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ALX-165-025
Revised 21-Dec-05
PACAP (1-38) (human, sheep, rat)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenylyl Cyclase Activators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-165-025-MC05
0.5 mg
260.00 USD
ALX-165-025-M001
1 mg
380.00 USD
Product Specification
SEQUENCE:
H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH
2
FORMULA:
C
203
H
331
N
63
O
53
S
MW:
4534.3
PURITY:
≥95%
APPEARANCE:
Lyophilized
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Adenylate cyclase activator. More potent than vasoactive intestinal peptide (VIP).
Product Specific Literature References
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells:
A. Miyata, et al.; BBRC
164
, 567 (1989)
Abstract
The novel VIP-like hypothalamic polypeptide PACAP interacts with high affinity receptors in the human neuroblastoma cell line NB-OK:
A. Cauvin, et al.; Peptides
11
, 773 (1990)
Abstract
A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs:
C. Kimura, et al.; BBRC
166
, 81 (1990)
Abstract
Molecular cloning and characterization of cDNA for the precursor of rat pituitary adenylate cyclase activating polypeptide (PACAP):
K. Ogi, et al.; BBRC
173
, 1271 (1990)
Abstract
Pituitary adenylate cyclase activating peptide (PACAP) in guinea-pig lung: distribution and dilatory effects:
L.O. Cardell, et al.; Regul. Pept.
36
, 379 (1991), (Review)
Abstract
A. Arimura; Regul. Pept.
37
, 287 (1992), (Review)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-026
Revised 15-Aug-08
PACAP (6-38) (human, sheep, rat)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenylyl Cyclase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-165-026-MC05
0.5 mg
210.00 USD
ALX-165-026-M001
1 mg
390.00 USD
Product Specification
SEQUENCE:
H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH
2
FORMULA:
C
182
H
300
N
56
O
45
S
MW:
4024.8
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent and selective inhibitor of PACAP (1-27) (human, sheep, rat) (Prod. No.
ALX-165-003
) stimulated pituitary adenylate cyclase.
Product Specific Literature References
Structural requirements for the occupancy of pituitary adenylate- cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist:
P. Robberecht, et al.; Eur. J. Biochem.
207
, 239 (1992)
Abstract
Receptor occupancy and adenylate cyclase activation in AR 4-2J rat pancreatic acinar cell membranes by analogs of pituitary adenylate cyclase-activating peptides amino-terminally shortened or modified at position 1, 2, 3, 20, or 21:
P. Robberecht, et al.; Mol. Pharmacol.
42
, 347 (1992)
Abstract
Further Categories Containing This Product:
Peptides
ALX-166-002
Revised 07-Feb-05
R-R-SRC-Peptide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-166-002-M001
1 mg
80.00 USD
ALX-166-002-M005
5 mg
350.00 USD
Product Specification
SEQUENCE:
H-Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly-OH
FORMULA:
C
64
H
106
N
22
O
21
MW:
1519.7
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein tyrosine kinases. The peptide sequence corresponds to the tyrosine phosphorylation site in the
Rous sarcoma
virus (RSV)-encoded transforming protein pp60
v-src
.
In vitro
tyrosine phosphorylation of the peptide is stimulated by epidermal growth factor (EGF).
Product Specific Literature References
Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line:
J.E. Casnellie, et al.; PNAS
79
, 282 (1982)
Abstract
Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function:
L.J. Pike, et al.; J. Biol. Chem.
261
, 3782 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-167-006
Revised 25-Feb-03
S6 Phosphate Acceptor Peptide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-167-006-M001
1 mg
40.00 USD
ALX-167-006-M005
5 mg
160.00 USD
Product Specification
SEQUENCE:
H-Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala-OH
FORMULA:
C
39
H
75
N
17
O
11
MW:
958.1
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for cAMP-dependent protein kinase (PKA) and for protein kinase C (PKC).
Product Specific Literature References
Phosphorylation of ribosomal protein S6 and a peptide analogue of S6 by a protease-activated kinase isolated from rat liver:
B. Gabrielli, et al.; FEBS Lett.
175
, 219 (1984)
Abstract
Distinct structural requirements of Ca2+/phospholipid-dependent protein kinase (protein kinase C) and cAMP-dependent protein kinase as evidenced by synthetic peptide substrates:
S. Ferrari, et al.; FEBS Lett.
184
, 72 (1985)
Abstract
Fibroblast growth factor treatment of Swiss 3T3 cells activates a subunit S6 kinase that phosphorylates a synthetic peptide substrate:
S.L. Pelech, et al.; PNAS
83
, 5968 (1986)
Abstract
Further Categories Containing This Product:
Peptides
•
PKC Substrates
ALX-167-007
Revised 12-Jun-03
Syntide 2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
CAM Kinase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-167-007-M001
1 mg
70.00 USD
ALX-167-007-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OH
FORMULA:
C
68
H
122
N
20
O
18
MW:
1507.8
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for Ca
2+
/calmodulin-dependent protein kinase II and protein kinase C (PKC). The peptide sequence is homologous to the phosphorylation site 2 in glycogen synthase.
Product Specific Literature References
Calcium . calmodulin-dependent protein kinase II and calcium . phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide:
Y. Hashimoto & T.R. Soderling; Arch. Biochem. Biophys.
252
, 418 (1987)
Abstract
Further Categories Containing This Product:
Peptides
•
PKC Substrates
ALX-168-003
Revised 02-Apr-03
Tyrosine Phosphorylation Site Inhibitor
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-003-M001
1 mg
60.00 USD
ALX-168-003-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Gly-Ser-Phe-Leu-Val-Arg-Glu-Ser-OH
FORMULA:
C
39
H
63
N
11
O
13
MW:
894.0
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of EGF receptor binding to SH2. The peptide corresponds to a highly conserved amino acid sequence common in a variety of SH2-containing proteins. It is the minimum essential sequence for recognition of the phosphotyrosine site.
