & T. Narahashi; Mol. Pharmacol. 43, 626 (1993) Abstract
Further Categories Containing This Product:
Pyrethroids • Na+ Channels
 
 
ALX-430-046 Revised 06-Dec-06
Permethrin
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SYNONYMS 3-Phenoxybenzyl (1R,S)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclo-propanecarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Serine / Threonine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-046-M010   10 mg 18.00 USD Add To Cart
Product Specification
FORMULA: C21H20Cl2O3
MW: 391.3
CAS NUMBER: 52645-53-1
MERCK INDEX: 14: 7180
RTECS: GZ1255000
PURITY: Mixture of cis and trans isomers
APPEARANCE: Clear or whitish film adhered to inside of vial.
SOLUBILITY: Soluble in DMSO, 100% ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Type I pyrethroid. Structurally similar to the protein phosphatase 2B (calcineurin) inhibitors cypermethrin and deltamethrin, but only weakly active or inactive, depending on assay conditions. May be used as a negative control for cypermethrin (Prod. No. ALX-430-044) and deltamethrin (Prod. No. ALX-430-045).
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-430-047 Revised 24-Feb-05
Resmethrin
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SYNONYMS 5-Benzyl-3-furylmethyl(1R,S)-cis,trans-chrysanthemate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Serine / Threonine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-047-M010   10 mg 25.00 USD Add To Cart
ALX-430-047-M025   25 mg 50.00 USD Add To Cart
ALX-430-047-M100   100 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C22H26O3
MW: 338.4
CAS NUMBER: 10453-86-8
PURITY: ≥90%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Type I pyrethroid. Weakly active negative control for studies of calcineurin inhibition by the more active type II pyrethroids.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
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