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G-Protein Coupled Receptors & Ligands / Related Products
You are here: Product Lines > Signal Transduction > Receptors > G-Protein Coupled Receptors & Ligands / Related Products
 
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ALX-152-012 Revised 14-Dec-04
Big Endothelin-1 (22-38) (human)
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SYNONYMS Big ET-1 (22-38) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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ALX-152-012-MC05   0.5 mg 100.00 USD Add To Cart
ALX-152-012-M001   1 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
FORMULA: C80H125N23O25
MW: 1809.0
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-004 Revised 12-May-03
Big Endothelin-2 (1-37) (human)
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SYNONYMS Big ET-2 (1-37) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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ALX-152-004-PC01   0.1 mg* 110.00 USD Add To Cart
ALX-152-004-PC05   0.5 mg* 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Gln-Thr-Ala-Pro-Tyr-Gly-Leu-Gly-Asn-Pro-Pro-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C188H269N45O56S4
MW: 4183.8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization: S. Ohkubo, et al.; FEBS Lett. 274, 136 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
Further Categories Containing This Product:
Peptides • NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-550-375 Revised 28-Jan-05
BRL 15572 . hydrochloride
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SYNONYMS 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-375-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C25H27ClN2O . HCl
MW: 406.9 . 36.5
CAS NUMBER: 193611-72-2
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective human 5-HT1D antagonist.
Product Specific Literature References
Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig: J.J. Hagan, et al.; Eur. J. Pharmacol. 331, 169 (1997) Abstract
SB-216641 and BRL-15572-compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors: G.W. Price, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 356, 312 (1997) Abstract
Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors: E. Schlicker, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 356, 321 (1997) Abstract
5-HT1-like receptors: a time to bid goodbye: P.R. Saxena, et al.; TIPS 19, 311 (1998), (Review) Abstract
The canine external carotid vasoconstrictor 5-HT1 receptor: blockade by 5-HT1B (SB224289), but not by 5-HT1D (BRL15572) receptor antagonists: P. De Vries, et al.; Eur. J. Pharmacol. 362, 69 (1998) Abstract
5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression: R. Verheggen, et al.; Br. J. Pharmacol. 124, 1345 (1998) Abstract
Pharmacological diversity between native human 5-HT1B and 5-HT1D receptors sited on different neurons and involved in different functions: M. Marcoli, et al.; Br. J. Pharmacol. 126, 607 (1999) Abstract
 
 
ALX-550-161 Revised 14-Dec-04
N-(4-Bromobenzyl)-5-methoxytryptamine . oxalate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-161-M001   1 mg 20.00 USD Add To Cart
ALX-550-161-M005   5 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C18H19N2OBr . C2H2O4
MW: 359.3 . 90.0
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Very potent and selective ligand for 5-HT2A receptors.
Product Specific Literature References
Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines: R.A. Glennon, et al.; J. Med. Chem. 37, 1929 (1994) Abstract
 
 
ALX-550-041 Revised 10-Sep-07
(+)-Bromocriptine . methanesulfonate
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SYNONYMS 2-Bromo-α-ergocryptine . methanesulfonate
(+)-2-Bromo-12'-hydroxy-2'-(1-methyletyhl)-5'-(2-methylpropyl)-ergotaman-3',6'-18-trionemethanesulfonate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Dopaminergics & Dopamine Receptors / Related Products
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ALX-550-041-M010   10 mg 25.00 USD Add To Cart
ALX-550-041-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C32H40BrN5O5 . CH3SO3H
MW: 654.6 . 96.1
CAS NUMBER: 22260-51-1
MERCK INDEX: 14: 1416
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Agonist at D2 and D3 dopamine receptors.
Product Specific Literature References
Bromocriptine produces decreases in cocaine self-administration in the rat: C.B. Hubner & G.F. Koob; Neuropsychopharmacology 3, 101 (1990) Abstract
 
 
ALX-550-155 Revised 28-Jan-05
(RS)-4-Bromo-homo-ibotenic acid
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SYNONYMS Br-HIBO
(RS)-α-Amino-4-bromo-3-hydroxy-5-isoazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-155-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C6H7N2O4Br
MW: 251.0
CAS NUMBER: 71366-32-0
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent AMPA receptor agonist. Selective but relatively non-potent group I mGluR agonist.
Product Specific Literature References
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid: J.J. Hansen, et al.; J. Med. Chem. 32, 2254 (1989) Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS 11, 25 (1990) Abstract
4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane- 1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices: D.S. Chung, et al.; J. Neurochem. 63, 133 (1994) Abstract
Effects of bromohomoibotenate on metabotropic glutamate receptors: C. Thomsen, et al.; Neuroreport 5, 2417 (1994) Abstract
4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis: D.S. Chung, et al.; J. Pharmacol. Exp. Ther. 283, 742 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-550-315 Revised 22-Aug-02
2-Bromomelatonin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-315-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H16N2O2Br
MW: 312.2
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Melatonin agonist with high affinity for chicken brain membrane melatonin receptors.
Product Specific Literature References
2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist: E. Duranti, et al.; Life Sci. 51, 479 (1992) Abstract
2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity: G. Spadoni, et al.; J. Med. Chem. 36, 4069 (1993) Abstract
 
 
ALX-550-524 Revised 19-Jul-07
1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione
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SYNONYMS Compound 25
CB1 Cannabinoid Receptor Inverse Agonist
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-550-524-M005   5 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C21H14Br2N2O2
MW: 486.2
CAS NUMBER: 878533-35-8
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at -20°C.

Product Description
Potent and selective inverse agonist of CB1 receptor (Ki=243nM and EC50=195nM).
Product Specific Literature References
Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists: G.G. Muccioli, et al.; J. Med. Chem. 49, 872 (2006) Abstract
 
 
ALX-550-144 Revised 09-Dec-04
Buspirone . hydrochloride
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SYNONYMS 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-144-G001   1 g 48.00 USD Add To Cart
Product Specification
FORMULA: C21H31N5O2 . HCl
MW: 385.5 . 36.5
CAS NUMBER: 33386-08-2
MERCK INDEX: 14: 1504
PURITY: ≥96%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
5-HT1A serotonin receptor agonist.
Product Specific Literature References
The discovery and development of buspirone: a new approach to the treatment of anxiety: J.S. New; Med. Res. Rev. 10, 283 (1990), (Review) Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products • Benzodiazepines / Related Products • Adrenergics & Adrenergic Receptors / Related Products
 
 
ALX-550-197 Revised 03-Mar-05
(S)-3C4H-PG
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SYNONYMS (S)-3-Carboxy-4-hydroxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-197-M001   1 mg 50.00 USD Add To Cart
ALX-550-197-M005   5 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C9H9NO5
MW: 211.2
CAS NUMBER: 55136-48-6
PURITY: ≥97%