Product Specific Literature References
Highly conserved eight amino acid sequence in SH2 is important for recognition of phosphotyrosine site:
M. Hidaka, et al.; BBRC
180
, 1490 (1991)
Abstract
Further Categories Containing This Product:
Peptides
•
SH2 & SH3 Domains
ALX-168-004
Revised 02-Apr-03
H-Tyr-Ile-Tyr-Gly-Ser-Phe-Lys-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-004-M001
1 mg
90.00 USD
ALX-168-004-M005
5 mg
360.00 USD
Product Specification
FORMULA:
C
44
H
60
N
8
O
11
MW:
877.0
PURITY:
97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Peptide selected from a random combinatorial peptide library. Specific and efficient substrate for the
Src
-family protein tyrosine kinase than cdc2 (6-20).
Product Specific Literature References
Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases:
K.S. Lam, et al.; Int. J. Peptide Protein Res.
45
, 587 (1995)
Abstract
Further Categories Containing This Product:
Peptides
ALX-168-005
Revised 04-Mar-05
Tyrosine Hydroxylase (24-33) (rat)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
MAPK Pathway Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-005-M001
1 mg
85.00 USD
Product Specification
SEQUENCE:
H-Lys-Gln-Ala-Glu-Ala-Val-Thr-Ser-Pro-Arg-OH
FORMULA:
C
45
H
79
N
15
O
16
MW:
1086.2
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Represents consensus site for MAP kinase (MAPK/ERK) phosphorylation. Includes the Ser
31
phosphorylation site.
Product Specific Literature References
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ:
J.W. Haycock, et al.; PNAS
89
, 2365 (1992)
Abstract
Further Categories Containing This Product:
Peptides
ALX-168-009/1
Revised 07-Nov-08
L-TAT Control Peptide (for Prod. No. ALX-159-600)
SYNONYMS
JNK Inhibitor 1 (L-stereoisomer) Control Peptide (for Prod. No.
ALX-159-600
)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-009/1-R050
50 µl
40.00 USD
Product Specification
SEQUENCE:
GRKKRRQRRR-amide
FORMULA:
C
55
H
109
N
31
O
12
MW:
1396.6
CONCENTRATION:
1mM
PURITY:
≥95% (HPLC)
FORMULATION:
Liquid. Sterile solution in PBS.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. Keep on ice at all times.
Product Description
Control peptide for L-JNKI. For more details see L-JNKI1 (Prod.No.
ALX-159-600
).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death:
C. Bonny, et al.; Diabetes
50
, 77 (2001)
Abstract
;
Full Text
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation:
R. Reinehr, et al.; FASEB J.
17
, 731 (2003)
Abstract
;
Full Text
Related Products
ALX-159-600
JNK Inhibitor 1 (L-stereoisomer)
ALX-152-027
Bim
L
(147-164) (human) (cell permeable)
ALX-152-028
Bax (58-75) (human) (cell permeable)
ALX-152-029
Bok (66-83) (human) (cell permeable)
ALX-163-011
NBD Peptide / NF-κB Blocker (cell permeable)
Further Categories Containing This Product:
Peptides
ALX-168-009F
Revised 28-Jul-08
L-TAT Control Peptide (for Prod. No. ALX-159-600) (FITC)
SYNONYMS
JNK Inhibitor 1 (L-stereoisomer) Control Peptide (for Prod. No.
ALX-159-600
) (FITC)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-009F-R050
FITC
50 µl
110.00 USD
Product Specification
SEQUENCE:
FITC-β-A-RKKRRQRRRA-amide
FORMULA:
C
80
H
128
N
34
O
17
S
MW:
1870.2
CONCENTRATION:
1mM
PURITY:
≥90% (HPLC)
FORMULATION:
Liquid. In sterile PBS.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. Keep on ice at all times.
Product Description
Control peptide for L-JNKI. For more details see L-JNKI1 (Prod.No.
ALX-159-600
).
Product Specific Literature References
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death:
C. Bonny, et al.; Diabetes
50
, 77 (2001)
Abstract
;
Full Text
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation:
R. Reinehr, et al.; FASEB J.
17
, 731 (2003)
Abstract
;
Full Text
Related Products
ALX-159-600
JNK Inhibitor 1 (L-stereoisomer)
ALX-152-028
Bax (58-75) (human) (cell permeable)
ALX-163-011
NBD Peptide / NF-κB Blocker (cell permeable)
ALX-152-027
Bim
L
(147-164) (human) (cell permeable)
ALX-152-029
Bok (66-83) (human) (cell permeable)
Further Categories Containing This Product:
Peptides
ALX-168-010
Revised 14-Aug-06
D-TAT Control Peptide (for Prod. No. ALX-159-601)
SYNONYMS
JNK Inhibitor 1 (D-stereoisomer) Control Peptide (for Prod. No.
ALX-159-601
)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-010-R025
25 µl
95.00 USD
ALX-168-010F-R025
FITC
25 µl
145.00 USD
Product Specification
SEQUENCE:
Unconjugated peptide
: rrrqrrkkr-amide
FITC-conjugated peptide
: FITC-β-a-rkkrrqrrra-amide
FORMULA:
Unconjugated peptide:
C
53
H
107
N
31
O
10
FITC-conjugated peptide:
C
80
H
128
N
34
O
17
S
